Research Topics
| Steven AbramsonSummaryAffiliation: New York University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Nitric oxide in inflammation and pain associated with osteoarthritisSteven B Abramson
Division of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, 301 E, 17th Street, New York, NY 10003, USA
Arthritis Res Ther 10:S2. 2008..Further research may help to elucidate a potential role for NO-donating agents in the management of OA...- Developments in the scientific understanding of osteoarthritisSteven B Abramson
Division of Rheumatology, NYU School of Medicine, NYU Hospital for Joint Diseases, New York, NY 10003, USA
Arthritis Res Ther 11:227. 2009..In this review we summarize current scientific understanding of osteoarthritis and examine the pathobiologic mechanisms that contribute to progressive disease... - Current state of therapy for pain and inflammationSteven B Abramson
New York University School of Medicine, New York, USA
Arthritis Res Ther 7:S1-6. 2005.... 
Do nonsteroidal anti-inflammatory drugs accelerate disease progression in osteoarthritis?Steven B Abramson
Department of Rheumatology Medicin, New York University Hospital for Joint Diseases, New York, NY 10003, USA
Nat Clin Pract Rheumatol 2:302-3. 2006- Osteoarthritis: a tale of three tissuesJonathan Samuels
New York University School of Medicine, New York, NY, USA
Bull NYU Hosp Jt Dis 66:244-50. 2008..Thus current therapies focus on controlling symptoms, while research efforts search for reliable imaging and molecular biomarkers to help guide future trials of potential disease-modifying agents... 
Clinical guidelines: Expert recommendations for NSAID use: a user-friendly model?Steven B Abramson
Department of Medicine and Pathology, NYU Langone Medical Center, 550 First Avenue, New York, NY 10022, USA
Nat Rev Rheumatol 7:133-4. 2011..Evidence-based treatment guidelines and expert opinions have been promulgated, but will they actually translate to improved patient care? A new Web-based tool could aid physicians' treatment decision-making...- T1rho MRI of menisci and cartilage in patients with osteoarthritis at 3TLigong Wang
Quantitative Multinuclear Musculoskeletal Imaging Group QMMIG, Department of Radiology, New York University Langone Medical Center, New York, NY 10016, USA
Eur J Radiol 81:2329-36. 2012..To assess and compare subregional and whole T1rho values (median±interquartile range) of femorotibial cartilage and menisci in patients with doubtful (Kellgren-Lawrence (KL) grade 1) to severe (KL4) osteoarthritis (OA) at 3T... - Osteoarthritis and nitric oxideSteven B Abramson
Division of Rheumatology, Faculty and Academic Affairs, New York University Medical Center School of Medicine and Hospitals Center, NYU Hospital for Joint Diseases, New York, NY, USA
Osteoarthritis Cartilage 16:S15-20. 2008..More research is needed to elucidate the role of NO and its derivatives on both normal and osteoarthritis cartilage... - Assessment of coxib utilization by rheumatologists for nonsteroidal antiinflammatory drug gastroprotection prior to the coxib market withdrawalsJeffrey D Greenberg
New York University Hospital for Joint Diseases, New York 10003, USA
Arthritis Rheum 55:543-50. 2006..To examine cyclooxygenase 2 inhibitor (coxib) utilization by rheumatologists for patients receiving nonsteroidal antiinflammatory drugs (NSAIDs) prior to the coxib market withdrawals... - Regulation of metalloproteinases and NF-kappaB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNAMichael H Pillinger
The Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
Br J Pharmacol 142:973-82. 2004..In contrast, nabumetone demonstrates anti-inflammatory and potentially arthroprotective effects that have not been previously appreciated... - Rheumatoid arthritis treatment and monitoring of outcomes--where are we [corrected] in 2007?Yusuf Yazici
New York University School of Medicine, New York, NY, USA
Bull NYU Hosp Jt Dis 65:300-5. 2007.... - The use of musculoskeletal ultrasound by rheumatologists in the United StatesJonathan Samuels
Division of Rheumatology, Hospital for Joint Diseases, 301 E 17th Street, New York, NY 10003, USA
Bull NYU Hosp Jt Dis 68:292-8. 2010..Despite an inherent survey bias likely overstating interest in MSUS, this study is valuable as the first to document this trend among U.S. rheumatologists... - Effect of cardiovascular comorbidities and concomitant aspirin use on selection of cyclooxygenase inhibitor among rheumatologistsJeffrey D Greenberg
New York University Hospital for Joint Diseases, New York, New York, USA
Arthritis Rheum 53:12-7. 2005..To evaluate the effects of cardiovascular comorbidities and aspirin coprescription on cyclooxygenase (COX)-2 inhibitor (coxib) prescribing patterns among rheumatologists... - The role of microRNA in rheumatoid arthritis and other autoimmune diseasesVictoria Furer
Division of Rheumatology, Department of Medicine, NYU School of Medicine NYU Hospital for Joint Diseases, New York, NY 10009, USA
Clin Immunol 136:1-15. 2010..We conclude with a discussion of the implications of miRNA biology in rheumatoid arthritis and other autoimmune disorders... - Inflammation in osteoarthritisSteven B Abramson
Department of Rheumatology/Medicine, Hospital for Joint Diseases/NYU, 301 East 17th Street, New York, NY 10003, USA
J Rheumatol Suppl 70:70-6. 2004 - Biomarkers in osteoarthritisSteven Abramson
NYU Hospital for Joint Diseases, 301 East 17th Street, New York, New York 10003, USA
Bull NYU Hosp Jt Dis 64:77-81. 2006..Such biomarkers should be useful tools that will identify patients at risk for disease progression and predict responses to candidate structure-modifying drugs... - Prospects for disease modification in osteoarthritisSteven B Abramson
New York University Hospital for Joint Diseases, New York, NY 10003, USA
Nat Clin Pract Rheumatol 2:304-12. 2006..The challenges to drug development and the obstacles to disease modification strategies will also be addressed... - Biologics in development for rheumatoid arthritis: relevance to osteoarthritisSteven B Abramson
New York University School of Medicine, Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA
Adv Drug Deliv Rev 58:212-25. 2006.... - Resolution of inflammation: prostaglandin E2 dissociates nuclear trafficking of individual NF-kappaB subunits (p65, p50) in stimulated rheumatoid synovial fibroblastsPaul F Gomez
Department of Rheumatology, Hospital for Joint Diseases and Department of Medicine, New York University School of Medicine, New York, NY 10003, USA
J Immunol 175:6924-30. 2005..Our data indicate that PGE2 may act to attenuate cytokine-induced inflammatory responses in RA synovial fibroblasts via regulation of the localization of specific NF-kappaB family dimers... - Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptorMukundan Attur
Division of Rheumatology, New York University School of Medicine and New York University Hospital for Joint Diseases, New York, NY 10003, USA
J Immunol 181:5082-8. 2008..Targeting EP4, rather than cyclooxygenase 2, could represent a future strategy for OA disease modification... - F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activationMukundan G Attur
Division of Rheumatology, New York University School of Medicine, New York University Hospital for Joint Diseases, 301 E 17th St, New York, NY 10003, USA
FASEB J 23:79-89. 2009..05). Together these studies identify F-spondin as a novel protein in OA cartilage, where it may act in situ at lesional areas to activate latent TGF-beta and induce cartilage degradation via pathways that involve production of PGE2... - The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP productionMandar Dave
New York University Hospital for Joint Diseases, New York, New York 10003, USA
Arthritis Rheum 58:2786-97. 2008..To determine the effects of the antioxidant resveratrol on the functions of human chondrocytes in osteoarthritis (OA)... - Annexin-1 mediates TNF-alpha-stimulated matrix metalloproteinase secretion from rheumatoid arthritis synovial fibroblastsClement E Tagoe
Division of Rheumatology, New York University School of Medicine Hospital for Joint Diseases, New York, NY 10003, USA
J Immunol 181:2813-20. 2008.... - Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variationsMukundan Attur
Division of Rheumatology, New York University Hospital for Joint Diseases, New York, NY 10003, USA
Ann Rheum Dis 69:856-61. 2010..A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs... - Cyclooxygenase-2-derived E prostaglandins down-regulate matrix metalloproteinase-1 expression in fibroblast-like synoviocytes via inhibition of extracellular signal-regulated kinase activationMichael H Pillinger
Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Immunol 171:6080-9. 2003.... - Osteoarthritis in 2007Svetlana Krasnokutsky
New York University School of Medicine, Division of Rheumatology, NYU Hospital for Joint Diseases, New York, NY 10003, USA
Bull NYU Hosp Jt Dis 65:222-8. 2007..In this review, we summarize current pathological mechanisms occurring in the individual but interconnected compartments of OA joints, as well as discuss related therapeutic interventions that are currently available or on the horizon... - Nitric oxide synthases and osteoarthritisJose U Scher
The Division of Rheumatology, New York University School of Medicine New York University Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA
Curr Rheumatol Rep 9:9-15. 2007..Thus, NO produced by activated chondrocytes in diseased cartilage may modulate disease progression in osteoarthritis and should therefore be considered a potential target for therapeutic intervention... - The fibroblast-like synovial cell in rheumatoid arthritis: a key player in inflammation and joint destructionAdam Mor
Division of Rheumatology, NYU School of Medicine and The Hospital for Joint Disease, New York, NY 10003, USA
Clin Immunol 115:118-28. 2005..In this article, we consider the normal role of the FLS in healthy joints, and review evidence that implicates the FLS as a central player in the propagation of rheumatoid arthritis... - Assessment of subchondral bone marrow lipids in healthy controls and mild osteoarthritis patients at 3TLigong Wang
Quantitative Multinuclear Musculoskeletal Imaging Group QMMIG, Center for Biomedical Imaging, Department of Radiology, New York University, Langone Medical Center, New York, NY 10016, USA
NMR Biomed 25:545-55. 2012..03 p.p.m. (p < 0.05)... - Are NSAIDs and selective cyclo-oxygenase 2 inhibitors associated with increased risk of myocardial infarction?Steven B Abramson
New York University Hospital for Joint Diseases, New York, NY, USA
Nat Clin Pract Rheumatol 4:182-3. 2008..COX2 inhibitors were, however, associated with a reduced risk of serious gastrointestinal events. An analysis of previous systematic reviews showed increased risks of MI associated with rofecoxib and celecoxib... - Matrix metalloproteinase secretion by gastric epithelial cells is regulated by E prostaglandins and MAPKsMichael H Pillinger
Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 280:9973-9. 2005..pylori infection and/or cyclooxygenase inhibition may induce epithelial cell signaling to contribute to gastric ulcerogenesis... - Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence?Mukundan Attur
Division of Rheumatology, Department of Medicine and Pathology, NYU Hospital for Joint Diseases, NYU Langone Medical Center, New York, NY 10003, USA
Best Pract Res Clin Rheumatol 24:71-9. 2010.... - Protein kinase C-theta mediates negative feedback on regulatory T cell functionAlexandra Zanin-Zhorov
Molecular Pathogenesis Program, Helen and Martin Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
Science 328:372-6. 2010..Treg freed of PKC-theta-mediated inhibition can function in the presence of inflammatory cytokines and thus have therapeutic potential in control of inflammatory diseases... - APRIL and BAFF promote increased viability of replicating human B2 cells via mechanism involving cyclooxygenase 2Patricia K A Mongini
Department of Medicine, Division of Rheumatology, New York University Hospital for Joint Diseases, New York University Medical Center, New York, NY 10003, USA
J Immunol 176:6736-51. 2006..Increased yield of viable progeny was associated with elevated Mcl-1, suggesting that a BAFF/APRIL --> TACI --> COX-2 --> PGE2--> Mcl-1 pathway reduces activation-related, mitochondrial apoptosis in replicating human B2 cell clones... - Comparison of an in vitro tuberculosis interferon-gamma assay with delayed-type hypersensitivity testing for detection of latent Mycobacterium tuberculosis: a pilot study in rheumatoid arthritisJeffrey D Greenberg
Department of Rheumatology, NYU Hospital for Joint Diseases, New York, New York, USA
J Rheumatol 35:770-5. 2008..We estimated the prevalence of anergy in RA and evaluated different methods to detect MTB exposure... - F-spondin regulates chondrocyte terminal differentiation and endochondral bone formationGlyn D Palmer
Division of Rheumatology, New York University School of Medicine, Hospital for Joint Diseases, New York, New York, USA
J Orthop Res 28:1323-9. 2010..Our findings indicate that F-spondin is expressed in embryonic cartilage, where it has the capacity to enhance chondrocyte terminal differentiation and mineralization via interactions in its TSR domain and TGF-β dependent pathways... - Long-term risks associated with biologic response modifiers used in rheumatic diseasesAnna K Imperato
New York University School of Medicine Hospital for Joint Diseases, 301 East 17th Street, Room 1410, New York, NY 10003, USA
Curr Opin Rheumatol 16:199-205. 2004..However, as use of these agents has increased worldwide, infrequent adverse events that were not apparent in pivotal controlled clinical trials required for registration have emerged... - Anticancer effects of licofelone (ML-3000) in prostate cancer cellsNarayanan K Narayanan
Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
Anticancer Res 27:2393-402. 2007..However, the underlying mechanism of licofelone against human cancer is not understood... - The effect of moderate-dose corticosteroids in preventing severe flares in patients with serologically active, but clinically stable, systemic lupus erythematosus: findings of a prospective, randomized, double-blind, placebo-controlled trialChung E Tseng
New York University School of Medicine, Hospital for Joint Diseases, New York, New York 10003, USA
Arthritis Rheum 54:3623-32. 2006..We hypothesized that concomitant elevation of anti-dsDNA and C3a can predict SLE activity in patients with stable or inactive disease and that short-term treatment with corticosteroids can avert flares... - Et tu, acetaminophen?Steven B Abramson
Arthritis Rheum 46:2831-5. 2002 - Controversies in COX-2 selective inhibitionLee S Simon
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Rheumatol 29:1501-10. 2002 - Antiresorptive agents and osteoarthritis: more than a bone to pick?Steven B Abramson
Arthritis Rheum 56:2469-73. 2007 - Transcriptional repression of matrix metalloproteinase gene expression by the orphan nuclear receptor NURR1 in cartilageKimberlee S Mix
College of Life Sciences, Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland
J Biol Chem 282:9492-504. 2007..We propose a protective function for NURR1 in cartilage homeostasis by selectively repressing MMP gene expression during inflammation... - Recommendations for use of selective and nonselective nonsteroidal antiinflammatory drugs: an American College of Rheumatology white paperSonali P Desai
Arthritis Rheum 59:1058-73. 2008
Research Grants
- Leukocyte Gene Expression in OsteoarthritisSteven Abramson; Fiscal Year: 2009..We anticipate that these studies will enhance our understanding of the pathogenesis of OA and provide a combinatorial biomarker that may predict OA disease progression. ..
- COX-2 EICOSANOIDS IN ARTHRITISSteven Abramson; Fiscal Year: 2005..These studies will provide new insights into the role of eicosanoids in osteoarthritis and elucidate the potential consequences of chronic pharmacologic COX-2 inhibition on the structural integrity of articular cartilage. ..
- Regulation of chondrocytes by extracellular matrix protein.Steven B Abramson; Fiscal Year: 2010....