Zsolt Bagi

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. ncbi request reprint Preserved coronary arteriolar dilatation in patients with type 2 diabetes mellitus: implications for reactive oxygen species
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Pharmacol Rep 61:99-104. 2009
  2. doi request reprint Mechanisms of coronary microvascular adaptation to obesity
    Zsolt Bagi
    Dept of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Regul Integr Comp Physiol 297:R556-67. 2009
  3. pmc Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity
    Attila Feher
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Cardiovasc Res 87:732-9. 2010
  4. ncbi request reprint Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH(4)
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H626-33. 2004
  5. ncbi request reprint PECAM-1 mediates NO-dependent dilation of arterioles to high temporal gradients of shear stress
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Arterioscler Thromb Vasc Biol 25:1590-5. 2005
  6. ncbi request reprint Nitric oxide and H2O2 contribute to reactive dilation of isolated coronary arterioles
    Akos Koller
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H2461-7. 2004
  7. ncbi request reprint H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in Type 2 diabetic mice
    Nora Erdei
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 292:H649-56. 2007
  8. pmc High intraluminal pressure via H2O2 upregulates arteriolar constrictions to angiotensin II by increasing the functional availability of AT1 receptors
    Zsolt Bagi
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 295:H835-41. 2008
  9. ncbi request reprint PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Heart Circ Physiol 286:H742-8. 2004
  10. ncbi request reprint Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins
    Zsolt Bagi
    Division of Physiology, New York Medical College, Valhalla, NY, USA
    Arterioscler Thromb Vasc Biol 25:1610-6. 2005

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Preserved coronary arteriolar dilatation in patients with type 2 diabetes mellitus: implications for reactive oxygen species
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Pharmacol Rep 61:99-104. 2009
    ..In this review, we aim to highlight current findings supporting a potential role for ROS in preserving coronary arteriolar dilation in type 2 diabetes mellitus...
  2. doi request reprint Mechanisms of coronary microvascular adaptation to obesity
    Zsolt Bagi
    Dept of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Regul Integr Comp Physiol 297:R556-67. 2009
    ....
  3. pmc Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity
    Attila Feher
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Cardiovasc Res 87:732-9. 2010
    ..We investigated the role of Cav-1 in modulating BK(Ca) channel-mediated, endothelium-derived hyperpolarizing factor (EDHF)-dependent arteriolar dilation in normal condition and in an experimental model of obesity...
  4. ncbi request reprint Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH(4)
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H626-33. 2004
    ....
  5. ncbi request reprint PECAM-1 mediates NO-dependent dilation of arterioles to high temporal gradients of shear stress
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Arterioscler Thromb Vasc Biol 25:1590-5. 2005
    ....
  6. ncbi request reprint Nitric oxide and H2O2 contribute to reactive dilation of isolated coronary arterioles
    Akos Koller
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H2461-7. 2004
    ..Thus, mechanosensitive mechanisms that are sensitive to deformation, pressure, stretch, and wall shear stress elicit release of NO and H2O2, resulting in reactive dilation of isolated coronary arterioles...
  7. ncbi request reprint H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in Type 2 diabetic mice
    Nora Erdei
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 292:H649-56. 2007
    ..These alterations may contribute to disturbed regulation of skeletal muscle blood flow in Type 2 diabetes mellitus...
  8. pmc High intraluminal pressure via H2O2 upregulates arteriolar constrictions to angiotensin II by increasing the functional availability of AT1 receptors
    Zsolt Bagi
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 295:H835-41. 2008
    ..We propose that in hypertension-regardless of etiology-high intraluminal pressure, via oxidative stress, enhances the functional availability of AT1 receptors augmenting Ang II-induced constrictions...
  9. ncbi request reprint PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Heart Circ Physiol 286:H742-8. 2004
    ..Thus, in addition to the previously revealed beneficial metabolic effects, the antioxidant action of rosiglitazone may protect coronary arteriolar function in Type 2 DM...
  10. ncbi request reprint Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins
    Zsolt Bagi
    Division of Physiology, New York Medical College, Valhalla, NY, USA
    Arterioscler Thromb Vasc Biol 25:1610-6. 2005
    ..We hypothesized that in T2-DM, the regulation of peripheral vascular resistance is altered because of changes in local vasomotor mechanisms...
  11. pmc Exacerbation of endothelial dysfunction during the progression of diabetes: role of oxidative stress
    An Huang
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Regul Integr Comp Physiol 302:R674-81. 2012
    ....
  12. pmc Microvascular responsiveness in obesity: implications for therapeutic intervention
    Zsolt Bagi
    Department of Pharmacology, University of Oxford, UK Department of Physiology, New York Medical College, Valhalla, New York, USA
    Br J Pharmacol 165:544-60. 2012
    ..We further identify some of the important challenges and opportunities going forward...
  13. ncbi request reprint Biphasic effect of hydrogen peroxide on skeletal muscle arteriolar tone via activation of endothelial and smooth muscle signaling pathways
    Csongor Cseko
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    J Appl Physiol 97:1130-7. 2004
    ..Because H2O2 at low micromolar concentrations activates several intrinsic mechanisms, we suggest that H2O2 contributes to the local regulation of skeletal muscle blood flow in various physiological and pathophysiological conditions...
  14. ncbi request reprint Oxidative stress-induced dysregulation of arteriolar wall shear stress and blood pressure in hyperhomocysteinemia is prevented by chronic vitamin C treatment
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 285:H2277-83. 2003
    ..Thus our study provides evidence that oxidative stress is an important in vivo mechanism that is primarily responsible for the development of endothelial dysregulation of WSS in HHcy...
  15. pmc Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Heart Circ Physiol 297:H1876-81. 2009
    ....
  16. pmc Increased availability of angiotensin AT 1 receptors leads to sustained arterial constriction to angiotensin II in diabetes - role for Rho-kinase activation
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY, USA
    Br J Pharmacol 163:1059-68. 2011
    ..Antagonists of angiotensin AT(1) receptors elicit beneficial vascular effects in diabetes mellitus. We hypothesized that diabetes induces sustained availability of AT(1) receptors, causing enhanced arterial constriction to angiotensin II...
  17. pmc Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes
    Timea Beleznai
    Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    Am J Physiol Heart Circ Physiol 300:H777-83. 2011
    ..Collectively, we provided evidence for a distinct upregulation of arginase 1 in coronary arterioles of patients with DM, which contributes to a reduced NO production and consequently diminished vasodilation...
  18. ncbi request reprint On the role of mechanosensitive mechanisms eliciting reactive hyperemia
    Akos Koller
    Department of Pathophysiology, Semmelweis University, 1445 Budapest, Hungary
    Am J Physiol Heart Circ Physiol 283:H2250-9. 2002
    ....
  19. ncbi request reprint Superoxide-NO interaction decreases flow- and agonist-induced dilations of coronary arterioles in Type 2 diabetes mellitus
    Zsolt Bagi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 285:H1404-10. 2003
    ..This alteration in the regulation of coronary microvascular resistance may contribute to the development of IHD in T2-DM...