A Aviv

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi Telomeres, sex, reactive oxygen species, and human cardiovascular aging
    Abraham Aviv
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Mol Med (Berl) 80:689-95. 2002
  2. ncbi Growth, telomere dynamics and successful and unsuccessful human aging
    Abraham Aviv
    Room F 464, Hypertension Research Center, The Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Ave, Newark, NJ 07103 2714, USA
    Mech Ageing Dev 124:829-37. 2003
  3. ncbi Rise in insulin resistance is associated with escalated telomere attrition
    Jeffrey P Gardner
    Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Circulation 111:2171-7. 2005
  4. ncbi Telomeres and human somatic fitness
    Abraham Aviv
    The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    J Gerontol A Biol Sci Med Sci 61:871-3. 2006
  5. pmc Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule
    W Chen
    Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    J Gerontol A Biol Sci Med Sci 66:312-9. 2011
  6. pmc Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans
    Kenneth I Aston
    Andrology and IVF Laboratories, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Mol Hum Reprod 18:517-22. 2012
  7. pmc Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans
    Massimo Mangino
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Hum Mol Genet 21:5385-94. 2012
  8. pmc The telomere lengthening conundrum--artifact or biology?
    Troels Steenstrup
    Department of Biostatistics, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Nucleic Acids Res 41:e131. 2013
  9. pmc Telomeres shorten at equivalent rates in somatic tissues of adults
    Lily Daniali
    Division of Plastic Surgery, Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Nat Commun 4:1597. 2013
  10. pmc Tracking and fixed ranking of leukocyte telomere length across the adult life course
    Athanase Benetos
    Geriatric Service, Nancy University Hospital, Nancy, 54511, France
    Aging Cell 12:615-21. 2013

Research Grants

  1. Telomeres and Vascular Aging
    Abraham Aviv; Fiscal Year: 2005
  2. Genetics of the Sodium-Lithium Countertransport
    Abraham Aviv; Fiscal Year: 2006
  3. Telomeres and Vascular Aging
    Abraham Aviv; Fiscal Year: 2006
  4. Human Telomere Genetics
    Abraham Aviv; Fiscal Year: 2006
  5. Genetics of the Sodium-Lithium Countertransport
    Abraham Aviv; Fiscal Year: 2007
  6. Telomeres and Vascular Aging
    Abraham Aviv; Fiscal Year: 2007
  7. Human Telomere Genetics
    Abraham Aviv; Fiscal Year: 2007
  8. Leukocyte TelomerE Dynamics, Gender, Menopause, Insulin Resistance and Survival
    Abraham Aviv; Fiscal Year: 2009
  9. Genetics of the Sodium-Lithium Countertransport
    Abraham Aviv; Fiscal Year: 2005
  10. Genetics of the Sodium-Lithium Countertransport
    Abraham Aviv; Fiscal Year: 2004

Collaborators

Detail Information

Publications80

  1. ncbi Telomeres, sex, reactive oxygen species, and human cardiovascular aging
    Abraham Aviv
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Mol Med (Berl) 80:689-95. 2002
    ..In the final analysis, the biology of reactive oxygen species may offer a common explanation for some interindividual variation in cardiovascular aging and age-dependent telomere attrition in humans...
  2. ncbi Growth, telomere dynamics and successful and unsuccessful human aging
    Abraham Aviv
    Room F 464, Hypertension Research Center, The Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Ave, Newark, NJ 07103 2714, USA
    Mech Ageing Dev 124:829-37. 2003
    ..The models capture aspects of individual variation in successful and unsuccessful aging and the long-term consequences of rapid growth early in life...
  3. ncbi Rise in insulin resistance is associated with escalated telomere attrition
    Jeffrey P Gardner
    Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Circulation 111:2171-7. 2005
    ..We therefore tested the hypothesis that a rise in insulin resistance in concert with gain in body mass is associated with accelerated white blood cell telomere attrition...
  4. ncbi Telomeres and human somatic fitness
    Abraham Aviv
    The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    J Gerontol A Biol Sci Med Sci 61:871-3. 2006
    ..I also propose that, in exceptionally old humans, ultrashort leukocyte telomeres might be a determinant of life span...
  5. pmc Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule
    W Chen
    Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    J Gerontol A Biol Sci Med Sci 66:312-9. 2011
    ..Leukocyte telomere length (LTL) is considered a biomarker of human aging and based on cross-sectional studies it shortens with age. However, longitudinal studies reported that many adults display LTL lengthening...
  6. pmc Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans
    Kenneth I Aston
    Andrology and IVF Laboratories, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Mol Hum Reprod 18:517-22. 2012
    ..In this sense, germ cell TL dynamics could be driving the evolution of TL in modern humans and perhaps telomere-related diseases in the general population...
  7. pmc Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans
    Massimo Mangino
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    Hum Mol Genet 21:5385-94. 2012
    ..Overall, our results provide novel insights into the genetic architecture of inter-individual LTL variation in the general population...
  8. pmc The telomere lengthening conundrum--artifact or biology?
    Troels Steenstrup
    Department of Biostatistics, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Nucleic Acids Res 41:e131. 2013
    ..We offer specific suggestions for design of longitudinal studies of LTL attrition to diminish this artifact. ..
  9. pmc Telomeres shorten at equivalent rates in somatic tissues of adults
    Lily Daniali
    Division of Plastic Surgery, Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Nat Commun 4:1597. 2013
    ....
  10. pmc Tracking and fixed ranking of leukocyte telomere length across the adult life course
    Athanase Benetos
    Geriatric Service, Nancy University Hospital, Nancy, 54511, France
    Aging Cell 12:615-21. 2013
    ..Accordingly, the links of LTL with atherosclerosis and longevity appear to be established early in life. It is unlikely that lifestyle and its modification during adulthood exert a major impact on LTL ranking...
  11. pmc Leukocyte telomere dynamics in the elderly
    Troels Steenstrup
    Department of Biostatistics, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Eur J Epidemiol 28:181-7. 2013
    ..Measurement error is the probable explanation for LTL elongation in longitudinal studies...
  12. pmc Leukocyte telomere length and the father's age enigma: implications for population health and for life course
    Abraham Aviv
    The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Int J Epidemiol 42:457-62. 2013
    ..We draw together work across a range of disciplines to offer an integrated perspective of this issue...
  13. pmc Genetics of leukocyte telomere length and its role in atherosclerosis
    Abraham Aviv
    The Center for Human Development and Aging, University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ 07103, USA
    Mutat Res 730:68-74. 2012
    ..The mechanisms underlying these associations are still not well understood, but they stem in part from genetic factors in control of telomere maintenance and the rate of HSC replication...
  14. ncbi Sodium glomerulopathy: tubuloglomerular feedback and renal injury in African Americans
    Abraham Aviv
    Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Kidney Int 65:361-8. 2004
    ..Increased susceptibility to glomerular hyperfiltration of African Americans on a high salt intake may explain their proclivity to progressive renal injury associated with essential hypertension...
  15. ncbi Urinary potassium excretion and sodium sensitivity in blacks
    Abraham Aviv
    Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Hypertension 43:707-13. 2004
    ..In this sense, the biological implication of sodium sensitivity in blacks and in humans in general has ramifications above and beyond salt-evoked increase in blood pressure...
  16. pmc Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study
    Abraham Aviv
    The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Am J Epidemiol 169:323-9. 2009
    ..These findings underscore the complexity of leukocyte telomere dynamics in vivo and suggest that determinants in addition to the "end-replication problem" contribute to telomere shortening in vivo...
  17. ncbi The epidemiology of human telomeres: faults and promises
    Abraham Aviv
    The Center of Human Development and Aging, University of Medicine and Dentistry, New Jersey, Room F 464, MSB, UMDNJ, New Jersey Medical School, 185 South Orange Ave, MSB F 464, Newark, NJ 07103, USA
    J Gerontol A Biol Sci Med Sci 63:979-83. 2008
    ....
  18. ncbi Telomeres and human aging: facts and fibs
    Abraham Aviv
    Hypertension Research Center, The Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Sci Aging Knowledge Environ 2004:pe43. 2004
    ..However, it is unsettled whether human telomere dynamics is only a proxy for fundamental mechanisms that govern the course of aging or a key determinant in its progression...
  19. ncbi The longevity gender gap: are telomeres the explanation?
    Abraham Aviv
    Hypertension Research Center, The Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, NJ Medical School, Newark, NJ 07103, USA
    Sci Aging Knowledge Environ 2005:pe16. 2005
    ....
  20. ncbi Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation
    Abraham Aviv
    Room F 464 MSB, Department of Pediatrics, Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Clin Endocrinol Metab 91:635-40. 2006
    ..Leukocyte telomere length is inversely correlated with age, insulin resistance, serum leptin, and smoking...
  21. ncbi Human telomere biology: pitfalls of moving from the laboratory to epidemiology
    Abraham Aviv
    The Center of Human Development and Aging of New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Int J Epidemiol 35:1424-9. 2006
    ..Here we explain some of the reasons for this variability and propose several principles that should be considered in conducting epidemiological telomere research. Ignoring these principles could lead to misleading conclusions...
  22. ncbi Salt consumption, reactive oxygen species and cardiovascular ageing: a hypothetical link
    Abraham Aviv
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    J Hypertens 20:555-9. 2002
    ..These links suggest that, in a subset of the general population, salt consumption is a determinant in cardiovascular ageing...
  23. pmc Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR
    Abraham Aviv
    The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Nucleic Acids Res 39:e134. 2011
    ..We discuss the ramifications of these findings with regard to measurements of telomere length/DNA content in epidemiological/clinical circumstances...
  24. ncbi Telomeres, hidden mosaicism, loss of heterozygosity, and complex genetic traits
    A Aviv
    Hypertension Research Center, University of Medicine and Dentistry of NJ, New Jersey Medical School, Newark 07103 2714, USA
    Hum Genet 103:2-4. 1998
    ..In this way, telomere attrition might play a role not only in aging, but also in the diverse expression of complex genetic traits, such as essential hypertension, non-insulin-dependent diabetes mellitus, atherosclerosis, and cancer...
  25. ncbi Telomeres and essential hypertension
    A Aviv
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103 2714, USA
    Am J Hypertens 12:427-32. 1999
    ....
  26. ncbi Telomeres: the time factor in essential hypertension
    A Aviv
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
    Curr Hypertens Rep 3:33-5. 2001
    ..The incorporation of a temporal factor into models of essential hypertension may provide a heretofore missing link explaining variations in age-dependent increase in pulse pressure...
  27. ncbi How long should telomeres be?
    A Aviv
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Curr Hypertens Rep 3:145-51. 2001
    ..We also propose that the underlying dynamics of telomere biology is in line with broad principles of evolutionary theories...
  28. ncbi Hypothesis: pulse pressure and human longevity
    A Aviv
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103 2714, USA
    Hypertension 37:1060-6. 2001
    ..the field of hypertension: Why has it been so difficult to disentangle the genetic components of essential hypertension and to identify the variant genes responsible for elevated blood pressure in a large segment of the human population?..
  29. doi Telomeres, atherosclerosis, and the hemothelium: the longer view
    Abraham Aviv
    The Center of Human Development and Aging, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103 2714, USA
    Annu Rev Med 63:293-301. 2012
    ..Our model comes down to this proposition: Shortened LTL predicts increased atherosclerotic risk because the injurious component of atherosclerosis exceeds the repair capacity of HSC reserves, which largely depend on HSC telomere length...
  30. ncbi Chronology versus biology: telomeres, essential hypertension, and vascular aging
    Abraham Aviv
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Hypertension 40:229-32. 2002
    ....
  31. doi Homocysteine levels and leukocyte telomere length
    J B Richards
    Centre for Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, King s College London School of Medicine, London, UK
    Atherosclerosis 200:271-7. 2008
    ..As leukocyte telomere length (LTL) registers the cumulative oxidative stress and inflammation, we examined the relationship between homocysteine and LTL...
  32. pmc Leukocyte telomere length is associated with cognitive performance in healthy women
    A M Valdes
    Twin Research and Genetic Epidemiology Unit, Kings College London, School of Medicine, St Thomas Hospital, London, UK
    Neurobiol Aging 31:986-92. 2010
    ..Age-related cognitive decline begins in mid-life and continues with advancing age. Leukocyte telomere length (LTL) shortens with age, and inflammation and oxidative stress enhance this process. Shorter LTL is associated with dementia...
  33. ncbi The effects of social status on biological aging as measured by white-blood-cell telomere length
    L F Cherkas
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK, and The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103 2714, USA
    Aging Cell 5:361-5. 2006
    ..Comparison of TRFL in the 17 most discordant SES twin pairs confirmed this difference. Low SES, in addition to the harmful effects of smoking, obesity and lack of exercise, appears to have an impact on telomere length...
  34. ncbi Ca2+ in the dense tubules: a model of platelet Ca2+ load
    M Horiguchi
    Hypertension Research Center and the Department of Preventive Medicine and Community Health, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103 2714, USA
    Hypertension 31:595-602. 1998
    ....
  35. ncbi The relationship between Ca2+-ATPase and freely exchangeable Ca2+ in the dense tubules: a study in platelets from women
    M Horiguchi
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 071032-2714, USA
    Am J Hypertens 12:120-7. 1999
    ..However, in women, unlike previous observations in men, these platelet parameters are not correlated with blood pressure and serum lipoproteins...
  36. ncbi Age dependent aneuploidy and telomere length of the human vascular endothelium
    H Aviv
    The Center of Human and Molecular Genetics, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Atherosclerosis 159:281-7. 2001
    ..Aneuploidy and telomere attrition might thus play a role in the aging of the human vasculature...
  37. ncbi Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis
    A M Valdes
    Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London, SE1 7EH, UK
    Osteoporos Int 18:1203-10. 2007
    ..Clinical osteoporosis was associated with shorter telomeres, suggesting that telomere length can be used as a marker of bone aging...
  38. ncbi Leukocytes of exceptionally old persons display ultra-short telomeres
    M Kimura
    Center of Human Development and Aging, Room F 464, MSB, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Ave, Newark, New Jersey 07103, USA
    Am J Physiol Regul Integr Comp Physiol 293:R2210-7. 2007
    ..10 vs. 5.86 kb), and exceptionally old women exhibited fewer ultra-short telomeres than exceptionally old men. Our results have implications for gerontological studies of the limitation of lifespan in humans...
  39. pmc A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
    M Mangino
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK
    J Med Genet 46:451-4. 2009
    ..Telomere length is a predictor for a number of common age related diseases and is a heritable trait...
  40. ncbi Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study
    S Demissie
    Boston University School of Public Health, Department of Biostatistics, Boston, MA, USA
    Aging Cell 5:325-30. 2006
    ....
  41. ncbi Cytosolic Ca2+ regulation attenuates ANP-induced cGMP response in vascular smooth muscle cells of the SHR
    M Nakamura
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School 07103
    Am J Hypertens 2:111-3. 1989
    ....
  42. ncbi Age-dependent telomere attrition as a potential indicator of racial differences in renal growth patterns
    L Tchakmakjian
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Nephron Exp Nephrol 98:e82-8. 2004
    ..To test this idea, we monitored age-dependent telomere attrition rate, reflecting largely the replicative history of somatic cells, in the outer renal cortex and the inner renal medulla of African Americans and Caucasians...
  43. ncbi Obesity, cigarette smoking, and telomere length in women
    A M Valdes
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London, UK
    Lancet 366:662-4. 2005
    ..017), and each pack-year smoked was equivalent to an additional 5 bp of telomere length lost (18%) compared with the rate in the overall cohort. Our results emphasise the pro-ageing effects of obesity and cigarette smoking...
  44. ncbi Physiological and molecular characterization of the Na+/Ca2+ exchanger in human platelets
    M Kimura
    Hypertension Research Center, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Am J Physiol 277:H911-7. 1999
    ..We propose that the K+ dependence of the platelet Na+/Ca2+ exchanger could make platelets especially sensitive to daily fluctuations in salt intake...
  45. ncbi Lack of difference in oxalate-dependent Ca2+ uptake by membrane homogenate of African-American and white subjects
    X Y Yang
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103-2757, USA
    Am J Hypertens 10:434-9. 1997
    ..The findings do not exclude possible increased activity of this enzyme in intact cells of African-Americans where regulatory mechanisms not present in the membrane preparation may operate...
  46. ncbi Differences of Ca2+ regulation between fibroblasts from blacks and whites
    A Nakamura
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103
    Am J Hypertens 2:105-7. 1989
    ..We conclude that fibroblasts from blacks demonstrate increased responsiveness to agonists in serum. If the same trend exists in vascular smooth muscle cells, it may predispose blacks to essential hypertension...
  47. ncbi Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths
    Masayuki Kimura
    The Center for Human Development and Aging, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
    Nat Protoc 5:1596-607. 2010
    ..A skilled technician can measure TRF length in ∼130 samples per week...
  48. ncbi Telomere dynamics in macaques and humans
    Jeffrey P Gardner
    The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    J Gerontol A Biol Sci Med Sci 62:367-74. 2007
    ..Similar to humans, telomerase activity was detected in spleen, thymus, digestive tract, and gonads. We conclude that factors that modify telomere attrition and aging in humans may also operate in the macaque...
  49. doi Sex differences in pulse pressure trends with age are cross-cultural
    Joan H Skurnick
    Medical Sciences Building F506, 185 South Orange Ave, Department of Preventive Medicine and Community Health, UMDNJ New Jersey Medical School, Newark, NJ 07101 1709, USA
    Hypertension 55:40-7. 2010
    ..Accordingly, the biological principles of arterial aging, as expressed in pulse pressure, are the same in all humans, regardless of demography...
  50. ncbi The links between cellular Ca2+ and Na+/H+ exchange in the pathophysiology of essential hypertension
    A Aviv
    Hypertension Research Program, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103-2714, USA
    Am J Hypertens 9:703-7. 1996
    ..It is suggested that, in essential hypertension, an increased cellular Ca2+ load or an enhanced external Ca2+ entry stimulate the NHE-1 through protein kinase/phosphatase and Ca2+/calmodulin systems, thereby increasing its activity...
  51. ncbi Cytosolic Ca2+, Na+/H+ antiport, protein kinase C trio in essential hypertension
    A Aviv
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103
    Am J Hypertens 7:205-12. 1994
    ....
  52. ncbi The Na+/H+ antiport, cytosolic free Ca2+, and essential hypertension: a hypothesis
    A Aviv
    Hypertension Research Center, University of Medicine and Dentistry, Newark, New Jersey 07103-2757
    Am J Hypertens 1:410-3. 1988
    ..These agents are, therefore, particularly effective in the treatment of essential hypertension in blacks and older individuals with the low-renin form of the disease, who are known to be salt sensitive...
  53. ncbi Potassium chloride supplementation diminishes platelet reactivity in humans
    Masayuki Kimura
    Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, Newark 07103, USA
    Hypertension 44:969-73. 2004
    ..We conclude that potassium supplementation diminishes platelet reactivity, a phenomenon that provides a link between platelet biology and occlusive stroke...
  54. ncbi Loss of chromosome 16 from renal epithelial cells in humans
    Jeffrey P Gardner
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103 2714, USA
    Hypertension 40:928-33. 2002
    ....
  55. ncbi Proliferation dynamics in cultured skin fibroblasts from Down syndrome subjects
    Masayuki Kimura
    Hypertension Research Center, MSB, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark NJ 07103, USA
    Free Radic Biol Med 39:374-80. 2005
    ..e., Gpx and catalase) and confirmed previous observations about inverse relationships between SOD activity and telomere repeat loss per cellular replication...
  56. pmc Telomere length and mortality: a study of leukocytes in elderly Danish twins
    Masayuki Kimura
    Center of Human Development and Aging, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Am J Epidemiol 167:799-806. 2008
    ..Leukocyte telomere dynamics might help explain the boundaries of the human life span...
  57. ncbi Homocysteine thiolactone and protein homocysteinylation in human endothelial cells: implications for atherosclerosis
    H Jakubowski
    Department of Microbiology, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Circ Res 87:45-51. 2000
    ..These data support a hypothesis that metabolic conversion of homocysteine to thiolactone and protein homocysteinylation by thiolactone may play a role in homocysteine-induced vascular damage...
  58. pmc Synchrony of telomere length among hematopoietic cells
    Masayuki Kimura
    The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Exp Hematol 38:854-9. 2010
    ..This information is relevant because telomere dynamics in granulocytes were postulated to mirror those of hematopoietic stem cells (HSCs)...
  59. ncbi Survival advantage of cultured human vascular endothelial cells that lost chromosome 13
    Masayuki Kimura
    Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Chromosoma 112:317-22. 2004
    ..HUVECs losing chromosome 13 demonstrated increased migratory potential and loss of heterozygosity. Collectively, these observations suggest that the loss of chromosome 13 gives cultured HUVECs a replicative advantage...
  60. pmc Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm
    Masayuki Kimura
    The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jeresey, United States of America
    PLoS Genet 4:e37. 2008
    ..Paternal age exerts a considerable effect on the offspring's LTL, a phenomenon which might relate to telomere elongation in sperm from older men. The implications of this effect deserve detailed study...
  61. ncbi Telomere length in the newborn
    Koji Okuda
    The Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    Pediatr Res 52:377-81. 2002
    ....
  62. ncbi Calcium adaptation to sodium pump inhibition in a human megakaryocytic cell line
    Masayuki Kimura
    Hypertension Research Center, MSB, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Ave, Newark, New Jersey 07103, USA
    Am J Physiol Cell Physiol 289:C891-7. 2005
    ..The implications of these findings in platelet biology are discussed...
  63. pmc Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs
    Toby Andrew
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, United Kingdom
    Am J Hum Genet 78:480-6. 2006
    ..9) at 14q23.2, and suggestive linkage at 10q26.13 (LOD 2.4) and 3p26.1 (LOD 2.7). This is the first report of loci, mapped in a sample of healthy individuals, that influence mean telomere variation in humans...
  64. pmc Short telomeres in short-lived males: what are the molecular and evolutionary causes?
    Stephanie Jemielity
    Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland
    Aging Cell 6:225-33. 2007
    ..In addition, we discuss the evolutionary causes of such patterns in ants and in other species...
  65. pmc Reduced telomere length in rheumatoid arthritis is independent of disease activity and duration
    Sophia E Steer
    Department of Rheumatology, Twin Research and Genetic Epidemiology Unit, Kings College London School of Medicine at Guy s, King s and St Thomas, London SE1 7EH, UK
    Ann Rheum Dis 66:476-80. 2007
    ..Telomere loss in white blood cells (WBC) is accelerated by oxidative stress and inflammation in vitro. It was postulated that the accelerated WBC telomere shortening in RA occurs as a result of exposure to chronic inflammation...
  66. ncbi Leukocyte telomere length and cardiovascular disease in the cardiovascular health study
    Annette L Fitzpatrick
    Department of Epidemiology, School of Public Health and Community Medicine, Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA 98115, USA
    Am J Epidemiol 165:14-21. 2007
    ..22, 95% confidence interval: 1.29, 8.02). These results support the hypotheses that telomere attrition may be related to diseases of aging through mechanisms involving oxidative stress, inflammation, and progression to CVD...
  67. pmc Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women
    J Brent Richards
    Twin Research and Genetic Epidemiology, St Thomas Hospital, King s College, London School of Medicine, London, United Kingdom
    Am J Clin Nutr 86:1420-5. 2007
    ..Leukocyte telomere length (LTL) is a predictor of aging-related disease and decreases with each cell cycle and increased inflammation...
  68. doi The association between physical activity in leisure time and leukocyte telomere length
    Lynn F Cherkas
    Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London SE1 7EH, England
    Arch Intern Med 168:154-8. 2008
    ..We therefore tested the hypothesis that physical activity level in leisure time (over the past 12 months) is associated with leukocyte telomere length (LTL) in normal healthy volunteers...
  69. ncbi Telomere length and possible link to X chromosome
    Tim S Nawrot
    Study Coordinating Centre, Laboratory of Hypertension, Department of Molecular and Cardiovascular Research, University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Lancet 363:507-10. 2004
    ..On the basis of findings of studies in twins, telomere length seems to be familial, but little is known about its mode of inheritance. We aimed to investigate the inheritance of telomere length...
  70. doi Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei mice
    Valerie Cattan
    INSERM, U684, 54500 Vandoeuvre les Nancy, France
    Free Radic Biol Med 44:1592-8. 2008
    ..The variable effect of BSO treatment on telomere length in different tissue may result from their different adaptive antioxidative capacity...
  71. pmc Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study
    Steven C Hunt
    Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT, USA NHLBI Family Heart Study
    Aging Cell 7:451-8. 2008
    ..029 kb year(-1) vs. 0.020 kb year(-1), respectively, p = 0.0001). We suggest that racial difference in LTL arises from a host of interacting biological factors, including replication rates of hematopoietic stem cells...
  72. pmc Leukocyte telomere length and carotid artery intimal medial thickness: the Framingham Heart Study
    Christopher J O'Donnell
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue 2, Framingham, MA 01702 5827, USA
    Arterioscler Thromb Vasc Biol 28:1165-71. 2008
    ..The purpose of this study was to examine the link between LTL and the predisposition to atherosclerosis, as determined by carotid artery intimal medial thickness (IMT) in participants of the Framingham Offspring Study...
  73. ncbi Aldosterone and telomere length in white blood cells
    Athanase Benetos
    INSERM Unit 684, University of Nancy, 54511 Nancy les Vandoeuvre, France
    J Gerontol A Biol Sci Med Sci 60:1593-6. 2005
    ..The aim of the present study was, therefore, to examine the relationship between plasma aldosterone and telomere length in WBCs...
  74. ncbi Genomic association/linkage of sodium lithium countertransport in CEPH pedigrees
    Nicholas J Schork
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Hypertension 40:619-28. 2002
    ..These findings support evidence that thiol groups play a central role in SLC activity...
  75. ncbi Renal and gastrointestinal potassium excretion in humans: new insight based on new data and review and analysis of published studies
    Leslie M Klevay
    Department of Agricultrue, Agricultural Research Service, Human Nutrition Research Center, Grand Forks, North Dakota, USA
    J Am Coll Nutr 26:103-10. 2007
    ..Little is known about the relationship between the renal and gastrointestinal excretion of potassium in humans. This information is important in light of strong associations of potassium intake with hypertension and occlusive stroke...
  76. ncbi Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo
    Veronique Bataille
    Twin Research and Genetic Epidemiology Unit, King s College London, St Thomas Hospital Campus, London SE1 7EH, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:1499-502. 2007
    ..Understanding mechanisms influencing the induction and involution of nevi will not only help in understanding the pathophysiology of melanoma but should also shed light on the complex relationship between aging and cancer...
  77. ncbi The reactive oxidative species-renin-angiotensin system link
    Abraham Aviv
    J Hypertens 20:2357-8. 2002
  78. ncbi Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects
    Athanase Benetos
    Centre d Investigations Préventives et Cliniques, 6 14 rue la Pérouse, 75116 Paris, France
    Hypertension 43:182-5. 2004
    ....
  79. pmc Association of leukocyte telomere length with circulating biomarkers of the renin-angiotensin-aldosterone system: the Framingham Heart Study
    Ramachandran S Vasan
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, MA 01702 5827, USA
    Circulation 117:1138-44. 2008
    ..Activation of the renin-angiotensin-aldosterone system is associated with increased oxidative stress and inflammation. Therefore, LTL may be related to circulating biomarkers of the renin-angiotensin-aldosterone system...

Research Grants27

  1. Telomeres and Vascular Aging
    Abraham Aviv; Fiscal Year: 2005
    ..abstract_text> ..
  2. Genetics of the Sodium-Lithium Countertransport
    Abraham Aviv; Fiscal Year: 2006
    ..abstract_text> ..
  3. Telomeres and Vascular Aging
    Abraham Aviv; Fiscal Year: 2006
    ..abstract_text> ..
  4. Human Telomere Genetics
    Abraham Aviv; Fiscal Year: 2006
    ..Results will serve to define genes as determinants of telomere length. Such information would lead to new diagnostic and therapeutic approaches to treat age-related diseases. ..
  5. Genetics of the Sodium-Lithium Countertransport
    Abraham Aviv; Fiscal Year: 2007
    ..abstract_text> ..
  6. Telomeres and Vascular Aging
    Abraham Aviv; Fiscal Year: 2007
    ..abstract_text> ..
  7. Human Telomere Genetics
    Abraham Aviv; Fiscal Year: 2007
    ..Results will serve to define genes as determinants of telomere length. Such information would lead to new diagnostic and therapeutic approaches to treat age-related diseases. ..
  8. Leukocyte TelomerE Dynamics, Gender, Menopause, Insulin Resistance and Survival
    Abraham Aviv; Fiscal Year: 2009
    ..Our findings will provide a new insight into the gender gap in human longevity (women live longer than men) and the role of insulin resistance in the human lifespan. ..
  9. Genetics of the Sodium-Lithium Countertransport
    Abraham Aviv; Fiscal Year: 2005
    ..abstract_text> ..
  10. Genetics of the Sodium-Lithium Countertransport
    Abraham Aviv; Fiscal Year: 2004
    ..abstract_text> ..
  11. Telomeres and Vascular Aging
    Abraham Aviv; Fiscal Year: 2004
    ..abstract_text> ..
  12. PLATELET CALCIUM-SODIUM LINK AND HYPERTENSION IN BLACKS
    Abraham Aviv; Fiscal Year: 1993
    ....
  13. CELLULAR PHENOTYPES OF SALT SENSITIVITY
    Abraham Aviv; Fiscal Year: 1999
    ..The investigators state that the results of the study will generate a novel perspective about phenotypes of salt sensitivity and, an insight into the cardiovascular effects of high salt in humans. ..
  14. CELLULAR PHENOTYPES OF SALT SENSITIVITY
    Abraham Aviv; Fiscal Year: 2000
    ..The investigators state that the results of the study will generate a novel perspective about phenotypes of salt sensitivity and, an insight into the cardiovascular effects of high salt in humans. ..
  15. CELLULAR PHENOTYPES OF SALT SENSITIVITY
    Abraham Aviv; Fiscal Year: 2001
    ..The investigators state that the results of the study will generate a novel perspective about phenotypes of salt sensitivity and, an insight into the cardiovascular effects of high salt in humans. ..
  16. Telomeres and Vascular Aging
    Abraham Aviv; Fiscal Year: 2003
    ..abstract_text> ..
  17. Human Telomere Genetics
    Abraham Aviv; Fiscal Year: 2005
    ..Results will serve to define genes as determinants of telomere length. Such information would lead to new diagnostic and therapeutic approaches to treat age-related diseases. ..
  18. Leukocyte TelomerE Dynamics, Gender, Menopause, Insulin Resistance and Survival
    Abraham Aviv; Fiscal Year: 2010
    ..Our findings will provide a new insight into the gender gap in human longevity (women live longer than men) and the role of insulin resistance in the human lifespan. ..