Research Topics
Genomes and GenesSpecies | A AvivSummaryAffiliation: New Jersey Country: USA Publications
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Publications
Telomeres, sex, reactive oxygen species, and human cardiovascular agingAbraham Aviv
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
J Mol Med (Berl) 80:689-95. 2002..In the final analysis, the biology of reactive oxygen species may offer a common explanation for some interindividual variation in cardiovascular aging and age-dependent telomere attrition in humans...- Growth, telomere dynamics and successful and unsuccessful human agingAbraham Aviv
Room F 464, Hypertension Research Center, The Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Ave, Newark, NJ 07103 2714, USA
Mech Ageing Dev 124:829-37. 2003..The models capture aspects of individual variation in successful and unsuccessful aging and the long-term consequences of rapid growth early in life... - Rise in insulin resistance is associated with escalated telomere attritionJeffrey P Gardner
Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Circulation 111:2171-7. 2005..531, P<0.001) and changes in the body mass index (r=-0.423, P<0.001). CONCLUSIONS: These findings provide the first tangible nexus of telomere biology with insulin resistance and adiposity in humans... - Telomeres and human somatic fitnessAbraham Aviv
The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
J Gerontol A Biol Sci Med Sci 61:871-3. 2006..I also propose that, in exceptionally old humans, ultrashort leukocyte telomeres might be a determinant of life span... 
Genetics of leukocyte telomere length and its role in atherosclerosisAbraham Aviv
The Center for Human Development and Aging, University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ 07103, USA
Mutat Res 730:68-74. 2012..The mechanisms underlying these associations are still not well understood, but they stem in part from genetic factors in control of telomere maintenance and the rate of HSC replication...- Salt consumption, reactive oxygen species and cardiovascular ageing: a hypothetical linkAbraham Aviv
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
J Hypertens 20:555-9. 2002..These links suggest that, in a subset of the general population, salt consumption is a determinant in cardiovascular ageing... - How long should telomeres be?A Aviv
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
Curr Hypertens Rep 3:145-51. 2001..We also propose that the underlying dynamics of telomere biology is in line with broad principles of evolutionary theories... - Hypothesis: pulse pressure and human longevityA Aviv
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103 2714, USA
Hypertension 37:1060-6. 2001..the field of hypertension: Why has it been so difficult to disentangle the genetic components of essential hypertension and to identify the variant genes responsible for elevated blood pressure in a large segment of the human population?.. - Telomeres and human aging: facts and fibsAbraham Aviv
Hypertension Research Center, The Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Sci Aging Knowledge Environ 2004:pe43. 2004..However, it is unsettled whether human telomere dynamics is only a proxy for fundamental mechanisms that govern the course of aging or a key determinant in its progression... - Urinary potassium excretion and sodium sensitivity in blacksAbraham Aviv
Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
Hypertension 43:707-13. 2004..In this sense, the biological implication of sodium sensitivity in blacks and in humans in general has ramifications above and beyond salt-evoked increase in blood pressure... - Human telomere biology: pitfalls of moving from the laboratory to epidemiologyAbraham Aviv
The Center of Human Development and Aging of New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
Int J Epidemiol 35:1424-9. 2006..Here we explain some of the reasons for this variability and propose several principles that should be considered in conducting epidemiological telomere research. Ignoring these principles could lead to misleading conclusions... - Chronology versus biology: telomeres, essential hypertension, and vascular agingAbraham Aviv
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Hypertension 40:229-32. 2002.... - Sodium glomerulopathy: tubuloglomerular feedback and renal injury in African AmericansAbraham Aviv
Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
Kidney Int 65:361-8. 2004..Increased susceptibility to glomerular hyperfiltration of African Americans on a high salt intake may explain their proclivity to progressive renal injury associated with essential hypertension... - Telomeres: the time factor in essential hypertensionA Aviv
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
Curr Hypertens Rep 3:33-5. 2001..The incorporation of a temporal factor into models of essential hypertension may provide a heretofore missing link explaining variations in age-dependent increase in pulse pressure... - The longevity gender gap: are telomeres the explanation?Abraham Aviv
Hypertension Research Center, The Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, NJ Medical School, Newark, NJ 07103, USA
Sci Aging Knowledge Environ 2005:pe16. 2005.... - Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCRAbraham Aviv
The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Nucleic Acids Res 39:e134. 2011..We discuss the ramifications of these findings with regard to measurements of telomere length/DNA content in epidemiological/clinical circumstances... - Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart StudyAbraham Aviv
The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Am J Epidemiol 169:323-9. 2009..These findings underscore the complexity of leukocyte telomere dynamics in vivo and suggest that determinants in addition to the "end-replication problem" contribute to telomere shortening in vivo... 
Telomeres, atherosclerosis, and the hemothelium: the longer viewAbraham Aviv
The Center of Human Development and Aging, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103 2714, USA
Annu Rev Med 63:293-301. 2012..Our model comes down to this proposition: Shortened LTL predicts increased atherosclerotic risk because the injurious component of atherosclerosis exceeds the repair capacity of HSC reserves, which largely depend on HSC telomere length...- Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammationAbraham Aviv
Room F 464 MSB, Department of Pediatrics, Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
J Clin Endocrinol Metab 91:635-40. 2006..Leukocyte telomere length is inversely correlated with age, insulin resistance, serum leptin, and smoking... - Telomeres, hidden mosaicism, loss of heterozygosity, and complex genetic traitsA Aviv
Hypertension Research Center, University of Medicine and Dentistry of NJ, New Jersey Medical School, Newark 07103 2714, USA
Hum Genet 103:2-4. 1998..In this way, telomere attrition might play a role not only in aging, but also in the diverse expression of complex genetic traits, such as essential hypertension, non-insulin-dependent diabetes mellitus, atherosclerosis, and cancer... - The epidemiology of human telomeres: faults and promisesAbraham Aviv
The Center of Human Development and Aging, University of Medicine and Dentistry, New Jersey, Room F 464, MSB, UMDNJ, New Jersey Medical School, 185 South Orange Ave, MSB F 464, Newark, NJ 07103, USA
J Gerontol A Biol Sci Med Sci 63:979-83. 2008.... - Telomeres and essential hypertensionA Aviv
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103 2714, USA
Am J Hypertens 12:427-32. 1999.... - The relationship between Ca2+-ATPase and freely exchangeable Ca2+ in the dense tubules: a study in platelets from womenM Horiguchi
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 071032-2714, USA
Am J Hypertens 12:120-7. 1999..However, in women, unlike previous observations in men, these platelet parameters are not correlated with blood pressure and serum lipoproteins... - Ca2+ in the dense tubules: a model of platelet Ca2+ loadM Horiguchi
Hypertension Research Center and the Department of Preventive Medicine and Community Health, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103 2714, USA
Hypertension 31:595-602. 1998.... - Age dependent aneuploidy and telomere length of the human vascular endotheliumH Aviv
The Center of Human and Molecular Genetics, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
Atherosclerosis 159:281-7. 2001..Aneuploidy and telomere attrition might thus play a role in the aging of the human vasculature... - Leukocytes of exceptionally old persons display ultra-short telomeresM Kimura
Center of Human Development and Aging, Room F 464, MSB, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Ave, Newark, New Jersey 07103, USA
Am J Physiol Regul Integr Comp Physiol 293:R2210-7. 2007..10 vs. 5.86 kb), and exceptionally old women exhibited fewer ultra-short telomeres than exceptionally old men. Our results have implications for gerontological studies of the limitation of lifespan in humans... - The effects of social status on biological aging as measured by white-blood-cell telomere lengthL F Cherkas
Twin Research and Genetic Epidemiology Unit, St Thomas' Hospital, London, UK, and The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103-2714, USA
Aging Cell 5:361-5. 2006..Comparison of TRFL in the 17 most discordant SES twin pairs confirmed this difference. Low SES, in addition to the harmful effects of smoking, obesity and lack of exercise, appears to have an impact on telomere length... - Cytosolic Ca2+ regulation attenuates ANP-induced cGMP response in vascular smooth muscle cells of the SHRM Nakamura
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School 07103
Am J Hypertens 2:111-3. 1989.... - Physiological and molecular characterization of the Na+/Ca2+ exchanger in human plateletsM Kimura
Hypertension Research Center, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
Am J Physiol 277:H911-7. 1999..We propose that the K+ dependence of the platelet Na+/Ca2+ exchanger could make platelets especially sensitive to daily fluctuations in salt intake... - Lack of difference in oxalate-dependent Ca2+ uptake by membrane homogenate of African-American and white subjectsX Y Yang
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103-2757, USA
Am J Hypertens 10:434-9. 1997..The findings do not exclude possible increased activity of this enzyme in intact cells of African-Americans where regulatory mechanisms not present in the membrane preparation may operate... - Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the ruleW Chen
Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
J Gerontol A Biol Sci Med Sci 66:312-9. 2011..Leukocyte telomere length (LTL) is considered a biomarker of human aging and based on cross-sectional studies it shortens with age. However, longitudinal studies reported that many adults display LTL lengthening... - Age-dependent telomere attrition as a potential indicator of racial differences in renal growth patternsL Tchakmakjian
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Nephron Exp Nephrol 98:e82-8. 2004..Less proliferative growth of proximal tubular cells in kidneys from African Americans may be one factor explaining the slower age-dependent telomere attrition rate in the outer renal cortex of African Americans than in Caucasians... - Differences of Ca2+ regulation between fibroblasts from blacks and whitesA Nakamura
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103
Am J Hypertens 2:105-7. 1989..We conclude that fibroblasts from blacks demonstrate increased responsiveness to agonists in serum. If the same trend exists in vascular smooth muscle cells, it may predispose blacks to essential hypertension... - Telomere dynamics in macaques and humansJeffrey P Gardner
The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
J Gerontol A Biol Sci Med Sci 62:367-74. 2007..Similar to humans, telomerase activity was detected in spleen, thymus, digestive tract, and gonads. We conclude that factors that modify telomere attrition and aging in humans may also operate in the macaque... - Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengthsMasayuki Kimura
The Center for Human Development and Aging, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
Nat Protoc 5:1596-607. 2010..A skilled technician can measure TRF length in ∼130 samples per week... - Sex differences in pulse pressure trends with age are cross-culturalJoan H Skurnick
Medical Sciences Building F506, 185 South Orange Ave, Department of Preventive Medicine and Community Health, UMDNJ New Jersey Medical School, Newark, NJ 07101 1709, USA
Hypertension 55:40-7. 2010..Accordingly, the biological principles of arterial aging, as expressed in pulse pressure, are the same in all humans, regardless of demography... - Cytosolic Ca2+, Na+/H+ antiport, protein kinase C trio in essential hypertensionA Aviv
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103
Am J Hypertens 7:205-12. 1994.... - The Na+/H+ antiport, cytosolic free Ca2+, and essential hypertension: a hypothesisA Aviv
Hypertension Research Center, University of Medicine and Dentistry, Newark, New Jersey 07103-2757
Am J Hypertens 1:410-3. 1988..These agents are, therefore, particularly effective in the treatment of essential hypertension in blacks and older individuals with the low-renin form of the disease, who are known to be salt sensitive... - The links between cellular Ca2+ and Na+/H+ exchange in the pathophysiology of essential hypertensionA Aviv
Hypertension Research Program, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103-2714, USA
Am J Hypertens 9:703-7. 1996..It is suggested that, in essential hypertension, an increased cellular Ca2+ load or an enhanced external Ca2+ entry stimulate the NHE-1 through protein kinase/phosphatase and Ca2+/calmodulin systems, thereby increasing its activity... - Proliferation dynamics in cultured skin fibroblasts from Down syndrome subjectsMasayuki Kimura
Hypertension Research Center, MSB, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark NJ 07103, USA
Free Radic Biol Med 39:374-80. 2005..e., Gpx and catalase) and confirmed previous observations about inverse relationships between SOD activity and telomere repeat loss per cellular replication... - Loss of chromosome 16 from renal epithelial cells in humansJeffrey P Gardner
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103-2714, USA
Hypertension 40:928-33. 2002.... - Telomere length and mortality: a study of leukocytes in elderly Danish twinsMasayuki Kimura
Center of Human Development and Aging, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
Am J Epidemiol 167:799-806. 2008..Leukocyte telomere dynamics might help explain the boundaries of the human life span... - Potassium chloride supplementation diminishes platelet reactivity in humansMasayuki Kimura
Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, Newark 07103, USA
Hypertension 44:969-73. 2004..We conclude that potassium supplementation diminishes platelet reactivity, a phenomenon that provides a link between platelet biology and occlusive stroke... - Survival advantage of cultured human vascular endothelial cells that lost chromosome 13Masayuki Kimura
Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Chromosoma 112:317-22. 2004..HUVECs losing chromosome 13 demonstrated increased migratory potential and loss of heterozygosity. Collectively, these observations suggest that the loss of chromosome 13 gives cultured HUVECs a replicative advantage... - Offspring's leukocyte telomere length, paternal age, and telomere elongation in spermMasayuki Kimura
The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jeresey, United States of America
PLoS Genet 4:e37. 2008..Paternal age exerts a considerable effect on the offspring's LTL, a phenomenon which might relate to telomere elongation in sperm from older men. The implications of this effect deserve detailed study... - Synchrony of telomere length among hematopoietic cellsMasayuki Kimura
The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
Exp Hematol 38:854-9. 2010..This information is relevant because telomere dynamics in granulocytes were postulated to mirror those of hematopoietic stem cells (HSCs)... - Homocysteine thiolactone and protein homocysteinylation in human endothelial cells: implications for atherosclerosisH Jakubowski
Department of Microbiology, UMDNJ New Jersey Medical School, Newark, NJ, USA
Circ Res 87:45-51. 2000..These data support a hypothesis that metabolic conversion of homocysteine to thiolactone and protein homocysteinylation by thiolactone may play a role in homocysteine-induced vascular damage... - Telomere length in the newbornKoji Okuda
The Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
Pediatr Res 52:377-81. 2002.... - Calcium adaptation to sodium pump inhibition in a human megakaryocytic cell lineMasayuki Kimura
Hypertension Research Center, MSB, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Ave, Newark, New Jersey 07103, USA
Am J Physiol Cell Physiol 289:C891-7. 2005..The implications of these findings in platelet biology are discussed... - Leukocyte telomere length and carotid artery intimal medial thickness: the Framingham Heart StudyChristopher J O'Donnell
National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue 2, Framingham, MA 01702 5827, USA
Arterioscler Thromb Vasc Biol 28:1165-71. 2008..The purpose of this study was to examine the link between LTL and the predisposition to atherosclerosis, as determined by carotid artery intimal medial thickness (IMT) in participants of the Framingham Offspring Study... - Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart StudySteven C Hunt
Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT, USA NHLBI Family Heart Study
Aging Cell 7:451-8. 2008..029 kb year(-1) vs. 0.020 kb year(-1), respectively, p = 0.0001). We suggest that racial difference in LTL arises from a host of interacting biological factors, including replication rates of hematopoietic stem cells... - Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in womenJ Brent Richards
Twin Research and Genetic Epidemiology, St Thomas Hospital, King s College, London School of Medicine, London, United Kingdom
Am J Clin Nutr 86:1420-5. 2007..Leukocyte telomere length (LTL) is a predictor of aging-related disease and decreases with each cell cycle and increased inflammation... - Reduced telomere length in rheumatoid arthritis is independent of disease activity and durationSophia E Steer
Department of Rheumatology, Twin Research and Genetic Epidemiology Unit, Kings College London School of Medicine at Guy s, King s and St Thomas, London SE1 7EH, UK
Ann Rheum Dis 66:476-80. 2007..Telomere loss in white blood cells (WBC) is accelerated by oxidative stress and inflammation in vitro. It was postulated that the accelerated WBC telomere shortening in RA occurs as a result of exposure to chronic inflammation... - Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei miceValerie Cattan
INSERM, U684, 54500 Vandoeuvre les Nancy, France
Free Radic Biol Med 44:1592-8. 2008..The variable effect of BSO treatment on telomere length in different tissue may result from their different adaptive antioxidative capacity... - The association between physical activity in leisure time and leukocyte telomere lengthLynn F Cherkas
Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London SE1 7EH, England
Arch Intern Med 168:154-8. 2008..We therefore tested the hypothesis that physical activity level in leisure time (over the past 12 months) is associated with leukocyte telomere length (LTL) in normal healthy volunteers... - Short telomeres in short-lived males: what are the molecular and evolutionary causes?Stephanie Jemielity
Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland
Aging Cell 6:225-33. 2007..In addition, we discuss the evolutionary causes of such patterns in ants and in other species... - Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairsToby Andrew
Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, United Kingdom
Am J Hum Genet 78:480-6. 2006..9) at 14q23.2, and suggestive linkage at 10q26.13 (LOD 2.4) and 3p26.1 (LOD 2.7). This is the first report of loci, mapped in a sample of healthy individuals, that influence mean telomere variation in humans... - Telomere length and possible link to X chromosomeTim S Nawrot
Study Coordinating Centre, Laboratory of Hypertension, Department of Molecular and Cardiovascular Research, University of Leuven, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
Lancet 363:507-10. 2004..61; p< or =0.0004). INTERPRETATION: X-linked inheritance of TRF length is the most probable explanation for our findings. Pending confirmation, our observations suggest that the process of ageing might be an X-linked trait... - Leukocyte telomere length and cardiovascular disease in the cardiovascular health studyAnnette L Fitzpatrick
Department of Epidemiology, School of Public Health and Community Medicine, Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA 98115, USA
Am J Epidemiol 165:14-21. 2007..22, 95% confidence interval: 1.29, 8.02). These results support the hypotheses that telomere attrition may be related to diseases of aging through mechanisms involving oxidative stress, inflammation, and progression to CVD... - The reactive oxidative species-renin-angiotensin system linkAbraham Aviv
J Hypertens 20:2357-8. 2002 - Aldosterone and telomere length in white blood cellsAthanase Benetos
INSERM Unit 684, University of Nancy, 54511 Nancy les Vandoeuvre, France
J Gerontol A Biol Sci Med Sci 60:1593-6. 2005..The aim of the present study was, therefore, to examine the relationship between plasma aldosterone and telomere length in WBCs... - Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjectsAthanase Benetos
Centre d Investigations Préventives et Cliniques, 6 14 rue la Pérouse, 75116 Paris, France
Hypertension 43:182-5. 2004.... - Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart StudyRamachandran S Vasan
Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, MA 01702 5827, USA
Circulation 117:1138-44. 2008..Activation of the renin-angiotensin-aldosterone system is associated with increased oxidative stress and inflammation. Therefore, LTL may be related to circulating biomarkers of the renin-angiotensin-aldosterone system... - Renal and gastrointestinal potassium excretion in humans: new insight based on new data and review and analysis of published studiesLeslie M Klevay
Department of Agricultrue, Agricultural Research Service, Human Nutrition Research Center, Grand Forks, North Dakota, USA
J Am Coll Nutr 26:103-10. 2007..Little is known about the relationship between the renal and gastrointestinal excretion of potassium in humans. This information is important in light of strong associations of potassium intake with hypertension and occlusive stroke... - Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivoVeronique Bataille
Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London SE1 7EH, United Kingdom
Cancer Epidemiol Biomarkers Prev 16:1499-502. 2007..Understanding mechanisms influencing the induction and involution of nevi will not only help in understanding the pathophysiology of melanoma but should also shed light on the complex relationship between aging and cancer... - Genomic association/linkage of sodium lithium countertransport in CEPH pedigreesNicholas J Schork
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
Hypertension 40:619-28. 2002..These findings support evidence that thiol groups play a central role in SLC activity...
Research Grants
- Genetics of the Sodium-Lithium CountertransportAbraham Aviv; Fiscal Year: 2007..abstract_text> ..
- Telomeres and Vascular AgingAbraham Aviv; Fiscal Year: 2007..abstract_text> ..
- Human Telomere GeneticsAbraham Aviv; Fiscal Year: 2007..Results will serve to define genes as determinants of telomere length. Such information would lead to new diagnostic and therapeutic approaches to treat age-related diseases. ..
- Leukocyte TelomerE Dynamics, Gender, Menopause, Insulin Resistance and SurvivalAbraham Aviv; Fiscal Year: 2009..Our findings will provide a new insight into the gender gap in human longevity (women live longer than men) and the role of insulin resistance in the human lifespan. ..
- PLATELET CALCIUM-SODIUM LINK AND HYPERTENSION IN BLACKSAbraham Aviv; Fiscal Year: 1993....
- CELLULAR PHENOTYPES OF SALT SENSITIVITYAbraham Aviv; Fiscal Year: 2001..The investigators state that the results of the study will generate a novel perspective about phenotypes of salt sensitivity and, an insight into the cardiovascular effects of high salt in humans. ..
- Leukocyte TelomerE Dynamics, Gender, Menopause, Insulin Resistance and SurvivalAbraham Aviv; Fiscal Year: 2010..Our findings will provide a new insight into the gender gap in human longevity (women live longer than men) and the role of insulin resistance in the human lifespan. ..