Jianchang Yang

Summary

Affiliation: Nevada Cancer Institute
Country: USA

Publications

  1. pmc Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases
    Jianchang Yang
    Division of Cancer Biology, Nevada Cancer Institute, Las Vegas, Nevada 89135, USA
    J Biol Chem 287:1996-2005. 2012
  2. pmc Enhanced self-renewal of hematopoietic stem/progenitor cells mediated by the stem cell gene Sall4
    Jianchang Yang
    Department of Cancer Biology, Nevada Cancer Institute, 1 Breakthrough Way, Las Vegas, NV 89135, USA
    J Hematol Oncol 4:38. 2011
  3. pmc Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells
    Jianchang Yang
    Division of Laboratory Medicine, Nevada Cancer Institute, One Breakthrough Way, Las Vegas, NV 89135, USA
    Proc Natl Acad Sci U S A 105:19756-61. 2008
  4. pmc A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells
    Jianchang Yang
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, Nevada, USA
    PLoS ONE 5:e10766. 2010
  5. pmc SALL4 is a key regulator of survival and apoptosis in human leukemic cells
    Jianchang Yang
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, Nevada 89135, USA
    Blood 112:805-13. 2008
  6. pmc Phenotypic correction of murine hemophilia A using an iPS cell-based therapy
    Dan Xu
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, NV 89135, USA
    Proc Natl Acad Sci U S A 106:808-13. 2009
  7. pmc Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells
    Jianchang Yang
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, NV 89135, USA
    Proc Natl Acad Sci U S A 104:10494-9. 2007
  8. pmc Isolation, characterization, and in vitro propagation of infantile hemangioma stem cells and an in vivo mouse model
    Dan Xu
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, NV 89135, USA
    J Hematol Oncol 4:54. 2011
  9. ncbi Epithelial to mesenchymal transition (EMT) induced by bleomycin or TFG(b1)/EGF in murine induced pluripotent stem cell-derived alveolar Type II-like cells
    Zaida A Alipio
    Division of Laboratory Medicine, Nevada Cancer Institute, 1 Breakthrough Way, Las Vegas, NV 89135, USA
    Differentiation 82:89-98. 2011
  10. ncbi Methods for studies of protein interactions with different DNA methyltransferases
    Jianchang Yang
    Human Health and Environment Program, Desert Research Institute DRI, Las Vegas, NV, USA
    Methods Mol Biol 977:385-95. 2013

Collaborators

Detail Information

Publications11

  1. pmc Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases
    Jianchang Yang
    Division of Cancer Biology, Nevada Cancer Institute, Las Vegas, Nevada 89135, USA
    J Biol Chem 287:1996-2005. 2012
    ..Furthermore, DNMTs and histone deacetylase repressors synergistically contribute to the regulatory effects of SALL4. These findings provide new insights into stem cell self-renewal mediated by SALL4 via epigenetic machinery...
  2. pmc Enhanced self-renewal of hematopoietic stem/progenitor cells mediated by the stem cell gene Sall4
    Jianchang Yang
    Department of Cancer Biology, Nevada Cancer Institute, 1 Breakthrough Way, Las Vegas, NV 89135, USA
    J Hematol Oncol 4:38. 2011
    ..The purpose of the current study is to further evaluate how Sall4 may affect HSC/HPC activities in a murine system...
  3. pmc Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells
    Jianchang Yang
    Division of Laboratory Medicine, Nevada Cancer Institute, One Breakthrough Way, Las Vegas, NV 89135, USA
    Proc Natl Acad Sci U S A 105:19756-61. 2008
    ..This suggests that Sall4 plays a diverse role in regulating stem cell pluripotency during early embryonic development through integration of transcriptional and epigenetic controls...
  4. pmc A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells
    Jianchang Yang
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, Nevada, USA
    PLoS ONE 5:e10766. 2010
    ..To date, little is known about the molecular mechanisms controlling the regulation of expressions of SALL4 or other SALL gene family members...
  5. pmc SALL4 is a key regulator of survival and apoptosis in human leukemic cells
    Jianchang Yang
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, Nevada 89135, USA
    Blood 112:805-13. 2008
    ..In addition, NB4 cells that express low levels of SALL4 have significantly decreased tumorigenecity in immunodeficient mice. Our studies provide a foundation in the development of leukemia stem cell-specific therapy by targeting SALL4...
  6. pmc Phenotypic correction of murine hemophilia A using an iPS cell-based therapy
    Dan Xu
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, NV 89135, USA
    Proc Natl Acad Sci U S A 106:808-13. 2009
    ..Our studies provide additional evidence that iPS cell therapy may be able to treat human monogenetic disorders in the future...
  7. pmc Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells
    Jianchang Yang
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, NV 89135, USA
    Proc Natl Acad Sci U S A 104:10494-9. 2007
    ..An increase in histone H3-K4 and H3-K79 methylation within the Bmi-1 promoter provides an epigenetic mechanism for histone modifications in SALL4-mediated Bmi-1 gene deregulation...
  8. pmc Isolation, characterization, and in vitro propagation of infantile hemangioma stem cells and an in vivo mouse model
    Dan Xu
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, NV 89135, USA
    J Hematol Oncol 4:54. 2011
    ..The development of an in vitro cell culture system and an animal model would allow new insights into the biological processes involved in the development and pathogenesis of IH...
  9. ncbi Epithelial to mesenchymal transition (EMT) induced by bleomycin or TFG(b1)/EGF in murine induced pluripotent stem cell-derived alveolar Type II-like cells
    Zaida A Alipio
    Division of Laboratory Medicine, Nevada Cancer Institute, 1 Breakthrough Way, Las Vegas, NV 89135, USA
    Differentiation 82:89-98. 2011
    ..These cells provide a valuable tool for screening of agents that can potentially ameliorate or prevent diseases involving lung fibrosis...
  10. ncbi Methods for studies of protein interactions with different DNA methyltransferases
    Jianchang Yang
    Human Health and Environment Program, Desert Research Institute DRI, Las Vegas, NV, USA
    Methods Mol Biol 977:385-95. 2013
    ..Though one mammalian cell is described, investigators can use the same method with other cell lines or primary cells for in vivo protein interaction studies...
  11. doi Role of SALL4 in hematopoiesis
    Jianchang Yang
    Department of Pathology, The State University of New York at Stony Brook, Stony Brook, New York, USA
    Curr Opin Hematol 19:287-91. 2012
    ..In this review we attempt to summarize SALL4 roles for normal hematopoiesis, and how the knowledge obtained can be used to develop advanced cell therapies...