Research Topics
Genomes and Genes | Ariel Ruiz i AltabaSummaryAffiliation: New York University Country: USA Publications
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Detail Information
Publications
Brain as a paradigm of organ growth: Hedgehog-Gli signaling in neural stem cells and brain tumorsBarbara Stecca
Department of Genetic Medicine and Development, University of Geneva Medical School, 8242 CMU, 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland
J Neurobiol 64:476-90. 2005....
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicityVirginie Clement
Department of Genetic Medicine and Development, University of Geneva Medical School, 8242 CMU, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
Curr Biol 17:165-72. 2007..Our results reveal the essential role of HH-GLI signaling in controlling the behavior of human glioma cancer stem cells and offer new therapeutic possibilities...- Sonic hedgehog regulates the growth and patterning of the cerebellumN Dahmane
The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
Development 126:3089-100. 1999..In addition, they provide a cellular context for medulloblastomas, childhood cancers of the cerebellum... - Hedgehog--Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancerAriel Ruiz i Altaba
The Skirball Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
Cancer Lett 204:145-57. 2004..Moreover, they highlight the components of this pathway as prime targets for drug development, with special emphasis on the GLI proteins. Such reagents would allow a rational therapeutic approach to highly intractable diseases... - In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in micePilar Sanchez
The Skirball Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10012, USA
Mech Dev 122:223-30. 2005..They also demonstrate that even the complete loss of the well-known tumor suppressor p53 does not render the tumor independent of Hh pathway function... 
The therapeutic potential of modulators of the Hedgehog-Gli signaling pathwayBarbara Stecca
Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
J Biol 1:9. 2002....- Embryonic regionalization of the neocortexA Ruiz i Altaba
Developmental Genetics Program, Skirball Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
Mech Dev 107:3-11. 2001.... - Gli and hedgehog in cancer: tumours, embryos and stem cellsAriel Ruiz i Altaba
The Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
Nat Rev Cancer 2:361-72. 2002.... - Gli proteins and Hedgehog signaling: development and cancerA Ruiz i Altaba
The Skirball Institute of Biomolecular Medicine, Developmental Genetics Program and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Trends Genet 15:418-25. 1999.... - Gli proteins encode context-dependent positive and negative functions: implications for development and diseaseA Ruiz i Altaba
The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
Development 126:3205-16. 1999..Interpretation of Hh signals by Gli proteins therefore appears to involve a fine balance of divergent functions within each and among different Gli proteins, the misregulation of which has profound biological consequences... - Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehogA Ruiz i Altaba
The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU Medical Center, New York, NY 10016, USA
Development 125:2203-12. 1998..In addition, Gli3 inhibits motor neuron differentiation by Gli2. Thus, combinatorial Gli function may pattern the neural tube, integrating positional information and cell type differentiation... - The emergent design of the neural tube: prepattern, SHH morphogen and GLI codeAriel Ruiz i Altaba
The Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
Curr Opin Genet Dev 13:513-21. 2003.... - Coexpression of HNF-3 beta and Isl-1/2 and mixed distribution of ventral cell types in the early neural tubeA Ruiz i Altaba
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York, USA
Int J Dev Biol 40:1081-8. 1996.... - Involvement of Livertine, a hepatocyte growth factor family member, in neural morphogenesisA Ruiz i Altaba
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York, NY, USA
Mech Dev 60:207-20. 1996..These results suggest that one of the normal functions of Livertine is the control of neural morphogenesis in the vertebrate embryo... - Hedgehog-Gli signalling and the growth of the brainAriel Ruiz i Altaba
The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York 10016, USA
Nat Rev Neurosci 3:24-33. 2002..We also highlight future directions of research that could help to clarify the mechanisms and consequences of Sonic hedgehog signalling in the brain... - Gli1 is a target of Sonic hedgehog that induces ventral neural tube developmentJ Lee
The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU Medical Center, New York, NY 10016, USA
Development 124:2537-52. 1997..Thus, our results identify Gli1 as a midline target of Shh and suggest that it mediates the induction of floor plate cells and ventral neurons by Shh acting as a transcriptional regulator... - Gli/Zic factors pattern the neural plate by defining domains of cell differentiationR Brewster
The Skirball Institute, Developmental Genetics Program, Department of Cell Biology, NYU Medical Center, New York 10016, USA
Nature 393:579-83. 1998..We propose that the combined function of Gli/Zic genes responds to inductive signals and induces patterned neural cell differentiation... - The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesisN Dahmane
Skirball Institute of Biomolecular Medicine, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
Development 128:5201-12. 2001..SHH-GLI signaling thus modulates normal dorsal brain growth by controlling precursor proliferation, an evolutionarily important and plastic process that is deregulated in brain tumors... - Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryosA Ruiz i Altaba
Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
Mol Cell Neurosci 6:106-21. 1995..The ability of winged-helix and vertebrate hedgehog genes to induce floor plate differentiation in vivo may, therefore, be constrained by additional signals that specify the time and position of floor plate differentiation... - Early stages of notochord and floor plate development in the chick embryo defined by normal and induced expression of HNF-3 betaA Ruiz i Altaba
Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
Dev Biol 170:299-313. 1995.... - Hexokinase I is a Gli2-responsive gene expressed in the embryonic CNSR Brewster
The Skirball Institute, Developmental Genetics Program, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
Mech Dev 99:159-62. 2000.... - Wnt signals are targets and mediators of Gli functionJ L Mullor
The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
Curr Biol 11:769-73. 2001..Such a mechanism may link signals that induce Gli activity, such as FGFs and Hedgehogs, with Wnt function... - Pathways and consequences: Hedgehog signaling in human diseaseJose L Mullor
Developmental Genetics Program and Dept of Cell Biology, Skirball Institute, NYU School of Medicine, New York, NY 10016, USA
Trends Cell Biol 12:562-9. 2002..The human phenotypes generally fit the findings in model organisms and help to identify some potential targets for therapy... - Catching a Gli-mpse of HedgehogA Ruiz i Altaba
The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU Medical Center, New York, New York 10016, USA
Cell 90:193-6. 1997 - Sonic hedgehog controls stem cell behavior in the postnatal and adult brainVeronica Palma
The Skirball Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
Development 132:335-44. 2005.... - Growth, hedgehog and the price of GASJose L Mullor
Skirball Institute, Developmental Genetics Program and Dept of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
Bioessays 24:22-6. 2002..Moreover, GAS1, a GPI-linked membrane protein, can bind SHH, suggesting an interacting link between growth and patterning through SHH and GAS1... - Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortexVeronica Palma
The Skirball Institute and Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
Development 131:337-45. 2004..These findings identify a crucial mechanism for the regulation of the number of cells with stem cell properties that is unexpectedly conserved in different stem cell niches... - Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signalingPilar Sanchez
Skirball Institute and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Proc Natl Acad Sci U S A 101:12561-6. 2004..Our data demonstrate the dependence of prostate cancer on SHH-GLI function and suggest a novel therapeutic approach... 
Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?Ariel Ruiz i Altaba
Department of Genetic Medicine and Development, University of Geneva Medical School, CH 1211 Geneva, Switzerland
Cancer Cell 14:281-3. 2008..Surprisingly, a recent study by Yauch et al. (2008) proposes that HH-GLI signaling acts only on the tumor stroma. The mode of action of HH-GLI signaling in cancer may shape the development of therapeutic antagonists...- The Gli code: an information nexus regulating cell fate, stemness and cancerAriel Ruiz i Altaba
Department of Genetic Medicine and Development, 8242 CMU, University of Geneva Medical School, 1 rue Michel Servet, CH 1211 Geneva, Switzerland
Trends Cell Biol 17:438-47. 2007..Recent data confirm this idea and suggest that the Gli code regulates stemness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies... - Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathwaysBarbara Stecca
Department of Genetic Medicine and Development, University of Geneva School of Medicine, 1 rue Michel Servet, 1211 Geneva, Switzerland
Proc Natl Acad Sci U S A 104:5895-900. 2007.... - Interference with HH-GLI signaling inhibits prostate cancerBarbara Stecca
Department of Genetic Medicine and Development, University of Geneva Medical School, 8242 CMU, 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland
Trends Mol Med 11:199-203. 2005..These data raise the possibility of a new therapeutic approach to treat this often lethal disease... - Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancerPilar Sanchez
Department of Genetic Medicine and Development, University of Geneva Medical School, CH-1211 Geneva 4, Switzerland
Cancer Res 65:2990-2. 2005..These findings have prompted a novel rational strategy for therapeutic treatment of prostate tumors, including metastatic tumors... - Development. Longing for ligand: hedgehog, patched, and cell deathIsabel Guerrero
, CSIC-UAM, , Madrid E-28049, Spain
Science 301:774-6. 2003 - A gene expression map of human chromosome 21 orthologues in the mouseYorick Gitton
Skirball Institute, Developmental Genetics Program and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Nature 420:586-90. 2002..This chromosome-scale expression annotation associates many of the genes tested with a potential biological role and suggests candidates for the pathogenesis of Down's syndrome... - Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like featuresErich Roessler
Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1852, USA
Proc Natl Acad Sci U S A 100:13424-9. 2003..We also demonstrate that these mutations lack GLI2 activity. We report on a functional association between GLI2 and human disease and highlight the role of GLI2 in human head development...