G B Stefano

Summary

Affiliation: Neuroscience Research Institute
Country: USA

Publications

  1. ncbi request reprint Integrative medical therapy: examination of meditation's therapeutic and global medicinal outcomes via nitric oxide (review)
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 16:621-30. 2005
  2. ncbi request reprint Morphine modulation of the ubiquitin-proteasome complex is neuroprotective
    Suraj Rambhia
    Neuroscience Research Institute, State University of New York Old Westbury, Old Westbury NY 11568, USA
    Med Sci Monit 11:BR386-96. 2005
  3. ncbi request reprint Homeopathic ethanol
    Richard M Kream
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 14:SC11-3. 2008
  4. pmc Opioid peptides and opiate alkaloids in immunoregulatory processes
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, USA
    Arch Med Sci 6:456-60. 2010
  5. pmc Interactive effects of endogenous morphine, nitric oxide, and ethanol on mitochondrial processes
    Richard M Kream
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY, USA
    Arch Med Sci 6:658-62. 2010
  6. pmc Convergent dysregulation of frontal cortical cognitive and reward systems in eating disorders
    George B Stefano
    Center for Molecular and Cognitive Neuroscience, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Med Sci Monit 19:353-8. 2013
  7. pmc Low dose morphine adjuvant therapy for enhanced efficacy of antipsychotic drug action: potential involvement of endogenous morphine in the pathophysiology of schizophrenia
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 18:HY23-6. 2012
  8. ncbi request reprint Endogenous morphine: up-to-date review 2011
    G B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, 11568, USA
    Folia Biol (Praha) 58:49-56. 2012
  9. ncbi request reprint Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution (Review)
    George B Stefano
    Neuroscience Research Institute, SUNY College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 20:837-41. 2007
  10. ncbi request reprint A hormonal role for endogenous opiate alkaloids: vascular tissues
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    Neuro Endocrinol Lett 23:21-6. 2002

Research Grants

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Integrative medical therapy: examination of meditation's therapeutic and global medicinal outcomes via nitric oxide (review)
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 16:621-30. 2005
    ..We conclude that constitutive nitric oxide may crucially contribute to potentially beneficial outcomes and effects in diverse pathologies, exerting a global healing effect...
  2. ncbi request reprint Morphine modulation of the ubiquitin-proteasome complex is neuroprotective
    Suraj Rambhia
    Neuroscience Research Institute, State University of New York Old Westbury, Old Westbury NY 11568, USA
    Med Sci Monit 11:BR386-96. 2005
    ....
  3. ncbi request reprint Homeopathic ethanol
    Richard M Kream
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 14:SC11-3. 2008
    ..Perturbation of this subtle regulatory relationship by exogenous intake of ethanol may shed light on the biochemical and molecular bases of reward and addictive states...
  4. pmc Opioid peptides and opiate alkaloids in immunoregulatory processes
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, USA
    Arch Med Sci 6:456-60. 2010
    ..Among them the recently identified, opioid insensitive µ(3) receptor deserves attention on account of its specificity for opiate alkaloids...
  5. pmc Interactive effects of endogenous morphine, nitric oxide, and ethanol on mitochondrial processes
    Richard M Kream
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY, USA
    Arch Med Sci 6:658-62. 2010
    ..Basic physiological processes involving "morphinergic"/NO-coupled regulation of cardiovascular mitochondrial function, with special emphasis on the interactive effects of ethanol, are discussed within the context of our review...
  6. pmc Convergent dysregulation of frontal cortical cognitive and reward systems in eating disorders
    George B Stefano
    Center for Molecular and Cognitive Neuroscience, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Med Sci Monit 19:353-8. 2013
    ..g., autism spectrum disorders and Parkinson's disease) and co-morbid eating disorders to elucidate basic mechanisms involving dopaminergic transmission and its regulation by endogenously expressed morphine in these same cortical regions...
  7. pmc Low dose morphine adjuvant therapy for enhanced efficacy of antipsychotic drug action: potential involvement of endogenous morphine in the pathophysiology of schizophrenia
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 18:HY23-6. 2012
    ....
  8. ncbi request reprint Endogenous morphine: up-to-date review 2011
    G B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, 11568, USA
    Folia Biol (Praha) 58:49-56. 2012
    ..The implications of endogenous morphine coupling to nitric oxide regulation of mitochondrial function, with special reference to the cardiovascular system, are now formulated after many years of neglect...
  9. ncbi request reprint Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution (Review)
    George B Stefano
    Neuroscience Research Institute, SUNY College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 20:837-41. 2007
    ....
  10. ncbi request reprint A hormonal role for endogenous opiate alkaloids: vascular tissues
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    Neuro Endocrinol Lett 23:21-6. 2002
    ..With this in mind, morphine and other endogenous opiate alkaloids may function as a hormone...
  11. ncbi request reprint Endogenous opiates, opioids, and immune function: evolutionary brokerage of defensive behaviors
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Semin Cancer Biol 18:190-8. 2008
    ..Finally, structural similarities between the intracellular domains of mu3 opiate receptors and chemokine receptors CCR2 and CCR5 provide an additional chemical basis for these contentions...
  12. pmc Endogenous morphine/nitric oxide-coupled regulation of cellular physiology and gene expression: implications for cancer biology
    George B Stefano
    Neuroscience Research Institute, State University of New York SUNY College at Old Westbury, P O Box 210, Old Westbury, NY 11568, USA
    Semin Cancer Biol 18:199-210. 2008
    ..Thus, it would appear that morphinergic signaling has inserted itself in many processes taking a long time to evolve, including those regulating the proliferation of cells across diverse phyla...
  13. ncbi request reprint Endocannabinoids as autoregulatory signaling molecules: coupling to nitric oxide and a possible association with the relaxation response
    George B Stefano
    The Mind Body Medical Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Med Sci Monit 9:RA63-75. 2003
    ..e, norepinephrine. Here, a possible association of NO and endocannabinoid signaling with the relaxation response, a physiological counterpart of the stress response, may exist...
  14. doi request reprint The presence of endogenous morphine signaling in animals
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, P O Box 210, Old Westbury, NY 11568, USA
    Neurochem Res 33:1933-9. 2008
    ....
  15. ncbi request reprint Xenobiotic perturbation of endogenous morphine signaling: paradoxical opiate hyperalgesia
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury NY 11568, USA
    Med Sci Monit 15:RA107-10. 2009
    ....
  16. ncbi request reprint The blueprint for stress can be found in invertebrates
    George B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 23:85-93. 2002
    ..Thus, it would appear that these responses evolved first in simpler organisms and were then maintained and enhanced during evolution...
  17. ncbi request reprint Estrogen signaling at the cell surface coupled to nitric oxide release in Mytilus edulis nervous system
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, New York 11568, USA
    Endocrinology 144:1234-40. 2003
    ..In summary, our results suggest that a physiological dose of estrogen acutely stimulates NO release within pedal ganglia via an estrogen cell surface receptor...
  18. ncbi request reprint Cyclic nitric oxide release by human granulocytes, and invertebrate ganglia and immunocytes: nano-technological enhancement of amperometric nitric oxide determination
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568 0210, USA
    Med Sci Monit 8:BR199-204. 2002
    ..Various tissues from vertebrates and invertebrates respond to external signal molecules by rapid release of nitric oxide (NO) mediated by constitutive nitric oxide synthase...
  19. ncbi request reprint Nicotine, alcohol and cocaine coupling to reward processes via endogenous morphine signaling: the dopamine-morphine hypothesis
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 13:RA91-102. 2007
    ..Additionally, addictive drugs are capable of directly acting on reward pathways, now, in part, via endogenous morphine processes...
  20. ncbi request reprint Communication between animal cells and the plant foods they ingest: phyto-zooidal dependencies and signaling (Review)
    George B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, NY 11568, USA
    Int J Mol Med 10:413-21. 2002
    ....
  21. ncbi request reprint Music as an aid in the development of the social self
    Elliott Salamon
    The Long Island Conservatory, Albertson, NY, USA
    Med Sci Monit 8:SR35-8. 2002
    ..Specifically we propose that participation in musical or band related activities aids in the emergence of adolescence independence and a healthy self concept...
  22. ncbi request reprint Relaxation: molecular and physiological significance
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 12:HY21-31. 2006
    ..We conclude that enough scientific information exists to support these phenotmena as actual physical processes that can be harnessed to provide better patient care...
  23. ncbi request reprint Morphine enhances nitric oxide release in the mammalian gastrointestinal tract via the micro(3) opiate receptor subtype: a hormonal role for endogenous morphine
    G B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    J Physiol Pharmacol 55:279-88. 2004
    ..Taken together, we surmise morphine acts as a hormone to limit gut activity via micro(3) coupled to NO release since micro opiate receptors are found in the gut and endogenous morphine is not but is found in blood...
  24. ncbi request reprint Pain, immunity, opiate and opioid compounds and health
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Med Sci Monit 11:MS47-53. 2005
    ..Thus, morphine down regulates immune processes in addiction, an action/function that it appears to normally perform when the situation calls for this action and by so doing in this natural setting, sustains life...
  25. ncbi request reprint Regulation of various genes in human leukocytes acutely exposed to morphine: expression microarray analysis
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Med Sci Monit 11:MS35-42. 2005
    ..This novel micro receptor is selective for the opiate alkaloid morphine, since this receptor does not bind other opioid peptides...
  26. ncbi request reprint Revisiting tolerance from the endogenous morphine perspective
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 15:RA189-98. 2009
    ..In other words, we become satisfied with sex, food, pleasure for the moment and disinterest creeps in until the "urges" return...
  27. ncbi request reprint Role of amygdala in mediating sexual and emotional behavior via coupled nitric oxide release
    Elliott Salamon
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, New York 11568, USA
    Acta Pharmacol Sin 26:389-95. 2005
    ..We begin with a brief anatomical and functional review of amygdalar function, and then proceed to demonstrate its relationship with NO...
  28. ncbi request reprint Nitric oxide modulates microglial activation
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, U S A
    Med Sci Monit 10:BR17-22. 2004
    ..Little is known about the processes in neural tissues, which stabilize microglia. This study attempts to answer this question by demonstrating a role for basal NO in maintaining microglia juxtaposed to neurons...
  29. ncbi request reprint Immunocytes modulate ganglionic nitric oxide release which later affects their activity level
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Neuro Endocrinol Lett 25:57-61. 2004
    ....
  30. ncbi request reprint 17-beta estradiol down regulates ganglionic microglial cells via nitric oxide release: presence of an estrogen receptor beta transcript
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    Neuro Endocrinol Lett 24:130-6. 2003
    ..We also demonstrated the presence of estrogen signaling in Mytilus edulis ganglia. In the present report, we sought to determine a function for these ganglionic estrogen receptors, transcending a reproductive role for estrogen...
  31. ncbi request reprint Music alters constitutively expressed opiate and cytokine processes in listeners
    George B Stefano
    Long Island Conservatory, Albertson, NY, U S A
    Med Sci Monit 10:MS18-27. 2004
    ..Although these effects are robust, little research has been conducted into exploring the underlying neurochemical changes, which must occur to provide an individual with these objective sensations...
  32. pmc Reciprocal regulation of cellular nitric oxide formation by nitric oxide synthase and nitrite reductases
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Med Sci Monit 17:RA221-6. 2011
    ..The profound implications of a reciprocal regulatory mechanism responsible for cytosolic and mitochondrial NO production are discussed below...
  33. ncbi request reprint Proinflammation and preconditioning protection are part of a common nitric oxide mediated process
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 16:RA125-30. 2010
    ..Simultaneously, preconditioning protection counter-intuitively may rely on the same molecular process involving nitric oxide as a chemical messenger...
  34. ncbi request reprint Dopamine, morphine, and nitric oxide: an evolutionary signaling triad
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, USA
    CNS Neurosci Ther 16:e124-37. 2010
    ..Our compelling hypothesis promises to initiate the reexamination of clinical studies, adding new information and treatment modalities in biomedicine...
  35. ncbi request reprint Anticipatory stress response: a significant commonality in stress, relaxation, pleasure and love responses
    George B Stefano
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Med Sci Monit 14:RA17-21. 2008
    ..Therefore, love and relaxation responses may be considered as intrinsic health promoting physiological capabilities...
  36. ncbi request reprint Estradiol coupling to human monocyte nitric oxide release is dependent on intracellular calcium transients: evidence for an estrogen surface receptor
    G B Stefano
    Neuroscience Research Institute, State University of New York, Old Westbury 11568, USA
    J Immunol 163:3758-63. 1999
    ..Taken together, a physiological dose of estrogen acutely stimulates NO release from human monocytes via the activation of an estrogen surface receptor that is coupled to increases in intracellular calcium...
  37. ncbi request reprint Macrophage behavior associated with acute and chronic exposure to HIV GP120, morphine and anandamide: endothelial implications
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York College at Old Westbury, 11568, USA
    Int J Cardiol 64:S3-13. 1998
    ..Thus. the chemokinetic inducing activities of these agents may be the basis for excitotoxin liberation in neural tissues and/or a higher viral load in various organ systems since cellular adherence and random migration are stimulated...
  38. ncbi request reprint Morphine- and anandamide-stimulated nitric oxide production inhibits presynaptic dopamine release
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Brain Res 763:63-8. 1997
    ..We postulate that cannabinoids and their endogenous effectors play a prominent role in the regulation of catecholamine release in invertebrates via NO release as is the case for opiate alkaloids...
  39. ncbi request reprint Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation
    G B Stefano
    Cardiac Research Program, University Medical Center, State University of New York, Stony Brook 11794, USA
    J Biol Chem 270:30290-3. 1995
    ..In conclusion, the data presented above reveal a novel site of morphine action, endothelial cells, where a mu3 receptor is coupled to nitric oxide release and vasodilation...
  40. ncbi request reprint Identification and characterization of the leech CNS cannabinoid receptor: coupling to nitric oxide release
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, 11568, USA
    Brain Res 753:219-24. 1997
    ..The presence of a cannabinoid receptor in these organisms indicates that this signaling system has been conserved during evolution...
  41. ncbi request reprint Morphine coupling to invertebrate immunocyte nitric oxide release is dependent on intracellular calcium transients
    F E Nieto-Fernandez
    Neuroscience Research Institute, State University of New York at Old Westbury 11568 0210, USA
    Comp Biochem Physiol B Biochem Mol Biol 123:295-9. 1999
    ..The opiate stimulation of [Ca2+]i- was attenuated in cells leached of calcium. strongly suggesting that intracellular calcium levels regulate cNOS activity in invertebrate immunocytes...
  42. ncbi request reprint Psychiatric implications of endogenous morphine: up-to-date review
    R M Kream
    Neuroscience Research Institute, State University of New York at Old Westbury, New York 11568, USA
    Folia Biol (Praha) 56:231-41. 2010
    ....
  43. ncbi request reprint 2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Pharmacol Res 42:317-22. 2000
    ..Taken together these results indicate that 2-AG exerts immune and vascular actions similar to those observed with anandamide...
  44. ncbi request reprint Nociceptin, endomorphin-1 and -2 do not interact with invertebrate immune and neural mu 3 opiate receptor
    C M Rialas
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568 0210, USA
    Acta Pharmacol Sin 21:516-20. 2000
    ..To determine if endomorphin-1, -2 and nociceptin (orphanin FQ) bind to the mu 3 opiate receptor subtype or release nitric oxide as mu 3 selective ligands do...
  45. ncbi request reprint Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: autocrine/paracrine feedback inhibition
    Kirk J Mantione
    Neuroscience Research Institute, State University of New York College at Old Westbury, 11568, USA
    Addict Biol 13:118-23. 2008
    ..Taken together, it appears that morphine has the ability to modulate its own synthesis via autocrine and paracrine signaling...
  46. ncbi request reprint Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues
    G B Stefano
    Multidisciplinary Center for the Study of Aging, Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568 0210, USA
    Brain Res 793:341-5. 1998
    ..2+/-1.3 nM to 8.6+/-2.1 nM. Taken together, the results indirectly demonstrate the presence of anandamide amidase in these tissues, suggesting that the enzyme may serve as an endogenous regulator of anandamide action...
  47. ncbi request reprint Cholinergic regulation of morphine release from human white blood cells: evidence for a novel nicotinic receptor via pharmacological and microarray analysis
    W Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Immunopathol Pharmacol 20:229-37. 2007
    ..The number of variants suggests that indeed a novel nicotinic receptor may be mediating this effect, while simultaneously demonstrating the significance of the cholinergic receptor expression in these immune cells...
  48. ncbi request reprint Cell behavior and signal molecule involvement in a case study of malignant histiocytosis: a negative model of morphine as an immunoregulator
    G L Fricchione
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Hematol 56:197-205. 1997
    ..Additionally, the data indicate that MCSF deregulation may be involved as an initiating factor for this disorder...
  49. ncbi request reprint The presence of morphine in ganglionic tissues of Modiolus deminissus: a highly sensitive method of quantitation for morphine and its derivatives
    Y Goumon
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Brain Res Mol Brain Res 86:184-8. 2001
    ..Furthermore, both morphine and morphine-6-glucuronide were identified in this mollusk's pedal ganglia by mass spectrometry analysis...
  50. ncbi request reprint Presence of endogenous morphine and morphine 6 glucuronide in human heart tissue
    W Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 7:419-22. 2001
    ..14 da) yields morphine (286.14 Da) obtained from the heart tissues and with the authentic material, further demonstrating the presence of endogenous morphine. Thus, vascular tissues appear to contain endogenous opiate alkaloids...
  51. ncbi request reprint Cell surface estrogen receptors coupled to cNOS mediate immune and vascular tissue regulation: therapeutic implications
    G B Stefano
    Neuroscience Research Institute, State University of New York Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 7:1066-74. 2001
    ....
  52. ncbi request reprint Real-time RT-PCR measurement of the modulation of Mu opiate receptor expression by nitric oxide in human mononuclear cells
    P Cadet
    Neuroscience Research Institute, State University of New York at Old Westbury, New York 11568-0210, USA
    Med Sci Monit 7:1123-8. 2001
    ..CONCLUSIONS: This study confirms that human mononuclear cells express the mu opiate receptor transcript and demonstrates that nitric oxide is involved in regulation of its expression...
  53. ncbi request reprint Invertebrate opiate immune and neural signaling
    George B Stefano
    Neuroscience Research Institute, State University of New York, Old Westbury, USA
    Adv Exp Med Biol 521:126-47. 2003
  54. ncbi request reprint The stress response and autoimmunoregulation
    G L Fricchione
    Division of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Adv Neuroimmunol 4:13-27. 1994
    ..The study of immunocyte behavior in certain clinical conditions associated with a variant stress response may help illuminate the functioning of the neuroendocrine-neuroimmune stress response system...
  55. ncbi request reprint HIV gp120 and morphine alter mu opiate receptor expression in human vascular endothelium
    P Cadet
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 8:165-9. 2001
    ..Therefore, the immune down-regulating action of morphine may prevent viral replication because this process requires immune activation that can, in part, be provided for by gp120 proinflammatory actions...
  56. ncbi request reprint Presence of morphine and morphine-6-glucuronide in the marine mollusk Mytilus edulis ganglia determined by GC/MS and Q-TOF-MS. Starvation increases opiate alkaloid levels
    W Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Brain Res Mol Brain Res 88:155-60. 2001
    ..These new method of opiate alkaloid detection, conclusively proves that morphine and morphine-6-glucuronide are present in animal tissues...
  57. ncbi request reprint Estradiol-stimulated nitric oxide release in human granulocytes is dependent on intracellular calcium transients: evidence of a cell surface estrogen receptor
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568 0210, USA
    Blood 95:3951-8. 2000
    ..Blood. 2000;95:3951-3958)..
  58. ncbi request reprint Morphine 6 glucuronide stimulates nitric oxide release in mussel neural tissues: evidence for a morphine 6 glucuronide opiate receptor subtype
    K Mantione
    Neuroscience Research Institute, State University of New York at Old Westbury, 11568, USA
    Cell Mol Life Sci 59:570-4. 2002
    ..However, morphine exhibited a twofold higher affinity, again suggesting that a novel mu opiate receptor may be present...
  59. ncbi request reprint Endogenous morphine: opening new doors for the treatment of pain and addiction
    Stephen C Pryor
    State University of New York College at Old Westbury, Neuroscience Research Institute, Old Westbury, NY 11568, USA
    Expert Opin Biol Ther 5:893-906. 2005
    ..Taken together, a select morphinergic signalling system utilising NO opens the gate for the development of novel pharmaceuticals and/or the use of old pharmaceuticals in new ways...
  60. ncbi request reprint Morphine down regulates human vascular tissue estrogen receptor expression determined by real-time RT-PCR
    Patrick Cadet
    Neuroscience Research Institute, State University of New York at Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 23:95-100. 2002
    ..Human vascular endothelial cells express the estrogen receptor-beta (ER-beta), which can be modulated by the opiate alkaloid morphine...
  61. ncbi request reprint TENS stimulates constitutive nitric oxide release via opiate signaling in invertebrate neural tissues
    Jeanette Cheng
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 13:BR163-7. 2007
    ..An extremely promising method for treatment of low to moderate levels of chronic pain in humans is transcutaneous electrical nerve stimulation (TENS)...
  62. ncbi request reprint Placebo neural systems: nitric oxide, morphine and the dopamine brain reward and motivation circuitries
    Gregory Fricchione
    Department of Psychiatry, Division of Psychiatry and Medicine, Massachusetts General Hospital, Boston, 02114, USA
    Med Sci Monit 11:MS54-65. 2005
    ..In addition, mesolimbic/mesocortical control of the stress response systems may provide a way for the placebo response to benefit other medical conditions...
  63. ncbi request reprint Endogenous morphinergic signaling and tumor growth
    Patrick Cadet
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Front Biosci 9:3176-86. 2004
    ..This review will focus on the influence of opiate alkaloids, e.g., morphine, on tumor growth, with emphasis on immuno-regulatory and antiproliferative mechanisms...
  64. ncbi request reprint Basal nitric oxide limits immune, nervous and cardiovascular excitation: human endothelia express a mu opiate receptor
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, 11568 0210, USA
    Prog Neurobiol 60:513-30. 2000
    ..Taken together, cNOS derived NO enhances basal NO actions, i.e., cellular activation state, and these actions are further enhanced by iNOS derived NO...
  65. ncbi request reprint Dracunculus medinensis and Schistosoma mansoni contain opiate alkaloids
    W Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Ann Trop Med Parasitol 96:309-16. 2002
    ....
  66. ncbi request reprint Nitric oxide inhibits norepinephrine stimulated contraction of human internal thoracic artery and rat aorta
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, Westbury NY, 11568, USA
    Pharmacol Res 43:199-203. 2001
    ....
  67. ncbi request reprint The biochemical substrate of nitric oxide signaling is present in primitive non-cognitive organisms
    George B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Brain Res 924:82-9. 2002
    ..We conclude that basal nitric oxide functioning was established in these organisms and that this molecule was later employed in man, including its involvement in cognitive neural processes...
  68. ncbi request reprint The American lobster, Homarus americanus, contains morphine that is coupled to nitric oxide release in its nervous and immune tissues: Evidence for neurotransmitter and hormonal signaling
    Federico M Casares
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 26:89-97. 2005
    ..In this regard, it was also important to determine if lobster immune and neural tissues express the mu opiate receptor subtype, which was coupled to constitutive nitric oxide synthase derived nitric oxide release...
  69. ncbi request reprint Alcohol-, nicotine-, and cocaine-evoked release of morphine from invertebrate ganglia: model system for screening drugs of abuse
    Wei Zhu
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 12:BR155-61. 2006
    ..We hypothesized that invertebrate neural systems may serve as models by which to evaluate the interactive pharmacological effects of these agents...
  70. ncbi request reprint Opiate alkaloids and nitric oxide production in the nematode Ascaris suum
    Wei Zhu
    State University of New York, Old Westbury Neuroscience Research Institute, P O Box 210, Old Westbury, New York 11568, USA
    J Parasitol 90:15-22. 2004
    ..This suggests that a novel mu opiate receptor was possibly present and selective toward M6G...
  71. ncbi request reprint Presence of reticuline in rat brain: a pathway for morphine biosynthesis
    Wei Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Brain Res Mol Brain Res 117:83-90. 2003
    ..This finding adds information which suggests that morphine biosynthesis may occur in rat neural tissues, and that its biosynthesis pathway may be similar to that reported in the poppy plant...
  72. ncbi request reprint The nongenomic protective effects of estrogen on the male cardiovascular system: clinical and therapeutic implications in aging men
    John J Cho
    Neuroscience Research Institute State University of New York Old Westbury, Old Westbury, NY 11568 0210, USA
    Med Sci Monit 9:RA63-8. 2003
    ..Therapeutic strategies to preserve basal nitric oxide levels through the maintenance of normal physiological estradiol levels may confer cardiovascular benefits to aging males...
  73. ncbi request reprint Ischemic preconditioning - an opiate constitutive nitric oxide molecular hypothesis
    G B Stefano
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    Med Sci Monit 7:1357-75. 2001
    ..In conclusion, it appears as though endogenous nitric oxide stimulators offer their selective preconditioning protection by joining an already existing process that limits activation following normal physical exertion...
  74. ncbi request reprint Cold stress alters Mytilus edulis pedal ganglia expression of mu opiate receptor transcripts determined by real-time RT-PCR and morphine levels
    Patrick Cadet
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Brain Res Mol Brain Res 99:26-33. 2002
    ..This study provides further evidence that mu-type opiate receptors and morphine are expressed in mollusk ganglia and appear to be involved in physiological processes responding to thermal stress...
  75. ncbi request reprint Endogenous morphine and nitric oxide coupled regulation of mitochondrial processes
    Richard M Kream
    Neuroscience Research Institute, State University of New York, College at Old Westbury, NY 11568, USA
    Med Sci Monit 15:RA263-8. 2009
    ..Critical to this concept may be the phenomenon of mitochondrial enslavement in eukaryotic evolution via morphine...
  76. ncbi request reprint Identification of a µ opiate receptor signaling mechanism in human placenta
    Kirk J Mantione
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY, USA
    Med Sci Monit 16:BR347-52. 2010
    ..We determined if a µ opiate receptor was present and which subtype was expressed in human placenta. We also sought to demonstrate a functional µ opiate receptor in human placenta...
  77. doi request reprint Comparative aspects of endogenous morphine synthesis and signaling in animals
    Wei Zhu
    Neuroscience Research Institute, College at Old Westbury, State University of New York, Old Westbury, New York, USA
    Ann N Y Acad Sci 1163:330-9. 2009
    ....
  78. ncbi request reprint Alcohol-, nicotine-, and cocaine-evoked release of morphine from human white blood cells: substances of abuse actions converge on endogenous morphine release
    Wei Zhuu
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 12:BR350-4. 2006
    ..Furthermore, invertebrate neural tissues incubated with ethanol, cocaine, or nicotine results in a statistically significant enhancement of labeled morphine release. We now demonstrate that this also occurs with human WBC...
  79. ncbi request reprint Cholinergic regulation of endogenous morphine release from lobster nerve cord
    Wei Zhu
    Neuroscience Research Institute, State University of New York College at Old Westbury, P O Box 210, Old Westbury, NY 11568, USA
    Med Sci Monit 12:BR295-301. 2006
    ..Thus, invertebrate nervous tissue preparations can be used as predictive model systems by which to evaluate underlying pharmacological mechanisms of addictive processes...
  80. ncbi request reprint Pain and relaxation (review)
    Elliott Salamon
    Neuroscience Research Institute, State University of New York at Old Westbury, NY 11568, USA
    Int J Mol Med 18:465-70. 2006
    ..We further propose a new paradigm which links pain, endogenous opiates, and the catecholamines in a unique robust fashion demonstrating a complex symbiotic signaling system...
  81. ncbi request reprint Morphine regulates gill ciliary activity via coupling to nitric oxide release in a bivalve mollusk: opiate receptor expression in gill tissues
    Kirk J Mantione
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 12:BR195-200. 2006
    ..We hypothesized that morphinergic signaling may also take place in Mytilus edulis gill since they are innervated, in part, with dopamine nerves...
  82. ncbi request reprint Effects of cold stress on morphine-induced nitric oxide production and mu-opiate receptor gene expression in Mytilus edulis pedal ganglia
    Kirk Mantione
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Neuro Endocrinol Lett 24:68-72. 2003
    ..edulis ganglionic mu receptors exposed to morphine was coupled to the immediate release nitric oxide (NO). In this study, we measured morphine-induced NO release in M. edulis subjected to acute cold stress...
  83. ncbi request reprint Differential expression of the human mu opiate receptor from different primary vascular endothelial cells
    Patrick Cadet
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    Med Sci Monit 10:BR351-5. 2004
    ..This novel mu receptor has been shown to be selective for opiate alkaloids, insensitive to opioid peptides, and also is coupled to constitutive nitric oxide release...
  84. ncbi request reprint The placebo effect and relaxation response: neural processes and their coupling to constitutive nitric oxide
    G B Stefano
    The Mind Body Medical Institute, CareGroup, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 02115, Boston, MA, USA
    Brain Res Brain Res Rev 35:1-19. 2001
    ..In closing, we conclude that enough scientific information exists to support these phenomena as actual physical processes that can be harnessed to provide better patient care...
  85. ncbi request reprint Converging cellular processes for substances of abuse: endogenous morphine
    Wei Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 29:63-6. 2008
    ....
  86. ncbi request reprint Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: cyp2d6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling
    Wei Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, New York 11568, USA
    Med Sci Monit 11:BR397-404. 2005
    ..Studies have demonstrated that animals do contain morphine precursors and metabolites, as well as the ability to use some morphine precursors to make morphine...
  87. ncbi request reprint Reticuline exposure to invertebrate ganglia increases endogenous morphine levels
    Wei Zhu
    Neuroscience Research Institute, State University of New York College at Old Westbury, NY 11568, USA
    Neuro Endocrinol Lett 25:323-30. 2004
    ....
  88. ncbi request reprint Human white blood cells synthesize morphine: CYP2D6 modulation
    Wei Zhu
    Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, NY 11568, USA
    J Immunol 175:7357-62. 2005
    ..3) WBC can release morphine into the environment to regulate themselves and other cells, suggesting involvement in autocrine signaling since these cells express the mu3 opiate receptor subtype...
  89. ncbi request reprint Cyclic exercise induces anti-inflammatory signal molecule increases in the plasma of Parkinson's patients
    Patrick Cadet
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 12:485-92. 2003
    ....
  90. ncbi request reprint Vascular pulsations stimulating nitric oxide release during cyclic exercise may benefit health: a molecular approach (review)
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury, Old Westbury, NY 11568, USA
    Int J Mol Med 7:119-29. 2001
    ..We conclude that mild exercise represents an alternate and economical therapy to preserve health and/or diminish the rate of decline of the normal physiological processes that may even be associated with aging...
  91. ncbi request reprint The presence of the mu3 opiate receptor in invertebrate neural tissues
    G B Stefano
    Neuroscience Research Institute, State University of New York at Old Westbury 11568, USA
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 113:369-73. 1996
    ..This view is supported by additional data, in particular the demonstration of endogenous morphine in nervous tissue and its localization within distinct neurons...
  92. ncbi request reprint Risk factors for breast cancer and the prognosis of African American women: estrogen's role
    Dolisha A Jones
    Neuroscience Research Institute, State University of New York College at Old Westbury, U S A
    Med Sci Monit 9:RA111-9. 2003
    ..By determining the relative concentration of estrogen and related proteins within black and white populations we hope to better understand the above mentioned disparity...
  93. ncbi request reprint Presence of morphine in rat amygdala: evidence for the mu3 opiate receptor subtype via nitric oxide release in limbic structures
    Wei Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Med Sci Monit 10:BR433-9. 2004
    ..We, and others, have also demonstrated the presence of opiate alkaloids as endogenous substances in various nerve tissues taken from mammals, man and invertebrates...
  94. ncbi request reprint The presence of 17-beta estradiol in Mytilus edulis gonadal tissues: evidence for estradiol isoforms
    Wei Zhu
    Neuroscience Institute, State University of New York College at Old Westbury, Old Westbury, New York 11568, USA
    Neuro Endocrinol Lett 24:137-40. 2003
    ..We further demonstrated this phenomenon in the marine mussel Mytilus edulis ganglionic tissues. In the present report we sought to determine if estrogen can be found in M. edulis reproductive tissues...
  95. ncbi request reprint Persistence of evolutionary memory: primordial six-transmembrane helical domain mu opiate receptors selectively linked to endogenous morphine signaling
    Richard M Kream
    Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY 11568 0210, USA
    Med Sci Monit 13:SC5-6. 2007
    ....
  96. ncbi request reprint Norlaudanosoline and nicotine increase endogenous ganglionic morphine levels: nicotine addiction
    Wei Zhu
    Neuroscience Research Institute, State University of New York, College at Old Westbury, P O Box 210, Old Westbury, New York 11568, USA
    Cell Mol Neurobiol 26:1037-45. 2006
    ..5. We surmise that norlaudanosoline is being converted to morphine, demonstrating that invertebrate neural tissue can synthesize morphine...
  97. ncbi request reprint The therapeutic use of the relaxation response in stress-related diseases
    Tobias Esch
    The Mind Body Medical Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Med Sci Monit 9:RA23-34. 2003
    ..Further studies are necessary to elucidate the complex physiology underlying the RR and its impact upon stress-related disease states...
  98. ncbi request reprint Neuroimmunologic influences in neuropsychiatric and psychophysiologic disorders
    G Fricchione
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Acta Pharmacol Sin 22:577-87. 2001
    ..This may provide new strategies for pharmacologic anti inflammatory treatments. The monocyte /macrophage, which crosses the blood brain barrier is an essential candidate cell in the study of psychoneuroimmunology...
  99. ncbi request reprint Mu3 opiate receptor expression in lung and lung carcinoma: ligand binding and coupling to nitric oxide release
    C Fimiani
    Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, USA
    Cancer Lett 146:45-51. 1999
    ..Our findings identify a unique role for the mu3 opiate receptor in opiate-mediated NO release and suggest that endogenous opiates, through their release of NO, may play a role in cancer progression...
  100. ncbi request reprint Variations in critical morphine biosynthesis genes and their potential to influence human health
    Kirk Mantione
    St Elizabeth s University College of Health and Social Sciences, School of Public Health, Clinical Medicine Program, Bratislava, Slovakia
    Neuro Endocrinol Lett 31:11-8. 2010
    ..The presence of morphine signaling in almost all organ systems suggests that it is most likely playing a role in maintaining the health and promoting the normal functioning of these physiological systems...
  101. ncbi request reprint Immune processes in the pathogenesis of Parkinson's disease - a potential role for microglia and nitric oxide
    Anna Członkowska
    2nd Department of Neurology, Institute of Psychiatry and Neurology, Department of Clinical and Experimental Pharmacology, Medical University, Warsaw, Poland
    Med Sci Monit 8:RA165-77. 2002
    ..These observations suggest that treatment with anti-inflammatory drugs may act to slow progression of PD...

Research Grants2

  1. Old Westbury Neuroscience Research Institute MIDARP
    George Stefano; Fiscal Year: 2007
    ..abstract_text> ..
  2. Old Westbury Neuroscience Research Institute MIDARP
    George Stefano; Fiscal Year: 2008
    ..abstract_text> ..