Research Topics
Species | Mary Helen Barcellos-HoffSummaryAffiliation: New York University School of Medicine Country: USA Publications
Research Grants
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Publications
Does microenvironment contribute to the etiology of estrogen receptor-negative breast cancer?Mary Helen Barcellos-Hoff
Author s Affiliation Department of Radiation Oncology and Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Clin Cancer Res 19:541-8. 2013..Understanding the contribution of tissue microenvironment during carcinogenesis could lead to prevention strategies that are personalized to age, agent, and exposure to reduce the risk of aggressive breast cancer...- New biological insights on the link between radiation exposure and breast cancer riskMary Helen Barcellos-Hoff
Department of Radiation Oncology, New York University School of Medicine, 566 First Avenue, New York, NY 10016, USA
J Mammary Gland Biol Neoplasia 18:3-13. 2013.... 
Transforming growth factor-beta in breast cancer: too much, too lateMary Helen Barcellos-Hoff
New York University Langone School of Medicine, New York, NY 10016, USA
Breast Cancer Res 11:202. 2009..Too much TGFbeta, too late in cancer progression is the fundamental motivation for pharmaceutical inhibition...- Radiation carcinogenesis in context: how do irradiated tissues become tumors?Mary Helen Barcellos-Hoff
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94705, USA
Health Phys 97:446-57. 2009..The implications of this perspective in terms of reducing cancer risk after exposure are discussed... - Stromal mediation of radiation carcinogenesisMary Helen Barcellos-Hoff
Departments of Radiation Oncology and Cell Biology, New York University School of Medicine, 566 First Avenue, New York, NY 10016, USA
J Mammary Gland Biol Neoplasia 15:381-7. 2010.... - Lack of radiation dose or quality dependence of epithelial-to-mesenchymal transition (EMT) mediated by transforming growth factor βKumari L Andarawewa
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
Int J Radiat Oncol Biol Phys 79:1523-31. 2011..In this study we determined whether radiation dose or quality affected TGF-β-mediated EMT... 
Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblastsSylvain V Costes
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Radiat Res 165:505-15. 2006..Thus, even though double-strand breaks and radiation-induced foci are correlated, the dynamic nature of both contradicts their accepted equivalence for low doses of different radiation qualities...- Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-βMatthew E Hardee
Department of Radiation Oncology, New York University School of Medicine, New York, New York 10016, USA
Cancer Res 72:4119-29. 2012..These data motivate the use of TGF-β inhibitors with radiation to improve therapeutic response in patients with GBM... - Transforming growth factor-beta1 mediates cellular response to DNA damage in situKenneth B Ewan
Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
Cancer Res 62:5627-31. 2002..These data indicate that TGF-beta1 is essential for rapid p53-mediated cellular responses that mediate cell fate decisions in situ... - Limiting-dilution transplantation assays in mammary stem cell studiesIrineu Illa-Bochaca
Langone School of Medicine, New York University, New York, NY 10016, USA
Methods Mol Biol 621:29-47. 2010..Here, we give details on how to carry out all these steps... - Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferationKenneth B Ewan
Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
Am J Pathol 160:2081-93. 2002..Together these data indicate that ovarian hormones regulate TGF-beta 1 activation, which in turn restricts proliferative response to hormone signaling... - New highlights on stroma-epithelial interactions in breast cancerMary Helen Barcellos-Hoff
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
Breast Cancer Res 7:33-6. 2005..In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches... - A systems biology approach to multicellular and multi-generational radiation responsesMary Helen Barcellos-Hoff
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Building 74 355, Berkeley, CA 94705, USA
Mutat Res 597:32-8. 2006.... - A tool for the quantitative spatial analysis of complex cellular systemsRodrigo Fernandez-Gonzalez
University of California, Berkeley, CA 94720, USA
IEEE Trans Image Process 14:1300-13. 2005..Finally, we show a number of examples that demonstrate the feasibility of our approach... - Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult miceKenneth B R Ewan
Life Sciences Division, Bldg 74 355, 1 Cyclotron Rd, Lawrence Berkeley National Laboratory, Berkeley CA 94720, USA
Am J Pathol 167:409-17. 2005..Accordingly, we propose that TGF-beta1 dysregulation may promote proliferation of ER-alpha-positive cells associated with breast cancer risk in humans... - Multidimensional profiling of cell surface proteins and nuclear markersJu Han
Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
IEEE/ACM Trans Comput Biol Bioinform 7:80-90. 2010..We demonstrate that multidimensional representations of cell-by-cell phenotypes improve predictive and visualization capabilities among different treatment groups, and identify hidden variables... - Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studiesRituparna Mukhopadhyay
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Breast Cancer Res 12:R11. 2010..We investigated whether ionizing radiation, which increases breast cancer risk in women, affects the rate of vHMEC outgrowth... - Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor typeDavid H Nguyen
Department of Radiation Oncology, New York University School of Medicine, New York, NY 10016, USA
Cancer Cell 19:640-51. 2011..This effect was TGFβ independent and linked to mammary stem cell activity. Thus, the irradiated microenvironment affects latency and clinically relevant features of cancer through distinct and unexpected mechanisms... - In situ analysis of cell populations: long-term label-retaining cellsRodrigo Fernandez-Gonzalez
Development Biology Program, Sloan Kettering, Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Methods Mol Biol 621:1-28. 2010..The morphometric and spatial analyses described here are generally applicable to any mammary cell populations, and will therefore be useful to characterize mammary stem cells once bona fide mammary stem cell markers become available... - Targeted and nontargeted effects of ionizing radiation that impact genomic instabilityChristopher A Maxwell
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Cancer Res 68:8304-11. 2008..Together, these studies show that radiation deregulates centrosome stability, which underlies genomic instability in normal human epithelial cells, and that this can be opposed by radiation-induced TGFbeta signaling... - Cancer as an emergent phenomenon in systems radiation biologyMary Helen Barcellos-Hoff
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Bldg 977, Berkeley, CA 94720, USA
Radiat Environ Biophys 47:33-8. 2008..Given the current research goal to determine the consequences of high and low radiation exposures, broadening the scope of radiation studies to include systems biology concepts should benefit risk modeling of radiation carcinogenesis... - Integrative radiation carcinogenesis: interactions between cell and tissue responses to DNA damageMary Helen Barcellos-Hoff
Department of Cancer Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94705, USA
Semin Cancer Biol 15:138-48. 2005..Understanding the dynamic interactions between tissue and cell stress responses will be necessary for an accurate assessment of cancer risk and may also provide targets for prevention... - New rationales for using TGFbeta inhibitors in radiotherapyKumari L Andarawewa
Life Sciences Division, Berkeley, California 94720, USA
Int J Radiat Biol 83:803-11. 2007..Subsequent studies have shown that TGFbeta is a major mediator of cellular and tissue responses to IR and have revealed novel facets of its complex biology... - Estrogen and progesterone receptors have distinct roles in the establishment of the hyperplastic phenotype in PR-A transgenic miceMarina Simian
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Breast Cancer Res 11:R72. 2009..Our objective was to determine the roles of estrogen (E) and progesterone (P) in the genesis of mammary hyperplasias/preneoplasias in PR-A transgenics... - Radiation and the microenvironment - tumorigenesis and therapyMary Helen Barcellos-Hoff
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA
Nat Rev Cancer 5:867-75. 2005..These alterations in the microenvironment can contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples of these responses and their implications are discussed with a view to therapeutic intervention... - Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transitionKumari L Andarawewa
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
Cancer Res 67:8662-70. 2007..Together, these data show that the interactions between radiation-induced signaling pathways elicit heritable phenotypes that could contribute to neoplastic progression... - Consequences of epithelial or stromal TGFβ1 depletion in the mammary glandDavid H Nguyen
Endocrinology Graduate Group, University of California, Berkeley, CA, USA
J Mammary Gland Biol Neoplasia 16:147-55. 2011.... - Mapping mammary gland architecture using multi-scale in situ analysisRodrigo Fernandez-Gonzalez
Department of Cancer Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, CA 94720, USA
Integr Biol (Camb) 1:80-9. 2009.... - TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivoFanny Bouquet
Department of Radiation Oncology, New York University School of Medicine, New York, New York 10016, USA
Clin Cancer Res 17:6754-65. 2011..To determine whether inhibition of TGFβ signaling prior to irradiation sensitizes human and murine cancer cells in vitro and in vivo... - Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domainsSylvain V Costes
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
PLoS Comput Biol 3:e155. 2007..These data suggest that DNA damage-induced foci are restricted to certain regions of the nucleus of human epithelial cells. It is possible that DNA lesions are collected in these nuclear sub-domains for more efficient repair... - The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expressionParaic A Kenny
Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
Mol Oncol 1:84-96. 2007..We further demonstrate that consistent differences in genes encoding signal transduction proteins emerge when even tumor cells are cultured in 3D microenvironments... - Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypesDavid H Nguyen
Department of Radiation Oncology, New York University School of Medicine, New York, New York 10016, USA
Clin Cancer Res 19:1353-62. 2013..We asked whether expression metaprofiles could discern radiation-preceded human cancer or be informative in sporadic breast cancers... - The not-so innocent bystander: the microenvironment as a therapeutic target in cancerAnna C Erickson
Life Sciences Division, Building 74-174, 1 Cyclotron Road, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Expert Opin Ther Targets 7:71-88. 2003..Therefore, controlling and eliminating cancer may be more readily achieved indirectly via the tissue microenvironment... - Iterative voting for inference of structural saliency and characterization of subcellular eventsBahram Parvin
Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
IEEE Trans Image Process 16:615-23. 2007..Iterative voting has been implemented in both 2-D and 3-D for multi image analysis... - Therapeutic targets in malignant glioblastoma microenvironmentMary Helen Barcellos-Hoff
Department of Radiation Oncology, New York University, Langone School of Medicine, New York, NY 10016, USA
Semin Radiat Oncol 19:163-70. 2009.... - Karyotypic instability and centrosome aberrations in the progeny of finite life-span human mammary epithelial cells exposed to sparsely or densely ionizing radiationHiroko Sudo
Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Radiat Res 170:23-32. 2008..Thus genomic instability occurs frequently in finite life-span HMEC exposed to sparsely or densely ionizing radiation and may contribute to radiation-induced breast cancer... - The pivotal role of insulin-like growth factor I in normal mammary developmentDavid L Kleinberg
Department of Medicine Endocrinology, New York University School of Medicine, New York, NY 10016, USA
Endocrinol Metab Clin North Am 40:461-71, vii. 2011..The orchestrated action of hormones, growth factors, and receptors necessary for mammary development and function are also critical in breast cancer... - Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen speciesMichael F Jobling
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Radiat Res 166:839-48. 2006..We propose that LTGF-beta1 contains a redox switch centered at methionine 253, which allows LTGF-beta1 to act uniquely as an extracellular sensor of oxidative stress in tissues... - Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contextsFei Wang
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
J Natl Cancer Inst 94:1494-503. 2002..This approach may be useful to design therapeutic intervention strategies for aggressive breast cancers...
Research Grants
- TGFb Regulation of ER Receptor Positive Mammary CellsMARY BARCELLOS HOFF; Fiscal Year: 2006..3: To determine whether TGF-beta regulation of the ER+ subpopulation contributes to progression and/or features of preneoplastic lesions. ..