Research Topics
Species | W BorkowskySummaryAffiliation: New York University Country: USA Publications
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Publications
Correlation between HIV-Specific CD8 cell production of interferon- gamma and plasma levels of HIV RNA in perinatally infected pediatric populationsWilliam Borkowsky
The Saul Krugman Division of Infectious Diseases, Division of Pediatrics, New York University School of Medicine, New York, New York 10016, USA
J Infect Dis 190:722-6. 2004..Attempts to establish the same correlation in small numbers of children have also been made, with similar controversy resulting...
Planned multiple exposures to autologous virus in HIV type 1-infected pediatric populations increases HIV-specific immunity and reduces HIV viremiaWilliam Borkowsky
NYU School of Medicine, New York, New York 10016, USA
AIDS Res Hum Retroviruses 24:401-11. 2008..Other studies may have failed due to an insufficient number of exposures to HIV; most of the studies had fewer than six drug interruptions...- Structured treatment interruptions (STIs) in HIV-1 infected pediatric populations increases interferon gamma production and reduces viremiaWilliam Borkowsky
NYU School of Medicine, New York, NY, USA
Vaccine 26:3086-9. 2008..This allowed us to conclude that exposure to autologous virus increased HIV-specific immune responses and decreased HIV RNA were seen in those who have had >13 interruptions, with STI intervals that exceeded 27 days... 
Distribution and evolution of T-cell receptor Vbeta repertoire on peripheral blood lymphocytes of newborn infants of human immunodeficiency virus (HIV)-infected mothers: differential display on CD4 and CD8 T cells and effect of HIV infectionWilliam Borkowsky
Department of Pediatrics, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
Clin Vaccine Immunol 14:1215-22. 2007..In conclusion, newborns demonstrate different distributions of TCR Vbeta types on CD4 and CD8 cells. HIV infection produces no change in neonatal TCR and little change over the course of 2 years compared to that seen in the uninfected...- Nucleoside analogs plus ritonavir in stable antiretroviral therapy-experienced HIV-infected children: a randomized controlled trial. Pediatric AIDS Clinical Trials Group 338 Study TeamS A Nachman
Department of Pediatrics, State University of New York at Stony Brook, 11794 8111, USA
JAMA 283:492-8. 2000..Although protease inhibitors are used routinely in adults with human immunodeficiency virus (HIV) infection, the role of these drugs in the treatment of clinically stable HIV-infected children is not clear... - Insulin-like growth factor-1 and lean body mass in HIV-infected childrenCaroline J Chantry
Department of Pediatrics, University of California Davis Medical Center, 2516 Stockton Boulevard, Sacramento, CA 95817, USA
J Acquir Immune Defic Syndr 48:437-43. 2008.... - Safety of 2 recombinant human immunodeficiency virus type 1 (HIV-1) envelope vaccines in neonates born to HIV-1-infected womenC K Cunningham
Department of Pediatrics, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
Clin Infect Dis 32:801-7. 2001..Thus, both vaccines were safe and well tolerated in neonates, and there was no evidence of accelerated immunologic decline in HIV-infected infants... - Lymphoproliferative responses to recombinant HIV-1 envelope antigens in neonates and infants receiving gp120 vaccines. AIDS Clinical Trial Group 230 CollaboratorsW Borkowsky
The Saul Krugman Division of Infectious Diseases and Immunology, New York University Medical School, New York, NY 10016, USA
J Infect Dis 181:890-6. 2000..Responses to heterologous envelope antigens were also detected. Immune responses to vaccination are achievable at an age when some infection (perinatal or breast milk exposure related) may be prevented... - Changes in frequency of HIV-1-specific cytotoxic T cell precursors and circulating effectors after combination antiretroviral therapy in childrenH M Spiegel
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
J Infect Dis 180:359-68. 1999..In children with complete viral suppression, the frequency of HIV-1-specific CTL responses decreased, suggesting that viral replication is required to maintain CTL responses in the systemic circulation... - Impact of medications prescribed for treatment of attention-deficit hyperactivity disorder on physical growth in children and adolescents with HIVPatricia A Sirois
Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
J Dev Behav Pediatr 30:403-12. 2009..To examine the relationships between physical growth and medications prescribed for symptoms of attention-deficit hyperactivity disorder in children with HIV... - Immunologic response to combination nucleoside analogue plus protease inhibitor therapy in stable antiretroviral therapy-experienced human immunodeficiency virus-infected childrenW Borkowsky
Division of Infectious Diseases, New York University School of Medicine, New York, NY 10016, USA
J Infect Dis 182:96-103. 2000..02) by week 48 in this clinically stable population. Changes in lymphoproliferative responses to HIV antigens and recall antigens did not increase over time and between groups... - The impact of early initiation of highly active antiretroviral therapy on the human immunodeficiency virus type 1-specific CD8 T cell response in childrenH M Spiegel
Aaron Diamond AIDS Research Center, Rockefeller University, New York, NY 10016, USA
J Infect Dis 182:88-95. 2000..Thus, the reduced magnitude and breadth of the HIV-1-specific CD8 T cell response in early HAART-treated children is due to their younger age... - Prevalence of the T215Y mutation in human immunodeficiency virus type 1-infected pregnant women in a New York cohort, 1995--1999Y Sitnitskaya
Division of Pediatric Infectious Diseases, New York University School of Medicine, New York, NY, USA
Clin Infect Dis 33:e3-7. 2001..All mutations were noted in women with zidovudine experience, which suggests that monotherapy may not be adequate prophylaxis for vertical transmission of HIV-1 infection in the current era... - Early changes in quasispecies repertoire in HIV-infected infants: correlation with disease progressionS M Essajee
Department of Pediatric Infectious Diseases, New York University Medical Center, New York City, New York 10016, USA
AIDS Res Hum Retroviruses 16:1949-57. 2000..These results show that in HIV-infected children, multiple variants may initiate infection and early quasispecies diversification is associated with a favorable clinical outcome... - Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infectionAimee El Hed
Departments of Microbiology, New York University School of Medicine, New York, NY 10016, USA
J Infect Dis 201:843-54. 2010..Identification of the Th17 T cell subset as important mediators of host defense and pathology prompted us to determine their susceptibility to human immunodeficiency virus (HIV) infection... - Metabolic abnormalities and viral replication are associated with biomarkers of vascular dysfunction in HIV-infected childrenT I Miller
Department of Pediatrics, Division of Pediatric Clinical Research, Miller School of Medicine at the University of Miami, Miami, FL, USA
HIV Med 13:264-75. 2012.... - Predictors of growth and body composition in HIV-infected children beginning or changing antiretroviral therapyC J Chantry
Department of Pediatrics, University of California Davis Medical Center, Sacramento, CA 95817, USA
HIV Med 11:573-83. 2010..The aim of the study was to describe growth and body composition changes in HIV-positive children after they had initiated or changed antiretroviral therapy (ART) and to correlate these with viral, immune and treatment parameters... - Human immunodeficiency virus type 1 antigenemia in childrenW Borkowsky
Department of Pediatrics, New York University Medical Center, NY 10016
J Pediatr 114:940-5. 1989..Plasma core antigen was less frequent in children without symptoms and was not detected in 10 infected children when they were tested at birth... - Dynamics of human immunodeficiency virus type 1 replication in vertically infected infantsK Luzuriaga
Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Boston, Massachusetts, USA
J Virol 73:362-7. 1999..These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication... - Immunoreconstitution in children receiving highly active antiretroviral therapy depends on the CD4 cell percentage at baselineDivna Nikolic-Djokic
New York University Medical Center, New York, NY 10016, USA
J Infect Dis 185:290-8. 2002..The results support the option of delaying HAART in early asymptomatic HIV-1 disease in children and the use of other markers of disease progression, in addition to virus load... - Assessment of adherence to antiretroviral therapy in perinatally HIV-infected children and youth using self-report measures and pill countJohn J Farley
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Dev Behav Pediatr 29:377-84. 2008..The purpose of this study was to compare these different methods with one another and with viral load... - Erythema induratum of Bazin in a child: evidence for a cell-mediated hyper-response to Mycobacterium tuberculosisJennifer Lighter
From the Department of Pediatrics, New York University School of Medicine, New York, NY, USA
Pediatr Infect Dis J 28:326-8. 2009..5 cm of induration and an interferon-gamma releasing assay was also markedly positive. A diagnosis of erythema induratum of Bazin was confirmed on skin biopsy. The patient was successfully treated with multi-drug antituberculosis therapy... - HIV protease inhibitors inhibit the development of preerythrocytic-stage plasmodium parasitesCharlotte V Hobbs
NYU School of Medicine, Dept of Pediatrics, Div of Infectious Disease, 550 First Ave, 8W New Bellevue, NY, NY 10010, USA
J Infect Dis 199:134-41. 2009..We found that lopinavir/ritonavir had a dose-dependent effect on liver-stage parasite development. Given that sub-Saharan Africa is where the HIV/AIDS pandemic intersects with malaria, these results merit analysis in clinical settings... - Hyper interleukin-10 in an HIV-positive child with t-cell lymphoma and candidal sepsisJennifer Lighter
Saul Krugman Division of Pediatric Infectious Diseases and Immunology, New York University School of Medicine, New York, New York
J Int Assoc Physicians AIDS Care (Chic) 7:228-31. 2008..Significantly elevated levels of Interleukin-10 (IL-10) were found in the patient's serum, which may have played a role in acute demise... - Mycobacterium tuberculosis-induced CXCR4 and chemokine expression leads to preferential X4 HIV-1 replication in human macrophagesYoshihiko Hoshino
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Immunol 172:6251-8. 2004..These changes explain in part why TB accelerates the course of AIDS. CXCR4 inhibitors are a rational therapeutic approach in HIV/TB coinfection... - Impaired immunity to recall antigens and neoantigens in severely immunocompromised children and adolescents during the first year of effective highly active antiretroviral therapyMona Rigaud
New York University School of Medicine, New York, NY, USA
J Infect Dis 198:1123-30. 2008.... - Recombinant glycoprotein vaccines for human immunodeficiency virus-infected children and their effects on viral quasispeciesShaffiq M Essajee
Department of Pediatrics, Division of Infectious Diseases, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
Clin Diagn Lab Immunol 9:79-82. 2002..These results suggest that the immune response elicited by RGP vaccines does not exert a significant selection pressure on the viral quasispecies and therefore may not be helpful in changing the course of the disease... - Implementation of HIV testing at 2 New York City bathhouses: from pilot to clinical serviceDemetre Daskalakis
Division of Infectious Diseases and Immunology, New York University Langone Medical Center, New York, New York 10016, USA
Clin Infect Dis 48:1609-16. 2009..Several cities in the United States have developed programs that offer HIV testing in these venues. Similar programs have not existed before in New York City... - Human immunodeficiency virus type 1 (HIV-1) gp120-specific antibodies in neonates receiving an HIV-1 recombinant gp120 vaccineE J McFarland
Department of Pediatrics, University of Colorado Health Science Center, Denver, CO 80262, USA
J Infect Dis 184:1331-5. 2001..These results provide support for further studies of vaccine strategies to prevent mother-to-infant HIV-1 transmission... - Natural history of HIV infected pediatric long-term or slow progressor population after the first decade of lifeJuliana A Ofori Mante
Department of Pediatrics, Division of Infectious Diseases, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
Pediatr Infect Dis J 26:217-20. 2007..There is very limited information on this group of children beyond the first decade of life. A group of HIV-infected long-term nonprogressor/slow progressor children was studied... - CCR5 expression and duration of high risk sexual activity among HIV-seronegative men who have sex with menSusan M Thomas
Department of Environmental Medicine, New York University School of Medicine, NY 10016-3240, USA
AIDS 20:1879-83. 2006..Individuals with high CCR5 expression who resisted infection despite long HIV risk duration form an interesting group within which to search for additional mechanisms of resistance to HIV infection... - Toxicities associated with dual nucleoside reverse-transcriptase inhibitor regimens in HIV-infected childrenRussell B Van Dyke
Department of Pediatrics, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
J Infect Dis 198:1599-608. 2008..Human immunodeficiency virus (HIV) therapy includes a backbone of nucleoside reverse-transcriptase inhibitors (NRTIs). Toxicities associated with NRTIs are not fully defined in children... - Group-specific antibody levels surrounding invasive pneumococcal illness in children infected with human immunodeficiency virusJ C King
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Infect Dis 181:1817-21. 2000..Heterologous, noninfecting group seroresponses were detected frequently (72%) in the paired serum samples from these 4 homologous group seroresponders... - Immunological memory after exposure to variola virus, monkeypox virus, and vaccinia virusSumathi Sivapalasingam
Division of Infectious Disease, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Infect Dis 195:1151-9. 2007..Survivors of variola virus infection demonstrated VV-specific CD4 memory cell responses and neutralizing antibodies >40 years after infection... - Safety and immunogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine in HIV-infected children 7 to 12 years oldMyron J Levin
Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO, USA
J Acquir Immune Defic Syndr 55:197-204. 2010..Quadrivalent human papillomavirus vaccine (QHPV) is > 95% effective in preventing infection with vaccine-type human papillomavirus. The safety and immunogenicity of QHPV are unknown in HIV-infected children... - Perinatal transmission and viral evolution of hepatitis C virus quasispecies in infants coinfected with HIVHenry Pollack
Department of Pediatrics, The Saul Krugman Division of Infectious Diseases and Immunology, New York University School of Medicine, NY 10016, USA
J Acquir Immune Defic Syndr 36:890-9. 2004..Variation after the 1st year of life may reflect immunologic pressure from the child. There was no trend suggesting that the presence or absence of selective immunologic pressure affected HCV load or liver transaminase values... - Lipid and glucose alterations in HIV-infected children beginning or changing antiretroviral therapyCaroline J Chantry
Department of Pediatrics, University of California Davis Medical Center, Sacramento, California 95817, USA
Pediatrics 122:e129-38. 2008.... - Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART eraSharon A Nachman
Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794 8111, USA
Arch Pediatr Adolesc Med 163:164-71. 2009.... - A phase I-II study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicellaAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Pediatr Infect Dis J 28:653-5. 2009..There were no serious adverse events. Two years after vaccination 82% of subjects remained VZV-antibody positive and 60% had VZV-specific cell-mediated immunity. No child developed herpes zoster... - Cutaneous anthrax associated with microangiopathic hemolytic anemia and coagulopathy in a 7-month-old infantAbigail Freedman
Department of Pediatrics, New York University Medical Center, 550 First Ave, New York, NY 10016, USA
JAMA 287:869-74. 2002..The systemic manifestations of the disease persisted for nearly a month despite corticosteroid therapy, but resolved... - Anti-influenza serum and mucosal antibody responses after administration of live attenuated or inactivated influenza vaccines to HIV-infected childrenAdriana Weinberg
Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA
J Acquir Immune Defic Syndr 55:189-96. 2010..Live-attenuated influenza vaccine (LAIV) prevents more cases of influenza in immune-competent children than the trivalent inactivated vaccine (TIV). We compared the antibody responses to LAIV or TIV in HIV-infected children... - Ritonavir-based highly active antiretroviral therapy in human immunodeficiency virus type 1-infected infants younger than 24 months of ageEllen Gould Chadwick
Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Pediatr Infect Dis J 24:793-800. 2005..Few data are available regarding clinical outcomes or dosing requirements for the protease inhibitor ritonavir in human immunodeficiency virus (HIV)-infected children younger than under 24 months of age... - Immunogenicity, safety, and predictors of response after a pneumococcal conjugate and pneumococcal polysaccharide vaccine series in human immunodeficiency virus-infected children receiving highly active antiretroviral therapyMark J Abzug
University of Colorado School of Medicine, Pediatric Infectious Disease, The Children s Hospital, Denver, CO 80218, USA
Pediatr Infect Dis J 25:920-9. 2006.... - Pertussis booster vaccination in HIV-infected children receiving highly active antiretroviral therapyMark J Abzug
School of Medicine, University of Colorado and Children s Hospital, Denver, Colorado, USA
Pediatrics 120:e1190-202. 2007..Our goal was to evaluate the immunogenicity and safety of pertussis booster vaccination in children infected with HIV on highly active antiretroviral therapy (HAART)... - Association of hypercholesterolemia incidence with antiretroviral treatment, including protease inhibitors, among perinatally HIV-infected childrenKatherine Tassiopoulos
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 47:607-14. 2008..Antiretroviral therapy has been associated with hypercholesterolemia in HIV-infected children. Few longitudinal studies have been conducted to examine this association, however... - Long-term effects of protease-inhibitor-based combination therapy on CD4 T-cell recovery in HIV-1-infected children and adolescentsChang-Heok Soh
Department of Biostatistics, Harvard School of Public Health, MA, Boston 02115, USA
Lancet 362:2045-51. 2003..Randomised investigation of when to start combination therapy in children, particularly infants, is needed... - Association of site-specific and participant-specific factors with retention of children in a long-term pediatric HIV cohort studyPaige L Williams
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115 6017, USA
Am J Epidemiol 167:1375-86. 2008..Although participant characteristics are difficult to modify, the authors identified several potentially modifiable site practices that could be targeted to improve retention... - Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and countingKunjal Patel
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Clin Infect Dis 46:1751-60. 2008.... - Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitorsBrian L Robbins
St Jude Children s Research Hospital, Memphis, Tennessee, USA
Antimicrob Agents Chemother 52:3276-83. 2008....
Research Grants
- ABI PRISM 7700 SEQUENCE DETECTION SYSTEMWilliam Borkowsky; Fiscal Year: 2001..The principal investigator will be responsible for helping design primers and probes for the instrument as well as insure that the assay and those who manage it undergo appropriate quality control procedures. ..
- BIOLOGY OF PEDIATRIC HEPATITIS C INFECTIONWilliam Borkowsky; Fiscal Year: 2001..The influence of both maternal and child alleles on transmission will be assessed. The correlation of immune responses measured in AIM 3 and the clinical outcome of HCV infection with HLA alleles in the child will be studied. ..
- PEDIATRIC AIDS CLINICAL TRIALS UNITWilliam Borkowsky; Fiscal Year: 2002..This effort will also be helped by established links to previously funded community resources, our community advisory board, and by our own local General Clinical Research Center. ..