Research Topics
| DEBRA BESSENSummaryAffiliation: New York Medical College Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Genomic localization of a T serotype locus to a recombinatorial zone encoding extracellular matrix-binding proteins in Streptococcus pyogenesDebra E Bessen
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Infect Immun 70:1159-67. 2002..The data provide evidence that the highly recombinatorial FCT region of the S. pyogenes genome is under strong selection for change in response to the host environment...- Influence of recombination and niche separation on the population genetic structure of the pathogen Streptococcus pyogenesAwdhesh Kalia
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520, USA
Infect Immun 70:1971-83. 2002..Maintenance of a relationship between emm pattern and tissue tropism in the face of underlying recombination suggests that tissue tropism is associated with emm or a closely linked gene... - Whole-genome association study on tissue tropism phenotypes in group A StreptococcusDebra E Bessen
New York Medical College, Department of Microbiology and Immunology, Valhalla, NY 10595, USA
J Bacteriol 193:6651-63. 2011..This study employs a novel synthesis of tools to help delineate the major genetic changes associated with key adaptive shifts in an extensively recombined bacterial species... - Tissue tropisms in group A streptococcal infectionsDebra E Bessen
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10573, USA
Future Microbiol 5:623-38. 2010..Recombinational replacement with orthologous gene forms, following interspecies transfer, appears to be an important genetic step leading up to the exploitation of new niches by GAS... - Population biology of the human restricted pathogen, Streptococcus pyogenesDebra E Bessen
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
Infect Genet Evol 9:581-93. 2009.... - Evolution of transcription regulatory genes is linked to niche specialization in the bacterial pathogen Streptococcus pyogenesDebra E Bessen
Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595, USA
J Bacteriol 187:4163-72. 2005.... - Relationships between emm and multilocus sequence types within a global collection of Streptococcus pyogenesDebra E Bessen
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
BMC Microbiol 8:59. 2008..A history of genetic change in emm was evaluated for a worldwide collection of > 500 S. pyogenes isolates that were defined for genetic background by multilocus sequence typing of housekeeping genes... - Heterogeneity in the polarity of Nra regulatory effects on streptococcal pilus gene transcription and virulenceFeng Luo
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
Infect Immun 76:2490-7. 2008..The findings demonstrate key strain-specific differences in the transcriptional circuitry governing virulence gene expression in S. pyogenes and its impact on pathogenesis... - Impact of orthologous gene replacement on the circuitry governing pilus gene transcription in streptococciSergio Lizano
Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, United States of America
PLoS ONE 3:e3450. 2008.... - Role of Mga in group A streptococcal infection at the skin epitheliumFeng Luo
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
Microb Pathog 45:217-24. 2008..Findings on numerous phenotypes for 7 mutants constructed on the same genetic background yield a detailed, integrated model for GAS pathogenesis at the skin... - Evolution and global dissemination of macrolide-resistant group A streptococciD Ashley Robinson
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
Antimicrob Agents Chemother 50:2903-11. 2006.... - Role of streptococcal T antigens in superficial skin infectionSergio Lizano
Dept of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
J Bacteriol 189:1426-34. 2007..The data provide direct evidence that streptococcal T antigens function as virulence factors in vivo, but they also reveal that a pilus-like structure is not essential for the most common form of streptococcal skin disease... - Detecting key structural features within highly recombined genesJohn E Wertz
Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, United States of America
PLoS Comput Biol 3:e14. 2007..BLAST Miner shares with phylogenetics the important predictive quality that leads to the generation of testable hypotheses based on sequence data... - Tetracycline resistance in group a streptococci: emergence on a global scale and influence on multiple-drug resistanceVanessa Ayer
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
Antimicrob Agents Chemother 51:1865-8. 2007..Of 244 clones, 38 and 25% displayed resistance to tetracycline and erythromycin, respectively; a relatively high proportion (15%) were resistant to both classes of drugs. tet(M) displayed a highly significant association with erm(B)... - Population genetics and linkage analysis of loci within the FCT region of Streptococcus pyogenesZerina Kratovac
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
J Bacteriol 189:1299-310. 2007..Overall, population genetic analysis supports the possibility that the FCT region gives rise to surface proteins that are largely necessary, but not always sufficient, to confer tissue site preference for infection... - Roles of the plasminogen activator streptokinase and the plasminogen-associated M protein in an experimental model for streptococcal impetigoMikael D Svensson
Department of Laboratory Medicine, Lund University, Lund, Sweden
Microbiology 148:3933-45. 2002..An integrated model for superficial infection at the skin is presented... - Presence of streptococcal pyrogenic exotoxin A and C genes in human isolates of group G streptococciAwdhesh Kalia
Department of Ecology and Evolutionary Biology, Yale University, 165 Prospect Street, Box 208106, 06520, New Haven, CT, USA
FEMS Microbiol Lett 219:291-5. 2003..The presence of shared speA and speC alleles in GAS and GGS is highly suggestive of recent interspecies transfer. Acquisition of GAS-like virulence genes by GGS may lead to enhanced pathogenicity in this usually commensal-like organism... - Natural selection and evolution of streptococcal virulence genes involved in tissue-specific adaptationsAwdhesh Kalia
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA
J Bacteriol 186:110-21. 2004.... - Group A streptococci from a remote community have novel multilocus genotypes but share emm types and housekeeping alleles with isolates from worldwide sourcesKaren F McGregor
Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom
J Infect Dis 189:717-23. 2004.... - Multilocus sequence typing of Streptococcus pyogenes representing most known emm types and distinctions among subpopulation genetic structuresKaren F McGregor
Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom
J Bacteriol 186:4285-94. 2004..The findings suggest that the population genetic structure differs for the tissue-defined subpopulations of S. pyogenes. The observed differences may partly reflect differential host immune selection pressures... - Prospective longitudinal study of children with tic disorders and/or obsessive-compulsive disorder: relationship of symptom exacerbations to newly acquired streptococcal infectionsFeng Luo
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA
Pediatrics 113:e578-85. 2004..CONCLUSIONS: The results suggest no clear relationship between new GABHS infections and symptom exacerbations in an unselected group of patients with TS and/or OCD... - The search for a genetic divide between streptococcal pathogens and commensalsDebra E Bessen
Clin Infect Dis 44:1455-6. 2007 - Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: a preliminary studyIvana Kawikova
Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06520, USA
Biol Psychiatry 61:273-8. 2007..We also postulated that group A beta hemolytic streptococcal infections could promote autoimmune responses by releasing exotoxins (streptococcal pyrogenic exotoxins [SPE])... - The Seventh International Conference on the Genetics of Streptococci, Lactococci, and EnterococciRobert A Burne
Department of Oral Biology, Gainesville, FL 32610-0424, USA
J Bacteriol 189:1209-18. 2007
Research Grants
- Population genomics of Streptococcus pyogenesDEBRA BESSEN; Fiscal Year: 2009..abstract_text> ..
- Tissue-Specific Infection by Group A StreptococciDEBRA BESSEN; Fiscal Year: 2007..A better understanding of the molecular basis for throat- and skin-specific infection might aid in the development of vaccines which target essential adaptive traits and thereby, break the chain of transmission. ..
- Molecular Evolution of Resistance in Strep. pyogenesDEBRA BESSEN; Fiscal Year: 2005..GAS provide a sound model system for understanding the molecular evolution underlying the early stages of the emergence and global spread of antibiotic resistance. ..
- EVOLUTION OF GROUP A STREPTOCOCCIDEBRA BESSEN; Fiscal Year: 2004..These sera will be tested to determine whether strain structure is determined by the immunogenicity of the emm and sof gene products. ..