Ariel Ruiz i Altaba

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Brain as a paradigm of organ growth: Hedgehog-Gli signaling in neural stem cells and brain tumors
    Barbara Stecca
    Department of Genetic Medicine and Development, University of Geneva Medical School, 8242 CMU, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    J Neurobiol 64:476-90. 2005
  2. pmc HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
    Virginie Clement
    Department of Genetic Medicine and Development, University of Geneva Medical School, 8242 CMU, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Curr Biol 17:165-72. 2007
  3. ncbi request reprint Sonic hedgehog regulates the growth and patterning of the cerebellum
    N Dahmane
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Development 126:3089-100. 1999
  4. ncbi request reprint Hedgehog--Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer
    Ariel Ruiz i Altaba
    The Skirball Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cancer Lett 204:145-57. 2004
  5. ncbi request reprint In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice
    Pilar Sanchez
    The Skirball Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10012, USA
    Mech Dev 122:223-30. 2005
  6. pmc The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway
    Barbara Stecca
    Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    J Biol 1:9. 2002
  7. ncbi request reprint Embryonic regionalization of the neocortex
    A Ruiz i Altaba
    Developmental Genetics Program, Skirball Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Mech Dev 107:3-11. 2001
  8. ncbi request reprint Gli and hedgehog in cancer: tumours, embryos and stem cells
    Ariel Ruiz i Altaba
    The Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Nat Rev Cancer 2:361-72. 2002
  9. ncbi request reprint Gli proteins and Hedgehog signaling: development and cancer
    A Ruiz i Altaba
    The Skirball Institute of Biomolecular Medicine, Developmental Genetics Program and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Trends Genet 15:418-25. 1999
  10. ncbi request reprint Gli proteins encode context-dependent positive and negative functions: implications for development and disease
    A Ruiz i Altaba
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Development 126:3205-16. 1999

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Brain as a paradigm of organ growth: Hedgehog-Gli signaling in neural stem cells and brain tumors
    Barbara Stecca
    Department of Genetic Medicine and Development, University of Geneva Medical School, 8242 CMU, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    J Neurobiol 64:476-90. 2005
    ....
  2. pmc HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
    Virginie Clement
    Department of Genetic Medicine and Development, University of Geneva Medical School, 8242 CMU, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Curr Biol 17:165-72. 2007
    ..Our results reveal the essential role of HH-GLI signaling in controlling the behavior of human glioma cancer stem cells and offer new therapeutic possibilities...
  3. ncbi request reprint Sonic hedgehog regulates the growth and patterning of the cerebellum
    N Dahmane
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Development 126:3089-100. 1999
    ..In addition, they provide a cellular context for medulloblastomas, childhood cancers of the cerebellum...
  4. ncbi request reprint Hedgehog--Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer
    Ariel Ruiz i Altaba
    The Skirball Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cancer Lett 204:145-57. 2004
    ..Moreover, they highlight the components of this pathway as prime targets for drug development, with special emphasis on the GLI proteins. Such reagents would allow a rational therapeutic approach to highly intractable diseases...
  5. ncbi request reprint In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice
    Pilar Sanchez
    The Skirball Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10012, USA
    Mech Dev 122:223-30. 2005
    ..They also demonstrate that even the complete loss of the well-known tumor suppressor p53 does not render the tumor independent of Hh pathway function...
  6. pmc The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway
    Barbara Stecca
    Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    J Biol 1:9. 2002
    ....
  7. ncbi request reprint Embryonic regionalization of the neocortex
    A Ruiz i Altaba
    Developmental Genetics Program, Skirball Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Mech Dev 107:3-11. 2001
    ....
  8. ncbi request reprint Gli and hedgehog in cancer: tumours, embryos and stem cells
    Ariel Ruiz i Altaba
    The Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Nat Rev Cancer 2:361-72. 2002
    ....
  9. ncbi request reprint Gli proteins and Hedgehog signaling: development and cancer
    A Ruiz i Altaba
    The Skirball Institute of Biomolecular Medicine, Developmental Genetics Program and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Trends Genet 15:418-25. 1999
    ....
  10. ncbi request reprint Gli proteins encode context-dependent positive and negative functions: implications for development and disease
    A Ruiz i Altaba
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Development 126:3205-16. 1999
    ..Interpretation of Hh signals by Gli proteins therefore appears to involve a fine balance of divergent functions within each and among different Gli proteins, the misregulation of which has profound biological consequences...
  11. ncbi request reprint Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
    A Ruiz i Altaba
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU Medical Center, New York, NY 10016, USA
    Development 125:2203-12. 1998
    ..In addition, Gli3 inhibits motor neuron differentiation by Gli2. Thus, combinatorial Gli function may pattern the neural tube, integrating positional information and cell type differentiation...
  12. ncbi request reprint The emergent design of the neural tube: prepattern, SHH morphogen and GLI code
    Ariel Ruiz i Altaba
    The Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Curr Opin Genet Dev 13:513-21. 2003
    ....
  13. ncbi request reprint Coexpression of HNF-3 beta and Isl-1/2 and mixed distribution of ventral cell types in the early neural tube
    A Ruiz i Altaba
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York, USA
    Int J Dev Biol 40:1081-8. 1996
    ....
  14. ncbi request reprint Involvement of Livertine, a hepatocyte growth factor family member, in neural morphogenesis
    A Ruiz i Altaba
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York, NY, USA
    Mech Dev 60:207-20. 1996
    ..These results suggest that one of the normal functions of Livertine is the control of neural morphogenesis in the vertebrate embryo...
  15. ncbi request reprint Hedgehog-Gli signalling and the growth of the brain
    Ariel Ruiz i Altaba
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York 10016, USA
    Nat Rev Neurosci 3:24-33. 2002
    ..We also highlight future directions of research that could help to clarify the mechanisms and consequences of Sonic hedgehog signalling in the brain...
  16. ncbi request reprint Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
    J Lee
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU Medical Center, New York, NY 10016, USA
    Development 124:2537-52. 1997
    ..Thus, our results identify Gli1 as a midline target of Shh and suggest that it mediates the induction of floor plate cells and ventral neurons by Shh acting as a transcriptional regulator...
  17. ncbi request reprint Gli/Zic factors pattern the neural plate by defining domains of cell differentiation
    R Brewster
    The Skirball Institute, Developmental Genetics Program, Department of Cell Biology, NYU Medical Center, New York 10016, USA
    Nature 393:579-83. 1998
    ..We propose that the combined function of Gli/Zic genes responds to inductive signals and induces patterned neural cell differentiation...
  18. ncbi request reprint The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
    N Dahmane
    Skirball Institute of Biomolecular Medicine, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 128:5201-12. 2001
    ..SHH-GLI signaling thus modulates normal dorsal brain growth by controlling precursor proliferation, an evolutionarily important and plastic process that is deregulated in brain tumors...
  19. ncbi request reprint Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryos
    A Ruiz i Altaba
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    Mol Cell Neurosci 6:106-21. 1995
    ..The ability of winged-helix and vertebrate hedgehog genes to induce floor plate differentiation in vivo may, therefore, be constrained by additional signals that specify the time and position of floor plate differentiation...
  20. ncbi request reprint Early stages of notochord and floor plate development in the chick embryo defined by normal and induced expression of HNF-3 beta
    A Ruiz i Altaba
    Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    Dev Biol 170:299-313. 1995
    ....
  21. ncbi request reprint Hexokinase I is a Gli2-responsive gene expressed in the embryonic CNS
    R Brewster
    The Skirball Institute, Developmental Genetics Program, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Mech Dev 99:159-62. 2000
    ....
  22. ncbi request reprint Wnt signals are targets and mediators of Gli function
    J L Mullor
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Curr Biol 11:769-73. 2001
    ..Such a mechanism may link signals that induce Gli activity, such as FGFs and Hedgehogs, with Wnt function...
  23. ncbi request reprint Pathways and consequences: Hedgehog signaling in human disease
    Jose L Mullor
    Developmental Genetics Program and Dept of Cell Biology, Skirball Institute, NYU School of Medicine, New York, NY 10016, USA
    Trends Cell Biol 12:562-9. 2002
    ..The human phenotypes generally fit the findings in model organisms and help to identify some potential targets for therapy...
  24. ncbi request reprint Catching a Gli-mpse of Hedgehog
    A Ruiz i Altaba
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU Medical Center, New York, New York 10016, USA
    Cell 90:193-6. 1997
  25. pmc Sonic hedgehog controls stem cell behavior in the postnatal and adult brain
    Veronica Palma
    The Skirball Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 132:335-44. 2005
    ....
  26. ncbi request reprint Growth, hedgehog and the price of GAS
    Jose L Mullor
    Skirball Institute, Developmental Genetics Program and Dept of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Bioessays 24:22-6. 2002
    ..Moreover, GAS1, a GPI-linked membrane protein, can bind SHH, suggesting an interacting link between growth and patterning through SHH and GAS1...
  27. ncbi request reprint Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex
    Veronica Palma
    The Skirball Institute and Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 131:337-45. 2004
    ..These findings identify a crucial mechanism for the regulation of the number of cells with stem cell properties that is unexpectedly conserved in different stem cell niches...
  28. pmc Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
    Pilar Sanchez
    Skirball Institute and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 101:12561-6. 2004
    ..Our data demonstrate the dependence of prostate cancer on SHH-GLI function and suggest a novel therapeutic approach...
  29. doi request reprint Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?
    Ariel Ruiz i Altaba
    Department of Genetic Medicine and Development, University of Geneva Medical School, CH 1211 Geneva, Switzerland
    Cancer Cell 14:281-3. 2008
    ..Surprisingly, a recent study by Yauch et al. (2008) proposes that HH-GLI signaling acts only on the tumor stroma. The mode of action of HH-GLI signaling in cancer may shape the development of therapeutic antagonists...
  30. pmc The Gli code: an information nexus regulating cell fate, stemness and cancer
    Ariel Ruiz i Altaba
    Department of Genetic Medicine and Development, 8242 CMU, University of Geneva Medical School, 1 rue Michel Servet, CH 1211 Geneva, Switzerland
    Trends Cell Biol 17:438-47. 2007
    ..Recent data confirm this idea and suggest that the Gli code regulates stemness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies...
  31. pmc Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
    Barbara Stecca
    Department of Genetic Medicine and Development, University of Geneva School of Medicine, 1 rue Michel Servet, 1211 Geneva, Switzerland
    Proc Natl Acad Sci U S A 104:5895-900. 2007
    ....
  32. ncbi request reprint Interference with HH-GLI signaling inhibits prostate cancer
    Barbara Stecca
    Department of Genetic Medicine and Development, University of Geneva Medical School, 8242 CMU, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Trends Mol Med 11:199-203. 2005
    ..These data raise the possibility of a new therapeutic approach to treat this often lethal disease...
  33. ncbi request reprint Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer
    Pilar Sanchez
    Department of Genetic Medicine and Development, University of Geneva Medical School, CH 1211 Geneva 4, Switzerland
    Cancer Res 65:2990-2. 2005
    ..These findings have prompted a novel rational strategy for therapeutic treatment of prostate tumors, including metastatic tumors...
  34. ncbi request reprint Development. Longing for ligand: hedgehog, patched, and cell death
    Isabel Guerrero
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Madrid E 28049, Spain
    Science 301:774-6. 2003
  35. ncbi request reprint A gene expression map of human chromosome 21 orthologues in the mouse
    Yorick Gitton
    Skirball Institute, Developmental Genetics Program and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nature 420:586-90. 2002
    ..This chromosome-scale expression annotation associates many of the genes tested with a potential biological role and suggests candidates for the pathogenesis of Down's syndrome...
  36. pmc Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features
    Erich Roessler
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1852, USA
    Proc Natl Acad Sci U S A 100:13424-9. 2003
    ..We also demonstrate that these mutations lack GLI2 activity. We report on a functional association between GLI2 and human disease and highlight the role of GLI2 in human head development...