D Cadavid

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Role of interleukin 10 during persistent infection with the relapsing fever Spirochete Borrelia turicatae
    Harald Gelderblom
    Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Clinical Studies Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Am J Pathol 170:251-62. 2007
  2. doi New acute and chronic black holes in patients with multiple sclerosis randomised to interferon beta-1b or glatiramer acetate
    D Cadavid
    Department of Neurology and Neuroscience, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    J Neurol Neurosurg Psychiatry 80:1337-43. 2009
  3. doi Impact of inflammation on brain volume in multiple sclerosis
    Jojy Cheriyan
    Departments of Neurology and Neuroscience, New JerseyMedical School, University of Medicine and Dentistry of New Jersey, Newark
    Arch Neurol 69:82-8. 2012
  4. ncbi Residual brain infection in relapsing-fever borreliosis
    Diego Cadavid
    Department of Neurology and Neuroscience and Center for the Study of Emerging Pathogens, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07103, USA
    J Infect Dis 193:1451-8. 2006
  5. ncbi Coinfection with Borrelia turicatae serotype 2 prevents the severe vestibular dysfunction and earlier mortality caused by serotype 1
    Diego Cadavid
    Department of Neurology and Neuroscience and the Center for the Study of Emerging Pathogens, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Infect Dis 195:1686-93. 2007
  6. ncbi Cardiac involvement in non-human primates infected with the Lyme disease spirochete Borrelia burgdorferi
    Diego Cadavid
    Department of Neurology and Neuroscience, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Lab Invest 84:1439-50. 2004
  7. doi Efficacy of treatment of MS with IFNbeta-1b or glatiramer acetate by monthly brain MRI in the BECOME study
    D Cadavid
    Department of Neurology and Neuroscience, UMDNJ New Jersey Medical School, Newark, USA
    Neurology 72:1976-83. 2009
  8. pmc Infection and inflammation in skeletal muscle from nonhuman primates infected with different genospecies of the Lyme disease spirochete Borrelia burgdorferi
    Diego Cadavid
    Department of Neuroscience, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Infect Immun 71:7087-98. 2003
  9. doi Clinical consequences of MRI activity in treated multiple sclerosis
    Diego Cadavid
    Department of Neurology and Neuroscience, University of Medicine and Dentistry of New Jersey New Jersey Medical School, USA
    Mult Scler 17:1113-21. 2011
  10. ncbi The mammalian host response to borrelia infection
    Diego Cadavid
    Department of Neurology and Neuroscience and Center for the Study of Emerging Pathogens, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Wien Klin Wochenschr 118:653-8. 2006

Research Grants

Collaborators

Detail Information

Publications29

  1. pmc Role of interleukin 10 during persistent infection with the relapsing fever Spirochete Borrelia turicatae
    Harald Gelderblom
    Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Clinical Studies Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Am J Pathol 170:251-62. 2007
    ..IL-10 injected systemically reduced disease and spirochetemia. The results suggest IL-10 plays a protective role as a down-regulator of inflammation and pathogen load during infection with relapsing fever spirochetes...
  2. doi New acute and chronic black holes in patients with multiple sclerosis randomised to interferon beta-1b or glatiramer acetate
    D Cadavid
    Department of Neurology and Neuroscience, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    J Neurol Neurosurg Psychiatry 80:1337-43. 2009
    ..There is some evidence that glatiramer acetate (GA) may decrease the conversion of new brain lesions to BH...
  3. doi Impact of inflammation on brain volume in multiple sclerosis
    Jojy Cheriyan
    Departments of Neurology and Neuroscience, New JerseyMedical School, University of Medicine and Dentistry of New Jersey, Newark
    Arch Neurol 69:82-8. 2012
    ..To study changes in brain volume measured monthly in patients treated for relapsing multiple sclerosis due to loss of tissue and the appearance of inflammation...
  4. ncbi Residual brain infection in relapsing-fever borreliosis
    Diego Cadavid
    Department of Neurology and Neuroscience and Center for the Study of Emerging Pathogens, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07103, USA
    J Infect Dis 193:1451-8. 2006
    ..Less understood is the persistence of RF borreliae in the brain after they are cleared from the blood, referred to as residual brain infection (RBI). Our goal was to investigate the phenomenon of RBI in RF...
  5. ncbi Coinfection with Borrelia turicatae serotype 2 prevents the severe vestibular dysfunction and earlier mortality caused by serotype 1
    Diego Cadavid
    Department of Neurology and Neuroscience and the Center for the Study of Emerging Pathogens, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Infect Dis 195:1686-93. 2007
    ..To investigate this, we compared the outcome of infection with isogenic serotypes 1 (Bt1) or 2 (Bt2) of the RF agent B. turicatae alone or in combination...
  6. ncbi Cardiac involvement in non-human primates infected with the Lyme disease spirochete Borrelia burgdorferi
    Diego Cadavid
    Department of Neurology and Neuroscience, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Lab Invest 84:1439-50. 2004
    ..We conclude that carditis in NHPs infected with B. burgdorferi is frequent and can persist for years but is mild unless they are immunosupressed...
  7. doi Efficacy of treatment of MS with IFNbeta-1b or glatiramer acetate by monthly brain MRI in the BECOME study
    D Cadavid
    Department of Neurology and Neuroscience, UMDNJ New Jersey Medical School, Newark, USA
    Neurology 72:1976-83. 2009
    ..There are no published MRI studies comparing interferon beta 1b (IFNbeta-1b) and glatiramer acetate (GA) for treatment of relapsing multiple sclerosis (MS)...
  8. pmc Infection and inflammation in skeletal muscle from nonhuman primates infected with different genospecies of the Lyme disease spirochete Borrelia burgdorferi
    Diego Cadavid
    Department of Neuroscience, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Infect Immun 71:7087-98. 2003
    ..We conclude that myositis can be a prominent feature of Lyme borreliosis depending on the infecting organism and host immune status...
  9. doi Clinical consequences of MRI activity in treated multiple sclerosis
    Diego Cadavid
    Department of Neurology and Neuroscience, University of Medicine and Dentistry of New Jersey New Jersey Medical School, USA
    Mult Scler 17:1113-21. 2011
    ..Inflammation on brain MRI is the most sensitive marker of disease activity in multiple sclerosis (MS) but its clinical consequences remain controversial...
  10. ncbi The mammalian host response to borrelia infection
    Diego Cadavid
    Department of Neurology and Neuroscience and Center for the Study of Emerging Pathogens, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Wien Klin Wochenschr 118:653-8. 2006
    ..Failure of this response leads to persistent infection, which can lead to tissue injury, most notably in the heart...
  11. ncbi Spinal cord involvement in the nonhuman primate model of Lyme disease
    Yunhong Bai
    Department of Neurology and Neuroscience, and Center for the Study of Emerging Pathogens, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Lab Invest 84:160-72. 2004
    ..C1q mRNA expression was significantly increased in inflamed spinal cord. This is the first comprehensive study of spinal cord involvement in Lyme borreliosis...
  12. ncbi The rhesus model of Lyme neuroborreliosis
    A R Pachner
    Neurosciences, UMDNJ - New Jersey Medical School, Newark, NJ, USA
    Immunol Rev 183:186-204. 2001
    ..The NHP model continues to provide important insight into the disease process in humans...
  13. pmc Cardiac apoptosis in severe relapsing fever borreliosis
    Diana Londoño
    Department of Neurology and Neuroscience and Center for the Study of Emerging Pathogens, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB H506, Newark, NJ 07103, USA
    Infect Immun 73:7669-76. 2005
    ..We conclude that persistent infection with relapsing fever borrelias causes significant loss of cardiomyocytes associated with prominent infiltration by activated macrophages, upregulation of IL-6, induction of caspase-1, and apoptosis...
  14. pmc Isogenic serotypes of Borrelia turicatae show different localization in the brain and skin of mice
    D Cadavid
    Department of Neuroscience, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    Infect Immun 69:3389-97. 2001
    ..VspA, VspB, and the periplasmic flagellin protein were expressed in all tissues examined. These findings indicate that isogenic but antigenically distinct Borrelia serotypes can have marked differences in their localization in tissues...
  15. ncbi High production of CXCL13 in blood and brain during persistent infection with the relapsing fever spirochete Borrelia turicatae
    Harald Gelderblom
    Department of Neurology and Neuroscience and Center for Emerging Pathogens, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    J Neuropathol Exp Neurol 66:208-17. 2007
    ..We concluded that brain involvement in B cell-deficient mice persistently infected with B. turicatae is characterized by prominent microgliosis and production of CXCL13 without detectable injury...
  16. ncbi Increased expression of B-lymphocyte chemoattractant, but not pro-inflammatory cytokines, in muscle tissue in rhesus chronic Lyme borreliosis
    Andrew R Pachner
    Department of Neurosciences, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    Cytokine 19:297-307. 2002
    ..This study is the first to extensively characterize cytokine gene expression in chronically inflamed tissue in Lyme borreliosis...
  17. ncbi Central and peripheral nervous system infection, immunity, and inflammation in the NHP model of Lyme borreliosis
    A R Pachner
    Department of Neurosciences, UMDNJ New Jersey Medical School, Newark 07103, USA
    Ann Neurol 50:330-8. 2001
    ....
  18. doi Effect of anti-IFN{beta} antibodies on MRI lesions of MS patients in the BECOME study
    Andrew R Pachner
    UMDNJ New Jersey Medical School, 185 South Orange Ave, MSBH506, Newark, NJ 07103, USA
    Neurology 73:1485-92. 2009
    ..Considerable evidence has accumulated that NAbs diminish or abolish IFNbeta bioactivity, but there is less evidence that NAbs impact clinical efficacy of the drug...
  19. ncbi Genotype determines phenotype in experimental Lyme borreliosis
    Andrew R Pachner
    University of Medicine and Dentristry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Ann Neurol 56:361-70. 2004
    ..The results explain to a large extent the disparities between LNB in humans in the United States and Europe...
  20. pmc Interaction of a neurotropic strain of Borrelia turicatae with the cerebral microcirculation system
    Nilay Sethi
    Department of Neurology and Neuroscience, Center for the Study of Emerging Pathogens, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, MSB H506, Newark, NJ 07103, USA
    Infect Immun 74:6408-18. 2006
    ..We concluded that the interaction of B. turicatae with the cerebral microcirculation involves both binding and crossing brain microvascular endothelial cells, with significant differences among isogenic serotypes...
  21. ncbi Internet-based cognitive testing in multiple sclerosis
    M Younes
    Departments of Neurology and Neuroscience, Newark, NJ 07103, USA
    Mult Scler 13:1011-9. 2007
    ..We conclude that the CSI, because of its availability over the Internet, has great potential as a tool for screening and follow up of cognitive function in multiple sclerosis...
  22. ncbi Cladribine in aggressive forms of multiple sclerosis
    J E Martinez-Rodriguez
    Department of Neurology and Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07107 3001, USA
    Eur J Neurol 14:686-9. 2007
    ..In the follow-up period (49.33 +/- 39.66 months), the mean relapse rate decreased to 0.71 +/- 0.55 and no unexpected or serious adverse events were observed...
  23. pmc Relapsing fever borreliosis in interleukin-10-deficient mice
    Diana Londoño
    Department of Neurology and Neuroscience and Center for Emerging Pathogens at UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Infect Immun 76:5508-13. 2008
    ..Our results revealed that production of IL-10 is highly regulated during RF and plays an important protective role in the prevention of hemorrhagic and thrombotic complications at the cost of reduced pathogen control...
  24. ncbi The nervous system as ectopic germinal center: CXCL13 and IgG in lyme neuroborreliosis
    Kavitha Narayan
    University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Ann Neurol 57:813-23. 2005
    ..We conclude that persistent production of CXCL13 and IgG within infected tissue, two characteristics of ectopic germinal centers, are definitive features of LNB...
  25. pmc Structure-function investigation of vsp serotypes of the spirochete Borrelia hermsii
    Rohit Mehra
    Department of Neurology, Neuroscience and Center for Emerging Pathogens at UMDNJ New Jersey Medical School, Newark, New Jersey, USA
    PLoS ONE 4:e7597. 2009
    ....
  26. pmc IL-10 helps control pathogen load during high-level bacteremia
    Diana Londoño
    Department of Neurology and Neuroscience and Center for Emerging Pathogens, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    J Immunol 181:2076-83. 2008
    ..Our results indicate that at times of high pathogen load, as during peak bacteremia in relapsing fever borreliosis, IL-10 protects innate immune cells from apoptosis via inhibition of TNF resulting in improved pathogen control...
  27. pmc Bacterial lipoproteins can disseminate from the periphery to inflame the brain
    Diana Londoño
    Department of Neurology and Neuroscience and Center for Emerging Pathogens, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA
    Am J Pathol 176:2848-57. 2010
    ..In contrast, LVsp2 disseminated better to peripheral organs. We conclude that some bacterial lipoproteins can disseminate from the periphery to inflame the brain...
  28. doi Serum levels of CXCL13 are elevated in active multiple sclerosis
    Eugene D Festa
    UMDNJ New Jersey Medical School, Newark, NJ, USA
    Mult Scler 15:1271-9. 2009
    ..35, p < 0.01) of the study. Treatment with interferon beta 1b or glatiramer acetate did not affect serum CXCL13. We conclude that the serum levels of the B cell chemokine CXCL13 are associated with active MS...
  29. pmc Interleukin 10 protects the brain microcirculation from spirochetal injury
    Diana Londoño
    Department of Neurology and Neuroscience and Center for Emerging Pathogens at UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    J Neuropathol Exp Neurol 67:976-83. 2008
    ..We conclude that IL-10 plays a critical role protecting the cerebral microcirculation from spirochetal injury possibly by inhibition effects of tumor necrosis factor...

Research Grants1

  1. Borrelia lipoproteins with the cerebral microcirculation
    Diego Cadavid; Fiscal Year: 2007
    ..Determine whether Vspl crosses the BBB in vivo. 2. Investigate whether Vspl enters BMEC. 3. Determine whether Vspl crosses BMEC barriers. 4. Identify the structural features that mediate the interaction of Vspl with BMEC. ..