C Aoki

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint The subcellular distribution of nitric oxide synthase relative to the NR1 subunit of NMDA receptors in the cerebral cortex
    C Aoki
    Center for Neural Science, New York University, USA
    Prog Brain Res 118:83-97. 1998
  2. ncbi request reprint Postnatal changes in the laminar and subcellular distribution of NMDA-R1 subunits in the cat visual cortex as revealed by immuno-electron microscopy
    C Aoki
    Center for Neural Science and Biology Department, New York University, NY 10003, USA
    Brain Res Dev Brain Res 98:41-59. 1997
  3. pmc In vivo, competitive blockade of N-methyl-D-aspartate receptors induces rapid changes in filamentous actin and drebrin A distributions within dendritic spines of adult rat cortex
    S Fujisawa
    Center for Neural Science, New York University, 4 Washington Place 809, New York, NY 10003, USA
    Neuroscience 140:1177-87. 2006
  4. ncbi request reprint Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses
    Chiye Aoki
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Comp Neurol 483:383-402. 2005
  5. pmc Chemical and morphological alterations of spines within the hippocampus and entorhinal cortex precede the onset of Alzheimer's disease pathology in double knock-in mice
    Chiye Aoki
    Center for Neural Science, New York University, New York, NY 10003, USA
    J Comp Neurol 505:352-62. 2007
  6. ncbi request reprint NMDA receptor blockade in intact adult cortex increases trafficking of NR2A subunits into spines, postsynaptic densities, and axon terminals
    Chiye Aoki
    Center for Neural Science, New York University, Rm 809, 4 Washington Pl, New York, NY 10003, USA
    Brain Res 963:139-49. 2003
  7. ncbi request reprint Electron microscopic immunocytochemical detection of PSD-95, PSD-93, SAP-102, and SAP-97 at postsynaptic, presynaptic, and nonsynaptic sites of adult and neonatal rat visual cortex
    C Aoki
    Center for Neural Science, New York University, New York, New York 10003, USA
    Synapse 40:239-57. 2001
  8. ncbi request reprint NMDA-R1 subunit of the cerebral cortex co-localizes with neuronal nitric oxide synthase at pre- and postsynaptic sites and in spines
    C Aoki
    Center for Neural Science, New York University, NY 10003, USA
    Brain Res 750:25-40. 1997
  9. ncbi request reprint Cellular and subcellular sites for noradrenergic action in the monkey dorsolateral prefrontal cortex as revealed by the immunocytochemical localization of noradrenergic receptors and axons
    C Aoki
    Center for Neural Science, New York University, NY 10003, USA
    Cereb Cortex 8:269-77. 1998
  10. ncbi request reprint Stability of the distribution of spines containing drebrin A in the sensory cortex layer I of mice expressing mutated APP and PS1 genes
    Veeravan Mahadomrongkul
    Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
    Brain Res 1064:66-74. 2005

Research Grants

Collaborators

Detail Information

Publications31

  1. ncbi request reprint The subcellular distribution of nitric oxide synthase relative to the NR1 subunit of NMDA receptors in the cerebral cortex
    C Aoki
    Center for Neural Science, New York University, USA
    Prog Brain Res 118:83-97. 1998
    ..Together, these findings point to plasticity of nNOS neurons within adult brain tissue, involving regulation of subcellular nNOS distribution...
  2. ncbi request reprint Postnatal changes in the laminar and subcellular distribution of NMDA-R1 subunits in the cat visual cortex as revealed by immuno-electron microscopy
    C Aoki
    Center for Neural Science and Biology Department, New York University, NY 10003, USA
    Brain Res Dev Brain Res 98:41-59. 1997
    ....
  3. pmc In vivo, competitive blockade of N-methyl-D-aspartate receptors induces rapid changes in filamentous actin and drebrin A distributions within dendritic spines of adult rat cortex
    S Fujisawa
    Center for Neural Science, New York University, 4 Washington Place 809, New York, NY 10003, USA
    Neuroscience 140:1177-87. 2006
    ..Alternatively or in addition, the cytoskeletal redistribution within spine cytoplasm may be triggered by the D-APV-induced, homeostatic up-regulation of NMDAR...
  4. ncbi request reprint Drebrin A is a postsynaptic protein that localizes in vivo to the submembranous surface of dendritic sites forming excitatory synapses
    Chiye Aoki
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Comp Neurol 483:383-402. 2005
    ..Thus, drebrin A may be involved in organizing the dendritic pool of actin for the formation of spines and of axospinous excitatory synapses during early postnatal periods...
  5. pmc Chemical and morphological alterations of spines within the hippocampus and entorhinal cortex precede the onset of Alzheimer's disease pathology in double knock-in mice
    Chiye Aoki
    Center for Neural Science, New York University, New York, NY 10003, USA
    J Comp Neurol 505:352-62. 2007
    ....
  6. ncbi request reprint NMDA receptor blockade in intact adult cortex increases trafficking of NR2A subunits into spines, postsynaptic densities, and axon terminals
    Chiye Aoki
    Center for Neural Science, New York University, Rm 809, 4 Washington Pl, New York, NY 10003, USA
    Brain Res 963:139-49. 2003
    ....
  7. ncbi request reprint Electron microscopic immunocytochemical detection of PSD-95, PSD-93, SAP-102, and SAP-97 at postsynaptic, presynaptic, and nonsynaptic sites of adult and neonatal rat visual cortex
    C Aoki
    Center for Neural Science, New York University, New York, New York 10003, USA
    Synapse 40:239-57. 2001
    ..These results suggest that MAGUKs have dual roles: to maintain receptors at synapses and to regulate shuttling of receptors between nonsynaptic and synaptic sites...
  8. ncbi request reprint NMDA-R1 subunit of the cerebral cortex co-localizes with neuronal nitric oxide synthase at pre- and postsynaptic sites and in spines
    C Aoki
    Center for Neural Science, New York University, NY 10003, USA
    Brain Res 750:25-40. 1997
    ..Together, our observations point to a greater complexity than previously recognized for glutamatergic neurotransmission, based on the joint versus independent actions of NO relative to NMDA receptors at pre- versus postsynaptic sites...
  9. ncbi request reprint Cellular and subcellular sites for noradrenergic action in the monkey dorsolateral prefrontal cortex as revealed by the immunocytochemical localization of noradrenergic receptors and axons
    C Aoki
    Center for Neural Science, New York University, NY 10003, USA
    Cereb Cortex 8:269-77. 1998
    ..These results indicate that noradrenergic modulation of prefrontal cortex involves synaptic interactions at spines of pyramidal neurons and nonsynaptic volume transmission to glia, dendritic shafts and axons...
  10. ncbi request reprint Stability of the distribution of spines containing drebrin A in the sensory cortex layer I of mice expressing mutated APP and PS1 genes
    Veeravan Mahadomrongkul
    Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
    Brain Res 1064:66-74. 2005
    ..This pattern may reflect an altered trafficking of synaptic molecules within spines, a factor adding to the decline of synaptic function and plasticity...
  11. ncbi request reprint A method of combining biocytin tract-tracing with avidin-biotin-peroxidase complex immunocytochemistry for pre-embedding electron microscopic labeling in neonatal tissue
    A Erisir
    Center for Neural Science, New York University, New York 10003, USA
    J Neurosci Methods 81:189-97. 1998
    ..The presence of biocytin was evident by silver particles, while accumulation of peroxidase reaction product marked only the antibody labeling: no cross-reaction between biocytin and the avidin-biotin-peroxidase was observed...
  12. ncbi request reprint Preservation of ultrastructure and antigenicity for EM immunocytochemistry following intracellular recording and labeling of single cortical neurons in brain slices
    M Lubin
    Center for Neural Science, New York University, New York 10003 6677, USA
    J Neurosci Methods 81:91-102. 1998
    ..This combination of methods should be widely applicable for analyzing the subcellular distribution of neuronal molecules such as receptors, channels and enzymes on physiologically characterized mammalian neurons...
  13. pmc Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex
    Robert B Levy
    New York University Center for Neural Science, New York, New York 10003, USA
    J Neurosci 22:5001-15. 2002
    ..These observations support the idea that acetylcholine receptors can aid in activating glutamatergic synapses and work together with AMPA receptors to mediate postsynaptic excitation throughout life...
  14. pmc AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice
    Eric H Chang
    Center for Neural Science, New York University, NY 10003, USA
    Proc Natl Acad Sci U S A 103:3410-5. 2006
    ..These results suggest that AMPARs are important synaptic targets for AD and provide evidence that cognitive impairment may involve downscaling of postsynaptic AMPAR function...
  15. pmc In vivo blockade of N-methyl-D-aspartate receptors induces rapid trafficking of NR2B subunits away from synapses and out of spines and terminals in adult cortex
    S Fujisawa
    Center for Neural Science, New York University, 4 Washington Place, Room 809, New York, NY 10003, USA
    Neuroscience 121:51-63. 2003
    ..These findings point to yet unknown, NMDA receptor activity-dependent mechanisms that separately regulate the localization of NR2A and NR2B subunits at synapses...
  16. pmc Hearing loss alters the subcellular distribution of presynaptic GAD and postsynaptic GABAA receptors in the auditory cortex
    Emma C Sarro
    Center for Neural Science, New York University, New York, NY 10003, USA
    Cereb Cortex 18:2855-67. 2008
    ..Thus, both, the pre- and postsynaptic sides of inhibitory synapses that form upon pyramidal neurons of the ACx are regulated by neonatal auditory experience...
  17. pmc Drebrin a knockout eliminates the rapid form of homeostatic synaptic plasticity at excitatory synapses of intact adult cerebral cortex
    Chiye Aoki
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Comp Neurol 517:105-21. 2009
    ..These findings indicate that drebrin A is required for the rapid (<30 minutes) form of HSP at excitatory synapses of adult cortices, whereas drebrin E is sufficient for maintaining basal NR2A levels within spines...
  18. pmc Increased levels of NMDA receptor NR2A subunits at pre- and postsynaptic sites of the hippocampal CA1: an early response to conditional double knockout of presenilin 1 and 2
    Chiye Aoki
    Center for Neural Science, New York University, New York, NY 10003, USA
    J Comp Neurol 517:512-23. 2009
    ..These observations point to an early-onset trapping of NMDAR at synapses that are subtle but may underlie the reduced synaptic plasticity at 2 months of age and excitotoxicity at later stages...
  19. pmc Muscarinic acetylcholine receptors in macaque V1 are most frequently expressed by parvalbumin-immunoreactive neurons
    Anita A Disney
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Comp Neurol 507:1748-62. 2008
    ....
  20. pmc Gain modulation by nicotine in macaque v1
    Anita A Disney
    Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
    Neuron 56:701-13. 2007
    ..We demonstrate that at the site of thalamic input to visual cortex, the effect of this nAChR-mediated gain is an enhancement of the detection of visual stimuli...
  21. pmc Cholinergic modulation of local pyramid-interneuron synapses exhibiting divergent short-term dynamics in rat sensory cortex
    Robert B Levy
    New York University Center for Neural Science, New York, NY 10003, USA
    Brain Res 1215:97-104. 2008
    ..It is suggested that selective influence on STP contributes fundamentally to cholinergic "switching" between cortical rhythms that underlie different behavioral states...
  22. pmc Hearing loss raises excitability in the auditory cortex
    Vibhakar C Kotak
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 25:3908-18. 2005
    ..These alterations in cellular properties after deafness reflect an attempt by A1 to sustain an operative level of cortical excitability that may involve homeostatic mechanisms...
  23. pmc Nicotinic and muscarinic reduction of unitary excitatory postsynaptic potentials in sensory cortex; dual intracellular recording in vitro
    Robert B Levy
    New York University Center for Neural Science, New York, NY 10003, USA
    J Neurophysiol 95:2155-66. 2006
    ..As a result of NMDA receptor dependence, nicotinic EPSP reduction may serve to reduce the local spread of cortical excitation during heightened sensory activity...
  24. ncbi request reprint Differential expression of muscarinic acetylcholine receptors across excitatory and inhibitory cells in visual cortical areas V1 and V2 of the macaque monkey
    Anita A Disney
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Comp Neurol 499:49-63. 2006
    ....
  25. pmc α4βδ-GABAARs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia
    C Aoki
    Center for Neural Science, New York University, New York, NY 10003, United States Electronic address
    Neuroscience 265:108-23. 2014
    ..The data also indicate that, although exercise has many health benefits, it can be maladaptive to individuals with low levels of α4βδ-GABAARs in the CA1, particularly when combined with FR. ..
  26. pmc Silencing of neuroligin function by postsynaptic neurexins
    Hiroki Taniguchi
    Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, Physicians and Surgeons 11 511, New York, New York 10032, USA
    J Neurosci 27:2815-24. 2007
    ....
  27. pmc Adolescent female C57BL/6 mice with vulnerability to activity-based anorexia exhibit weak inhibitory input onto hippocampal CA1 pyramidal cells
    T G Chowdhury
    Center for Neural Science, New York University, USA
    Neuroscience 241:250-67. 2013
    ....
  28. pmc Reversal of neurosteroid effects at alpha4beta2delta GABAA receptors triggers anxiety at puberty
    Hui Shen
    Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA
    Nat Neurosci 10:469-77. 2007
    ..Therefore, inhibition of alpha4beta2delta GABAA receptors by THP provides a mechanism for the generation of anxiety at puberty...
  29. pmc The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons
    Weizhi Chen
    Department of Neurology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 24:1136-48. 2004
    ..Thus, the originally cloned form of GLT1, GLT1a, is expressed as protein in neurons in the mature hippocampus and may contribute significantly to glutamate uptake into excitatory terminals...
  30. pmc Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain
    Weizhi Chen
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 22:2142-52. 2002
    ....
  31. pmc Drebrin a content correlates with spine head size in the adult mouse cerebral cortex
    Chiho Kobayashi
    Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    J Comp Neurol 503:618-26. 2007
    ..These differences between the DIP and the DIN spines indicate that spine sizes and synaptic protein composition of mature brains are regulated, at least in part, by drebrin A levels...

Research Grants9

  1. SYNAPTOGENESIS IN THE CEREBRAL CORTEX
    Chiye Aoki; Fiscal Year: 2003
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  2. SYNAPTOGENESIS IN THE CEREBRAL CORTEX
    Chiye Aoki; Fiscal Year: 2000
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  3. Chemically specified synaptogenesis in the visual cortex
    Chiye Aoki; Fiscal Year: 2001
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  4. SYNAPTOGENESIS IN THE CEREBRAL CORTEX
    Chiye Aoki; Fiscal Year: 2001
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  5. SYNAPTOGENESIS IN THE CEREBRAL CORTEX
    Chiye Aoki; Fiscal Year: 2001
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  6. Chemically specified synaptogenesis in the visual cortex
    Chiye Aoki; Fiscal Year: 2002
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  7. SYNAPTOGENESIS IN THE CEREBRAL CORTEX
    Chiye Aoki; Fiscal Year: 2002
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  8. Chemically specified synaptogenesis in the visual cortex
    Chiye Aoki; Fiscal Year: 2003
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  9. Chemically specified synaptogenesis in the visual cortex
    Chiye Aoki; Fiscal Year: 2004
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..