Adriana Arita

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. pmc A genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiae
    Adriana Arita
    New York University School of Medicine, Nelson Institute of Environmental Medicine, NY 10987, USA
    BMC Genomics 10:524. 2009
  2. pmc Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing
    Haobin Chen
    Nelson Institute of Environmental Medicine, New York University Medical Center, 57 Old Forge Road, Tuxedo, New York 10987, USA
    Mol Cell Biol 26:3728-37. 2006
  3. ncbi request reprint Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression
    Weiming Ouyang
    Nelson Institute of Environmental Medicine, School of Medicine, New York University, Tuxedo, New York 10987, USA
    Mol Cell Biochem 279:35-43. 2005
  4. pmc Mechanisms of c-myc degradation by nickel compounds and hypoxia
    Qin Li
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA
    PLoS ONE 4:e8531. 2009
  5. pmc Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway
    Qingdong Ke
    Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Carcinogenesis 29:1276-81. 2008
  6. ncbi request reprint JNK1, but not JNK2, is required for COX-2 induction by nickel compounds
    Dongyun Zhang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Carcinogenesis 28:883-91. 2007
  7. pmc Gene expression profiles in peripheral blood mononuclear cells of Chinese nickel refinery workers with high exposures to nickel and control subjects
    Adriana Arita
    New York University School of Medicine, NelsonInstitute of Environmental Medicine, New York, NY, USA
    Cancer Epidemiol Biomarkers Prev 22:261-9. 2013
  8. ncbi request reprint Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells
    Jingxia Li
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA
    Mol Carcinog 40:104-15. 2004
  9. pmc Arsenite alters global histone H3 methylation
    Xue Zhou
    Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Carcinogenesis 29:1831-6. 2008
  10. pmc Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium
    Hong Sun
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, New York 10987, USA
    Toxicol Appl Pharmacol 237:258-66. 2009

Collaborators

Detail Information

Publications67

  1. pmc A genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiae
    Adriana Arita
    New York University School of Medicine, Nelson Institute of Environmental Medicine, NY 10987, USA
    BMC Genomics 10:524. 2009
    ..cerevisiae gene deletion strains (the entire set of nonessential genes for this organism) to identify gene products that modulate cellular toxicity to nickel sulfate (NiSO(4))...
  2. pmc Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing
    Haobin Chen
    Nelson Institute of Environmental Medicine, New York University Medical Center, 57 Old Forge Road, Tuxedo, New York 10987, USA
    Mol Cell Biol 26:3728-37. 2006
    ..Collectively, our data strongly indicate that nickel ions induce transgene silencing by increasing histone H3K9 dimethylation, and this effect is mediated by the inhibition of H3K9 demethylation...
  3. ncbi request reprint Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression
    Weiming Ouyang
    Nelson Institute of Environmental Medicine, School of Medicine, New York University, Tuxedo, New York 10987, USA
    Mol Cell Biochem 279:35-43. 2005
    ..Collectively these data demonstrate that PI-3K, ERKs and cytosolic calcium, but not p38 kinase, play essential roles in VEGF induction by nickel compounds...
  4. pmc Mechanisms of c-myc degradation by nickel compounds and hypoxia
    Qin Li
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA
    PLoS ONE 4:e8531. 2009
    ..Our study demonstrated that Nickel and hypoxia exposure increased c-myc T58 phosphorylation and decreased USP28 protein levels in cancer cells, which both lead to enhanced c-myc ubiquitination and proteasomal degradation...
  5. pmc Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway
    Qingdong Ke
    Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Carcinogenesis 29:1276-81. 2008
    ..It is likely that modification of H3S10 is one of a growing number of epigenetic changes believed to be involved in the carcinogenesis caused by Ni...
  6. ncbi request reprint JNK1, but not JNK2, is required for COX-2 induction by nickel compounds
    Dongyun Zhang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Carcinogenesis 28:883-91. 2007
    ..Our results demonstrate that the JNK1/c-Jun/AP-1 pathway, but not the JNK2 pathway, plays a critical role in nickel-induced COX-2 expression...
  7. pmc Gene expression profiles in peripheral blood mononuclear cells of Chinese nickel refinery workers with high exposures to nickel and control subjects
    Adriana Arita
    New York University School of Medicine, NelsonInstitute of Environmental Medicine, New York, NY, USA
    Cancer Epidemiol Biomarkers Prev 22:261-9. 2013
    ....
  8. ncbi request reprint Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells
    Jingxia Li
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA
    Mol Carcinog 40:104-15. 2004
    ..This study may help in better understanding the tumor promotion effects of PAHs...
  9. pmc Arsenite alters global histone H3 methylation
    Xue Zhou
    Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Carcinogenesis 29:1831-6. 2008
    ..Future studies in our laboratory will address the genomic location of these silencing and activating marks using ChIP-on-chip technology...
  10. pmc Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium
    Hong Sun
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, New York 10987, USA
    Toxicol Appl Pharmacol 237:258-66. 2009
    ....
  11. ncbi request reprint Alterations of histone modifications and transgene silencing by nickel chloride
    Qingdong Ke
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Carcinogenesis 27:1481-8. 2006
    ..This study is the first to show that nickel compounds increase histone ubiquitination in cells. These new findings will further our understanding of the epigenetic mechanisms of nickel-mediated carcinogenesis...
  12. pmc A genome-wide screen in Saccharomyces cerevisiae reveals pathways affected by arsenic toxicity
    Xue Zhou
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Genomics 94:294-307. 2009
    ..Our studies have potential implications for understanding toxicity and carcinogenesis in arsenic-induced human conditions, such as cancer and aging...
  13. ncbi request reprint Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells
    Haobin Chen
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Cancer Res 66:9009-16. 2006
    ..Collectively, these results indicate that G9a plays an important role in the hypoxia-induced H3K9me2, which would inhibit the expression of several genes that would likely lead to solid tumor progression...
  14. pmc PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells
    Jingxia Li
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Rd, Tuxedo, NY 10987, USA
    J Cell Biol 165:77-86. 2004
    ..These results demonstrate that 5-MCDE is able to induce AP-1 activation, and the AP-1 induction is specifically through a PI-3K/Akt-dependent and p70(S6K)-independent pathway...
  15. pmc Phosphorylation of H3S10 blocks the access of H3K9 by specific antibodies and histone methyltransferase. Implication in regulating chromatin dynamics and epigenetic inheritance during mitosis
    Qing Duan
    Department of Environmental Medicine and Pharmacology, New York University School of Medicine, Tuxedo, New York 10987, USA
    J Biol Chem 283:33585-90. 2008
    ....
  16. ncbi request reprint Nickel carcinogenesis: epigenetics and hypoxia signaling
    Max Costa
    Department of Environmental Medicine, NYU School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Mutat Res 592:79-88. 2005
    ..This effect may in part be responsible for the gene silencing following nickel exposure and during hypoxia...
  17. ncbi request reprint Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter
    Ping Zhang
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Cancer Res 67:9125-33. 2007
    ..These results showed for the first time that Egr-1 regulates NDRG1 transcription through an overlapping Egr-1/Sp1 binding site that acts as a major site of positive regulation of the NDRG1 promoter by hypoxia signaling...
  18. pmc JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70
    Dongyun Zhang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Cancer Res 70:813-23. 2010
    ..Taken together, our studies define a novel function for JNK1 in regulating HIF-1alpha turnover by a VHL-independent mechanism...
  19. pmc Alterations of histone modifications by cobalt compounds
    Qin Li
    Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Carcinogenesis 30:1243-51. 2009
    ....
  20. ncbi request reprint Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway
    Jin Ding
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    J Biol Chem 281:39022-32. 2006
    ....
  21. pmc Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 down-regulation
    Weiming Ouyang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA
    J Cell Physiol 218:205-14. 2009
    ....
  22. ncbi request reprint Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure
    Yan Yan
    Department of Environmental Medicine and The NYU Cancer Institute, New York University School of Medicine, Tuxedo 10987, USA
    Toxicol Appl Pharmacol 190:272-7. 2003
    ..Both H4 and H3 histone acetylation were lost in the silenced clones and these clones exhibited an increase in the methylation of the lysine 9 in histone H3...
  23. ncbi request reprint Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A
    Qunwei Zhang
    Department of Environmental Medicine, NYU School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 192:201-11. 2003
    ..In contrast, treatment with TSA was not able to revert established cancer cell lines as readily as the nickel-transformed cells. These data indicated that modulation of gene expression is important for nickel-induced transformation...
  24. ncbi request reprint Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling
    Max Costa
    Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Environ Monit 5:222-3. 2003
    ....
  25. pmc Associations between arsenic exposure and global posttranslational histone modifications among adults in Bangladesh
    Yana Chervona
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA
    Cancer Epidemiol Biomarkers Prev 21:2252-60. 2012
    ..Arsenic compounds are weakly mutagenic, alter gene expression and posttranslational histone modifications (PTHMs) in vitro...
  26. pmc Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase
    Xue Zhou
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Cancer Res 70:4214-21. 2010
    ..Thus, these results indicate that hypoxia might target JARID1A activity, which in turn increases H3K4me3 at both the global and gene-specific levels, leading to the altered programs of gene expression and tumor progression...
  27. ncbi request reprint Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice
    Ahmed N Uddin
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 221:329-38. 2007
    ....
  28. ncbi request reprint ERKs activation and calcium signaling are both required for VEGF induction by vanadium in mouse epidermal Cl41 cells
    Jingxia Li
    Nelson Institute of Environmental Medicine, School of Medicine, New York University, Old Forge Road, Tuxedo, New York 10987, USA
    Mol Cell Biochem 279:25-33. 2005
    ..PI-3K is partially involved in VEGF induction by vanadium, while p38K and mTOR are not involved. Those results will help us to understand the molecular mechanisms involved in vanadium-induced biological effects...
  29. pmc Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells
    Hakan Cangul
    Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Environ Health Perspect 110:783-8. 2002
    ..We hypothesize that the mechanism of Cap43 overexpression in cancer cells involves a state of hypoxia characteristic of cancer cells where the Cap43 protein becomes a signature for this hypoxic state...
  30. doi request reprint Roles of MAPK pathway activation during cytokine induction in BEAS-2B cells exposed to fine World Trade Center (WTC) dust
    Shang Wang
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    J Immunotoxicol 7:298-307. 2010
    ....
  31. ncbi request reprint Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway
    Jianhua Zhao
    Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 196:404-9. 2004
    ..Because the hypoxic signaling pathway is believed to be important in the initiation and progression of carcinogenesis, it is important to study genes regulated by this pathway...
  32. ncbi request reprint Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells
    Haobin Chen
    Nelson Institute of Environmental Medicine, New York University, School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 206:275-87. 2005
    ..These effects may be very important in how nickel exerts phenotypic selection pressure to convert a normal initiated cell into a cancer cell...
  33. pmc Comparison of gene expression profiles in chromate transformed BEAS-2B cells
    Hong Sun
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, United States of America
    PLoS ONE 6:e17982. 2011
    ....
  34. pmc Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha
    Dazhong Xu
    Department of Environmental Medicine and Pharmacology, New York University School of Medicine, Tuxedo, New York 10987, USA
    J Biol Chem 285:38944-50. 2010
    ..Combined, our study identifies Plk3 as a new and essential player in the regulation of the hypoxia signaling pathway...
  35. ncbi request reprint Carcinogenic effect of nickel compounds
    Haitian Lu
    Nelson Institute of Environmental Medicine, School of Medicine, New York University, Tuxedo, New York 10987, USA
    Mol Cell Biochem 279:45-67. 2005
    ..The present review summarizes our current knowledge on the molecular mechanisms of nickel carcinogenesis, with special emphasis on the role of nickel induced reactive oxygen species (ROS) and signal transduction pathways...
  36. ncbi request reprint Soluble nickel interferes with cellular iron homeostasis
    Todd Davidson
    Nelson Institute of Environmental Medicine, School of Medicine, New York University, Tuxedo, New York 10987, USA
    Mol Cell Biochem 279:157-62. 2005
    ..In addition, understanding the mechanisms by which nickel activates the HIF-1alpha pathway may lead to new molecular targets in fighting cancer...
  37. ncbi request reprint Down-regulation of the expression of the FIH-1 and ARD-1 genes at the transcriptional level by nickel and cobalt in the human lung adenocarcinoma A549 cell line
    Qingdong Ke
    Nelson Institute of Environmental Medicine, New York University, School of Medicine, 57 Old Forge Road, Tuxedo, New York 10987, USA
    Int J Environ Res Public Health 2:10-3. 2005
    ....
  38. pmc Altered iron homeostasis involvement in arsenite-mediated cell transformation
    Jing Wu
    Department of Environmental Medicine and NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, PHL, Room 802, New York, NY 10016, USA
    Free Radic Biol Med 40:444-52. 2006
    ..In conclusion, our results suggest that altered iron homeostasis contributes to arsenite-induced oxidative stress and, thus, may be involved in arsenite-mediated cell transformation...
  39. ncbi request reprint NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states
    Thomas P Ellen
    Department of Environmental Medicine, Pharmacology and the NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Carcinogenesis 29:2-8. 2008
    ..We survey the data for clues to the NDRG1 gene's mechanism and for indications that the NDRG1 gene may be an efficient diagnostic tool and therapy in many types of cancers...
  40. pmc Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes
    Qin Li
    Nelson Institute of Environmental Medicine, New York University, School of Medicine, 57 Old Forge Road, NY 10987, USA
    Toxicol Appl Pharmacol 213:245-55. 2006
    ..It is important to study effects of these metals in human lung cells since this represents a major route of human environmental and occupational exposure to these metal ions...
  41. ncbi request reprint GeneChip analysis of signaling pathways effected by nickel
    Konstantin Salnikow
    Nelson Institute of Environmental Medicine, NYU NIEHS Center of Excellence, The NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Environ Monit 5:206-9. 2003
    ..The activation of the same signaling pathways by soluble and insoluble nickel compounds suggested that both nickel compounds have similar carcinogenic potential in vitro...
  42. pmc The effect of exposure to carcinogenic metals on histone tail modifications and gene expression in human subjects
    Adriana Arita
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    J Trace Elem Med Biol 26:174-8. 2012
    ....
  43. pmc Heterochromatinization as a potential mechanism of nickel-induced carcinogenesis
    Thomas P Ellen
    Department of Environmental Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Biochemistry 48:4626-32. 2009
    ..We conclude that condensation of chromatin by nickel is a potential mechanism of nickel-mediated gene regulation...
  44. pmc Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity
    Haobin Chen
    Department of Environmental Medicine, New York University School of Medicine, New York, NY 10987, USA
    Biometals 22:191-6. 2009
    ..Future studies on nickel's effects on these iron- and 2-oxoglutarate-dependent dioxygenases would deepen our understanding on nickel toxicity and carcinogenicity...
  45. ncbi request reprint Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells
    Jingxia Li
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Mol Cell Biochem 255:217-25. 2004
    ..These results indicate that there was a differential role of aPKC in vanadate-induced phosphorylation of Akt and p70S6k, suggesting that signal transduction pathways leading to the activation of Akt and p70S6k were different...
  46. ncbi request reprint Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells
    Todd L Davidson
    Nelson Institute of Environmental Medicine, New York University, School of Medicine, Tuxedo, New York 10987, USA
    Mol Carcinog 45:479-89. 2006
    ..Understanding the mechanisms by which nickel can inhibit HIF-PHD's and stabilize HIF-1alpha may be important in the treatment of cancer and ischemic diseases...
  47. ncbi request reprint Nickel-induced down-regulation of serpin by hypoxic signaling
    Jianhua Zhao
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 194:60-8. 2004
    ..Serpina3g gene expression returned to basal levels following Ni removal, suggesting that the observed silencing was a dynamic and reversible process...
  48. ncbi request reprint Fluorescent tracking of nickel ions in human cultured cells
    Qingdong Ke
    Nelson Institute of Environmental Medicine, New York University, School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 219:18-23. 2007
    ..These effects are discussed in terms of whole body exposure to water-soluble and -insoluble Ni compounds and consistency with animal carcinogenicity studies...
  49. pmc Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity
    Qingdong Ke
    Department of Environmental Medicine, New York University School of Medicine, 650 First Avenue, New York, NY 10016, USA
    Toxicol Appl Pharmacol 228:190-9. 2008
    ..The study provides further evidence that supports the notion that nickel ions alter epigenetic homeostasis in cells, which may lead to altered programs of gene expression and carcinogenesis...
  50. ncbi request reprint Molecular mechanisms of arsenic carcinogenesis
    Chuanshu Huang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Mol Cell Biochem 255:57-66. 2004
    ..In this article, we summarize current knowledge on the molecular mechanisms of arsenic carcinogenesis with an emphasis on ROS and signal transduction pathways...
  51. ncbi request reprint Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells
    Jingxia Li
    Nelson Institute of Environmental Medicine, New York University, School of Medicine, Tuxedo, New York 10987, USA
    Cancer Res 64:94-101. 2004
    ..This study should help us understand the signal transduction pathways involved in the carcinogenic effects of nickel compounds...
  52. ncbi request reprint Essential role of ROS-mediated NFAT activation in TNF-alpha induction by crystalline silica exposure
    Qingdong Ke
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, 10987, USA
    Am J Physiol Lung Cell Mol Physiol 291:L257-64. 2006
    ..This study demonstrated that silica was able to activate NFAT in an O(2)(-).-dependent manner, which was required for TNF-alpha induction...
  53. pmc c-Myc mediates a hypoxia-induced decrease in acetylated histone H4
    Qin Li
    New York University School of Medicine, Nelson Institute of Environmental Medicine, Tuxedo, NY 10987, USA
    Biochimie 91:1307-10. 2009
    ..The decrease in c-Myc protein levels induced by hypoxia may contribute to hypoxia-induced gene repression...
  54. pmc Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium
    Yana Chervona
    New York University School of Medicine, Nelson Institute of Environmental Medicine, 57 Old Forge Road, NY 10987, USA
    Metallomics 4:619-27. 2012
    ..Given the effects that these metals can exert on the epigenome, future studies of their involvement in histone modifying enzymes dynamics would deepen our understanding on their respective toxicities and carcinogenicities...
  55. ncbi request reprint Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity
    Minori Koshiji
    Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    World J Gastroenterol 13:2803-10. 2007
    ..To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds...
  56. ncbi request reprint Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites
    Hirohumi Arakawa
    Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Carcinogenesis 27:639-45. 2006
    ..It has been found that Cr(III)-DNA adducts induce mainly G to T mutations. Therefore, these results suggest that Cr(III)-DNA adduct formation contributes to the p53 gene mutations in lung carcinogenesis...
  57. pmc Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions
    Yali Yang
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Cancer Res 68:4077-85. 2008
    ....
  58. ncbi request reprint Chromatin immunoprecipitation assays
    Yan Yan
    Department of Environmental Medical, New York University School of Medicine, Tuxedo, NY, USA
    Methods Mol Biol 287:9-19. 2004
    ..Here, we show the step-by-step methods currently used in our lab to immunoprecipitate the formaldehyde crosslinked chromatin and further analyze the immuprecipitated DNA by semiquantitative PCR...
  59. ncbi request reprint Effect of soluble nickel on cellular energy metabolism in A549 cells
    Haobin Chen
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Exp Biol Med (Maywood) 231:1474-80. 2006
    ....
  60. pmc Nickel compounds induce apoptosis in human bronchial epithelial Beas-2B cells by activation of c-Myc through ERK pathway
    Qin Li
    New York University School of Medicine, Nelson Institute of Environmental Medicine, 57 Old Forge Road, NY 10987, USA
    Toxicol Appl Pharmacol 235:191-8. 2009
    ..Collectively, the results demonstrate that c-Myc induction by nickel ions occurs via an ERK-dependent pathway and plays a crucial role in nickel-induced apoptosis in Beas-2B cells...
  61. pmc Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel
    Adriana Arita
    Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA
    Environ Health Perspect 120:198-203. 2012
    ..Ni compounds exhibit weak mutagenic activity, cause gene amplification, and disrupt cellular epigenetic homeostasis. However, the Ni-induced changes in global histone modification levels have only been tested in vitro...
  62. pmc The role of hypoxia-inducible signaling pathway in nickel carcinogenesis
    Konstantin Salnikow
    Nelson Institute of Environmental Medicine, NIEHS Center and Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 11016, USA
    Environ Health Perspect 110:831-4. 2002
    ....
  63. ncbi request reprint Exposure to chromium (VI) in the drinking water increases susceptibility to UV-induced skin tumors in hairless mice
    Todd Davidson
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10016, USA
    Toxicol Appl Pharmacol 196:431-7. 2004
    ....
  64. ncbi request reprint Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel
    Todd Davidson
    Nelson Institute of Environmental Medicine, New York University School of Medicine, NewYork, USA
    Mol Pharmacol 64:1485-93. 2003
    ..Our data suggest that an Fe(II)-, oxoglutarate-, and oxygen-dependent enzyme may directly or indirectly be involved in the regulation of AhR-dependent transcriptional activity by nickel and other hypoxia-mimicking agents...
  65. pmc Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium
    Adriana Arita
    Nelson Institute of Environmental Medicine, New York University School of Medicine, NY 10987, USA
    Metallomics 1:222-8. 2009
    ....
  66. pmc CrVI exposure and biomarkers: Cr in erythrocytes in relation to exposure and polymorphisms of genes encoding anion transport proteins
    Qingshan Qu
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Biomarkers 13:467-77. 2008
    ..88. The study suggests that Cr in RBC may serve as a sensitive and reliable biomarker for long-term exposure to CrVI...
  67. pmc Effects of nickel, chromate, and arsenite on histone 3 lysine methylation
    Xue Zhou
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, NY 10987, USA
    Toxicol Appl Pharmacol 236:78-84. 2009
    ....