Nader Abraham

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. ncbi Heme oxygenase: the key to renal function regulation
    Nader G Abraham
    New York Medical College, Department of Pharmacology, Valhalla, NY 10595, USA
    Am J Physiol Renal Physiol 297:F1137-52. 2009
  2. ncbi Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes
    Nader G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H2468-77. 2004
  3. ncbi Expression of human heme oxygenase-1 in the thick ascending limb attenuates angiotensin II-mediated increase in oxidative injury
    Shuo Quan
    Department of Pharmacology, Division of Nephrology, New York Medical College, Valhalla, New York 10595, USA
    Kidney Int 65:1628-39. 2004
  4. ncbi Heme oxygenase -1 gene therapy: recent advances and therapeutic applications
    Nader G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Curr Gene Ther 7:89-108. 2007
  5. ncbi Metabolic syndrome: psychosocial, neuroendocrine, and classical risk factors in type 2 diabetes
    N G Abraham
    New York Medical College, Department of Pharmacology, Valhalla, NY 10595 USA
    Ann N Y Acad Sci 1113:256-75. 2007
  6. ncbi Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells
    Nader G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1117-24. 2002
  7. ncbi Human heme oxygenase: cell cycle-dependent expression and DNA microarray identification of multiple gene responses after transduction of endothelial cells
    N G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    J Cell Biochem 90:1098-111. 2003
  8. ncbi Heme oxygenase attenuated angiotensin II-mediated increase in cyclooxygenase activity and decreased isoprostane F2alpha in endothelial cells
    N G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Thromb Res 110:305-9. 2003
  9. ncbi Therapeutic applications of human heme oxygenase gene transfer and gene therapy
    Nader G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Curr Pharm Des 9:2513-24. 2003
  10. ncbi Bone marrow stem cell transplant into intra-bone cavity prevents type 2 diabetes: role of heme oxygenase-adiponectin
    Nader G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Autoimmun 30:128-35. 2008

Research Grants

  1. Oxidative Stress and Vascular HO in Diabetes
    Nader Abraham; Fiscal Year: 2007
  2. Oxidative Stress and Vascular HO in Diabetes
    Nader Abraham; Fiscal Year: 2009

Detail Information

Publications81

  1. ncbi Heme oxygenase: the key to renal function regulation
    Nader G Abraham
    New York Medical College, Department of Pharmacology, Valhalla, NY 10595, USA
    Am J Physiol Renal Physiol 297:F1137-52. 2009
    ....
  2. ncbi Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes
    Nader G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H2468-77. 2004
    ..Upregulation of HO-1 decreases oxidant production and endothelial cell damage and shedding and may attenuate vascular complications in diabetes...
  3. ncbi Expression of human heme oxygenase-1 in the thick ascending limb attenuates angiotensin II-mediated increase in oxidative injury
    Shuo Quan
    Department of Pharmacology, Division of Nephrology, New York Medical College, Valhalla, New York 10595, USA
    Kidney Int 65:1628-39. 2004
    ..We hypothesize that selective upregulation of HO-1 in TALH by gene transfer attenuates oxidative stress caused by angiotensin II (Ang II)...
  4. ncbi Heme oxygenase -1 gene therapy: recent advances and therapeutic applications
    Nader G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Curr Gene Ther 7:89-108. 2007
    ....
  5. ncbi Metabolic syndrome: psychosocial, neuroendocrine, and classical risk factors in type 2 diabetes
    N G Abraham
    New York Medical College, Department of Pharmacology, Valhalla, NY 10595 USA
    Ann N Y Acad Sci 1113:256-75. 2007
    ..If this proves to be the case, then the scene will be set to develop glutathione peroxidase mimetics for use in preclinical and clinical trials...
  6. ncbi Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells
    Nader G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Lung Cell Mol Physiol 283:L1117-24. 2002
    ..Heme activates sGC and enhances cGMP levels via a mechanism that is largely insensitive to NOS inhibition...
  7. ncbi Human heme oxygenase: cell cycle-dependent expression and DNA microarray identification of multiple gene responses after transduction of endothelial cells
    N G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    J Cell Biochem 90:1098-111. 2003
    ..These findings identify an array of gene responses to overexpression of human HO-1 and elucidate new aspects of human HO-1 signaling involved in cell growth...
  8. ncbi Heme oxygenase attenuated angiotensin II-mediated increase in cyclooxygenase activity and decreased isoprostane F2alpha in endothelial cells
    N G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Thromb Res 110:305-9. 2003
    ..These results indicate that overexpression of the HO system in EC exerts an inhibitory influence on Ang II-induced synthesis of prostaglandins and attenuates DNA damage caused by exposure to Ang II...
  9. ncbi Therapeutic applications of human heme oxygenase gene transfer and gene therapy
    Nader G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Curr Pharm Des 9:2513-24. 2003
    ..The ability to transfect human HO gene and to demonstrate its expression may offer a new therapeutic strategy for treating pathological conditions, such as hypertension, trauma and hemorrhage...
  10. ncbi Bone marrow stem cell transplant into intra-bone cavity prevents type 2 diabetes: role of heme oxygenase-adiponectin
    Nader G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Autoimmun 30:128-35. 2008
    ..Thus, transplantation of BMSC using the IBM-BMT strategy in conjunction with HO-1 induction offers a novel approach for the treatment of type 2 diabetes...
  11. ncbi Heme oxygenase: a target gene for anti-diabetic and obesity
    N G Abraham
    New York Medical College, Director of Gene Therapy, Room 527, Valhalla NY 10595, USA
    Curr Pharm Des 14:412-21. 2008
    ..A review of the mechanism(s) of action is included. This may lead to the development of pharmacological and genetic approaches to mitigate the clinical complications associated with the progression of diabetes and obesity...
  12. ncbi Heme oxygenase-1 attenuates glucose-mediated cell growth arrest and apoptosis in human microvessel endothelial cells
    Nader G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 93:507-14. 2003
    ..These findings identify a novel effect of HO-1 on endothelial cell growth and indicate that heme metabolism and HO-1 expression regulate signaling systems in cells exposed to high glucose, which controls cell-cycle progression...
  13. ncbi Pharmacological and clinical aspects of heme oxygenase
    Nader G Abraham
    New York Medical College, Basic Science Building, Valhalla, NY 10595, USA
    Pharmacol Rev 60:79-127. 2008
    ..This information is critical in both drug development and the implementation of clinical approaches to moderate and to alleviate the numerous chronic disorders in humans affected by perturbations in the HO system...
  14. ncbi Differential effect of cobalt protoporphyrin on distributions of heme oxygenase in renal structure and on blood pressure in SHR
    N G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Cell Mol Biol (Noisy-le-grand) 48:895-902. 2002
    ....
  15. ncbi Heme oxygenase and the cardiovascular-renal system
    Nader G Abraham
    New York Medical College, Basic Science Building, Valhalla, NY 10595, USA
    Free Radic Biol Med 39:1-25. 2005
    ....
  16. ncbi Heme oxygenase-1 expression levels are cell cycle dependent
    C Colombrita
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Biochem Biophys Res Commun 308:1001-8. 2003
    ..Inducibility of HO-1 in G(0)/G(1) phase is essential and probably regulated by a complex system involving oxygen species to assure controlled cell growth...
  17. ncbi Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats
    H E Sabaawy
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Hypertension 38:210-5. 2001
    ..Thus, delivery of HHO-1 gene by retroviral vector attenuates the development of hypertension and promotes body growth in spontaneously hypertensive rats...
  18. ncbi Renal cytochrome P-450-dependent metabolism of arachidonic acid in spontaneously hypertensive rats
    D Sacerdoti
    Department of Pharmacology, New York Medical College, Valhalla 10595
    Biochem Pharmacol 37:521-7. 1988
    ..We conclude that renal cytochrome P-450-dependent metabolites of arachidonic acid may participate in the circulatory changes of SHR, particularly during the developmental stage...
  19. ncbi Regulation of human heme oxygenase in endothelial cells by using sense and antisense retroviral constructs
    S Quan
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 98:12203-8. 2001
    ....
  20. ncbi Adenoviral vector-mediated transfer of human heme oxygenase in rats decreases renal heme-dependent arachidonic acid epoxygenase activity
    N G Abraham
    The Rockefeller University, New York, New York, USA
    J Pharmacol Exp Ther 293:494-500. 2000
    ....
  21. ncbi Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors
    J I Kaide
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    J Clin Invest 107:1163-71. 2001
    ..Collectively, these data suggest that vascular CO serves as an inhibitory modulator of vascular reactivity to vasoconstrictors via a mechanism that involves a TEA-sensitive K channel...
  22. ncbi Carbon monoxide produced by isolated arterioles attenuates pressure-induced vasoconstriction
    F Zhang
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Heart Circ Physiol 281:H350-8. 2001
    ..Collectively, these data suggest that CO of vascular origin attenuates pressure-induced arteriolar constriction via a mechanism involving a TEA-sensitive K(+) channel...
  23. ncbi Induction of heme oxygenase-1 in renovascular hypertension is associated with inhibition of apoptosis
    F T Botros
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Cell Mol Biol (Noisy-le-grand) 53:51-60. 2007
    ....
  24. ncbi TNF-alpha-mediated cell death is attenuated by retrovirus delivery of human heme oxygenase-1 gene into human microvessel endothelial cells
    T Kushida
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Transplant Proc 34:2973-8. 2002
  25. ncbi Heme oxygenase-1 gene expression increases vascular relaxation and decreases inducible nitric oxide synthase in diabetic rats
    M Ahmad
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Cell Mol Biol (Noisy-le-grand) 51:371-6. 2005
    ..Therefore, overexpression of HO-1 may mediate an increase in eNOS and a decrease in iNOS, potentially contributing to restoration of vascular responses in diabetic rats...
  26. ncbi Vasoregulatory function of the heme-heme oxygenase-carbon monoxide system
    F Zhang
    Department of Pharmacology, New York Medical College, Valhalla 10595, USA
    Am J Hypertens 14:62S-67S. 2001
    ..Carbon monoxide produced in central nervous system structures, for example, the nucleus tractus solitarii, also appears to support a blood pressure-lowering mechanism linked to inhibitory modulation of baroreceptor reflex activity...
  27. ncbi Fatty acid omega and (omega-1)-oxidation within intrasplenically transplanted fetal hepatocytes
    K Kato
    Department of Gastrointestinal Surgery, New York Medical College, Valhalla 10595, USA
    Transplantation 66:441-5. 1998
    ..The expression and enzymatic activity of the cytochrome P450 LAomega within intrasplenically transplanted hepatocytes was investigated...
  28. ncbi Distinct effect of retroviral-mediated IFN-alpha gene transfer on human erythroleukemic and CD34+ cell growth and differentiation
    S Quan
    Department of Pharmacology, Saint Vincent Hospital, New York Medical College, Valhalla 10595, USA
    J Hematother Stem Cell Res 8:491-502. 1999
    ..These studies indicate that retrovirus-mediated IFN-alpha gene transfer may provide a useful tool for studying the effect of IFN-alpha gene transfer on leukemic cells and long-lived CD34+ cells...
  29. ncbi Circulating endothelial cells are elevated in patients with type 2 diabetes mellitus independently of HbA(1)c
    J A McClung
    Cardiology Division and Medicine, New York Medical College, Valhalla, NY, 10595, USA
    Diabetologia 48:345-50. 2005
    ..CONCLUSIONS: Our study suggests that the higher number of CECs in patients with type 2 diabetes may reflect ongoing vascular injury that is not directly dependent on glucose control...
  30. ncbi Heme oxygenase isoform-specific expression and distribution in the rat kidney
    J L da Silva
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Kidney Int 59:1448-57. 2001
    ....
  31. ncbi Heme oxygenase-1 protects against radiocontrast-induced acute kidney injury by regulating anti-apoptotic proteins
    A I Goodman
    Department of Pharmacology, New York Medical College, Valhalla, New York, USA
    Kidney Int 72:945-53. 2007
    ..Our study suggests that increased levels of heme oxygenase-1 are protective against acute kidney injury due to radiocontrast exposure...
  32. ncbi Comparison of hemin enhancement of burst-forming units-erythroid clonal efficiency by progenitor cells from normal and HIV-infected patients
    N G Abraham
    Department of Medicine, New York Medical College, Valhalla
    Acta Haematol 86:189-93. 1991
    ....
  33. ncbi Impact of silencing HO-2 on EC-SOD and the mitochondrial signaling pathway
    S Turkseven
    Department of Pharmacology, New York Medical College, Valhalla, NY, USA
    J Cell Biochem 100:815-23. 2007
    ..In addition, localization of HO-1 in the mitochondrial compartment plays a critical role in mitochondria-mediated apoptosis...
  34. ncbi Genetic suppression of HO-1 exacerbates renal damage: reversed by an increase in the antiapoptotic signaling pathway
    Rafal Olszanecki
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Renal Physiol 292:F148-57. 2007
    ..These findings underscore the prominent role of HO-1 in counteracting apoptosis in this 2K1C renovascular hypertension model...
  35. ncbi A significant role for the heme oxygenase-1 gene in endothelial cell cycle progression
    Taketoshi Kushida
    Department of Medicine and Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Biochem Biophys Res Commun 291:68-75. 2002
    ....
  36. ncbi Heme oxygenase-1 enhances renal mitochondrial transport carriers and cytochrome C oxidase activity in experimental diabetes
    Maria Antonietta Di Noia
    Department of Pharmaco Biology, University of Bari, 70125 Bari, Italy
    J Biol Chem 281:15687-93. 2006
    ..These observations in experimental diabetes suggest that the cytoprotective mechanism of HO-1 against oxidative stress involves an increase in the levels of MCs and anti-apoptotic proteins as well as in cytochrome c oxidase activity...
  37. ncbi Protoporphyrin IX generation from delta-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation
    Christopher J Mingone
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Lung Cell Mol Physiol 291:L337-44. 2006
    ..Thus control of endogenous formation of protoporphyrin IX from ALA by the availability of iron is potentially a novel physiological mechanism of controlling vascular function through regulating the activity of sGC...
  38. ncbi Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus
    Ji Shi Wang
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 98:962-9. 2006
    ....
  39. ncbi Carbon monoxide and biliverdin prevent endothelial cell sloughing in rats with type I diabetes
    Luigi Rodella
    University of Texas Southwestern Medical Center, Dallas, USA
    Free Radic Biol Med 40:2198-205. 2006
    ....
  40. ncbi Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes
    Marco Di Pascoli
    Department of Pharmacology, New York Medical College, Valhalla, NY, USA
    Biochem Biophys Res Commun 340:935-43. 2006
    ....
  41. ncbi Increase in heme oxygenase-1 levels ameliorates renovascular hypertension
    Fady T Botros
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Kidney Int 68:2745-55. 2005
    ..We examined whether HO-1 overexpression, as a prophylactic approach, would attenuate renovascular hypertension and evaluated potential mechanisms that may account for its effect...
  42. ncbi Regulation of cyclooxygenase- and cytochrome p450-derived eicosanoids by heme oxygenase in the rat kidney
    Fady T Botros
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Hypertension 39:639-44. 2002
    ..Such interactions may play an important role in the regulation of renal function...
  43. ncbi Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects
    Adam L Kruger
    Division of Cardiology, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    J Pharmacol Exp Ther 319:1144-52. 2006
    ....
  44. ncbi Heme oxygenase-1 inhibition of Nox oxidase activation is a microvascular endothelial antioxidant effect of NO
    Michael S Wolin
    Hypertension 48:826-7. 2006
  45. ncbi Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance
    Ming Li
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Diabetes 57:1526-35. 2008
    ....
  46. ncbi Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells
    Dong Hyun Kim
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 325:833-40. 2008
    ..These findings highlight the pivotal role and symbiotic relationship of HO-1 and adiponectin in the modulation of the metabolic syndrome phenotype...
  47. ncbi Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats
    Antonio L'Abbate
    Scuola Superiore Sant Anna and CNR Institute of Clinical Physiology, University of Pisa, Pisa 56124, Italy
    Am J Physiol Heart Circ Physiol 293:H3532-41. 2007
    ....
  48. ncbi Targeting endothelial cells with heme oxygenase-1 gene using VE-cadherin promoter attenuates hyperglycemia-mediated cell injury and apoptosis
    Amit Asija
    Department of Medicine, New York Medical College, Valhalla, New York 10595, USA
    Antioxid Redox Signal 9:2065-74. 2007
    ..These results demonstrate that endothelial cell survival after oxidative stress injury may be enhanced by targeting HO-1 expression, thus blocking inflammation, apoptosis, and thereby attenuating cardiovascular risk factors...
  49. ncbi Heme oxygenase-1 prevents superoxide anion-associated endothelial cell sloughing in diabetic rats
    Shou Quan
    Department of Pharmacology, New York Medical College, Valhalla, NY, USA
    Biochem Biophys Res Commun 315:509-16. 2004
    ..05). In conclusion, HO-1 upregulation in diabetic rats brings about an increase in serum bilirubin, a reduction in O*-2 production, and a decrease in endothelial cell sloughing...
  50. ncbi Interdiction of the diabetic state in NOD mice by sustained induction of heme oxygenase: possible role of carbon monoxide and bilirubin
    Ming Li
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Antioxid Redox Signal 9:855-63. 2007
    ....
  51. ncbi Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats
    Stephen J Peterson
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 322:514-20. 2007
    ....
  52. ncbi Regulation of cyclooxygenase by the heme-heme oxygenase system in microvessel endothelial cells
    Asifa Haider
    New York Medical College, Department of Pharmacology, Valhalla, New York 10595, USA
    J Pharmacol Exp Ther 300:188-94. 2002
    ..These results demonstrate that the heme-HO system can function as a cellular regulator of the expression of vascular COX, thus influencing the generation of prostanoids, PGE(2) and PGI(2), known to play a role in vascular homeostasis...
  53. ncbi CD163-Mediated hemoglobin-heme uptake activates macrophage HO-1, providing an antiinflammatory function
    Nader G Abraham
    Circ Res 99:911-4. 2006
  54. ncbi Heme oxygenase overexpression attenuates glucose-mediated oxidative stress in quiescent cell phase: linking heme to hyperglycemia complications
    David Sacerdoti
    University of Padova, Department of Clinical and Experimental Medicine, Italy
    Curr Neurovasc Res 2:103-11. 2005
    ..These results imply that expression of HO-1 in G0/G1 cells may be a key player in decreasing cellular heme, associated with increased generation of bilirubin, and in attenuating glucose mediated oxidative stress...
  55. ncbi D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes
    Adam L Kruger
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circulation 111:3126-34. 2005
    ....
  56. ncbi Role of human heme oxygenase-1 in attenuating TNF-alpha-mediated inflammation injury in endothelial cells
    Taketoshi Kushida
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    J Cell Biochem 87:377-85. 2002
    ..These results demonstrate that overexpressing HO-1 mitigated the TNF-alpha-mediated changes in cell cycle progression and apoptosis, perhaps by a decrease in the levels of COX activity...
  57. ncbi COX-2 lack of function in hypoxia-induced ocular surface inflammation
    Michal Laniado Schwartzman
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Thromb Res 110:293-8. 2003
    ..Furthermore, this study provides an explanation for the ineffectiveness of classical NSAIDs in the treatment of hypoxia-related ocular surface inflammation...
  58. ncbi Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner
    Marta Salinas
    , Facultad de Medicina, , Spain
    J Biol Chem 278:13898-904. 2003
    ..These observations indicate that the PI3K/Akt pathway controls the intracellular levels of ROS by regulating the expression of the antioxidant enzyme HO-1...
  59. ncbi CO modulates pulmonary vascular response to acute hypoxia: relation to endothelin
    Fan Zhang
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 286:H137-44. 2004
    ..These data suggest that a product of HO activity, most likely CO, inhibits hypoxia-induced pulmonary vasoconstriction by reducing ET-1 vascular levels and sensitivity...
  60. ncbi Heme oxygenase attenuates angiotensin II-mediated increase in cyclooxygenase-2 activity in human femoral endothelial cells
    Giovanni Li Volti
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Hypertension 41:715-9. 2003
    ..These results indicate that overexpression of the HO system exerts an inhibitory influence on Ang II-induced synthesis of prostaglandins by endothelial cells...
  61. ncbi Functional expression of human heme oxygenase-1 gene in renal structure of spontaneously hypertensive rats
    Alvin I Goodman
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Exp Biol Med (Maywood) 228:454-8. 2003
    ....
  62. ncbi Methods for measurements of heme oxygenase (HO) isoforms-mediated synthesis of carbon monoxide and HO-1 and HO-2 proteins
    Nader G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, NY, USA
    Methods Mol Med 86:399-411. 2003
  63. ncbi Different faces of the heme-heme oxygenase system in inflammation
    Frank A D T G Wagener
    Department of Tumor Immunology, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Pharmacol Rev 55:551-71. 2003
    ..Pre-induction of HO activity has been demonstrated to ameliorate inflammation and mediate potent resistance to oxidative injury. A better understanding of the complex heme-heme..
  64. ncbi Cyclooxygenase activity is regulated by the heme oxygenase system in microvessel endothelial cells
    Nader G Abraham
    New York Medical College, Valhalla 10595, USA
    Adv Exp Med Biol 525:59-66. 2003
  65. ncbi Heme oxygenase-1 gene expression attenuates angiotensin II-mediated DNA damage in endothelial cells
    Francesco Mazza
    Department of Medicine and Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Exp Biol Med (Maywood) 228:576-83. 2003
    ..The results presented indicated that stimulation or overexpression of HO-1 attenuated DNA damages caused by exposures of Ang II...
  66. ncbi Influence of heme and heme oxygenase-1 transfection of pulmonary microvascular endothelium on oxidant generation and cGMP
    Christopher J Mingone
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Exp Biol Med (Maywood) 228:535-9. 2003
    ..This enables heme and HO to regulate sGC through mechanisms involving NO and CO, which are normally inhibited by superoxide...
  67. ncbi Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels
    Miao Jiang
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 94:167-74. 2004
    ..We conclude that Ad-SM22-4A1 drives a smooth muscle-specific functional expression of CYP4A1 and demonstrates increased angiogenesis, presumably via increased production of 20-HETE...
  68. ncbi Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis
    Xuchen Zhang
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8057, USA
    J Biol Chem 279:10677-84. 2004
    ....
  69. ncbi Protective effect of HO-1 against oxidative stress in human hepatoma cell line (HepG2) is independent of telomerase enzyme activity
    Maivel H Ghattas
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Int J Biochem Cell Biol 34:1619-28. 2002
    ..Suppression of HO activity by SnMP decreased cell resistance to oxidant stressors without altering telomerase activity...
  70. ncbi Functional expression of human heme oxygenase-1 (HO-1) driven by HO-1 promoter in vitro and in vivo
    Shuo Quan
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    J Cell Biochem 85:410-21. 2002
    ..We hypothesize that degree of HO-1 gene expression resulted in a differential rate of cellular heme-dependent enzyme gene expression, which may play a vital role in maintaining cellular homeostasis...
  71. ncbi Carbon monoxide signaling in promoting angiogenesis in human microvessel endothelial cells
    Giovanni Li Volti
    Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, Italy
    Antioxid Redox Signal 7:704-10. 2005
    ..The addition of bilirubin did not restore angiogenesis. These data suggest that HO-mediated angiogenesis and cell proliferation were dependent on HO-1- and not HO-2-derived CO...
  72. ncbi Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes
    Saadet Turkseven
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 289:H701-7. 2005
    ..These observations in experimental diabetes suggest that the vascular cytoprotective mechanism of HO-1 against oxidative stress requires an increase in EC-SOD and catalase...
  73. ncbi Change in renal heme oxygenase expression in cyclosporine A-induced injury
    Rita Rezzani
    Department of Biomedical Sciences and Biotechnology, Division of Human Anatomy, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    J Histochem Cytochem 53:105-12. 2005
    ..The observations indicate that HO-1 downregulation and ET-1 upregulation by CsA might be one mechanism underlying CsA-induced nephrotoxicity. Therefore, attempts to preserve HO levels attenuate CsA nephrotoxicity...
  74. ncbi Augmented heme oxygenase-1 induces prostaglandin uptake via the prostaglandin transporter in micro-vascular endothelial cells
    Michael L Pucci
    Department of Pharmacology, New York Medical College, Valhalla, NY, USA
    Biochem Biophys Res Commun 323:1299-305. 2004
    ..Therefore, PG clearance via PGT may contribute to the cellular regulation of PG levels by HO-1...
  75. ncbi Retroviral IFN-alpha gene transfer combined with gemcitabine acts synergistically via cell cycle alteration in human pancreatic carcinoma cells implanted orthotopically in nude mice
    Carsten Ziske
    Medizinische Klinik und Poliklinik I, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    J Interferon Cytokine Res 24:490-6. 2004
    ..3%) compared with gemcitabine alone (62.9% +/- 7.3%) or IFN-alpha alone (24.4% +/- 5.2%) compared with untreated animals. We conclude that gemcitabine and IFN-alpha concomitantly inhibited tumor cell proliferation significantly...
  76. ncbi Differential effect of heme oxygenase-1 in endothelial and smooth muscle cell cycle progression
    Giovanni Li Volti
    Department of Medicine, New York Medical College, 10595, Valhalla, NY, USA
    Biochem Biophys Res Commun 296:1077-82. 2002
    ..Nevertheless, these findings suggest that cell-specific targeting of HO-1 expression may provide a novel therapeutic strategy for the treatment of cardiovascular diseases...
  77. ncbi Transfection and functional expression of CYP4A1 and CYP4A2 using bicistronic vectors in vascular cells and tissues
    Ji-Shi Wang
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    J Pharmacol Exp Ther 311:913-20. 2004
    ....
  78. ncbi Angiotensin II induces carbon monoxide production in the perfused kidney: relationship to protein kinase C activation
    Ping Li
    Dept of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Renal Physiol 287:F914-20. 2004
    ..The study suggests upregulation of renal HO-1 and CO release are protagonic events in a counterregulatory mechanism that attenuates ANG II-induced renal vasoconstriction...
  79. ncbi Heme oxygenase-1 gene expression modulates angiotensin II-induced increase in blood pressure
    Liming Yang
    Department of Pharmacology, New York Medical College, Valhalla 10595, USA
    Hypertension 43:1221-6. 2004
    ....
  80. ncbi Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells
    Lucia Malaguarnera
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Int J Mol Med 10:433-40. 2002
    ..Our results demonstrated for the first time, that prolactin-mediated angiogenesis and cell proliferation was dependent on HO-1 gene expression...
  81. ncbi Diminished heme oxygenase potentiates cell death: pyrrolidinedithiocarbamate mediates oxidative stress
    Lucia Malaguarnera
    Department of Pharmacology, New York Medical College Valhalla, New York 10595, USA
    Exp Biol Med (Maywood) 228:459-65. 2003
    ..Collectively, these results demonstrate that upregulation of HO-1 was able to attenuate the PDTC-mediated cell proliferation, but was unable to reverse the high concentration of PDTC-induced decrease in angiogenesis...

Research Grants5

  1. Oxidative Stress and Vascular HO in Diabetes
    Nader Abraham; Fiscal Year: 2007
    ..It will allow for the first time, an in-depth analysis of the function of HO-1 in vascular protection and for the development of innovative gene-targeting therapies for the treatment of type I diabetes. ..
  2. Oxidative Stress and Vascular HO in Diabetes
    Nader Abraham; Fiscal Year: 2009
    ..It will allow for the first time, an in-depth analysis of the function of HO-1 in vascular protection and for the development of innovative gene-targeting therapies for the treatment of type I diabetes. ..