DEBRA BESSEN

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. pmc Genomic localization of a T serotype locus to a recombinatorial zone encoding extracellular matrix-binding proteins in Streptococcus pyogenes
    Debra E Bessen
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Infect Immun 70:1159-67. 2002
  2. pmc Influence of recombination and niche separation on the population genetic structure of the pathogen Streptococcus pyogenes
    Awdhesh Kalia
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520, USA
    Infect Immun 70:1971-83. 2002
  3. pmc Impact of orthologous gene replacement on the circuitry governing pilus gene transcription in streptococci
    Sergio Lizano
    Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, United States of America
    PLoS ONE 3:e3450. 2008
  4. pmc Population genetics of Streptococcus dysgalactiae subspecies equisimilis reveals widely dispersed clones and extensive recombination
    David J McMillan
    Bacterial Pathogenesis Laboratory, The Queensland Institute of Medical Research and Griffith Medical Research College, Herston, Queensland, Australia
    PLoS ONE 5:e11741. 2010
  5. pmc Whole-genome association study on tissue tropism phenotypes in group A Streptococcus
    Debra E Bessen
    New York Medical College, Department of Microbiology and Immunology, Valhalla, NY 10595, USA
    J Bacteriol 193:6651-63. 2011
  6. pmc Tissue tropisms in group A streptococcal infections
    Debra E Bessen
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10573, USA
    Future Microbiol 5:623-38. 2010
  7. pmc Population biology of the human restricted pathogen, Streptococcus pyogenes
    Debra E Bessen
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Infect Genet Evol 9:581-93. 2009
  8. pmc Evolution of transcription regulatory genes is linked to niche specialization in the bacterial pathogen Streptococcus pyogenes
    Debra E Bessen
    Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595, USA
    J Bacteriol 187:4163-72. 2005
  9. pmc Relationships between emm and multilocus sequence types within a global collection of Streptococcus pyogenes
    Debra E Bessen
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    BMC Microbiol 8:59. 2008
  10. pmc Heterogeneity in the polarity of Nra regulatory effects on streptococcal pilus gene transcription and virulence
    Feng Luo
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Infect Immun 76:2490-7. 2008

Research Grants

  1. EVOLUTION OF GROUP A STREPTOCOCCI
    DEBRA BESSEN; Fiscal Year: 2000
  2. Population genomics of Streptococcus pyogenes
    DEBRA BESSEN; Fiscal Year: 2009
  3. Population genomics of Streptococcus pyogenes
    DEBRA BESSEN; Fiscal Year: 2007
  4. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2007
  5. Population genomics of Streptococcus pyogenes
    DEBRA BESSEN; Fiscal Year: 2006
  6. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2006
  7. Population genomics of Streptococcus pyogenes
    DEBRA BESSEN; Fiscal Year: 2005
  8. Molecular Evolution of Resistance in Strep. pyogenes
    DEBRA BESSEN; Fiscal Year: 2005
  9. EVOLUTION OF GROUP A STREPTOCOCCI
    DEBRA BESSEN; Fiscal Year: 2004
  10. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2005

Collaborators

Detail Information

Publications25

  1. pmc Genomic localization of a T serotype locus to a recombinatorial zone encoding extracellular matrix-binding proteins in Streptococcus pyogenes
    Debra E Bessen
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Infect Immun 70:1159-67. 2002
    ..The data provide evidence that the highly recombinatorial FCT region of the S. pyogenes genome is under strong selection for change in response to the host environment...
  2. pmc Influence of recombination and niche separation on the population genetic structure of the pathogen Streptococcus pyogenes
    Awdhesh Kalia
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520, USA
    Infect Immun 70:1971-83. 2002
    ..Maintenance of a relationship between emm pattern and tissue tropism in the face of underlying recombination suggests that tissue tropism is associated with emm or a closely linked gene...
  3. pmc Impact of orthologous gene replacement on the circuitry governing pilus gene transcription in streptococci
    Sergio Lizano
    Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, United States of America
    PLoS ONE 3:e3450. 2008
    ....
  4. pmc Population genetics of Streptococcus dysgalactiae subspecies equisimilis reveals widely dispersed clones and extensive recombination
    David J McMillan
    Bacterial Pathogenesis Laboratory, The Queensland Institute of Medical Research and Griffith Medical Research College, Herston, Queensland, Australia
    PLoS ONE 5:e11741. 2010
    ..To gain a better understanding of their molecular epidemiology and evolutionary relationships, multilocus sequence typing (MLST) analysis was performed on SDSE isolates collected from Australia, Europe and North America...
  5. pmc Whole-genome association study on tissue tropism phenotypes in group A Streptococcus
    Debra E Bessen
    New York Medical College, Department of Microbiology and Immunology, Valhalla, NY 10595, USA
    J Bacteriol 193:6651-63. 2011
    ..This study employs a novel synthesis of tools to help delineate the major genetic changes associated with key adaptive shifts in an extensively recombined bacterial species...
  6. pmc Tissue tropisms in group A streptococcal infections
    Debra E Bessen
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10573, USA
    Future Microbiol 5:623-38. 2010
    ..Recombinational replacement with orthologous gene forms, following interspecies transfer, appears to be an important genetic step leading up to the exploitation of new niches by GAS...
  7. pmc Population biology of the human restricted pathogen, Streptococcus pyogenes
    Debra E Bessen
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Infect Genet Evol 9:581-93. 2009
    ....
  8. pmc Evolution of transcription regulatory genes is linked to niche specialization in the bacterial pathogen Streptococcus pyogenes
    Debra E Bessen
    Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595, USA
    J Bacteriol 187:4163-72. 2005
    ....
  9. pmc Relationships between emm and multilocus sequence types within a global collection of Streptococcus pyogenes
    Debra E Bessen
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    BMC Microbiol 8:59. 2008
    ..A history of genetic change in emm was evaluated for a worldwide collection of > 500 S. pyogenes isolates that were defined for genetic background by multilocus sequence typing of housekeeping genes...
  10. pmc Heterogeneity in the polarity of Nra regulatory effects on streptococcal pilus gene transcription and virulence
    Feng Luo
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Infect Immun 76:2490-7. 2008
    ..The findings demonstrate key strain-specific differences in the transcriptional circuitry governing virulence gene expression in S. pyogenes and its impact on pathogenesis...
  11. pmc Role of Mga in group A streptococcal infection at the skin epithelium
    Feng Luo
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Microb Pathog 45:217-24. 2008
    ..Findings on numerous phenotypes for 7 mutants constructed on the same genetic background yield a detailed, integrated model for GAS pathogenesis at the skin...
  12. pmc Evolution and global dissemination of macrolide-resistant group A streptococci
    D Ashley Robinson
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Antimicrob Agents Chemother 50:2903-11. 2006
    ....
  13. pmc Role of streptococcal T antigens in superficial skin infection
    Sergio Lizano
    Dept of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    J Bacteriol 189:1426-34. 2007
    ..The data provide direct evidence that streptococcal T antigens function as virulence factors in vivo, but they also reveal that a pilus-like structure is not essential for the most common form of streptococcal skin disease...
  14. pmc Detecting key structural features within highly recombined genes
    John E Wertz
    Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, United States of America
    PLoS Comput Biol 3:e14. 2007
    ..BLAST Miner shares with phylogenetics the important predictive quality that leads to the generation of testable hypotheses based on sequence data...
  15. pmc Tetracycline resistance in group a streptococci: emergence on a global scale and influence on multiple-drug resistance
    Vanessa Ayer
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    Antimicrob Agents Chemother 51:1865-8. 2007
    ..Of 244 clones, 38 and 25% displayed resistance to tetracycline and erythromycin, respectively; a relatively high proportion (15%) were resistant to both classes of drugs. tet(M) displayed a highly significant association with erm(B)...
  16. pmc Population genetics and linkage analysis of loci within the FCT region of Streptococcus pyogenes
    Zerina Kratovac
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
    J Bacteriol 189:1299-310. 2007
    ..Overall, population genetic analysis supports the possibility that the FCT region gives rise to surface proteins that are largely necessary, but not always sufficient, to confer tissue site preference for infection...
  17. ncbi Roles of the plasminogen activator streptokinase and the plasminogen-associated M protein in an experimental model for streptococcal impetigo
    Mikael D Svensson
    Department of Laboratory Medicine, Lund University, Lund, Sweden
    Microbiology 148:3933-45. 2002
    ..An integrated model for superficial infection at the skin is presented...
  18. ncbi Presence of streptococcal pyrogenic exotoxin A and C genes in human isolates of group G streptococci
    Awdhesh Kalia
    Department of Ecology and Evolutionary Biology, Yale University, 165 Prospect Street, Box 208106, 06520, New Haven, CT, USA
    FEMS Microbiol Lett 219:291-5. 2003
    ..The presence of shared speA and speC alleles in GAS and GGS is highly suggestive of recent interspecies transfer. Acquisition of GAS-like virulence genes by GGS may lead to enhanced pathogenicity in this usually commensal-like organism...
  19. pmc Natural selection and evolution of streptococcal virulence genes involved in tissue-specific adaptations
    Awdhesh Kalia
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA
    J Bacteriol 186:110-21. 2004
    ....
  20. ncbi Group A streptococci from a remote community have novel multilocus genotypes but share emm types and housekeeping alleles with isolates from worldwide sources
    Karen F McGregor
    Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom
    J Infect Dis 189:717-23. 2004
    ....
  21. pmc Multilocus sequence typing of Streptococcus pyogenes representing most known emm types and distinctions among subpopulation genetic structures
    Karen F McGregor
    Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom
    J Bacteriol 186:4285-94. 2004
    ..The findings suggest that the population genetic structure differs for the tissue-defined subpopulations of S. pyogenes. The observed differences may partly reflect differential host immune selection pressures...
  22. ncbi Prospective longitudinal study of children with tic disorders and/or obsessive-compulsive disorder: relationship of symptom exacerbations to newly acquired streptococcal infections
    Feng Luo
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA
    Pediatrics 113:e578-85. 2004
    ..It has been proposed that infection by group A beta-hemolytic streptococci (GABHS) can trigger acute symptom exacerbations among patients with Tourette's syndrome (TS) or obsessive-compulsive disorder (OCD), via autoimmune mechanisms...
  23. ncbi The search for a genetic divide between streptococcal pathogens and commensals
    Debra E Bessen
    Clin Infect Dis 44:1455-6. 2007
  24. ncbi Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: a preliminary study
    Ivana Kawikova
    Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Biol Psychiatry 61:273-8. 2007
    ..We also postulated that group A beta hemolytic streptococcal infections could promote autoimmune responses by releasing exotoxins (streptococcal pyrogenic exotoxins [SPE])...
  25. pmc The Seventh International Conference on the Genetics of Streptococci, Lactococci, and Enterococci
    Robert A Burne
    Department of Oral Biology, Gainesville, FL 32610 0424, USA
    J Bacteriol 189:1209-18. 2007

Research Grants17

  1. EVOLUTION OF GROUP A STREPTOCOCCI
    DEBRA BESSEN; Fiscal Year: 2000
    ..These sera will be tested to determine whether strain structure is determined by the immunogenicity of the emm and sof gene products. ..
  2. Population genomics of Streptococcus pyogenes
    DEBRA BESSEN; Fiscal Year: 2009
    ..abstract_text> ..
  3. Population genomics of Streptococcus pyogenes
    DEBRA BESSEN; Fiscal Year: 2007
    ..abstract_text> ..
  4. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2007
    ..A better understanding of the molecular basis for throat- and skin-specific infection might aid in the development of vaccines which target essential adaptive traits and thereby, break the chain of transmission. ..
  5. Population genomics of Streptococcus pyogenes
    DEBRA BESSEN; Fiscal Year: 2006
    ..abstract_text> ..
  6. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2006
    ..A better understanding of the molecular basis for throat- and skin-specific infection might aid in the development of vaccines which target essential adaptive traits and thereby, break the chain of transmission. ..
  7. Population genomics of Streptococcus pyogenes
    DEBRA BESSEN; Fiscal Year: 2005
    ..abstract_text> ..
  8. Molecular Evolution of Resistance in Strep. pyogenes
    DEBRA BESSEN; Fiscal Year: 2005
    ..GAS provide a sound model system for understanding the molecular evolution underlying the early stages of the emergence and global spread of antibiotic resistance. ..
  9. EVOLUTION OF GROUP A STREPTOCOCCI
    DEBRA BESSEN; Fiscal Year: 2004
    ..These sera will be tested to determine whether strain structure is determined by the immunogenicity of the emm and sof gene products. ..
  10. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2005
    ..A better understanding of the molecular basis for throat- and skin-specific infection might aid in the development of vaccines which target essential adaptive traits and thereby, break the chain of transmission. ..
  11. EVOLUTION OF GROUP A STREPTOCOCCI
    DEBRA BESSEN; Fiscal Year: 2003
    ..These sera will be tested to determine whether strain structure is determined by the immunogenicity of the emm and sof gene products. ..
  12. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2003
    ..A better understanding of the molecular basis for throat- and skin-specific infection might aid in the development of vaccines which target essential adaptive traits and thereby, break the chain of transmission. ..
  13. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2004
    ..A better understanding of the molecular basis for throat- and skin-specific infection might aid in the development of vaccines which target essential adaptive traits and thereby, break the chain of transmission. ..
  14. EVOLUTION OF GROUP A STREPTOCOCCI
    DEBRA BESSEN; Fiscal Year: 2002
    ..These sera will be tested to determine whether strain structure is determined by the immunogenicity of the emm and sof gene products. ..
  15. EVOLUTION OF GROUP A STREPTOCOCCI
    DEBRA BESSEN; Fiscal Year: 2001
    ..These sera will be tested to determine whether strain structure is determined by the immunogenicity of the emm and sof gene products. ..