William Borkowsky

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc Correlation of HIV-specific immunity, viral control, and diversification following planned multiple exposures to autologous HIV in a pediatric population
    William Borkowsky
    NYU School of Medicine, 550 First Ave, New York, NY 10016, USA
    Clin Vaccine Immunol 18:1628-31. 2011
  2. pmc Structured treatment interruptions (STIs) in HIV-1 infected pediatric populations increases interferon gamma production and reduces viremia
    William Borkowsky
    NYU School of Medicine, New York, NY, USA
    Vaccine 26:3086-9. 2008
  3. doi request reprint Impaired immunity to recall antigens and neoantigens in severely immunocompromised children and adolescents during the first year of effective highly active antiretroviral therapy
    Mona Rigaud
    New York University School of Medicine, New York, NY, USA
    J Infect Dis 198:1123-30. 2008
  4. doi request reprint Planned multiple exposures to autologous virus in HIV type 1-infected pediatric populations increases HIV-specific immunity and reduces HIV viremia
    William Borkowsky
    NYU School of Medicine, New York, New York 10016, USA
    AIDS Res Hum Retroviruses 24:401-11. 2008
  5. pmc Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection
    Aimee El Hed
    Departments of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Infect Dis 201:843-54. 2010
  6. pmc A phase I-II study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicella
    Anne A Gershon
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Pediatr Infect Dis J 28:653-5. 2009
  7. ncbi request reprint Correlation between HIV-Specific CD8 cell production of interferon- gamma and plasma levels of HIV RNA in perinatally infected pediatric populations
    William Borkowsky
    The Saul Krugman Division of Infectious Diseases, Division of Pediatrics, New York University School of Medicine, New York, New York 10016, USA
    J Infect Dis 190:722-6. 2004
  8. ncbi request reprint Natural history of HIV infected pediatric long-term or slow progressor population after the first decade of life
    Juliana A Ofori-Mante
    Department of Pediatrics, Division of Infectious Diseases, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Pediatr Infect Dis J 26:217-20. 2007
  9. pmc Distribution and evolution of T-cell receptor Vbeta repertoire on peripheral blood lymphocytes of newborn infants of human immunodeficiency virus (HIV)-infected mothers: differential display on CD4 and CD8 T cells and effect of HIV infection
    William Borkowsky
    Department of Pediatrics, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Clin Vaccine Immunol 14:1215-22. 2007
  10. doi request reprint Hyper interleukin-10 in an HIV-positive child with t-cell lymphoma and candidal sepsis
    Jennifer Lighter
    Saul Krugman Division of Pediatric Infectious Diseases and Immunology, New York University School of Medicine, New York, New York
    J Int Assoc Physicians AIDS Care (Chic) 7:228-31. 2008

Collaborators

Detail Information

Publications22

  1. pmc Correlation of HIV-specific immunity, viral control, and diversification following planned multiple exposures to autologous HIV in a pediatric population
    William Borkowsky
    NYU School of Medicine, 550 First Ave, New York, NY 10016, USA
    Clin Vaccine Immunol 18:1628-31. 2011
    ..There was a trend toward correlation between the response to multiple HIV antigens and diversification...
  2. pmc Structured treatment interruptions (STIs) in HIV-1 infected pediatric populations increases interferon gamma production and reduces viremia
    William Borkowsky
    NYU School of Medicine, New York, NY, USA
    Vaccine 26:3086-9. 2008
    ..This allowed us to conclude that exposure to autologous virus increased HIV-specific immune responses and decreased HIV RNA were seen in those who have had >13 interruptions, with STI intervals that exceeded 27 days...
  3. doi request reprint Impaired immunity to recall antigens and neoantigens in severely immunocompromised children and adolescents during the first year of effective highly active antiretroviral therapy
    Mona Rigaud
    New York University School of Medicine, New York, NY, USA
    J Infect Dis 198:1123-30. 2008
    ....
  4. doi request reprint Planned multiple exposures to autologous virus in HIV type 1-infected pediatric populations increases HIV-specific immunity and reduces HIV viremia
    William Borkowsky
    NYU School of Medicine, New York, New York 10016, USA
    AIDS Res Hum Retroviruses 24:401-11. 2008
    ..Other studies may have failed due to an insufficient number of exposures to HIV; most of the studies had fewer than six drug interruptions...
  5. pmc Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection
    Aimee El Hed
    Departments of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Infect Dis 201:843-54. 2010
    ..Identification of the Th17 T cell subset as important mediators of host defense and pathology prompted us to determine their susceptibility to human immunodeficiency virus (HIV) infection...
  6. pmc A phase I-II study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicella
    Anne A Gershon
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Pediatr Infect Dis J 28:653-5. 2009
    ..There were no serious adverse events. Two years after vaccination 82% of subjects remained VZV-antibody positive and 60% had VZV-specific cell-mediated immunity. No child developed herpes zoster...
  7. ncbi request reprint Correlation between HIV-Specific CD8 cell production of interferon- gamma and plasma levels of HIV RNA in perinatally infected pediatric populations
    William Borkowsky
    The Saul Krugman Division of Infectious Diseases, Division of Pediatrics, New York University School of Medicine, New York, New York 10016, USA
    J Infect Dis 190:722-6. 2004
    ..Attempts to establish the same correlation in small numbers of children have also been made, with similar controversy resulting...
  8. ncbi request reprint Natural history of HIV infected pediatric long-term or slow progressor population after the first decade of life
    Juliana A Ofori-Mante
    Department of Pediatrics, Division of Infectious Diseases, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Pediatr Infect Dis J 26:217-20. 2007
    ..There is very limited information on this group of children beyond the first decade of life. A group of HIV-infected long-term nonprogressor/slow progressor children was studied...
  9. pmc Distribution and evolution of T-cell receptor Vbeta repertoire on peripheral blood lymphocytes of newborn infants of human immunodeficiency virus (HIV)-infected mothers: differential display on CD4 and CD8 T cells and effect of HIV infection
    William Borkowsky
    Department of Pediatrics, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Clin Vaccine Immunol 14:1215-22. 2007
    ..In conclusion, newborns demonstrate different distributions of TCR Vbeta types on CD4 and CD8 cells. HIV infection produces no change in neonatal TCR and little change over the course of 2 years compared to that seen in the uninfected...
  10. doi request reprint Hyper interleukin-10 in an HIV-positive child with t-cell lymphoma and candidal sepsis
    Jennifer Lighter
    Saul Krugman Division of Pediatric Infectious Diseases and Immunology, New York University School of Medicine, New York, New York
    J Int Assoc Physicians AIDS Care (Chic) 7:228-31. 2008
    ..Significantly elevated levels of Interleukin-10 (IL-10) were found in the patient's serum, which may have played a role in acute demise...
  11. ncbi request reprint Mycobacterium tuberculosis-induced CXCR4 and chemokine expression leads to preferential X4 HIV-1 replication in human macrophages
    Yoshihiko Hoshino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 172:6251-8. 2004
    ..These changes explain in part why TB accelerates the course of AIDS. CXCR4 inhibitors are a rational therapeutic approach in HIV/TB coinfection...
  12. ncbi request reprint Immunoreconstitution in children receiving highly active antiretroviral therapy depends on the CD4 cell percentage at baseline
    Divna Nikolic-Djokic
    New York University Medical Center, New York, NY 10016, USA
    J Infect Dis 185:290-8. 2002
    ..The results support the option of delaying HAART in early asymptomatic HIV-1 disease in children and the use of other markers of disease progression, in addition to virus load...
  13. ncbi request reprint Perinatal transmission and viral evolution of hepatitis C virus quasispecies in infants coinfected with HIV
    Henry Pollack
    Department of Pediatrics, The Saul Krugman Division of Infectious Diseases and Immunology, New York University School of Medicine, NY 10016, USA
    J Acquir Immune Defic Syndr 36:890-9. 2004
    ..Sequences of the hypervariable region in the N terminus of the E2/NS1 region (HVR-1) of the children and their mothers were compared. HCV quasispecies changes in the infants were tracked over several years...
  14. pmc Role of molecular mimicry of hepatitis C virus protein with platelet GPIIIa in hepatitis C-related immunologic thrombocytopenia
    Wei Zhang
    Department of Medicine, New York University School of Medicine, NY 10016, USA
    Blood 113:4086-93. 2009
    ..001). Thus, HCV core envelope 1 can induce thrombocytopenia by molecular mimicry with GPIIIa49-66...
  15. doi request reprint Implementation of HIV testing at 2 New York City bathhouses: from pilot to clinical service
    Demetre Daskalakis
    Division of Infectious Diseases and Immunology, New York University Langone Medical Center, New York, New York 10016, USA
    Clin Infect Dis 48:1609-16. 2009
    ..Several cities in the United States have developed programs that offer HIV testing in these venues. Similar programs have not existed before in New York City...
  16. pmc Immunological memory after exposure to variola virus, monkeypox virus, and vaccinia virus
    Sumathi Sivapalasingam
    Division of Infectious Disease, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Infect Dis 195:1151-9. 2007
    ..Survivors of variola virus infection demonstrated VV-specific CD4 memory cell responses and neutralizing antibodies >40 years after infection...
  17. doi request reprint Erythema induratum of Bazin in a child: evidence for a cell-mediated hyper-response to Mycobacterium tuberculosis
    Jennifer Lighter
    From the Department of Pediatrics, New York University School of Medicine, New York, NY, USA
    Pediatr Infect Dis J 28:326-8. 2009
    ..5 cm of induration and an interferon-gamma releasing assay was also markedly positive. A diagnosis of erythema induratum of Bazin was confirmed on skin biopsy. The patient was successfully treated with multi-drug antituberculosis therapy...
  18. doi request reprint Usefulness of urinary immune biomarkers in the evaluation of neonatal sepsis: a pilot project
    Sukumar Suguna Narasimhulu
    New York University, New York, NY 10016, USA
    Clin Pediatr (Phila) 52:520-6. 2013
    ..We conducted a pilot, prospective hospital-based longitudinal observational study to test the urine of term neonates with a 13 biomarker panel of cytokines...
  19. ncbi request reprint Severe varicella caused by varicella-vaccine strain in a child with significant T-cell dysfunction
    Patrick Jean-Philippe
    Department of Pediatrics, New York University School of Medicine, New York, New York, USA
    Pediatrics 120:e1345-9. 2007
    ..We report here an 18-month-old girl with cell-mediated immunodeficiency who developed a severe vaccine-associated rash and clinical evidence of vaccine-associated pneumonia 1 month after inadvertent receipt of varicella vaccine...
  20. doi request reprint HIV protease inhibitors inhibit the development of preerythrocytic-stage plasmodium parasites
    Charlotte V Hobbs
    NYU School of Medicine, Dept of Pediatrics, Div of Infectious Disease, 550 First Ave, 8W New Bellevue, NY, NY 10010, USA
    J Infect Dis 199:134-41. 2009
    ..We found that lopinavir/ritonavir had a dose-dependent effect on liver-stage parasite development. Given that sub-Saharan Africa is where the HIV/AIDS pandemic intersects with malaria, these results merit analysis in clinical settings...
  21. pmc Recombinant glycoprotein vaccines for human immunodeficiency virus-infected children and their effects on viral quasispecies
    Shaffiq M Essajee
    Department of Pediatrics, Division of Infectious Diseases, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Clin Diagn Lab Immunol 9:79-82. 2002
    ..These results suggest that the immune response elicited by RGP vaccines does not exert a significant selection pressure on the viral quasispecies and therefore may not be helpful in changing the course of the disease...
  22. ncbi request reprint Cutaneous anthrax associated with microangiopathic hemolytic anemia and coagulopathy in a 7-month-old infant
    Abigail Freedman
    Department of Pediatrics, New York University Medical Center, 550 First Ave, New York, NY 10016, USA
    JAMA 287:869-74. 2002
    ..The systemic manifestations of the disease persisted for nearly a month despite corticosteroid therapy, but resolved...