J F Reilly

Summary

Affiliation: Neurome Inc
Country: USA

Publications

  1. pmc Importin beta-mediated nuclear import of fibroblast growth factor receptor: role in cell proliferation
    J F Reilly
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Biol 152:1307-12. 2001
  2. ncbi Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner
    J F Reilly
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 275:7771-8. 2000
  3. pmc A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction
    John F Reilly
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 366:501-10. 2002
  4. pmc Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis
    Jeffrey M Redwine
    Neurome, Incorporated, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:1381-6. 2003
  5. pmc Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model
    John F Reilly
    Neurome, Inc, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:4837-42. 2003
  6. ncbi Ligand dependent and independent internalization and nuclear translocation of fibroblast growth factor (FGF) receptor 1
    John F Reilly
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    DNA Cell Biol 23:538-48. 2004
  7. ncbi Mouse models of human neurodegenerative disorders: requirements for medication development
    Floyd E Bloom
    Neurome Inc, La Jolla, CA 92037, USA
    Arch Neurol 62:185-7. 2005
  8. ncbi High-throughput morphometric analysis of individual neurons
    Chi Cheng Wu
    Neurome, Inc, 11149 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Cereb Cortex 14:543-54. 2004
  9. ncbi Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
    Guillermo Garcia-Manero
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 111:1060-6. 2008

Research Grants

Detail Information

Publications9

  1. pmc Importin beta-mediated nuclear import of fibroblast growth factor receptor: role in cell proliferation
    J F Reilly
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Biol 152:1307-12. 2001
    ..These data are the first description of a nuclear import pathway for transmembrane growth factor receptors and elucidate a novel signal transduction pathway from the cell surface to the nucleus...
  2. ncbi Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner
    J F Reilly
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 275:7771-8. 2000
    ..These data demonstrate an interaction between activated FGFR1 and Grb14 and suggest a role for Grb14 in FGF signaling...
  3. pmc A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction
    John F Reilly
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem J 366:501-10. 2002
    ..These data suggest that, in addition to its role in isoprenoid biosynthesis, FPPS may function as a modulator of the cellular response to FGF treatment...
  4. pmc Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis
    Jeffrey M Redwine
    Neurome, Incorporated, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:1381-6. 2003
    ....
  5. pmc Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model
    John F Reilly
    Neurome, Inc, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:4837-42. 2003
    ....
  6. ncbi Ligand dependent and independent internalization and nuclear translocation of fibroblast growth factor (FGF) receptor 1
    John F Reilly
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    DNA Cell Biol 23:538-48. 2004
    ..In addition, we identified a cell cycle-dependent pathway of FGFR1 nuclear translocation that appears to be independent of ligand binding...
  7. ncbi Mouse models of human neurodegenerative disorders: requirements for medication development
    Floyd E Bloom
    Neurome Inc, La Jolla, CA 92037, USA
    Arch Neurol 62:185-7. 2005
    ..Evidence for Alzheimer disease suggests some starting requirements for the experimental data that could enhance the likelihood of developing medications in these mouse models that would also be effective in humans...
  8. ncbi High-throughput morphometric analysis of individual neurons
    Chi Cheng Wu
    Neurome, Inc, 11149 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Cereb Cortex 14:543-54. 2004
    ....
  9. ncbi Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
    Guillermo Garcia-Manero
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 111:1060-6. 2008
    ..Increased histone acetylation was observed at all doses. Antioxidant gene expression may confer vorinostat resistance. Further evaluation of vorinostat in AML/MDS is warranted...

Research Grants1

  1. Development of ASP: An Antidepressant Screening Platform
    John Reilly; Fiscal Year: 2004
    ..This screening platform will have great impact and value for pharmaceutical research and development. ..