David Araten

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. doi request reprint Selective splenic artery embolization for the treatment of thrombocytopenia and hypersplenism in paroxysmal nocturnal hemoglobinuria
    David J Araten
    Division of Hematology, NYU School of Medicine, and the New York Harbor VA Medical Center, New York, NY, USA
    J Hematol Oncol 7:27. 2014
  2. doi request reprint The rate of spontaneous mutations in human myeloid cells
    David J Araten
    Division of Hematology, Department of Veterans Affairs New York Harbor Healthcare System, United States Division of Hematology, Department of Medicine, NYU School of Medicine and the NYU Langone Cancer Center, United States Electronic address
    Mutat Res 749:49-57. 2013
  3. pmc Leukemic blasts with the paroxysmal nocturnal hemoglobinuria phenotype in children with acute lymphoblastic leukemia
    David J Araten
    Division of Hematology, New York University School of Medicine, New York University Langone Clinical Cancer Center, New York, USA
    Am J Pathol 181:1862-9. 2012
  4. pmc Thrombolytic therapy is effective in paroxysmal nocturnal hemoglobinuria: a series of nine patients and a review of the literature
    David J Araten
    Division of Hematology, NYU School of Medicine, NYU Langone Cancer Center, New York, NY 10016, USA
    Haematologica 97:344-52. 2012
  5. pmc Multiple myeloma involving skin and pulmonary parenchyma after autologous stem cell transplantation
    Yuan Yuan
    Division of Hematology, New York Veteran s Hospital, New York, USA
    J Hematol Oncol 2:48. 2009
  6. pmc Spontaneously arising red cells with a McLeod-like phenotype in normal donors
    David J Araten
    Division of Hematology, Department of Medicine, NYU School of Medicine, New York, NY, United States
    Mutat Res 671:1-5. 2009
  7. pmc A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene
    David J Araten
    Division of Hematology, NYU School of Medicine, NYU Langone Cancer Center, NY, USA
    Mutat Res 686:1-8. 2010
  8. pmc The mutation rate in PIG-A is normal in patients with paroxysmal nocturnal hemoglobinuria (PNH)
    David J Araten
    Division of Hematology, New York University School of Medicine and the New York Veterans Administration Medical Center, 10016, USA
    Blood 108:734-6. 2006
  9. ncbi request reprint A quantitative measurement of the human somatic mutation rate
    David J Araten
    Division of Hematology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Res 65:8111-7. 2005
  10. ncbi request reprint Severe telomere shortening in patients with paroxysmal nocturnal hemoglobinuria affects both GPI- and GPI+ hematopoiesis
    Anastasios Karadimitris
    Memorial Sloan Kettering Cancer Center, Department of Human Genetics, New York, NY, USA
    Blood 102:514-6. 2003

Research Grants

Collaborators

Detail Information

Publications13

  1. doi request reprint Selective splenic artery embolization for the treatment of thrombocytopenia and hypersplenism in paroxysmal nocturnal hemoglobinuria
    David J Araten
    Division of Hematology, NYU School of Medicine, and the New York Harbor VA Medical Center, New York, NY, USA
    J Hematol Oncol 7:27. 2014
    ..We therefore sought to determine whether selective splenic artery embolization (SSAE) is a safe and effective alternative to splenectomy for TST in patients with PNH...
  2. doi request reprint The rate of spontaneous mutations in human myeloid cells
    David J Araten
    Division of Hematology, Department of Veterans Affairs New York Harbor Healthcare System, United States Division of Hematology, Department of Medicine, NYU School of Medicine and the NYU Langone Cancer Center, United States Electronic address
    Mutat Res 749:49-57. 2013
    ..Knockdown of p53 or introduction of mutant NRAS or FLT3 alleles did not have much of an effect on μ. Based on these data, we provide a model to predict whether hypermutability must occur in the process of leukemogenesis...
  3. pmc Leukemic blasts with the paroxysmal nocturnal hemoglobinuria phenotype in children with acute lymphoblastic leukemia
    David J Araten
    Division of Hematology, New York University School of Medicine, New York University Langone Clinical Cancer Center, New York, USA
    Am J Pathol 181:1862-9. 2012
    ..We conclude that in ALL, there are two distinct phenotypes with respect to hypermutability, which we hypothesize will correlate with the number of pathogenic mutations required to produce the leukemia...
  4. pmc Thrombolytic therapy is effective in paroxysmal nocturnal hemoglobinuria: a series of nine patients and a review of the literature
    David J Araten
    Division of Hematology, NYU School of Medicine, NYU Langone Cancer Center, New York, NY 10016, USA
    Haematologica 97:344-52. 2012
    ..Thrombosis is the major risk factor for death in patients with paroxysmal nocturnal hemoglobinuria. Previous case reports indicate that venous thrombosis in patients with paroxysmal nocturnal hemoglobinuria is amenable to thrombolysis...
  5. pmc Multiple myeloma involving skin and pulmonary parenchyma after autologous stem cell transplantation
    Yuan Yuan
    Division of Hematology, New York Veteran s Hospital, New York, USA
    J Hematol Oncol 2:48. 2009
    ..Here we describe what may be the first reported case of a patient with relapse in both of these sites following autologous peripheral blood stem cell transplantation...
  6. pmc Spontaneously arising red cells with a McLeod-like phenotype in normal donors
    David J Araten
    Division of Hematology, Department of Medicine, NYU School of Medicine, New York, NY, United States
    Mutat Res 671:1-5. 2009
    ..004). It may be possible to further investigate the relationship between aging, mutations, and cancer using this approach...
  7. pmc A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene
    David J Araten
    Division of Hematology, NYU School of Medicine, NYU Langone Cancer Center, NY, USA
    Mutat Res 686:1-8. 2010
    ..We conclude that the type of genomic instability detected in this assay is a common but not universal feature of hematologic malignancies...
  8. pmc The mutation rate in PIG-A is normal in patients with paroxysmal nocturnal hemoglobinuria (PNH)
    David J Araten
    Division of Hematology, New York University School of Medicine and the New York Veterans Administration Medical Center, 10016, USA
    Blood 108:734-6. 2006
    ..24 x 10(-7) to 11.2 x 10(-7), against a normal range of 2.4 x 10(-7) to 29.6 x 10(-7) mutations per cell division. We conclude that genetic instability of the PIG-A gene is not a factor in the pathogenesis of PNH...
  9. ncbi request reprint A quantitative measurement of the human somatic mutation rate
    David J Araten
    Division of Hematology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Res 65:8111-7. 2005
    ..This system should be useful in evaluating cancer risk and in the design of preventive strategies...
  10. ncbi request reprint Severe telomere shortening in patients with paroxysmal nocturnal hemoglobinuria affects both GPI- and GPI+ hematopoiesis
    Anastasios Karadimitris
    Memorial Sloan Kettering Cancer Center, Department of Human Genetics, New York, NY, USA
    Blood 102:514-6. 2003
    ..The short telomeres of the GPI+ cells indicate that the residual hematopoiesis contributed by these cells is not normal. This epigenetic change is an additional feature shared by PNH and aplastic anemia...
  11. doi request reprint Paroxysmal nocturnal hemoglobinuria in pediatric patients
    Kevin J Curran
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center Bone Marrow Transplant Service, New York, New York, USA
    Pediatr Blood Cancer 59:525-9. 2012
    ..To further characterize the clinical presentation and outcome to treatment we performed a retrospective analysis of pediatric patients with PNH...
  12. doi request reprint Splenic infarction and subsequent splenic rupture in a patient with paroxysmal nocturnal hemoglobinuria and heparin-induced thrombocytopenia
    Heather Magnan
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Pediatr Blood Cancer 53:472-4. 2009
    ..The patient's anticoagulation was complicated by heparin-induced thrombocytopenia (HIT) highlighting the unique management challenge presented by PNH in combination with HIT...
  13. ncbi request reprint High incidence of thrombosis in African-American and Latin-American patients with Paroxysmal Nocturnal Haemoglobinuria
    David J Araten
    Division of Hematology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Thromb Haemost 93:88-91. 2005
    ..These findings demonstrate that ethnicity is a risk factor for thrombosis in PNH and have implications for decision-making regarding the management of these patients, including the prevention of thrombosis...

Research Grants4

  1. Measurement & modulation of the mutation rate in humans
    David Araten; Fiscal Year: 2007
    ..These studies will begin to elucidate the relationship between f and cancer risk and provide a highly relevant in vitro parameter with which to evaluate chemoprevention. ..