Mary Helen Barcellos-Hoff

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. doi request reprint Systems biology perspectives on the carcinogenic potential of radiation
    Mary Helen Barcellos-Hoff
    Department of Radiation Oncology, New York University School of Medicine, 566 First Avenue, New York, NY 10016, USA
    J Radiat Res 55:i145-i154. 2014
  2. doi request reprint Does microenvironment contribute to the etiology of estrogen receptor-negative breast cancer?
    Mary Helen Barcellos-Hoff
    Author s Affiliation Department of Radiation Oncology and Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Clin Cancer Res 19:541-8. 2013
  3. doi request reprint New biological insights on the link between radiation exposure and breast cancer risk
    Mary Helen Barcellos-Hoff
    Department of Radiation Oncology, New York University School of Medicine, 566 First Avenue, New York, NY 10016, USA
    J Mammary Gland Biol Neoplasia 18:3-13. 2013
  4. pmc Stromal mediation of radiation carcinogenesis
    Mary Helen Barcellos-Hoff
    Departments of Radiation Oncology and Cell Biology, New York University School of Medicine, 566 First Avenue, New York, NY 10016, USA
    J Mammary Gland Biol Neoplasia 15:381-7. 2010
  5. pmc Transforming growth factor-beta in breast cancer: too much, too late
    Mary Helen Barcellos-Hoff
    New York University Langone School of Medicine, New York, NY 10016, USA
    Breast Cancer Res 11:202. 2009
  6. pmc Radiation carcinogenesis in context: how do irradiated tissues become tumors?
    Mary Helen Barcellos-Hoff
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94705, USA
    Health Phys 97:446-57. 2009
  7. doi request reprint Lack of radiation dose or quality dependence of epithelial-to-mesenchymal transition (EMT) mediated by transforming growth factor β
    Kumari L Andarawewa
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Int J Radiat Oncol Biol Phys 79:1523-31. 2011
  8. ncbi request reprint Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts
    Sylvain V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Radiat Res 165:505-15. 2006
  9. ncbi request reprint Transforming growth factor-beta1 mediates cellular response to DNA damage in situ
    Kenneth B Ewan
    Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
    Cancer Res 62:5627-31. 2002
  10. doi request reprint Targeted and nontargeted effects of ionizing radiation that impact genomic instability
    Christopher A Maxwell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 68:8304-11. 2008

Research Grants

  1. TGFb Regulation of ER Receptor Positive Mammary Cells
    MARY BARCELLOS HOFF; Fiscal Year: 2006

Collaborators

Detail Information

Publications47

  1. doi request reprint Systems biology perspectives on the carcinogenic potential of radiation
    Mary Helen Barcellos-Hoff
    Department of Radiation Oncology, New York University School of Medicine, 566 First Avenue, New York, NY 10016, USA
    J Radiat Res 55:i145-i154. 2014
    ....
  2. doi request reprint Does microenvironment contribute to the etiology of estrogen receptor-negative breast cancer?
    Mary Helen Barcellos-Hoff
    Author s Affiliation Department of Radiation Oncology and Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Clin Cancer Res 19:541-8. 2013
    ..Understanding the contribution of tissue microenvironment during carcinogenesis could lead to prevention strategies that are personalized to age, agent, and exposure to reduce the risk of aggressive breast cancer...
  3. doi request reprint New biological insights on the link between radiation exposure and breast cancer risk
    Mary Helen Barcellos-Hoff
    Department of Radiation Oncology, New York University School of Medicine, 566 First Avenue, New York, NY 10016, USA
    J Mammary Gland Biol Neoplasia 18:3-13. 2013
    ....
  4. pmc Stromal mediation of radiation carcinogenesis
    Mary Helen Barcellos-Hoff
    Departments of Radiation Oncology and Cell Biology, New York University School of Medicine, 566 First Avenue, New York, NY 10016, USA
    J Mammary Gland Biol Neoplasia 15:381-7. 2010
    ....
  5. pmc Transforming growth factor-beta in breast cancer: too much, too late
    Mary Helen Barcellos-Hoff
    New York University Langone School of Medicine, New York, NY 10016, USA
    Breast Cancer Res 11:202. 2009
    ..Too much TGFbeta, too late in cancer progression is the fundamental motivation for pharmaceutical inhibition...
  6. pmc Radiation carcinogenesis in context: how do irradiated tissues become tumors?
    Mary Helen Barcellos-Hoff
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94705, USA
    Health Phys 97:446-57. 2009
    ..The implications of this perspective in terms of reducing cancer risk after exposure are discussed...
  7. doi request reprint Lack of radiation dose or quality dependence of epithelial-to-mesenchymal transition (EMT) mediated by transforming growth factor β
    Kumari L Andarawewa
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Int J Radiat Oncol Biol Phys 79:1523-31. 2011
    ..In this study we determined whether radiation dose or quality affected TGF-β-mediated EMT...
  8. ncbi request reprint Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts
    Sylvain V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Radiat Res 165:505-15. 2006
    ..Thus, even though double-strand breaks and radiation-induced foci are correlated, the dynamic nature of both contradicts their accepted equivalence for low doses of different radiation qualities...
  9. ncbi request reprint Transforming growth factor-beta1 mediates cellular response to DNA damage in situ
    Kenneth B Ewan
    Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
    Cancer Res 62:5627-31. 2002
    ..These data indicate that TGF-beta1 is essential for rapid p53-mediated cellular responses that mediate cell fate decisions in situ...
  10. doi request reprint Targeted and nontargeted effects of ionizing radiation that impact genomic instability
    Christopher A Maxwell
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cancer Res 68:8304-11. 2008
    ..Together, these studies show that radiation deregulates centrosome stability, which underlies genomic instability in normal human epithelial cells, and that this can be opposed by radiation-induced TGFbeta signaling...
  11. pmc Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β
    Matthew E Hardee
    Department of Radiation Oncology, New York University School of Medicine, New York, New York 10016, USA
    Cancer Res 72:4119-29. 2012
    ..These data motivate the use of TGF-β inhibitors with radiation to improve therapeutic response in patients with GBM...
  12. ncbi request reprint New rationales for using TGFbeta inhibitors in radiotherapy
    Kumari L Andarawewa
    Life Sciences Division, Berkeley, California 94720, USA
    Int J Radiat Biol 83:803-11. 2007
    ..Subsequent studies have shown that TGFbeta is a major mediator of cellular and tissue responses to IR and have revealed novel facets of its complex biology...
  13. doi request reprint Limiting-dilution transplantation assays in mammary stem cell studies
    Irineu Illa-Bochaca
    Langone School of Medicine, New York University, New York, NY 10016, USA
    Methods Mol Biol 621:29-47. 2010
    ..Here, we give details on how to carry out all these steps...
  14. ncbi request reprint Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition
    Kumari L Andarawewa
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Cancer Res 67:8662-70. 2007
    ..Together, these data show that the interactions between radiation-induced signaling pathways elicit heritable phenotypes that could contribute to neoplastic progression...
  15. pmc Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice
    Kenneth B R Ewan
    Life Sciences Division, Bldg 74 355, 1 Cyclotron Rd, Lawrence Berkeley National Laboratory, Berkeley CA 94720, USA
    Am J Pathol 167:409-17. 2005
    ..Accordingly, we propose that TGF-beta1 dysregulation may promote proliferation of ER-alpha-positive cells associated with breast cancer risk in humans...
  16. pmc Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation
    Kenneth B Ewan
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Am J Pathol 160:2081-93. 2002
    ..Together these data indicate that ovarian hormones regulate TGF-beta 1 activation, which in turn restricts proliferative response to hormone signaling...
  17. doi request reprint Multidimensional profiling of cell surface proteins and nuclear markers
    Ju Han
    Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    IEEE/ACM Trans Comput Biol Bioinform 7:80-90. 2010
    ..We demonstrate that multidimensional representations of cell-by-cell phenotypes improve predictive and visualization capabilities among different treatment groups, and identify hidden variables...
  18. ncbi request reprint A tool for the quantitative spatial analysis of complex cellular systems
    Rodrigo Fernandez-Gonzalez
    University of California, Berkeley, CA 94720, USA
    IEEE Trans Image Process 14:1300-13. 2005
    ..Finally, we show a number of examples that demonstrate the feasibility of our approach...
  19. ncbi request reprint A systems biology approach to multicellular and multi-generational radiation responses
    Mary Helen Barcellos-Hoff
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Building 74 355, Berkeley, CA 94705, USA
    Mutat Res 597:32-8. 2006
    ....
  20. pmc New highlights on stroma-epithelial interactions in breast cancer
    Mary Helen Barcellos-Hoff
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Breast Cancer Res 7:33-6. 2005
    ..In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches...
  21. pmc Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type
    David H Nguyen
    Department of Radiation Oncology, New York University School of Medicine, New York, NY 10016, USA
    Cancer Cell 19:640-51. 2011
    ..This effect was TGFβ independent and linked to mammary stem cell activity. Thus, the irradiated microenvironment affects latency and clinically relevant features of cancer through distinct and unexpected mechanisms...
  22. ncbi request reprint Cancer as an emergent phenomenon in systems radiation biology
    Mary Helen Barcellos-Hoff
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Bldg 977, Berkeley, CA 94720, USA
    Radiat Environ Biophys 47:33-8. 2008
    ..Given the current research goal to determine the consequences of high and low radiation exposures, broadening the scope of radiation studies to include systems biology concepts should benefit risk modeling of radiation carcinogenesis...
  23. doi request reprint Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors
    Jonathan Tang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley California, USA
    Stem Cells 32:649-61. 2014
    ..These studies suggest that irradiation during puberty transiently increases stem cell self-renewal, which increases susceptibility to developing ER-negative breast cancer...
  24. pmc Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies
    Rituparna Mukhopadhyay
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Breast Cancer Res 12:R11. 2010
    ..We investigated whether ionizing radiation, which increases breast cancer risk in women, affects the rate of vHMEC outgrowth...
  25. ncbi request reprint Integrative radiation carcinogenesis: interactions between cell and tissue responses to DNA damage
    Mary Helen Barcellos-Hoff
    Department of Cancer Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94705, USA
    Semin Cancer Biol 15:138-48. 2005
    ..Understanding the dynamic interactions between tissue and cell stress responses will be necessary for an accurate assessment of cancer risk and may also provide targets for prevention...
  26. doi request reprint In situ analysis of cell populations: long-term label-retaining cells
    Rodrigo Fernandez-Gonzalez
    Development Biology Program, Sloan Kettering, Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Methods Mol Biol 621:1-28. 2010
    ..The morphometric and spatial analyses described here are generally applicable to any mammary cell populations, and will therefore be useful to characterize mammary stem cells once bona fide mammary stem cell markers become available...
  27. pmc Mapping mammary gland architecture using multi-scale in situ analysis
    Rodrigo Fernandez-Gonzalez
    Department of Cancer Biology, Life Sciences Division, Lawrence Berkeley National Laboratory, CA 94720, USA
    Integr Biol (Camb) 1:80-9. 2009
    ....
  28. ncbi request reprint The pleiotropic roles of transforming growth factor beta in homeostasis and carcinogenesis of endocrine organs
    Markus C Fleisch
    Life Sciences Division, 1 Cyclotron Road, MS 977 225A, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Endocr Relat Cancer 13:379-400. 2006
    ....
  29. pmc Estrogen and progesterone receptors have distinct roles in the establishment of the hyperplastic phenotype in PR-A transgenic mice
    Marina Simian
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Breast Cancer Res 11:R72. 2009
    ..Our objective was to determine the roles of estrogen (E) and progesterone (P) in the genesis of mammary hyperplasias/preneoplasias in PR-A transgenics...
  30. pmc Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes
    David H Nguyen
    Department of Radiation Oncology, New York University School of Medicine, New York, New York 10016, USA
    Clin Cancer Res 19:1353-62. 2013
    ..We asked whether expression metaprofiles could discern radiation-preceded human cancer or be informative in sporadic breast cancers...
  31. pmc TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo
    Fanny Bouquet
    Department of Radiation Oncology, New York University School of Medicine, New York, New York 10016, USA
    Clin Cancer Res 17:6754-65. 2011
    ..To determine whether inhibition of TGFβ signaling prior to irradiation sensitizes human and murine cancer cells in vitro and in vivo...
  32. pmc Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains
    Sylvain V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS Comput Biol 3:e155. 2007
    ..These data suggest that DNA damage-induced foci are restricted to certain regions of the nucleus of human epithelial cells. It is possible that DNA lesions are collected in these nuclear sub-domains for more efficient repair...
  33. doi request reprint Consequences of epithelial or stromal TGFβ1 depletion in the mammary gland
    David H Nguyen
    Endocrinology Graduate Group, University of California, Berkeley, CA, USA
    J Mammary Gland Biol Neoplasia 16:147-55. 2011
    ....
  34. ncbi request reprint Radiation and the microenvironment - tumorigenesis and therapy
    Mary Helen Barcellos-Hoff
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA
    Nat Rev Cancer 5:867-75. 2005
    ..These alterations in the microenvironment can contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples of these responses and their implications are discussed with a view to therapeutic intervention...
  35. doi request reprint Tumors as organs: biologically augmenting radiation therapy by inhibiting transforming growth factor β activity in carcinomas
    Shisuo Du
    Department of Radiation Oncology, New York University School of Medicine, New York, NY
    Semin Radiat Oncol 23:242-51. 2013
    ....
  36. ncbi request reprint Intensity-based signal separation algorithm for accurate quantification of clustered centrosomes in tissue sections
    Markus C Fleisch
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Microsc Res Tech 69:964-72. 2006
    ..This was done by taking into account baseline centrosome amplification and proliferation rates measured in the tissue. Using this technique, the authors showed that 20-30% of cells have amplified centrosomes in Tp53 null mammary tumors...
  37. ncbi request reprint Iterative voting for inference of structural saliency and characterization of subcellular events
    Bahram Parvin
    Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    IEEE Trans Image Process 16:615-23. 2007
    ..Iterative voting has been implemented in both 2-D and 3-D for multi image analysis...
  38. doi request reprint Karyotypic instability and centrosome aberrations in the progeny of finite life-span human mammary epithelial cells exposed to sparsely or densely ionizing radiation
    Hiroko Sudo
    Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Radiat Res 170:23-32. 2008
    ..Thus genomic instability occurs frequently in finite life-span HMEC exposed to sparsely or densely ionizing radiation and may contribute to radiation-induced breast cancer...
  39. pmc The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Mol Oncol 1:84-96. 2007
    ..We further demonstrate that consistent differences in genes encoding signal transduction proteins emerge when even tumor cells are cultured in 3D microenvironments...
  40. doi request reprint The evolution of the cancer niche during multistage carcinogenesis
    Mary Helen Barcellos-Hoff
    The Department of Radiation Oncology, New York University School of Medicine, New York, New York 10016, USA
    Nat Rev Cancer 13:511-8. 2013
    ..As such, cancer niches represent an emergent property of a tumour that could be a robust target for cancer prevention and therapy. ..
  41. ncbi request reprint Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress
    Julia Kirshner
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Cancer Res 66:10861-9. 2006
    ....
  42. ncbi request reprint The not-so innocent bystander: the microenvironment as a therapeutic target in cancer
    Anna C Erickson
    Life Sciences Division, Building 74 174, 1 Cyclotron Road, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Expert Opin Ther Targets 7:71-88. 2003
    ..Therefore, controlling and eliminating cancer may be more readily achieved indirectly via the tissue microenvironment...
  43. pmc Therapeutic targets in malignant glioblastoma microenvironment
    Mary Helen Barcellos-Hoff
    Department of Radiation Oncology, New York University, Langone School of Medicine, New York, NY 10016, USA
    Semin Radiat Oncol 19:163-70. 2009
    ....
  44. pmc Ionizing radiation induces heritable disruption of epithelial cell interactions
    Catherine C Park
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 100:10728-33. 2003
    ..These data point to a heritable, nonmutational mechanism whereby IR compromises cell polarity and multicellular organization...
  45. doi request reprint The pivotal role of insulin-like growth factor I in normal mammary development
    David L Kleinberg
    Department of Medicine Endocrinology, New York University School of Medicine, New York, NY 10016, USA
    Endocrinol Metab Clin North Am 40:461-71, vii. 2011
    ..The orchestrated action of hormones, growth factors, and receptors necessary for mammary development and function are also critical in breast cancer...
  46. ncbi request reprint Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species
    Michael F Jobling
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Radiat Res 166:839-48. 2006
    ..We propose that LTGF-beta1 contains a redox switch centered at methionine 253, which allows LTGF-beta1 to act uniquely as an extracellular sensor of oxidative stress in tissues...
  47. pmc Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts
    Fei Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Natl Cancer Inst 94:1494-503. 2002
    ..We have now used this assay to identify reversion and/or death requirements of several more aggressive human breast cancer cell lines...

Research Grants4

  1. TGFb Regulation of ER Receptor Positive Mammary Cells
    MARY BARCELLOS HOFF; Fiscal Year: 2006
    ..3: To determine whether TGF-beta regulation of the ER+ subpopulation contributes to progression and/or features of preneoplastic lesions. ..