J P Buyon

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint More to death than dying: apoptosis in the pathogenesis of SSA/Ro-SSB/La-associated congenital heart block
    Robert M Clancy
    Division of Rheumatology, Department of Medicine, Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Rheum Dis Clin North Am 30:589-602, x. 2004
  2. ncbi request reprint Neonatal lupus: basic research and clinical perspectives
    Jill P Buyon
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY, USA
    Rheum Dis Clin North Am 31:299-313, vii. 2005
  3. doi request reprint Utility of cardiac monitoring in fetuses at risk for congenital heart block: the PR Interval and Dexamethasone Evaluation (PRIDE) prospective study
    Deborah M Friedman
    Department of Pediatrics, Saint Barnabas Medical Center, Livingston, NJ, USA
    Circulation 117:485-93. 2008
  4. pmc Autoimmune associated congenital heart block: integration of clinical and research clues in the management of the maternal / foetal dyad at risk
    J P Buyon
    Department of Medicine, New York University Langone School of Medicine, New York, 10016, USA
    J Intern Med 265:653-62. 2009
  5. pmc Evaluation of fetuses in a study of intravenous immunoglobulin as preventive therapy for congenital heart block: Results of a multicenter, prospective, open-label clinical trial
    Deborah M Friedman
    New York Medical College, Valhalla, NY, USA
    Arthritis Rheum 62:1138-46. 2010
  6. ncbi request reprint Neonatal lupus syndromes
    Jill P Buyon
    Department of Medicine, New York University School of Medicine, New York, New York, USA
    Curr Opin Rheumatol 15:535-41. 2003
  7. ncbi request reprint Cardiac 5-HT(4) serotoninergic receptors, 52kD SSA/Ro and autoimmune-associated congenital heart block
    Jill P Buyon
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10003, USA
    J Autoimmun 19:79-86. 2002
  8. ncbi request reprint Autoantibody-associated congenital heart block: the clinical perspective
    Jill P Buyon
    Department of Rheumatology, Hospital for Joint Diseases, 301 East 17th Avenue, Room 1608, New York, NY 10003, USA
    Curr Rheumatol Rep 5:374-8. 2003
  9. ncbi request reprint Maternal autoantibodies and congenital heart block: mediators, markers, and therapeutic approach
    Jill P Buyon
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, NY 10003, USA
    Semin Arthritis Rheum 33:140-54. 2003
  10. ncbi request reprint Neonatal lupus: review of proposed pathogenesis and clinical data from the US-based Research Registry for Neonatal Lupus
    Jill P Buyon
    Department of Rheumatology, Room 1608, Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Autoimmunity 36:41-50. 2003

Detail Information

Publications73

  1. ncbi request reprint More to death than dying: apoptosis in the pathogenesis of SSA/Ro-SSB/La-associated congenital heart block
    Robert M Clancy
    Division of Rheumatology, Department of Medicine, Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Rheum Dis Clin North Am 30:589-602, x. 2004
    ....
  2. ncbi request reprint Neonatal lupus: basic research and clinical perspectives
    Jill P Buyon
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY, USA
    Rheum Dis Clin North Am 31:299-313, vii. 2005
    ..Better echocardiographic measurements that identify first-degree block in utero may be the optimal approach for pregnant women at risk; prophylactic therapies, including treatment with intravenous immunoglobulin, await larger trials...
  3. doi request reprint Utility of cardiac monitoring in fetuses at risk for congenital heart block: the PR Interval and Dexamethasone Evaluation (PRIDE) prospective study
    Deborah M Friedman
    Department of Pediatrics, Saint Barnabas Medical Center, Livingston, NJ, USA
    Circulation 117:485-93. 2008
    ..Anti-SSA/Ro-associated third-degree congenital heart block is irreversible, prompting a search for early markers and effective therapy...
  4. pmc Autoimmune associated congenital heart block: integration of clinical and research clues in the management of the maternal / foetal dyad at risk
    J P Buyon
    Department of Medicine, New York University Langone School of Medicine, New York, 10016, USA
    J Intern Med 265:653-62. 2009
    ..Current strategies include the evaluation of an early echocardiographic marker of injury, such as a prolonged PR interval and the use of IVIG as a preventative measure for pregnancies of mothers with previously affected children...
  5. pmc Evaluation of fetuses in a study of intravenous immunoglobulin as preventive therapy for congenital heart block: Results of a multicenter, prospective, open-label clinical trial
    Deborah M Friedman
    New York Medical College, Valhalla, NY, USA
    Arthritis Rheum 62:1138-46. 2010
    ..Based on potential reduction of maternal autoantibody titers as well as fetal inflammatory responses, intravenous immunoglobulin (IVIG) was evaluated as preventive therapy for CHB...
  6. ncbi request reprint Neonatal lupus syndromes
    Jill P Buyon
    Department of Medicine, New York University School of Medicine, New York, New York, USA
    Curr Opin Rheumatol 15:535-41. 2003
    ..To further efforts both at the bench and bedside, national research registries established in the United States and Canada are critical...
  7. ncbi request reprint Cardiac 5-HT(4) serotoninergic receptors, 52kD SSA/Ro and autoimmune-associated congenital heart block
    Jill P Buyon
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10003, USA
    J Autoimmun 19:79-86. 2002
    ..Although 5-HT(4) receptors are present and functional in the human foetal heart, maternal antibodies to the 5-HT(4) receptor are not associated with the development of CHB...
  8. ncbi request reprint Autoantibody-associated congenital heart block: the clinical perspective
    Jill P Buyon
    Department of Rheumatology, Hospital for Joint Diseases, 301 East 17th Avenue, Room 1608, New York, NY 10003, USA
    Curr Rheumatol Rep 5:374-8. 2003
    ..Neonatal lupus was termed because the cutaneous lesions of the neonate resembled those seen in systemic lupus erythematosus...
  9. ncbi request reprint Maternal autoantibodies and congenital heart block: mediators, markers, and therapeutic approach
    Jill P Buyon
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, NY 10003, USA
    Semin Arthritis Rheum 33:140-54. 2003
  10. ncbi request reprint Neonatal lupus: review of proposed pathogenesis and clinical data from the US-based Research Registry for Neonatal Lupus
    Jill P Buyon
    Department of Rheumatology, Room 1608, Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Autoimmunity 36:41-50. 2003
    ..S. National Institute of Arthritis, Musculoskeletal and Skin Diseases. Maternal and fetal outcomes are addressed as well as recurrence rates. Laboratory evaluation and management decisions during pregnancy are provided...
  11. doi request reprint Dying right to live longer: positing apoptosis as a link between maternal autoantibodies and congenital heart block
    J P Buyon
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, NY, USA
    Lupus 17:86-90. 2008
    ..While CHB is rare, its study should set precedent for defining the role of autoantibodies in driving end organ disease...
  12. ncbi request reprint What's in a name?
    J P Buyon
    Hospital for Joint Diseases, New York University Medical Center, New York, NY, USA
    Ann Rheum Dis 67:732; discussion 732. 2008
  13. ncbi request reprint Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function
    F Di Donato
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, Room 1608, 301 East 17th Street, New York, NY 10003, USA
    Int J Biochem Cell Biol 33:924-34. 2001
    ..The absence of an interaction with 52 beta raises the consideration that regulation of protein ubiquitination might differ in fetal life...
  14. ncbi request reprint Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies
    A D Askanase
    Department of Rheumatology and Medicine, Hospital for Joint Diseases, New York University School of Medicine, New York 10003, USA
    Lupus 11:145-51. 2002
    ..Since subsequent progression of less-advanced degrees of block can occur, an EKG should be performed on all infants born to mothers with anti-SSA/Ro-SSB/La antibodies...
  15. pmc From antibody insult to fibrosis in neonatal lupus - the heart of the matter
    Jill P Buyon
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, USA
    Arthritis Res Ther 5:266-70. 2003
    ..Dissecting the individual components in this fibrotic pathway should provide insights into the rarity of irreversible injury and should form the basis of rational approaches to prevention and treatment...
  16. doi request reprint Frequency of neuro-psychiatric dysfunction in anti-SSA/SSB exposed children with and without neonatal lupus
    A D Askanase
    Department of Medicine, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10016, USA
    Lupus 19:300-6. 2010
    ..However, medication use was limited and although the frequency of this reporting was greater than friend controls, it did not reach significance...
  17. pmc Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block
    Robert M Clancy
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 184:2148-55. 2010
    ....
  18. ncbi request reprint Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry
    J P Buyon
    Department of Rheumatology and Medicine, Hospital for Joint Diseases, New York University School of Medicine, New York 10003, USA
    J Am Coll Cardiol 31:1658-66. 1998
    ..The present study describes the demographics, mortality, morbidity and recurrence rates of autoimmune-associated congenital heart block (CHB) using information from the Research Registry for Neonatal Lupus...
  19. ncbi request reprint Immunohistologic evidence supports apoptosis, IgG deposition, and novel macrophage/fibroblast crosstalk in the pathologic cascade leading to congenital heart block
    Robert M Clancy
    Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 50:173-82. 2004
    ..These opsonized cardiocytes are phagocytosed by macrophages, which secrete factors inducing fibrosis...
  20. pmc Disease progression in mothers of children enrolled in the Research Registry for Neonatal Lupus
    T L Rivera
    New York University School of Medicine, New York, 10016, USA
    Ann Rheum Dis 68:828-35. 2009
    ..To evaluate autoimmune disease progression in asymptomatic and pauci-symptomatic mothers of children with neonatal lupus (NL)...
  21. ncbi request reprint Neonatal lupus syndromes
    Peter M Izmirly
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, 560 First Avenue, TCH 407, New York, NY 10016, USA
    Rheum Dis Clin North Am 33:267-85, vi. 2007
    ....
  22. ncbi request reprint Role of hypoxia and cAMP in the transdifferentiation of human fetal cardiac fibroblasts: implications for progression to scarring in autoimmune-associated congenital heart block
    Robert M Clancy
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Arthritis Rheum 56:4120-31. 2007
    ..Accordingly, this study was carried out to explore the hypothesis that hypoxia potentiates a profibrosing phenotype of the fetal cardiac fibroblast...
  23. ncbi request reprint mRNA and protein expression of SSA/Ro and SSB/La in human fetal cardiac myocytes cultured using a novel application of the Langendorff procedure
    C E Tseng
    Department of Medicine, New York University School of Medicine, Hospital for Joint Diseases, New York 10003, USA
    Pediatr Res 45:260-9. 1999
    ....
  24. ncbi request reprint Neonatal lupus syndromes
    J P Buyon
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, USA
    Lupus 13:705-12. 2004
    ..Prophylactic therapies, including treatment with intravenous immunoglobulin, await larger trials. In order to achieve advances at both the bench and bedside, national research registries established in the US and Canada are critical...
  25. ncbi request reprint Autoimmune-associated congenital heart block: dissecting the cascade from immunologic insult to relentless fibrosis
    Robert M Clancy
    Department of Rheumatology, Room 1608, Hospital for Joint Diseases, New York University School of Medicine, 301 East 17th Street, New York, NY 10003, USA
    Anat Rec A Discov Mol Cell Evol Biol 280:1027-35. 2004
    ..Further elucidation of maternal and fetal contributory factors should provide insight into the pathogenesis of CHB and the rarity of irreversible injury...
  26. pmc Recurrence rates of cardiac manifestations associated with neonatal lupus and maternal/fetal risk factors
    Carolina Llanos
    New York University School of Medicine, New York, New York 10016, USA
    Arthritis Rheum 60:3091-7. 2009
    ..Accordingly, this study was undertaken to address the recurrence rates of cardiac NL and associated risk factors in a large US-based cohort...
  27. ncbi request reprint Maternal antibody responses to the 52-kd SSA/RO p200 peptide and the development of fetal conduction defects
    Robert M Clancy
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 52:3079-86. 2005
    ..To identify a finer level of antibody specificity for risk of congenital heart block (CHB) than reactivity to 52-kd SSA/Ro (Ro 52)...
  28. ncbi request reprint Autoantibody-associated congenital heart block: TGFbeta and the road to scar
    Jill P Buyon
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, Room 1608, 301 East 17th Street, New York, NY 10003, USA
    Autoimmun Rev 4:1-7. 2005
    ..Downregulation of TGFbeta (activation/secretion pathway) may provide the basis of a novel approach to treatment of CHB in the future...
  29. ncbi request reprint Congenital heart block in neonatal lupus: the pediatric cardiologist's perspective
    Deborah M Friedman
    Department of Pediatrics, St Luke s Roosevelt Hospital Center, New York, New York 10025, USA
    Indian J Pediatr 69:517-22. 2002
    ..Abnormalities in the skin, liver and blood of neonates are also associated with anti-Ro/La antibodies, and are usually self-limiting; these manifestations and CHB are collectively referred to as neonatal lupus syndromes (NLS)...
  30. pmc Evaluation of the risk of anti-SSA/Ro-SSB/La antibody-associated cardiac manifestations of neonatal lupus in fetuses of mothers with systemic lupus erythematosus exposed to hydroxychloroquine
    Peter M Izmirly
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, Th 407, New York, NY 10016, USA
    Ann Rheum Dis 69:1827-30. 2010
    ....
  31. ncbi request reprint Transdifferentiation of cardiac fibroblasts, a fetal factor in anti-SSA/Ro-SSB/La antibody-mediated congenital heart block
    Robert M Clancy
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10003, USA
    J Immunol 169:2156-63. 2002
    ..These data suggest that transdifferentiation of cardiac fibroblasts to a scarring phenotype is a pathologic process initiated by maternal Abs...
  32. ncbi request reprint The presence of IgG antibodies reactive with components of the SSA/Ro-SSB/La complex in human breast milk: implications in neonatal lupus
    Anca D Askanase
    Hospital for Joint Diseases, New York University School of Medicine, NY, USA
    Arthritis Rheum 46:269-71. 2002
  33. ncbi request reprint Updates on lupus and pregnancy
    Jill P Buyon
    Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York University Langone Medical Center, New York, New York 10019, USA
    Bull NYU Hosp Jt Dis 67:271-5. 2009
    ..Information on current approaches to prevention and treatment of heart complications of neonatal lupus is provided...
  34. pmc Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block
    Robert M Clancy
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, New York 10016, USA
    J Clin Invest 116:2413-22. 2006
    ....
  35. ncbi request reprint Cytokine polymorphisms and histologic expression in autopsy studies: contribution of TNF-alpha and TGF-beta 1 to the pathogenesis of autoimmune-associated congenital heart block
    Robert M Clancy
    Hospital for Joint Diseases, New York University School of Medicine, Department of Rheumatology, New York, NY 10003, USA
    J Immunol 171:3253-61. 2003
    ..This profibrosing cytokine and its secretion/activation circuitry may provide a novel direction for evaluating fetal factors in the development of a robust animal model of CHB as well as therapeutic strategies in humans...
  36. pmc Cutaneous manifestations of neonatal lupus and risk of subsequent congenital heart block
    Peter M Izmirly
    New York University School of Medicine, New York, New York 10016, USA
    Arthritis Rheum 62:1153-7. 2010
    ..The purpose of this study was to determine the recurrence rates of NL, with specific focus on cardiac NL following cutaneous NL in a child enrolled in the Research Registry for Neonatal Lupus (RRNL)...
  37. doi request reprint Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside
    Jill P Buyon
    Division of Rheumatology, New York Medical College, New York, NY, USA
    Nat Clin Pract Rheumatol 5:139-48. 2009
    ..Intravenous immunoglobulin is being evaluated as a potential prophylactic approach in mothers who have previously had an affected child...
  38. ncbi request reprint Epidemiology, etiology, detection, and treatment of autoantibody-associated congenital heart block in neonatal lupus
    Deborah M Friedman
    New York University School of Medicine, 560 First Avenue, TCH 407, New York, NY 10016, USA
    Curr Rheumatol Rep 9:101-8. 2007
    ..An intensive search is on for the specific etiopathophysiology and for new clinical tools to approach and treat this disease...
  39. doi request reprint Role of the urokinase plasminogen activator receptor in mediating impaired efferocytosis of anti-SSA/Ro-bound apoptotic cardiocytes: Implications in the pathogenesis of congenital heart block
    Paraskevi Briassouli
    Department of Medicine, New York University School of Medicine, New York, 10016, USA
    Circ Res 107:374-87. 2010
    ....
  40. ncbi request reprint Long-term followup of children with neonatal lupus and their unaffected siblings
    Victor Martin
    Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 46:2377-83. 2002
    ..To determine in a longitudinal cohort study whether children with varied manifestations of neonatal lupus or their unaffected siblings later develop autoantibodies and/or rheumatic diseases...
  41. doi request reprint Antibody reactivity to alpha-enolase in mothers of children with congenital heart block
    Carolina Llanos
    Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Rheumatol 36:565-9. 2009
    ....
  42. pmc Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus
    Robert M Clancy
    New York University Langone School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 62:3415-24. 2010
    ..There is strong evidence of a genetic contribution to the risk. This study was undertaken to evaluate single-nucleotide polymorphisms (SNPs) for associations with cardiac neonatal lupus...
  43. ncbi request reprint The role of biomarkers in the assessment of lupus
    Joan T Merrill
    Hospital for Joint Diseases, New York University Medical Center, NY, USA
    Best Pract Res Clin Rheumatol 19:709-26. 2005
    ..Several of the promising biomarkers are addressed in this chapter...
  44. ncbi request reprint Genetic association of cutaneous neonatal lupus with HLA class II and tumor necrosis factor alpha: implications for pathogenesis
    Robert M Clancy
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 50:2598-603. 2004
    ..Accordingly, this study was undertaken to seek genetic and histologic evidence for a role of TNFalpha in the pathogenesis of cutaneous neonatal lupus...
  45. ncbi request reprint The effect of moderate-dose corticosteroids in preventing severe flares in patients with serologically active, but clinically stable, systemic lupus erythematosus: findings of a prospective, randomized, double-blind, placebo-controlled trial
    Chung E Tseng
    New York University School of Medicine, Hospital for Joint Diseases, New York, New York 10003, USA
    Arthritis Rheum 54:3623-32. 2006
    ..We hypothesized that concomitant elevation of anti-dsDNA and C3a can predict SLE activity in patients with stable or inactive disease and that short-term treatment with corticosteroids can avert flares...
  46. doi request reprint Use of pharmacogenetics, enzymatic phenotyping, and metabolite monitoring to guide treatment with azathioprine in patients with systemic lupus erythematosus
    Anca D Askanase
    Department of Medicine, Hospital for Joint Diseases, Division of Rheumatology, New York University School of Medicine, 560 First Avenue, TCH 407, New York, NY 10016, USA
    J Rheumatol 36:89-95. 2009
    ..Our objective was to evaluate whether drug escalation based on metabolite levels improves efficacy and maintains safety in patients with systemic lupus erythematosus (SLE)...
  47. doi request reprint Systemic lupus international collaborating clinics renal activity/response exercise: development of a renal activity score and renal response index
    Michelle Petri
    Department of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Arthritis Rheum 58:1784-8. 2008
    ..To develop a measure of renal activity in systemic lupus erythematosus and use it to develop a renal response index...
  48. doi request reprint Systemic lupus international collaborating clinics renal activity/response exercise: comparison of agreement in rating renal response
    Michelle Petri
    Department of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Arthritis Rheum 58:1789-95. 2008
    ..To assess the degree to which physicians agree with each other and with ratings obtained with 3 existing responder indices, in rating the response to treatment of lupus nephritis...
  49. pmc Expression of endothelial protein C receptor in cortical peritubular capillaries associates with a poor clinical response in lupus nephritis
    Peter M Izmirly
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, NY, USA
    Rheumatology (Oxford) 48:513-9. 2009
    ..To study the membrane expression of endothelial protein C receptor (mEPCR) in the renal microvasculature in lupus nephritis (LN) as a potential marker of injury and/or prognostic indicator for response to therapy...
  50. ncbi request reprint The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial
    Jill P Buyon
    Hospital for Joint Diseases, New York University School of Medicine, New York, New York, USA
    Ann Intern Med 142:953-62. 2005
    ..There is concern that exogenous female hormones may worsen disease activity in women with systemic lupus erythematosus (SLE)...
  51. ncbi request reprint Reproductive health in SLE
    Anca D Askanase
    Clinical Medicine, New York University School of Medicine, Lupus Clinic, Hospital for Joint Diseases, New York, USA
    Best Pract Res Clin Rheumatol 16:265-80. 2002
    ..This chapter focuses on three broad categories: birth control, assisted reproduction and hormone replacement...
  52. ncbi request reprint Hypothyroidism and antithyroglobulin and antithyroperoxidase antibodies in the pathogenesis of autoimmune associated congenital heart block
    Anca Dinu Askanase
    J Rheumatol 33:2099. 2006
  53. ncbi request reprint Identifying an early marker for congenital heart block: when is a long PR interval too long? Comment on the article by Sonesson et al
    Jill P Buyon
    Arthritis Rheum 52:1341-2. 2005
  54. ncbi request reprint Myocardial-tissue-specific phenotype of maternal microchimerism in neonatal lupus congenital heart block
    Anne M Stevens
    Fred Hutchinson Cancer Research Center, Immunogenetics, Seattle, WA 98109, USA
    Lancet 362:1617-23. 2003
    ..The most serious complication of NLS is inflammation of the atrioventricular node leading to congenital heart block (CHB)...
  55. ncbi request reprint Does the cellular localization of antigens in or on apoptotic blebs influence the pathogenicity or benefit of cognate antibodies? Comment on the article by Dieudé et al
    Robert M Clancy
    Arthritis Rheum 48:2080-2; author reply 2082-3. 2003
  56. ncbi request reprint Intravenous immunoglobulin and placental transport of anti-Ro/La antibodies: comment on the letter by Kaaja and Julkunen
    Hai B Tran
    Arthritis Rheum 50:337-8; author reply 338. 2004
  57. ncbi request reprint Anti-La/SSB antibodies transported across the placenta bind apoptotic cells in fetal organs targeted in neonatal lupus
    Hai B Tran
    Department of Immunology, Allergy and Arthritis, Flinders Medical Centre, Flinders University, Bedford Park, Adelaide, 5042 SA, Australia
    Arthritis Rheum 46:1572-9. 2002
    ....
  58. ncbi request reprint Congenital heart block: do fetal factors fuel the fire from inflammation to fibrosis?
    Jill P Buyon
    Lupus 12:731-4. 2003
  59. ncbi request reprint Clearance of apoptotic cells: TGF-beta in the balance between inflammation and fibrosis
    Robert M Clancy
    J Leukoc Biol 74:959-60. 2003
    ..Prolonged secretion of this cytokine may contribute to the exuberant scarring seen in congenital heart block associated with maternal autoantibodies reactive with SSA/Rho and SSB/La antigens...
  60. ncbi request reprint Autoantibodies against the serotoninergic 5-HT4 receptor and congenital heart block: a reassessment
    Rehab Kamel
    UPR9021 du C N R S Immunologie et Chimie Thérapeutiques, I B M C, F 67084 Strasbourg, France
    J Autoimmun 25:72-6. 2005
    ....
  61. ncbi request reprint Exposure and binding of selected immunodominant La/SSB epitopes on human apoptotic cells
    Petra J Neufing
    Department of Immunology, Allergy and Arthritis, Flinders University, Adelaide, South Australia, Australia
    Arthritis Rheum 52:3934-42. 2005
    ..Accordingly, the objective of the current study was to delineate the epitope specificity of human La antibodies that are exposed on the surface of apoptotic cells...
  62. ncbi request reprint Anti-La/SSB antiidiotypic antibodies in maternal serum: a marker of low risk for neonatal lupus in an offspring
    Eleni A Stea
    Medical School of Athens, Athens, Greece
    Arthritis Rheum 54:2228-34. 2006
    ..This study evaluated the role of this network in pregnant women with anti-Ro/SSA and/or anti-La/SSB antibodies in the development of neonatal lupus syndrome (NLS)...
  63. pmc Autoimmunity as a result of escape from RNA surveillance
    Michael P Bachmann
    Institute of Immunology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    J Immunol 177:1698-707. 2006
    ..Consequently, escape of mutant La mRNA from RNA control can have two effects: it 1) results in the expression of an immunogenic (neo)epitope, and 2) predisposes to autoimmunity...
  64. ncbi request reprint Subcellular redistribution of la/SSB autoantigen during physiologic apoptosis in the fetal mouse heart and conduction system: a clue to the pathogenesis of congenital heart block
    Hai B Tran
    Flinders Medical Centre, Flinders University, Adelaide, Australia
    Arthritis Rheum 46:202-8. 2002
    ..This study further investigated the subcellular distribution of the La antigen during apoptosis in the fetal mouse heart and conduction system...
  65. pmc Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro-positive mothers of children with neonatal lupus
    Timothy B Niewold
    University of Chicago, Section of Rheumatology, Chicago, Illinois 60637, USA
    Arthritis Rheum 58:541-6. 2008
    ....
  66. ncbi request reprint Dispelling the preconceived notion that lupus pregnancies result in poor outcomes
    Jill P Buyon
    J Rheumatol 32:1641-2. 2005
  67. ncbi request reprint Estrogens and lupus: bubbling cauldron or another overrated Witches' Brew?
    Michael D Lockshin
    Arthritis Rheum 56:1048-50. 2007
  68. ncbi request reprint Hepatobiliary disease in neonatal lupus: prevalence and clinical characteristics in cases enrolled in a national registry
    Lela A Lee
    Departments of Dermatology and Medicine, University of Colorado School of Medicine, and Department of Medicine, Denver Health Medical Center, Denver, Colorado, USA
    Pediatrics 109:E11. 2002
    ..To extend the information base on the hepatobiliary manifestations of neonatal lupus erythematosus (NLE) with regard to frequency of occurrence, clinical characteristics, and outcome...
  69. ncbi request reprint Effects of prasterone on disease activity and symptoms in women with active systemic lupus erythematosus
    Michelle A Petri
    Johns Hopkins University Medical Center, Baltimore, Maryland 21205, USA
    Arthritis Rheum 50:2858-68. 2004
    ..To determine whether prasterone administration results in improvement or stabilization of systemic lupus erythematosus (SLE) disease activity and its symptoms...
  70. ncbi request reprint Challenges in bringing the bench to bedside in drug development for SLE
    Joan T Merrill
    Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street Oklahoma City, Oklahoma 73104, USA
    Nat Rev Drug Discov 3:1036-46. 2004
    ..With the current burst of drug discovery and increased public awareness of SLE, the impetus to overcome these obstacles has never been greater...
  71. ncbi request reprint Circulating endothelial cells. Biomarker of vascular disease
    Andrew D Blann
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, B18 7QH, UK
    Thromb Haemost 93:228-35. 2005
    ..The objective of the present communication is to condense existing data on CECs, briefly compare them with progenitor cells, and summarise possible mechanism(s) by which they may contribute to vascular pathology...
  72. ncbi request reprint Combined oral contraceptives in women with systemic lupus erythematosus
    Michelle Petri
    Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 353:2550-8. 2005
    ..In this double-blind, randomized, noninferiority trial, we prospectively evaluated the effect of oral contraceptives on lupus activity in premenopausal women with systemic lupus erythematosus...
  73. ncbi request reprint Birth order, gender and recurrence rate in autoantibody-associated congenital heart block: implications for pathogenesis and family counseling
    Daniel G Solomon
    Lupus 12:646-7. 2003