Iannis Aifantis

Summary

Affiliation: New York University
Country: USA

Publications

  1. pmc The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
    Benjamin J Thompson
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 204:1825-35. 2007
  2. ncbi request reprint Notches, NFkappaBs and the making of T cell leukemia
    Iannis Aifantis
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Cell Cycle 6:403-6. 2007
  3. ncbi request reprint Molecular pathogenesis of T-cell leukaemia and lymphoma
    Iannis Aifantis
    Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Nat Rev Immunol 8:380-90. 2008
  4. pmc Notch pathway activation targets AML-initiating cell homeostasis and differentiation
    Camille Lobry
    Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 210:301-19. 2013
  5. pmc In vivo mapping of notch pathway activity in normal and stress hematopoiesis
    Philmo Oh
    Howard Hughes Medical Institute and NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell Stem Cell 13:190-204. 2013
  6. ncbi request reprint Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential
    Colin H Martin
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute Boston, Massachusetts, 02115, USA
    Nat Immunol 4:866-73. 2003
  7. pmc The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability
    Bryan King
    Howard Hughes Medical Institute and NYU Cancer Institute, NYU School of Medicine, New York, NY 10016, USA
    Cell 153:1552-66. 2013
  8. ncbi request reprint A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development
    Iannis Aifantis
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Nat Immunol 3:483-8. 2002
  9. pmc Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development
    Christine Borowski
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Smith Building, 1 Jimmy Fund Way, Boston, MA 02115, USA
    J Exp Med 199:607-15. 2004
  10. pmc Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
    Benjamin J Thompson
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 205:1395-408. 2008

Research Grants

Collaborators

Detail Information

Publications51

  1. pmc The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
    Benjamin J Thompson
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 204:1825-35. 2007
    ..Our data suggest that FBW7 is a novel tumor suppressor in T cell leukemia, and implicate the loss of FBW7 function as a potential mechanism of drug resistance in T-ALL...
  2. ncbi request reprint Notches, NFkappaBs and the making of T cell leukemia
    Iannis Aifantis
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Cell Cycle 6:403-6. 2007
    ..We believe that these findings could be important for the understanding of Notch1 signaling and the therapeutic treatment of T-ALL...
  3. ncbi request reprint Molecular pathogenesis of T-cell leukaemia and lymphoma
    Iannis Aifantis
    Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Nat Rev Immunol 8:380-90. 2008
    ..Finally, we discuss potential new therapies that target oncogenic pathways in T-ALL...
  4. pmc Notch pathway activation targets AML-initiating cell homeostasis and differentiation
    Camille Lobry
    Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 210:301-19. 2013
    ..These data demonstrate a novel tumor suppressor role for Notch signaling in AML and elucidate the potential therapeutic use of Notch receptor agonists in the treatment of this devastating leukemia...
  5. pmc In vivo mapping of notch pathway activity in normal and stress hematopoiesis
    Philmo Oh
    Howard Hughes Medical Institute and NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell Stem Cell 13:190-204. 2013
    ..Moreover, they establish a previously unknown role for Notch signaling in the commitment of blood progenitors toward the erythrocytic lineage and link Notch signaling to optimal organismal response to stress erythropoiesis. ..
  6. ncbi request reprint Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential
    Colin H Martin
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute Boston, Massachusetts, 02115, USA
    Nat Immunol 4:866-73. 2003
    ..Although the CLP-2 subset may represent the most differentiated population with T cell potential before commitment to the B cell lineage, other subsets of thymic immigrants capable of generating T cells may exist...
  7. pmc The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability
    Bryan King
    Howard Hughes Medical Institute and NYU Cancer Institute, NYU School of Medicine, New York, NY 10016, USA
    Cell 153:1552-66. 2013
    ..Finally, we demonstrated that small-molecule-mediated suppression of MYC activity leads to T-ALL remission, suggesting an effective therapeutic strategy. ..
  8. ncbi request reprint A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development
    Iannis Aifantis
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Nat Immunol 3:483-8. 2002
    ..In contrast, the pTalpha juxtamembrane cysteine appeared to be dispensable for pre-TCR function...
  9. pmc Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development
    Christine Borowski
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Smith Building, 1 Jimmy Fund Way, Boston, MA 02115, USA
    J Exp Med 199:607-15. 2004
    ..We conclude that features intrinsic to the pre-TCR, which are absent in TCRalpha, are essential for its unique function...
  10. pmc Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
    Benjamin J Thompson
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 205:1395-408. 2008
    ....
  11. pmc Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression
    Linsey Reavie
    Howard Hughes Medical Institute and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Cancer Cell 23:362-75. 2013
    ..These studies identify a ubiquitin ligase:substrate pair regulating LIC activity, suggesting that targeting of the Fbw7:c-Myc axis is an attractive therapy target in refractory CML...
  12. pmc ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
    Omar Abdel-Wahab
    Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Cancer Cell 22:180-93. 2012
    ..We demonstrate that ASXL1 associates with the PRC2, and that loss of ASXL1 in vivo collaborates with NRASG12D to promote myeloid leukemogenesis...
  13. pmc Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system
    Shannon M Buckley
    Howard Hughes Medical Institute and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Cell Stem Cell 11:783-98. 2012
    ..This global characterization of the UPS as a key regulator of stem cell pluripotency opens the way for future studies that focus on specific UPS enzymes or ubiquitinated substrates...
  14. pmc Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex
    Linsey Reavie
    Howard Hughes Medical Institute and Department of Pathology, New York, New York, USA
    Nat Immunol 11:207-15. 2010
    ..Our studies show that a ubiquitin ligase-substrate pair can orchestrate the molecular program of HSC differentiation...
  15. pmc Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers
    Julie Chaumeil
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Cell Rep 3:359-70. 2013
    ..Our data identify higher-order loop formation as a key determinant of directed RAG targeting and the maintenance of genome stability...
  16. pmc Hedgehog signaling is dispensable for adult hematopoietic stem cell function
    Jie Gao
    Department of Pathology and NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell Stem Cell 4:548-58. 2009
    ..Our studies demonstrate that the Hh signaling pathway is dispensable for adult HSC function and suggest that Hh inhibition on leukemia-initiating cell maintenance can be targeted in future clinical trials...
  17. pmc The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage
    Julie Chaumeil
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Nat Commun 4:2231. 2013
    ..This limits the number of potential substrates for translocation and provides an important mechanism for protecting genome stability. ..
  18. pmc Notch signaling: switching an oncogene to a tumor suppressor
    Camille Lobry
    Howard Hughes Medical Institute and Department of Pathology, New York University School of Medicine, New York, NY
    Blood 123:2451-9. 2014
    ..In this review, we summarize and discuss latest advances in the understanding of this dual role in hematopoiesis and the possible consequences for the treatment of hematologic malignancies. ..
  19. pmc Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms
    Erica J Reschly
    Department of Pathology, MC1089, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Blood 107:4115-21. 2006
    ..Our findings indicate that the activation of Notch1 is an important "second hit" for the transformation of E2A(-/-) T cell lymphomas and that Notch1 promotes survival through pre-TCR-dependent and -independent mechanisms...
  20. pmc Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
    Pedro J Real
    Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
    Nat Med 15:50-8. 2009
    ..These results support a role for glucocorticoids plus GSIs in the treatment of glucocorticoid-resistant T-ALL...
  21. ncbi request reprint Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene
    Fotini Gounari
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Nat Immunol 3:489-96. 2002
    ..Thus, the pTalpha reporter can be used to trace lymphopoiesis between CLPs and alphabeta T cells. The slower extinction of the hCD25 reporter compared to pTalpha enabled us to define points at which pTalpha(-) lineages branched off...
  22. pmc Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
    Panagiotis Ntziachristos
    Howard Hughes Medical Institute and Department of Pathology, New York University School of Medicine, New York, New York, USA
    Nat Med 18:298-301. 2012
    ..These studies suggest a tumor suppressor role for PRC2 in human leukemia and suggest a hitherto unrecognized dynamic interplay between oncogenic NOTCH1 and PRC2 function for the regulation of gene expression and cell transformation...
  23. pmc Regulation of hematopoietic stem cell fate by the ubiquitin proteasome system
    Kelly Moran-Crusio
    Department of Pathology and NYU Cancer Institute, NYU School of Medicine, New York, NY 10016, USA
    Trends Immunol 33:357-63. 2012
    ..Thus, understanding the emerging field of how the UPS regulates HSC activity may lead to novel targets for therapy of leukemia...
  24. pmc TET family proteins and their role in stem cell differentiation and transformation
    Luisa Cimmino
    Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell Stem Cell 9:193-204. 2011
    ....
  25. pmc Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia
    Thomas Trimarchi
    Howard Hughes Medical Institute, Laura and Isaac Perlmutter Cancer Center, and Helen L and Martin S Kimmel Center for Stem Cell Biology, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA Department of Pathology, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Cell 158:593-606. 2014
    ..These results confirm that lncRNAs are important downstream targets of the Notch signaling pathway, and additionally they are key regulators of the oncogenic state in T-ALL. ..
  26. pmc Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis
    Michael G Poulos
    Department of Genetic Medicine, Ansary Stem Cell Instiute, Weill Cornell Medical College, New York, NY 10021, USA Department of Surgery, Weill Cornell Medical College, New York, NY 10021, USA
    Cell Rep 4:1022-34. 2013
    ..Taken together, these data demonstrate that the instructive function of endothelial-specific Jagged-1 is required to support the self-renewal and regenerative capacity of HSCs in the adult BM vascular niche...
  27. pmc From fly wings to targeted cancer therapies: a centennial for notch signaling
    Panagiotis Ntziachristos
    Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, NY 10016, USA NYU Cancer Institute and Helen L and Martin S Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Cancer Cell 25:318-34. 2014
    ..Finally, we link these mechanisms and observations to possible therapeutic strategies targeting the Notch pathway in human cancers. ..
  28. pmc Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia
    Catherine M Sawai
    Department of Pathology and Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
    Cancer Cell 22:452-65. 2012
    ..These studies identify unique functions for cyclin D3:CDK4/6 complexes and suggest potential therapeutic protocols for this devastating blood tumor...
  29. pmc Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
    Kelly Moran-Crusio
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, NY 10016, USA
    Cancer Cell 20:11-24. 2011
    ..In addition, Tet2(+/-) mice also displayed increased stem cell self-renewal and extramedullary hematopoiesis, suggesting that Tet2 haploinsufficiency contributes to hematopoietic transformation in vivo...
  30. doi request reprint Energy addiction and lymphocyte differentiation: a new role for the liver kinase B1 kinase
    Iannis Aifantis
    Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, NY 10016, USA
    Eur J Immunol 40:19-21. 2010
    ..This study highlights the importance of LKB1 in T-cell development and function, but as discussed in this Commentary, a number of intriguing questions concerning the regulation and additional functions of LKB1 remain...
  31. doi request reprint A new player SETs in myeloid malignancy
    Thomas Trimarchi
    Department of Pathology and The Howard Hughes Medical Institute, New York University School of Medicine, New York, New York, USA
    Nat Genet 45:846-7. 2013
    ..The identified mutations frequently target the SKI-homologous domain, although the exact pathogenic mechanisms remain unknown. ..
  32. pmc CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
    Silvia Buonamici
    Department of Pathology and New York University Cancer Institute, New York 10016, USA
    Nature 459:1000-4. 2009
    ..Targeted inhibition of CNS involvement in T-ALL could potentially decrease the intensity of CNS-targeted therapy, thus reducing its associated short- and long-term complications...
  33. pmc STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation
    Daniel J Gough
    Department of Pathology and NYU Cancer Institute, New York University School of Medicine, New York, NY
    Blood 124:2252-61. 2014
    ..However, abrogation of STAT3-S727 phosphorylation impaired factor-independent malignant growth. These data document that serine-phosphorylated mitochondrial STAT3 supports neoplastic hematopoietic cell growth induced by K-Ras...
  34. pmc Regulation of stem cell function by protein ubiquitylation
    Alexandros Strikoudis
    Howard Hughes Medical Institute New York University School of Medicine, New York, NY, USA
    EMBO Rep 15:365-82. 2014
    ..We also discuss deregulated processes of ubiquitin-mediated protein degradation that lead to the development of tumor-initiating cells. ..
  35. doi request reprint Fingerprinting acute leukemia: DNA methylation profiling of B-acute lymphoblastic leukemia
    Luisa Cimmino
    Department of Pathology and Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
    Cancer Discov 2:976-8. 2012
    ..The unique epigenetic and gene expression signatures of these clinically unfavorable B-ALL subtypes identify novel biomarkers and provide a strong rationale for repurposing existing therapies to treat these molecularly distinct diseases...
  36. pmc Hijacking T Cell Differentiation: New Insights in TLX Function in T-ALL
    Bryan King
    Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, NY 10016, USA
    Cancer Cell 21:453-5. 2012
    ..In this issue of Cancer Cell, Dadi et al. provide new insights into how these factors are recruited by ETS-1 to the TCRα enhancer and actively repress differentiation...
  37. ncbi request reprint On the brink of becoming a T cell
    Christine Borowski
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Curr Opin Immunol 14:200-6. 2002
    ..Receptor editing and lineage commitment of alphabeta T cells still represent controversial topics that need further study...
  38. pmc Assessing quality and completeness of human transcriptional regulatory pathways on a genome-wide scale
    Evgeny Shmelkov
    Department of Pharmacology, New York University School of Medicine, New York, NY, USA
    Biol Direct 6:15. 2011
    ..Then the lists of experimentally obtained direct targets are compared with relevant lists of transcriptional targets from 10 commonly used pathway databases...
  39. pmc Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think
    Camille Lobry
    Howard Hughes Medical Institute and Department of Pathology, New York University School of Medicine, New York, NY, USA
    J Exp Med 208:1931-5. 2011
    ..We discuss the intriguing possibility that the pleiotropic functions of Notch can be tumor suppressive or oncogenic depending on the cellular context...
  40. ncbi request reprint Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus
    Abdeljabar El Andaloussi
    Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois 60637, USA
    Nat Immunol 7:418-26. 2006
    ....
  41. ncbi request reprint Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor
    Iannis Aifantis
    University of Chicago, Department of Medicine, Section of Rheumatology, Committees of Immunology, Cancer and Developmental Biology, Chicago, IL 60637, USA
    Immunol Rev 209:159-69. 2006
    ..We also connect aberrant pre-TCR signaling to deregulated proliferation and apoptotic balances and thymocyte transformation...
  42. pmc Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages
    Philipp Oberdoerffer
    The CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 25:3896-905. 2005
    ..The extent of gene inactivation varies between different cell types and is least efficient in mature lymphocytes. Our data suggest that RNAi is affected by factors beyond small interfering RNA-mRNA stoichiometry...
  43. doi request reprint Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling
    Kristen Johnson
    Department of Molecular Genetics and Cell Biology, University of Chicago, 929 East 57 th Street, GCIS W522, Chicago, IL 60637, USA
    Immunity 28:335-45. 2008
    ..We propose that IRF-4 coordinates the two pathways regulating light-chain recombination by positioning pre-B cells away from IL-7-expressing stromal cells...
  44. ncbi request reprint Positive selection by the pre-TCR yields mature CD8+ T cells
    Yuriko Ito
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    J Immunol 169:4913-9. 2002
    ..The biased production of CD8(+) T cells via the pre-TCR might also support the potential involvement of signal strength in CD4/CD8 lineage commitment...
  45. ncbi request reprint Thymic selection revisited: how essential is it?
    Harald von Boehmer
    Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Immunol Rev 191:62-78. 2003
    ..Ectopically expressed organ-specific antigens contribute to thymic self-nonself discrimination, which represents an essential feature for the evolutionary fitness of mammalian species...
  46. pmc The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
    Malay Mandal
    Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 201:603-14. 2005
    ..Finally, we suggest that pre-TCR-induced A1 overexpression can contribute to T cell leukemia in both mice and humans...
  47. pmc A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus
    M Lucila Scimone
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:7006-11. 2006
    ..Preferential thymus-tropism of CLP-2 correlated with higher chemokine receptor 9 expression than on other BM progenitors. Thus, CLP access to the thymus is controlled by a tissue-specific and subset-selective multistep adhesion cascade...
  48. ncbi request reprint Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia
    Tomas Vilimas
    Department of Medicine, Section of Rheumatology, University of Chicago, 5841 South Maryland Avenue Chicago, Illinois 60637, USA
    Nat Med 13:70-7. 2007
    ..These findings identify NF-kappaB as one of the major mediators of Notch1-induced transformation and suggest that the NF-kappaB pathway is a potential target of future therapies of T-ALL...
  49. pmc The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells
    Iannis Aifantis
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:1543-50. 2006
    ..Thus, alphabetaTCR expression by CD4- CD8- thymocytes not only represents a transgenic artifact but occurs under physiological conditions...
  50. ncbi request reprint A unique function for cyclin D3 in early B cell development
    A Byron Cooper
    Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois 60637, USA
    Nat Immunol 7:489-97. 2006
    ..Cyclin D3 has a key function in B cell development by integrating cytokine and pre-B cell receptor-dependent signals to expand the pool of pre-B cells that have successfully rearranged immunoglobulin heavy chain...
  51. ncbi request reprint Requirement for cyclin D3 in lymphocyte development and T cell leukemias
    Ewa Sicinska
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 4:451-61. 2003
    ..These studies point to cyclin D3 as a potential target for therapeutic intervention in specific human malignancies...

Research Grants3

  1. Hedgehog signaling as a novel regulator of hematopoiesis
    Iannis Aifantis; Fiscal Year: 2007
    ..We will complement these experiments with the study of novel Hh activating mouse mutants in which we will define the exact role of the Gli factors in the regulation of mammalian lymphopoiesis and hematopoiesis. ..
  2. preTCR as an inducer of cell survival and transformation
    Iannis Aifantis; Fiscal Year: 2007
    ..The proposed experiments will help to identify the molecular mechanisms regulating pre-T cell survival and death and pinpoint pre-TCR-induced signaling pathways responsible for the malignant transformation of thymocytes. ..
  3. preTCR as an inducer of cell survival and transformation
    Iannis Aifantis; Fiscal Year: 2008
    ..The proposed experiments will help to identify the molecular mechanisms regulating pre-T cell survival and death and pinpoint pre-TCR-induced signaling pathways responsible for the malignant transformation of thymocytes. ..