M J Blaser

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint What are the consequences of the disappearing human microbiota?
    Martin J Blaser
    Department of Medicine and the Department of Microbiology, New York University Langone Medical Center, New York, New York 10017, USA
    Nat Rev Microbiol 7:887-94. 2009
  2. pmc Substantial alterations of the cutaneous bacterial biota in psoriatic lesions
    Zhan Gao
    Department of Medicine, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 3:e2719. 2008
  3. pmc Antibiotics in animal feed and spread of resistant Campylobacter from poultry to humans
    Nicole M Iovine
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Emerg Infect Dis 10:1158-9. 2004
  4. pmc Antimicrobial resistance in Campylobacter
    Nicole M Iovine
    Emerg Infect Dis 10:1346. 2004
  5. ncbi request reprint The microbiome explored: recent insights and future challenges
    Martin Blaser
    Department of Medicine, New York University Langone Medical Center, New York, New York 10016, USA
    Nat Rev Microbiol 11:213-7. 2013
  6. pmc Competition and resilience between founder and introduced bacteria in the Caenorhabditis elegans gut
    Cynthia Portal-Celhay
    Department of Medicine and Microbiology, New York University School of Medicine, New York, New York, USA
    Infect Immun 80:1288-99. 2012
  7. pmc Evidence of host-virus co-evolution in tetranucleotide usage patterns of bacteriophages and eukaryotic viruses
    David T Pride
    Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Genomics 7:8. 2006
  8. pmc Who are we? Indigenous microbes and the ecology of human diseases
    Martin J Blaser
    Internal Medicine, Department of Medicine, Microbiology at New York University School of Medicine, New York, USA
    EMBO Rep 7:956-60. 2006
  9. ncbi request reprint The equilibria that allow bacterial persistence in human hosts
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nature 449:843-9. 2007
  10. doi request reprint Understanding microbe-induced cancers
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Cancer Prev Res (Phila) 1:15-20. 2008

Collaborators

Detail Information

Publications123 found, 100 shown here

  1. ncbi request reprint What are the consequences of the disappearing human microbiota?
    Martin J Blaser
    Department of Medicine and the Department of Microbiology, New York University Langone Medical Center, New York, New York 10017, USA
    Nat Rev Microbiol 7:887-94. 2009
    ....
  2. pmc Substantial alterations of the cutaneous bacterial biota in psoriatic lesions
    Zhan Gao
    Department of Medicine, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 3:e2719. 2008
    ..001), whereas normal skin from the psoriatic patients showed intermediate levels (12.3+/-21.6%). We conclude that psoriasis is associated with substantial alteration in the composition and representation of the cutaneous bacterial biota...
  3. pmc Antibiotics in animal feed and spread of resistant Campylobacter from poultry to humans
    Nicole M Iovine
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Emerg Infect Dis 10:1158-9. 2004
  4. pmc Antimicrobial resistance in Campylobacter
    Nicole M Iovine
    Emerg Infect Dis 10:1346. 2004
  5. ncbi request reprint The microbiome explored: recent insights and future challenges
    Martin Blaser
    Department of Medicine, New York University Langone Medical Center, New York, New York 10016, USA
    Nat Rev Microbiol 11:213-7. 2013
    ....
  6. pmc Competition and resilience between founder and introduced bacteria in the Caenorhabditis elegans gut
    Cynthia Portal-Celhay
    Department of Medicine and Microbiology, New York University School of Medicine, New York, New York, USA
    Infect Immun 80:1288-99. 2012
    ..coli strain and against Salmonella. Our data provide evidence of active competition for colonization niches in the C. elegans gut, as determined by bacterial factors and subject to in vivo selection...
  7. pmc Evidence of host-virus co-evolution in tetranucleotide usage patterns of bacteriophages and eukaryotic viruses
    David T Pride
    Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Genomics 7:8. 2006
    ..Tetranucleotide usage deviation (TUD) patterns were chosen since they have previously been shown to contain phylogenetic signal similar to that of 16S rRNA...
  8. pmc Who are we? Indigenous microbes and the ecology of human diseases
    Martin J Blaser
    Internal Medicine, Department of Medicine, Microbiology at New York University School of Medicine, New York, USA
    EMBO Rep 7:956-60. 2006
  9. ncbi request reprint The equilibria that allow bacterial persistence in human hosts
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nature 449:843-9. 2007
    ..The model can aid prediction of equilibrium states in the context of further change: widespread immunodeficiency, changing population densities, or extinctions...
  10. doi request reprint Understanding microbe-induced cancers
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Cancer Prev Res (Phila) 1:15-20. 2008
    ..Finally, our challenge for the future is to better understand the steps in microbe-induced cancers to optimize both prevention and therapy...
  11. ncbi request reprint Trends in reported adenocarcinomas of the oesophagus and gastric cardia in Japan
    Martin J Blaser
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
    Eur J Gastroenterol Hepatol 14:107-13. 2002
    ..Lack of a parallel increase in oesophageal adenocarcinomas could be due to misclassification artefacts and/or coding preferences for gastro-oesophageal junction tumours...
  12. pmc Does Helicobacter pylori protect against asthma and allergy?
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, 550 First Avenue OBV A606, New York, NY 10016, USA
    Gut 57:561-7. 2008
  13. pmc Early-life family structure and microbially induced cancer risk
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, New York, New York, United States of America
    PLoS Med 4:e7. 2007
    ..In this study, we considered whether early-life family structure affects the risk of later developing gastric cancer among H. pylori+ men...
  14. pmc Helicobacter pylori persistence: biology and disease
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, and New York Harbor Veterans Affairs Medical Center, New York 10016, USA
    J Clin Invest 113:321-33. 2004
    ..A well-choreographed equilibrium between bacterial effectors and host responses permits microbial persistence and health of the host but confers risk of serious diseases, including peptic ulceration and gastric neoplasia...
  15. ncbi request reprint Bacteria and diseases of unknown cause: hemolytic-uremic syndrome
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, and New York Harbor Department of Veterans Affairs Medical Center, New York, New York 10016, USA
    J Infect Dis 189:552-5. 2004
  16. pmc Theodore E. Woodward Award: Global warming and the human stomach: microecology follows macroecology
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Trans Am Clin Climatol Assoc 116:65-75; discussion 75-6. 2005
    ..The disappearance of H. pylori (especially cag+ strains), possibly contributing to the risk of these esophageal diseases, may be an indicator for changing human microecology...
  17. pmc Quantitative detection of Helicobacter pylori gene expression in vivo and relationship to gastric pathology
    R M Peek
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2279, USA
    Infect Immun 68:5488-95. 2000
    ..pylori iceA1 strains reflects levels of iceA1 transcription in vivo...
  18. pmc Helicobacter pylori heat shock protein A: serologic responses and genetic diversity
    E K Ng
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Diagn Lab Immunol 6:377-82. 1999
    ..pylori infection are not related to HspA antigenicity or to sequence variation. However, B-domain sequence variation may be a marker for the study of the genetic diversity of H. pylori strains of different geographic origins...
  19. pmc Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses
    D A Israel
    Division of Gastroenterology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Invest 107:611-20. 2001
    ..Use of an H pylori whole genome microarray is an effective method to identify differences in gene content between H. pylori strains that induce distinct pathological outcomes in a rodent model of H. pylori infection...
  20. ncbi request reprint Role of Helicobacter pylori cagA(+) strains and specific host immune responses on the development of premalignant and malignant lesions in the gastric cardia
    R M Peek
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Int J Cancer 82:520-4. 1999
    ..pylori strains and induction of particular serological responses are significantly associated with marked histological findings in the gastric cardia but not with adenocarcinoma of either the gastric cardia or esophagus...
  21. pmc Quasispecies development of Helicobacter pylori observed in paired isolates obtained years apart from the same host
    E J Kuipers
    Division of Infectious Diseases, Vanderbilt University School of Medicine and VA Medical Center, Nashville, Tennessee, USA
    J Infect Dis 181:273-82. 2000
    ..The changes detected by RAPD-PCR and AFLP indicate that genetic drift occurs within H. pylori populations over the course of years of colonization of a single host...
  22. ncbi request reprint Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils
    R M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2279, USA
    Gastroenterology 118:48-59. 2000
    ..This study aimed to determine whether H. pylori virulence-related characteristics affect apoptosis, proliferation, and gastrin levels in a rodent model of gastric adenocarcinoma...
  23. pmc Campylobacter fetus surface layer proteins are transported by a type I secretion system
    S A Thompson
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605, USA
    J Bacteriol 180:6450-8. 1998
    ..E. coli expressing C. fetus sapA and sapCDEF secreted SapA, indicating that the sapCDEF genes are sufficient for SLP secretion. C. fetus SLPs therefore are transported to the cell surface by a type I secretion system...
  24. pmc Characterization of Helicobacter pylori dapE and construction of a conditionally lethal dapE mutant
    M Karita
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605, USA
    Infect Immun 65:4158-64. 1997
    ..The data imply that the H. pylori dapE mutant may be useful as a conditionally lethal vaccine...
  25. pmc Analysis of iceA1 transcription in Helicobacter pylori
    J P Donahue
    Divisions of Infectious Diseases and Gastroenterology, Department of Medicine, and Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Helicobacter 5:1-12. 2000
    ..pylori pathogenesis. Consequently, the current studies were undertaken to characterize iceA1 transcription and to define the structure of iceA1-containing transcripts to evaluate the potential of this gene to encode functional proteins...
  26. ncbi request reprint Host specificity of Helicobacter pylori strains and host responses in experimentally challenged nonhuman primates
    A Dubois
    Laboratory of Gastrointestinal and Liver Studies, Digestive Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    Gastroenterology 116:90-6. 1999
    ..The specificity of colonization by Helicobacter pylori and complex host-bacterium interactions cannot be readily examined in humans. The aim of this study was to perform such analyses in rhesus monkeys...
  27. pmc Anti-CagA immunoglobulin G responses correlate with interleukin-8 induction in human gastric mucosal biopsy culture
    T Ando
    Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Diagn Lab Immunol 7:803-9. 2000
    ..pylori density, and IL-8 levels, suggesting that the absolute levels of these antibodies may be markers for gastric inflammation and premalignant changes in individual hosts...
  28. ncbi request reprint Helicobacter pylori genotypes, host factors, and gastric mucosal histopathology in peptic ulcer disease
    K T Tham
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hum Pathol 32:264-73. 2001
    ..HUM PATHOL 32:264-273. This is a US Government work. There are no restrictions on its use...
  29. ncbi request reprint Hypothesis: the changing relationships of Helicobacter pylori and humans: implications for health and disease
    M J Blaser
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, and Medical Service, Department of Veterans Affairs Medical Center, Nashville, TN 37232 2605, USA
    J Infect Dis 179:1523-30. 1999
    ..Thus, in the 21st century, the continuing decline in H. pylori may lead to the disappearance of duodenal ulcers and distal gastric cancers and toward a marked increase in GERD, Barrett's esophagus, and esophageal adenocarcinoma...
  30. ncbi request reprint Overcoming the restriction barrier to plasmid transformation of Helicobacter pylori
    J P Donahue
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, A 3310, MCN, Nashville, TN 37232, USA
    Mol Microbiol 37:1066-74. 2000
    ..The approach described should significantly enhance the ability to manipulate gene function in H. pylori and other organisms that have substantial restriction barriers to transformation...
  31. ncbi request reprint Regulation of the HpyII restriction-modification system of Helicobacter pylori by gene deletion and horizontal reconstitution
    R A Aras
    Departments of Medicine and Microbiology, New York University School of Medicine and VA Medical Center, New York, USA
    Mol Microbiol 42:369-82. 2001
    ..pylori populations use mutation and transformation to regulate gene function...
  32. pmc The Helicobacter pylori genome is modified at CATG by the product of hpyIM
    Q Xu
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Bacteriol 179:6807-15. 1997
    ..We conclude that hpyIM encodes a DNA methyltransferase, M.HpyI, that is well conserved among diverse H. pylori strains and that modifies H. pylori genomes at CATG sites...
  33. ncbi request reprint Acid-induced expression of an LPS-associated gene in Helicobacter pylori
    C C McGowan
    Department of Medicine, Vanderbilt University Medical School, and Department of Veterans Affairs Medical Center, Nashville, TN, USA
    Mol Microbiol 30:19-31. 1998
    ..pylori cells grown at pH 5 compared with pH 7, which suggests that H. pylori may alter its LPS structure in response to acidic pH. This may be an important adaptation facilitating H. pylori colonization of the acidic gastric environment...
  34. pmc Promoters of the CATG-specific methyltransferase gene hpyIM differ between iceA1 and iceA2 Helicobacter pylori strains
    Q Xu
    Department of Microbiology and Immunology, Department of Medicine, Vanderbilt University School of Medicine and VA Medical Center, Nashville, Tennessee 37232, USA
    J Bacteriol 183:3875-84. 2001
    ....
  35. ncbi request reprint Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle
    R M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2279, USA
    Cancer Res 59:6124-31. 1999
    ..These results may explain heterogeneity in levels of gastric epithelial cell proliferation and apoptosis found within H. pyloricolonized mucosa...
  36. ncbi request reprint Country-specific constancy by age in cagA+ proportion of Helicobacter pylori infections
    G I Perez-Perez
    Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    Int J Cancer 72:453-6. 1997
    ..Variation in CagA positivity rates was not significantly associated with variation in either gastric or esophageal cancer rates. Our data suggest that CagA seroprevalence is not the major factor influencing gastric cancer rates...
  37. ncbi request reprint Analysis of hopQ alleles in East Asian and Western strains of Helicobacter pylori
    Ping Cao
    Department of Medicine, Division of Infectious Diseases, A2200 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    FEMS Microbiol Lett 251:37-43. 2005
    ..Geographic variation in the genetic characteristics of H. pylori strains may be a factor contributing to geographic variation in gastric cancer incidence...
  38. pmc Helicobacter pylori does not require Lewis X or Lewis Y expression to colonize C3H/HeJ mice
    Tohru Takata
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Infect Immun 70:3073-9. 2002
    ..Similarly, adherence to AGS and KatoIII cells was unaffected by the mutations. Together, these findings indicate that Le expression is not necessary for mouse gastric colonization or for H. pylori adherence to epithelial cells...
  39. ncbi request reprint Increased gastric epithelial cell apoptosis associated with colonization with cagA + Helicobacter pylori strains
    S F Moss
    Department of Medicine, St Luke s Roosevelt Hospital Center, New York, New York 10025, USA
    Cancer Res 61:1406-11. 2001
    ..Host factors may be more important than bacterial products in determining the long-term outcome of H. pylori colonization...
  40. pmc Repeat-associated plasticity in the Helicobacter pylori RD gene family
    Joshua R Shak
    Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Bacteriol 191:6900-10. 2009
    ..This novel family of hypervariable genes with conserved, repetitive, and allelic domains may represent an important locus for understanding H. pylori persistence in its natural host...
  41. ncbi request reprint Helicobacter pylori and gastrointestinal tract adenocarcinomas
    Richard M Peek
    Division of Gastroenterology, Vanderbilt University School of Medicine, Medical Center North, Nashville, Tennessee 37232 2279, USA
    Nat Rev Cancer 2:28-37. 2002
    ....
  42. pmc High frequency of gastric colonization with multiple Helicobacter pylori strains in Venezuelan subjects
    C Ghose
    Department of Microbiology, New York University School of Medicine, New York, New York, USA
    J Clin Microbiol 43:2635-41. 2005
    ..These results demonstrate the high prevalence of mixed colonization and indicate that the H. pylori East Asian vacA genotype has survived in all three populations tested...
  43. ncbi request reprint PEB1, the major cell-binding factor of Campylobacter jejuni, is a homolog of the binding component in gram-negative nutrient transport systems
    Z Pei
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    J Biol Chem 268:18717-25. 1993
    ..8%) and hisJ (28.9%), whereas ORF C has nearly 50% identity to glnQ and hisP. Thus, PEB1 could be involved both in binding to intestinal cells and in amino acid transport...
  44. pmc Dynamics of bacterial phenotype selection in a colonized host
    G F Webb
    Department of Mathematics, Vanderbilt University, Nashville, TN 37240, USA
    Proc Natl Acad Sci U S A 99:3135-40. 2002
    ....
  45. pmc Evidence that cagA(+) Helicobacter pylori strains are disappearing more rapidly than cagA(-) strains
    G I Perez-Perez
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10010, USA
    Gut 50:295-8. 2002
    ..In this study, we determined whether the proportion of subjects colonised by cagA(+) or cagA(-) H pylori strains has changed as the overall prevalence of H pylori(+) has declined...
  46. pmc Polymorphisms of Helicobacter pylori HP0638 reflect geographic origin and correlate with cagA status
    T Ando
    Department of Medicine, New York University School of Medicine, New York, New York, USA
    J Clin Microbiol 40:239-46. 2002
    ..Analysis of HP0638 CT polymorphisms may serve as a new typing system to discriminate H. pylori isolates for epidemiological purposes...
  47. ncbi request reprint A Helicobacter pylori restriction endonuclease-replacing gene, hrgA, is associated with gastric cancer in Asian strains
    Takafumi Ando
    Departments of Medicine and Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Cancer Res 62:2385-9. 2002
    ..Although a direct function for hrgA in virulence could not be demonstrated, our data indicate that hrgA is a strain-specific gene that might be associated with gastric cancer among H. pylori isolates from Asian patients...
  48. pmc Phenotypic and genotypic variation in methylases involved in type II restriction-modification systems in Helicobacter pylori
    Tohru Takata
    Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nucleic Acids Res 30:2444-52. 2002
    ....
  49. pmc Local and systemic immune and inflammatory responses to Helicobacter pylori strains
    Niranjan Bhat
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Diagn Lab Immunol 12:1393-400. 2005
    ..Furthermore, given the relationships demonstrated by multivariate analysis, determination of gastric juice antibodies may provide a better representation of serum, rather than secretory, immune response...
  50. ncbi request reprint Natural variation in populations of persistently colonizing bacteria affect human host cell phenotype
    Rahul A Aras
    Departments of Medicine and Microbiology, New York University School of Medicine, New York, New York, USA
    J Infect Dis 188:486-96. 2003
    ..These findings indicate that within an individual host, intragenomic recombination between H. pylori repetitive DNA produces strain variants differing in their signals to host cells...
  51. ncbi request reprint Association of caesarean delivery with child adiposity from age 6 weeks to 15 years
    J Blustein
    Department of Health Policy, Medicine, and Population Health, NYU School of Medicine, New York, NY 10012, USA
    Int J Obes (Lond) 37:900-6. 2013
    ..o assess associations of caesarean section with body mass from birth through adolescence...
  52. pmc Allelic Variation within Helicobacter pylori babA and babB
    D T Pride
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine and VA Medical Center, Nashville, Tennessee, USA
    Infect Immun 69:1160-71. 2001
    ..pylori strains...
  53. ncbi request reprint Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells
    M K Tummuru
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605, USA
    Mol Microbiol 18:867-76. 1995
    ....
  54. pmc Responses of endoscopy patients in Ladakh, India, to Helicobacter pylori whole-cell and Cag A antigens
    Judith Romero-Gallo
    Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Diagn Lab Immunol 9:1313-7. 2002
    ..In addition to establishing a collection of H. pylori isolates from a remote area in the world, we show that use of H. pylori whole-cell and Cag A serology together increases the sensitivity for the detection of colonization...
  55. ncbi request reprint Structure and genotypic plasticity of the Campylobacter fetus sap locus
    Zheng Chao Tu
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Microbiol 48:685-98. 2003
    ..As divergent SLP C-termini possess multiple antigenic sites, their reciprocal recombination behind the unique sap promoter leads to continuing antigenic variation...
  56. ncbi request reprint The association of gastric leptin with oesophageal inflammation and metaplasia
    F Francois
    New York University School of Medicine, New York, NY, USA
    Gut 57:16-24. 2008
    ..Gastro-oesophageal reflux disease complications may reflect imbalances between protective and injurious factors. Through its effects on cell growth, leptin may influence oesophageal mucosal homeostasis...
  57. pmc Analysis of F1F0-ATPase from Helicobacter pylori
    C C McGowan
    Department of Medicine, Vanderbilt University School of Medicine, and Department of Veterans Affairs Medical Center, Nashville, Tennessee 37232 2605, USA
    Infect Immun 65:2640-7. 1997
    ..The sensitivity of H. pylori to DCCD at pH 7 and 6, and failure to recover F1F0 H. pylori mutants under similar conditions, suggests that the function of this enzyme is required for survival of H. pylori at these pHs...
  58. ncbi request reprint Characteristics of Helicobacter pylori natural transformation
    D A Israel
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine and VA Medical Center, A 3310 Medical Center North, Nashville, TN 37232 2605, USA
    FEMS Microbiol Lett 186:275-80. 2000
    ..pylori and Helicobacter bilis) but not Escherichia coli suggests specificity based on DNA source. Finally, the cag island was determined to be unnecessary for high-frequency transformation...
  59. pmc Antimutator role of the DNA glycosylase mutY gene in Helicobacter pylori
    Shuyan Huang
    Department of Microbiology and Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Bacteriol 188:6224-34. 2006
    ..Our findings indicate that H. pylori possesses phase-variable base excision repair, consistent with a tension between repair and mutation...
  60. ncbi request reprint The genetic gymnastics of our indigenous microbes
    Martin J Blaser
    New York University School of Medicine, New York, NY 10016, USA
    N Engl J Med 346:2083-5. 2002
  61. pmc Conservation and diversity of sap homologues and their organization among Campylobacter fetus isolates
    Zheng Chao Tu
    Departments of Medicine Microbiology, New York University School of Medicine Department of Veterans Affairs Medical Center, New York, New York 10016, USA
    Infect Immun 72:1715-24. 2004
    ..In total, the observed differences suggest that the sap island has evolved differing genotypes that are plastic, perhaps enabling colonization of varied niches, in addition to antigenic variation...
  62. ncbi request reprint An endangered species in the stomach
    Martin J Blaser
    Department of Medicine, New York University School of Medicine, USA
    Sci Am 292:38-45. 2005
  63. pmc Helicobacter pylori colonization is inversely associated with childhood asthma
    Yu Chen
    Department of Environmental Medicine, School of Medicine, New York University, New York, New York 10016, USA
    J Infect Dis 198:553-60. 2008
    ..Asthma, a serious health problem worldwide, is becoming more common. Colonization with Helicobacter pylori, a major human indigenous (commensal) microbe, during early life may be relevant to the risk of childhood asthma...
  64. ncbi request reprint Role of dprA in transformation of Campylobacter jejuni
    Tohru Takata
    Department of Medicine, New York University School of Medicine, New York, NY, USA
    FEMS Microbiol Lett 252:161-8. 2005
    ..pylori>H. influenzae) restored electro-transformation. Thus, C. jejuni expresses a DprA ortholog that functionally most closely resembles that of H. pylori and is involved in DNA transformation...
  65. pmc Host Lewis phenotype-dependent Helicobacter pylori Lewis antigen expression in rhesus monkeys
    Hans Peter Wirth
    Division of Infectious Diseases, Vanderbilt University School of Medicine, and VA Medical Center, Nashville, Tennessee, USA
    FASEB J 20:1534-6. 2006
    ..pylori populations can change Lewis phenotypes during long-term colonization of natural hosts to resemble those of their hosts, providing evidence for host selection for bacterial phenotypes...
  66. ncbi request reprint Identification, purification, and characterization of major antigenic proteins of Campylobacter jejuni
    Z H Pei
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    J Biol Chem 266:16363-9. 1991
    ..jejuni and all 15 C. coli strains but none of the isolates of the other three bacterial species. The PEB1 and PEB3 proteins appear to be candidate antigens for both a Campylobacter vaccine and for serological assays for the pathogen...
  67. pmc Evidence that the Campylobacter fetus sap locus is an ancient genomic constituent with origins before mammals and reptiles diverged
    Z C Tu
    Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Infect Immun 69:2237-44. 2001
    ..fetus genome, integral to its biology...
  68. pmc Campylobacter fetus uses multiple loci for DNA inversion within the 5' conserved regions of sap homologs
    Z C Tu
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Bacteriol 183:6654-61. 2001
    ..In total, these data indicate that C. fetus can use multiple sites within the FCR for its sap-related DNA inversion...
  69. ncbi request reprint Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains
    T L Cover
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605
    J Biol Chem 269:10566-73. 1994
    ..8% amino acid identity with the corresponding region from tox+ strain 60190. Thus, sequence divergence in vacA genes may explain the lack of functionally active cytotoxin production by some H. pylori isolates...
  70. pmc Reactive nitrogen species contribute to innate host defense against Campylobacter jejuni
    Nicole M Iovine
    Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, New York 100161, USA
    Infect Immun 76:986-93. 2008
    ..jejuni and that nitric oxide and reactive nitrogen species comprise part of the innate defense mechanisms that contribute to the resolution of C. jejuni infection...
  71. pmc Bacterial biota in reflux esophagitis and Barrett's esophagus
    Zhiheng Pei
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    World J Gastroenterol 11:7277-83. 2005
    ..To identify the bacterial flora in conditions such as Barrettos esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora...
  72. ncbi request reprint Helicobacter pylori and overweight status in the United States: data from the Third National Health and Nutrition Examination Survey
    Ilseung Cho
    Department of Medicine, New York University School of Medicine, New York, NY, USA
    Am J Epidemiol 162:579-84. 2005
    ..pylori groups. In this US population-based study, there was no significant association between H. pylori colonization, cagA+ strains of H. pylori, and being overweight...
  73. pmc The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin
    Fritz Francois
    New York University Langone Medical Center, New York, NY, USA
    BMC Gastroenterol 11:37. 2011
    ..pylori colonization. We prospectively evaluated the effect of H. pylori eradication on meal-associated changes in serum ghrelin and leptin levels, and body weight...
  74. pmc UvrD helicase suppresses recombination and DNA damage-induced deletions
    Josephine Kang
    Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Bacteriol 188:5450-9. 2006
    ..pylori that face high-level genotoxic stress in vivo...
  75. pmc Longitudinal analysis of serological responses of adults to Helicobacter pylori antigens
    Guillermo I Perez-Perez
    Department of Medicine, New York University Langone Medical Center, New York, New York, USA
    J Infect Dis 202:916-23. 2010
    ..These findings indicate that H. pylori-specific antibody responses are host-specific with IgG1:IgG4 ratios stable over 21 years, IgG1 responses predominating, and HspA seroconversion with aging...
  76. pmc Host-dependent Lewis (Le) antigen expression in Helicobacter pylori cells recovered from Leb-transgenic mice
    Mary Ann Pohl
    Department of Medicine, New York University School of Medicine and Veteran s Administration Medical Center, New York, NY 10016, USA
    J Exp Med 206:3061-72. 2009
    ..These studies indicate that H. pylori evolves to resemble the host's gastric Le phenotype, and reveal a bacterial genetic locus that is subject to host-driven selection pressure...
  77. pmc Natural transformation of helicobacter pylori involves the integration of short DNA fragments interrupted by gaps of variable size
    Edward A Lin
    Department of Medicine, New York University School of Medicine, New York, New York, United States of America
    PLoS Pathog 5:e1000337. 2009
    ..Taken together, these observations support a system of highly efficient short-fragment recombination involving multiple recombination events within a single locus...
  78. ncbi request reprint A paradigm for direct stress-induced mutation in prokaryotes
    Josephine M Kang
    Department of Medicine, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    FASEB J 20:2476-85. 2006
    ..These studies provide a new paradigm for adaptation under increased selective pressures that may be present in other prokaryotes...
  79. pmc Asthma is inversely associated with Helicobacter pylori status in an urban population
    Joan Reibman
    Department of Medicine, New York University School of Medicine, New York City, New York, USA
    PLoS ONE 3:e4060. 2008
    ..Since the general prevalence of Helicobacter pylori has been decreasing, we hypothesized that H. pylori serostatus would be inversely related to the presence of asthma...
  80. pmc Molecular analysis of human forearm superficial skin bacterial biota
    Zhan Gao
    Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 104:2927-32. 2007
    ..4% of all clones. These results show that the bacterial biota in normal superficial skin is highly diverse, with few well conserved and well represented genera, but otherwise low-level interpersonal consensus...
  81. ncbi request reprint Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation
    Michael H Pillinger
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 282:18722-31. 2007
    ..These data indicate H. pylori effects on host epithelial MMP-1 expression via ERK, with p38 playing a potential regulatory role...
  82. pmc Repair and antirepair DNA helicases in Helicobacter pylori
    Josephine Kang
    Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Bacteriol 190:4218-24. 2008
    ..pylori RecG resolvase provides an "antirepair" pathway allowing for selection of varied strains. Such competition between repair and antirepair provides a novel mechanism to maximize fitness at a bacterial population level...
  83. ncbi request reprint The language used by Helicobacter pylori to regulate human cells
    Michael H Pillinger
    Department of Medicine, New York University School of Medicine, New York, NY 10010, USA
    J Infect Dis 196:6-9. 2007
  84. ncbi request reprint Plastic cells and populations: DNA substrate characteristics in Helicobacter pylori transformation define a flexible but conservative system for genomic variation
    Steven M Levine
    Dept of Medicine, New York University School of Medicine, New York, NY 10016, USA
    FASEB J 21:3458-67. 2007
    ..pylori population biology...
  85. pmc Leptin and ghrelin in relation to Helicobacter pylori status in adult males
    Jatin Roper
    New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Clin Endocrinol Metab 93:2350-7. 2008
    ..Leptin and ghrelin, hormones involved in human energy homeostasis, are both produced in the stomach...
  86. pmc Effect of host species on recG phenotypes in Helicobacter pylori and Escherichia coli
    Josephine Kang
    Department of Microbiology, New York University School of Medicine, VA Medical Center, New York, New York, USA
    J Bacteriol 186:7704-13. 2004
    ..Therefore, host context appears critical in defining the function of recG. The fact that in E. coli recG phenotypes are not constant in other species indicates the diverse roles for conserved recombination genes in prokaryotic evolution...
  87. pmc Extensive repetitive DNA facilitates prokaryotic genome plasticity
    Rahul A Aras
    Department of Medicine, New York University School of Medicine and Veterans Affairs Medical Center, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 100:13579-84. 2003
    ....
  88. pmc Bacterial biota in the human distal esophagus
    Zhiheng Pei
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 101:4250-5. 2004
    ..These findings provide evidence for a complex but conserved bacterial population in the normal distal esophagus...
  89. pmc Transient and persistent Helicobacter pylori colonization in Native American children
    Guillermo I Perez-Perez
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Clin Microbiol 41:2401-7. 2003
    ..pylori-negative children. Thus, H. pylori acquisition, accompanied by a transient PGI increase, was frequent in this population, especially in the second and third years of life, but often was brief...
  90. ncbi request reprint Matrix metalloproteinase secretion by gastric epithelial cells is regulated by E prostaglandins and MAPKs
    Michael H Pillinger
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 280:9973-9. 2005
    ..pylori infection and/or cyclooxygenase inhibition may induce epithelial cell signaling to contribute to gastric ulcerogenesis...
  91. pmc Structural and functional divergence of MutS2 from bacterial MutS1 and eukaryotic MSH4-MSH5 homologs
    Josephine Kang
    Department of Microbiology, New York University School of Medicine, and VA Medical Center, New York, NY 10016, USA
    J Bacteriol 187:3528-37. 2005
    ..This phenotypic analysis is consistent with the phylogenetic and biochemical data suggesting that MutS1 and MutS2 have divergent functions...
  92. ncbi request reprint Inhibition of Bacillus anthracis growth and virulence-gene expression by inhibitors of quorum-sensing
    Marcus B Jones
    Department of Microbiology, Sackler Institute, and Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Infect Dis 191:1881-8. 2005
    ..These data suggest that use of QS inhibitors could represent novel therapies for anthrax...
  93. pmc Evolutionary implications of microbial genome tetranucleotide frequency biases
    David T Pride
    Department of Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee 37235, USA
    Genome Res 13:145-58. 2003
    ..Because relationships demonstrated in TUD-based analyses utilize whole genomes, they should be considered complementary to phylogenies based on single genetic elements, such as 16S rRNA...
  94. pmc Helicobacter pylori interstrain restriction-modification diversity prevents genome subversion by chromosomal DNA from competing strains
    Rahul A Aras
    Department of Medicine and Microbiology, New York University School of Medicine and VA Medical Center, New York, NY, USA
    Nucleic Acids Res 30:5391-7. 2002
    ..pylori R-M diversity limits acquisition of chromosomal DNA fragments of >/=1 kb...
  95. pmc Host cell responses to genotypically similar Helicobacter pylori isolates from United States and Japan
    Takafumi Ando
    Department of Medicine, New York University School of Medicine, New York, NY, USA
    Clin Diagn Lab Immunol 9:167-75. 2002
    ..Inactivation of HP0638 does not alter epithelial responses mediated by the cag island in vitro. Assessment of apoptosis in vitro identified a group of H. pylori isolates that induce more severe gastric inflammation and atrophy...
  96. ncbi request reprint Internal medicine residency training in the 21st century: aligning requirements with professional needs
    Mitchell H Charap
    Department of Medicine, New York University School of Medicine, NY 10016, USA
    Am J Med 118:1042-6. 2005
  97. pmc Seroprevalence of Helicobacter pylori in New York City populations originating in East Asia
    Guillermo Ignacio Perez-Perez
    Department of Medicine, New York University School of Medicine, New York, NY, USA
    J Urban Health 82:510-6. 2005
    ..pylori is highly prevalent among recent East Asian immigrants, especially among Fujianese. The protective effects of history of dyspepsia and duration in the United States suggest that these may be markers for antibiotic therapies...
  98. ncbi request reprint Concerted evolution between duplicated genetic elements in Helicobacter pylori
    David T Pride
    Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA
    J Mol Biol 316:629-42. 2002
    ..pylori. That these events are recA-dependent and DNase-resistant indicates their likely cause is intragenomic recombination...
  99. pmc Infant antibiotic exposures and early-life body mass
    L Trasande
    Department of Pediatrics, New York University School of Medicine, New York, NY 10016, USA
    Int J Obes (Lond) 37:16-23. 2013
    ..To examine the associations of antibiotic exposures during the first 2 years of life and the development of body mass over the first 7 years of life...
  100. pmc Role of futC slipped strand mispairing in Helicobacter pylori Lewisy phase variation
    Edgardo Sanabria-Valentín
    Department of Microbiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Microbes Infect 9:1553-60. 2007
    ..Le(y) synthesis was restored and Le(x) expression was reciprocally lowered. From these studies, we confirmed the principal role of futC slipped-strand mispairing in Le antigenic variation in vitro and in vivo...
  101. pmc East Asian genotypes of Helicobacter pylori strains in Amerindians provide evidence for its ancient human carriage
    Chandrabali Ghose
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 99:15107-11. 2002
    ..These findings provide evidence that H. pylori has been present in humans at least since ancestors of Amerindians migrated from Asia more than 11,000 years ago...

Research Grants18

  1. H PYLORI RECOMBINATION AND GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 2000
    ..pylori infections. ..
  2. Mathematical models of H. pylori gastric colonization
    Martin J Blaser; Fiscal Year: 2010
    ..Including mathematical analyses in these studies also permits a generalization of the principles and their applications to other microbes involved in human health and disease. ..
  3. Mathematical models of H. pylori gastric colonization
    Martin Blaser; Fiscal Year: 2009
    ..Including mathematical analyses in these studies also permits a generalization of the principles and their applications to other microbes involved in human health and disease. ..
  4. Mathematical models of H. pylori gastric colonization
    Martin Blaser; Fiscal Year: 2007
    ..The experimental results will enable development of deterministic models relating genotypic and phenotypic variation with selection. ..
  5. Development of furanones for treatment of anthrax
    Martin Blaser; Fiscal Year: 2005
    ..In initial studies, spores will be given subcutaneosly. Efficacy parameters will be defined as above. Successful trials can lead to phase I studies in humans, and treatment studies in non-human primates. ..
  6. Mathematical models of H. pylori gastric colonization
    Martin Blaser; Fiscal Year: 2006
    ..The experimental results will enable development of deterministic models relating genotypic and phenotypic variation with selection. ..
  7. Mathematical models of H. pylori gastric colonization
    Martin Blaser; Fiscal Year: 2005
    ..The experimental results will enable development of deterministic models relating genotypic and phenotypic variation with selection. ..
  8. CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCE
    Martin Blaser; Fiscal Year: 2004
    ..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
  9. MATHEMATICAL MODELS OF H PYLORI GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 2003
    ..3) To examine the effect of recombination between two different H.pylori strains during experimental infections, and to develop representative mathematical models for this more complex phenomenon. ..
  10. CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCE
    Martin Blaser; Fiscal Year: 2003
    ..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
  11. CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCE
    Martin Blaser; Fiscal Year: 2002
    ..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
  12. MATHEMATICAL MODELS OF H PYLORI GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 2002
    ..3) To examine the effect of recombination between two different H.pylori strains during experimental infections, and to develop representative mathematical models for this more complex phenomenon. ..
  13. MATHEMATICAL MODELS OF H PYLORI GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 2001
    ..3) To examine the effect of recombination between two different H.pylori strains during experimental infections, and to develop representative mathematical models for this more complex phenomenon. ..
  14. H PYLORI RECOMBINATION AND GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 2001
    ..pylori infections. ..
  15. CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCE
    Martin Blaser; Fiscal Year: 2001
    ..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
  16. H PYLORI RECOMBINATION AND GASTRIC COLONIZATION
    Martin Blaser; Fiscal Year: 1999
    ..pylori infections. ..
  17. Disappearing gastrointestinal microbiota in epidemic obesity.
    Martin J Blaser; Fiscal Year: 2010
    ..We will focus on both maternal and antibiotic effects on the composition of the gastric and colonic bacterial populations, and their metabolic effects. ..