Antonia S New

Summary

Country: USA

Publications

  1. ncbi request reprint Amygdala-prefrontal disconnection in borderline personality disorder
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 32:1629-40. 2007
  2. ncbi request reprint Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression
    Antonia S New
    Psychiatry Service, Bronx Veterans Affairs Medical Center, NY 10468, USA
    Arch Gen Psychiatry 59:621-9. 2002
  3. ncbi request reprint Low prolactin response to fenfluramine in impulsive aggression
    Antonia S New
    Psychiatry Service 116 A, Bronx VA Medical Center, Bronx, NY 10468, USA
    J Psychiatr Res 38:223-30. 2004
  4. ncbi request reprint Fluoxetine increases relative metabolic rate in prefrontal cortex in impulsive aggression
    Antonia S New
    Psychiatry Service Mount Sinai School of Medicine and the Bronx VA Medical Center, 130 West Kingsbridge Road, PO Box 1168, Bronx, NY 10468, USA
    Psychopharmacology (Berl) 176:451-8. 2004
  5. pmc Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences
    M Mercedes Perez-Rodriguez
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10468, USA
    J Psychiatr Res 46:797-804. 2012
  6. pmc Laboratory induced aggression: a positron emission tomography study of aggressive individuals with borderline personality disorder
    Antonia S New
    James J Peters Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Biol Psychiatry 66:1107-14. 2009
  7. pmc Cingulate and temporal lobe fractional anisotropy in schizotypal personality disorder
    Erin A Hazlett
    Mental Illness Research, Education and Clinical Center VISN 3, James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Neuroimage 55:900-8. 2011
  8. doi request reprint Anterior cingulate volume reduction in adolescents with borderline personality disorder and co-morbid major depression
    Marianne Goodman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10468, USA
    J Psychiatr Res 45:803-7. 2011
  9. pmc Increased serotonin 2A receptor availability in the orbitofrontal cortex of physically aggressive personality disordered patients
    Daniel R Rosell
    James J Peters Veterans Affairs Medical Center, Bronx, New York, NY, USA
    Biol Psychiatry 67:1154-62. 2010
  10. ncbi request reprint The relationship of borderline personality disorder to posttraumatic stress disorder and traumatic events
    Julia A Golier
    Department of Psychiatry, Veterans Affairs Medical Center 116 A, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Am J Psychiatry 160:2018-24. 2003

Detail Information

Publications33

  1. ncbi request reprint Amygdala-prefrontal disconnection in borderline personality disorder
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 32:1629-40. 2007
    ..We demonstrated no significant differences in amygdala volumes or metabolism between BPD patients and controls...
  2. ncbi request reprint Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression
    Antonia S New
    Psychiatry Service, Bronx Veterans Affairs Medical Center, NY 10468, USA
    Arch Gen Psychiatry 59:621-9. 2002
    ..Preclinical and human studies suggest that the orbital frontal cortex and anterior cingulate cortex play an inhibitory role in the regulation of aggression...
  3. ncbi request reprint Low prolactin response to fenfluramine in impulsive aggression
    Antonia S New
    Psychiatry Service 116 A, Bronx VA Medical Center, Bronx, NY 10468, USA
    J Psychiatr Res 38:223-30. 2004
    ..This study represents a replication of previous studies, in a much larger sample, showing a blunted PRL response to fenfluramine of male patients with personality disorder in relation to impulsive aggression and to suicide attempts...
  4. ncbi request reprint Fluoxetine increases relative metabolic rate in prefrontal cortex in impulsive aggression
    Antonia S New
    Psychiatry Service Mount Sinai School of Medicine and the Bronx VA Medical Center, 130 West Kingsbridge Road, PO Box 1168, Bronx, NY 10468, USA
    Psychopharmacology (Berl) 176:451-8. 2004
    ..In addition, patients with impulsive aggression have an attenuation of symptoms with selective serotonin reuptake inhibitor (SSRI) treatment...
  5. pmc Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences
    M Mercedes Perez-Rodriguez
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10468, USA
    J Psychiatr Res 46:797-804. 2012
    ..These sex differences suggest differential involvement of frontal-striatal circuits in BPD-IED, and are discussed in relation to striatal involvement in affective learning and social decision-making...
  6. pmc Laboratory induced aggression: a positron emission tomography study of aggressive individuals with borderline personality disorder
    Antonia S New
    James J Peters Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Biol Psychiatry 66:1107-14. 2009
    ..Preclinical studies show that orbital frontal cortex (OFC) plays a role in regulating impulsive aggression. Prior work has found OFC dysfunction in BPD...
  7. pmc Cingulate and temporal lobe fractional anisotropy in schizotypal personality disorder
    Erin A Hazlett
    Mental Illness Research, Education and Clinical Center VISN 3, James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Neuroimage 55:900-8. 2011
    ..Lower fractional anisotropy (FA), a measure of white-matter integrity within prefrontal, temporal, and cingulate regions has been reported in schizophrenia but has been little studied in SPD...
  8. doi request reprint Anterior cingulate volume reduction in adolescents with borderline personality disorder and co-morbid major depression
    Marianne Goodman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10468, USA
    J Psychiatr Res 45:803-7. 2011
    ..Future studies examining samples of MDD patients with and without BPD co-morbidity will be needed to clarify whether BA24 volume reductions are specific to BPD...
  9. pmc Increased serotonin 2A receptor availability in the orbitofrontal cortex of physically aggressive personality disordered patients
    Daniel R Rosell
    James J Peters Veterans Affairs Medical Center, Bronx, New York, NY, USA
    Biol Psychiatry 67:1154-62. 2010
    ..We have previously hypothesized that increased 5-HT(2A)R function in the OFC is a state phenomenon that promotes impulsive aggression...
  10. ncbi request reprint The relationship of borderline personality disorder to posttraumatic stress disorder and traumatic events
    Julia A Golier
    Department of Psychiatry, Veterans Affairs Medical Center 116 A, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Am J Psychiatry 160:2018-24. 2003
    ..The authors examined the relationship of borderline personality disorder to posttraumatic stress disorder (PTSD) with respect to the role of trauma and its timing...
  11. doi request reprint A functional magnetic resonance imaging study of deliberate emotion regulation in resilience and posttraumatic stress disorder
    Antonia S New
    Mental Health Care Center, James J Peters Veterans Affairs Medical Center, Bronx, New York, New York 10468, USA
    Biol Psychiatry 66:656-64. 2009
    ..g., trauma-exposed non-PTSD). In this project, we examined the neural mechanisms underlying differences in response to sexual violence, focusing specifically on the deliberate modification of emotional responses to negative stimuli...
  12. ncbi request reprint Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups
    Michael J Minzenberg
    Bronx Veterans Affairs Medical Center, Bronx, New York, 14068, USA
    Psychiatr Genet 16:117-24. 2006
    ..We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder...
  13. ncbi request reprint Risperidone in the treatment of schizotypal personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10468, USA
    J Clin Psychiatry 64:628-34. 2003
    ..In addition, if SPD patients respond to an antipsychotic medication, this will provide support for the notion of a commonality in treatment response between SPD and schizophrenia...
  14. pmc Frontolimbic structural changes in borderline personality disorder
    Michael J Minzenberg
    Mount Sinai School of Medicine and Bronx VA Medical Center, Bronx, NY, USA
    J Psychiatr Res 42:727-33. 2008
    ..We tested the hypothesis that BPD patients exhibit gross structural changes that parallel the respective increases in amygdala activation and impairment of rostral/subgenual ACC activation...
  15. ncbi request reprint Abuse and neglect in childhood: relationship to personality disorder diagnoses
    Linda M Bierer
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:737-54. 2003
    ..Most of these findings have been generated from inpatient clinical samples...
  16. ncbi request reprint 24-h Monitoring of plasma norepinephrine, MHPG, cortisol, growth hormone and prolactin in depression
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Psychiatr Res 38:503-11. 2004
    ..The present study takes advantage of frequent plasma sampling over the 24-h period and a multioscillator cosinor model to fit the 24-h rhythms...
  17. doi request reprint Phenotype, endophenotype, and genotype comparisons between borderline personality disorder and major depressive disorder
    Marianne Goodman
    James J Peters VA Medical Center, Bronx, NY 10468, USA
    J Pers Disord 24:38-59. 2010
    ..Definitive clarification of what MDD and BPD have in common and in what ways they are distinct will only be derived from studies that examine both illnesses using the same study design and methodology...
  18. doi request reprint Recent advances in the biological study of personality disorders
    Antonia S New
    The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1217, New York, NY 10029, USA
    Psychiatr Clin North Am 31:441-61, vii. 2008
    ..Clearly SPD falls within the schizophrenia spectrum, but precisely the nature of what predicts full-blown schizophrenia as opposed to the milder symptoms of SPD is not yet clear...
  19. ncbi request reprint Dispositional impulsivity in normal and abnormal samples
    Janine D Flory
    Department of Psychiatry, Box 1230, One Gustave Levy Place, Mount Sinai School of Medicine, New York, NY 10029, United States
    J Psychiatr Res 40:438-47. 2006
    ..Results from these analyses also lend support to a large body of work that demonstrates that normal and abnormal personality features are related...
  20. ncbi request reprint Biochemical endophenotypes in personality disorders
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Med 77:199-213. 2003
  21. ncbi request reprint Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    Am J Psychiatry 162:915-23. 2005
    ..This study evaluated regional serotonin transporter distribution in the brain of individuals with impulsive aggression by using positron emission tomography (PET) with the serotonin transporter PET radiotracer [(11)C]McN 5652...
  22. ncbi request reprint Blunted hormone responses to Ipsapirone are associated with trait impulsivity in personality disorder patients
    Michael J Minzenberg
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Neuropsychopharmacology 31:197-203. 2006
    ..In addition, D(2) receptor dysfunction may play a role in impulsivity, whereas 5-HT(1A) cell-body autoreceptor function may be spared in these disorders...
  23. ncbi request reprint Characterizing affective instability in borderline personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 159:784-8. 2002
    ..The authors also examined the subjective intensity with which moods are experienced and the association between instability and intensity of affect...
  24. ncbi request reprint Exaggerated affect-modulated startle during unpleasant stimuli in borderline personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 62:250-5. 2007
    ..The affect-modulated startle response is a reliable indicator of emotional processing of stimuli. The aim of this study was to examine emotional processing in BPD patients (n = 27) and healthy control subjects (n = 21)...
  25. ncbi request reprint Neurobiologic function and temperament in subjects with personality disorders
    Vivian Mitropoulou
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:725-30. 2003
    ....
  26. ncbi request reprint The role of childhood trauma in differences in affective instability in those with personality disorders
    Marianne Goodman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:763-70. 2003
    ..This study examined the relationship of self-reported histories of childhood trauma to measures of affective instability in a sample of unmedicated outpatients with various personality disorders (n=174)...
  27. ncbi request reprint Effects of acute metabolic stress on the dopaminergic and pituitary-adrenal axis activity in patients with schizotypal personality disorder
    Vivian Mitropoulou
    Department of Psychiatry, Mt Sinai School of Medicine Clinical Reseach Center, New York, NY 10029, USA
    Schizophr Res 70:27-31. 2004
    ..We hypothesized that SPD patients would demonstrate comparable or lower DA and HPA responses after 2-DG to HV...
  28. ncbi request reprint Deficient attentional modulation of startle eyeblink is associated with symptom severity in the schizophrenia spectrum
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, United States
    Schizophr Res 93:288-95. 2007
    ..Among the schizophrenia-spectrum sample, more deficient PPI during the attended prepulses was associated with greater symptom severity as measured by the total 18-item Brief Psychiatric Rating Scale score...
  29. ncbi request reprint Reduced anterior and posterior cingulate gray matter in borderline personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, New York, NY 10029, USA
    Biol Psychiatry 58:614-23. 2005
    ..We extended this investigation by examining gray and white matter volume of frontal and cingulate gyrus Brodmann areas (BAs) in a large group of patients and healthy controls...
  30. pmc Fronto-limbic dysfunction in response to facial emotion in borderline personality disorder: an event-related fMRI study
    Michael J Minzenberg
    Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Psychiatry Res 155:231-43. 2007
    ..The neural substrates underlying processing of anger may also be altered. These changes may represent an expression of the volumetric and serotonergic deficits observed in these brain areas in BPD...
  31. pmc Cortical gray and white matter volume in unmedicated schizotypal and schizophrenia patients
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Schizophr Res 101:111-23. 2008
    ..Overall, our findings suggest that increased prefrontal volume in BA10 and sparing of volume loss in temporal cortex (BAs 22 and 20) may be a protective factor in SPD which reduces vulnerability to psychosis...
  32. ncbi request reprint Irritable assault and variation in the COMT gene
    Janine D Flory
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Psychiatr Genet 17:344-6. 2007
    ..These findings provide limited support for a role of COMT in modulating aggressive behavior, and are extended to people with personality disorders...
  33. ncbi request reprint Neuropsychological performance in schizotypal personality disorder: importance of working memory
    Vivian Mitropoulou
    Clinical Research Center, Box 1027, Mt Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Am J Psychiatry 162:1896-903. 2005
    ....