George Fein

Summary

Affiliation: Neurobehavioral Research
Country: USA

Publications

  1. pmc Age-related gray matter shrinkage in a treatment naïve actively drinking alcohol-dependent sample
    George Fein
    Neurobehavioral Research, Inc, Honolulu, Hawaii
    Alcohol Clin Exp Res 34:175-82. 2010
  2. doi request reprint Cortical and subcortical volumes in adolescents with alcohol dependence but without substance or psychiatric comorbidities
    George Fein
    Neurobehavioral Research Inc, Honolulu, HI, United States
    Psychiatry Res 214:1-8. 2013
  3. doi request reprint Antisocial symptoms decrease to normal levels in long-term abstinence
    George Fein
    Neurobehavioral Research, Inc, Honolulu, Hawaii 96814, USA
    Alcohol Clin Exp Res 37:E271-80. 2013
  4. pmc Gait and balance deficits in chronic alcoholics: no improvement from 10 weeks through 1 year abstinence
    George Fein
    Neurobehavioral Research Inc, Honolulu, HI 96814, USA
    Alcohol Clin Exp Res 37:86-95. 2013
  5. pmc Gait and balance in treatment-naïve active alcoholics with and without a lifetime drug codependence
    George Fein
    Neurobehavioral Research, Inc, Honolulu, Hawaii 96814, USA
    Alcohol Clin Exp Res 36:1550-62. 2012
  6. pmc Borderline personality symptoms in short-term and long-term abstinent alcohol dependence
    George Fein
    Neurobehavioral Research, Inc, Honolulu, HI 96814, USA
    Alcohol Clin Exp Res 36:1188-95. 2012
  7. pmc Growth and weight status in treatment-naïve 12-16 year old adolescents with alcohol use disorders in Cape Town, South Africa
    Celeste E Naude
    Division of Human Nutrition, Stellenbosch University, South Africa
    Nutr J 10:87. 2011
  8. pmc Older adults make less advantageous decisions than younger adults: cognitive and psychological correlates
    George Fein
    Neurobehavioral Research, Inc, Corte Madera, California 94925, USA
    J Int Neuropsychol Soc 13:480-9. 2007
  9. pmc Smaller feedback ERN amplitudes during the BART are associated with a greater family history density of alcohol problems in treatment-naïve alcoholics
    George Fein
    Neurobehavioral Research, Inc, 201 Tamal Vista Boulevard, Corte Madera, CA 94925 1110, USA
    Drug Alcohol Depend 92:141-8. 2008
  10. pmc Cognitive performance in long-term abstinent elderly alcoholics
    George Fein
    Neurobehavioral Research, Inc, Corte Madera, California 94925, and Honolulu, Hawaii, USA
    Alcohol Clin Exp Res 31:1788-99. 2007

Collaborators

Detail Information

Publications49

  1. pmc Age-related gray matter shrinkage in a treatment naïve actively drinking alcohol-dependent sample
    George Fein
    Neurobehavioral Research, Inc, Honolulu, Hawaii
    Alcohol Clin Exp Res 34:175-82. 2010
    ....
  2. doi request reprint Cortical and subcortical volumes in adolescents with alcohol dependence but without substance or psychiatric comorbidities
    George Fein
    Neurobehavioral Research Inc, Honolulu, HI, United States
    Psychiatry Res 214:1-8. 2013
    ..Our lack of findings in other brain regions, particularly the hippocampus, suggests that reports of smaller brain volumes in adolescent AUDs in the literature are a consequence of psychiatric and substance abuse comorbidities...
  3. doi request reprint Antisocial symptoms decrease to normal levels in long-term abstinence
    George Fein
    Neurobehavioral Research, Inc, Honolulu, Hawaii 96814, USA
    Alcohol Clin Exp Res 37:E271-80. 2013
    ..Current antisocial symptoms were reduced to subdiagnostic levels in long-term abstinence; however, the number of current symptoms was not measured beyond its being subdiagnostic...
  4. pmc Gait and balance deficits in chronic alcoholics: no improvement from 10 weeks through 1 year abstinence
    George Fein
    Neurobehavioral Research Inc, Honolulu, HI 96814, USA
    Alcohol Clin Exp Res 37:86-95. 2013
    ..We present longitudinal data on recovery of gait and balance in alcoholics 6 to 15 weeks abstinent at baseline assessment through follow-up assessment 4 to 16 months after baseline...
  5. pmc Gait and balance in treatment-naïve active alcoholics with and without a lifetime drug codependence
    George Fein
    Neurobehavioral Research, Inc, Honolulu, Hawaii 96814, USA
    Alcohol Clin Exp Res 36:1550-62. 2012
    ..In addition, few studies have addressed the associations of codependence on other drugs with alcoholic gait and balance disturbance...
  6. pmc Borderline personality symptoms in short-term and long-term abstinent alcohol dependence
    George Fein
    Neurobehavioral Research, Inc, Honolulu, HI 96814, USA
    Alcohol Clin Exp Res 36:1188-95. 2012
    ..The literature suggests a negative synergy between BPD and SUDs, which may impact an individual's ability to achieve and maintain remission of either disorder in the face of the other...
  7. pmc Growth and weight status in treatment-naïve 12-16 year old adolescents with alcohol use disorders in Cape Town, South Africa
    Celeste E Naude
    Division of Human Nutrition, Stellenbosch University, South Africa
    Nutr J 10:87. 2011
    ..The consequences of heavy alcohol use during adolescence on nutritional status, specifically growth and weight status are largely unknown at this time...
  8. pmc Older adults make less advantageous decisions than younger adults: cognitive and psychological correlates
    George Fein
    Neurobehavioral Research, Inc, Corte Madera, California 94925, USA
    J Int Neuropsychol Soc 13:480-9. 2007
    ..Performance on the IGT was positively associated with auditory working memory and psychomotor function in young adults, and in immediate memory in older adults...
  9. pmc Smaller feedback ERN amplitudes during the BART are associated with a greater family history density of alcohol problems in treatment-naïve alcoholics
    George Fein
    Neurobehavioral Research, Inc, 201 Tamal Vista Boulevard, Corte Madera, CA 94925 1110, USA
    Drug Alcohol Depend 92:141-8. 2008
    ..We recorded F-ERNs during the BART and during a BART simulation, where individuals observed the rewards and consequences of (someone else's) BART performance...
  10. pmc Cognitive performance in long-term abstinent elderly alcoholics
    George Fein
    Neurobehavioral Research, Inc, Corte Madera, California 94925, and Honolulu, Hawaii, USA
    Alcohol Clin Exp Res 31:1788-99. 2007
    ..However, there is still a dearth of published findings on cognitive functioning in very long-term abstinence alcoholics, especially in the elderly population...
  11. pmc Psychiatric comorbidity in older long-term abstinent alcoholics
    George Fein
    Neurobehavioral Research, Inc, 2800 Woodlawn DR Ste 129, Honolulu, HI 96822 1862, USA
    Addict Behav 33:1564-71. 2008
    ..We compared these findings with our previously reported results in analogous middle-aged samples (MAA versus MNC)...
  12. pmc Increased white matter signal hyperintensities in long-term abstinent alcoholics compared with nonalcoholic controls
    George Fein
    Neurobehavioral Research, Inc, Honolulu, HI 96822 1862, USA
    Alcohol Clin Exp Res 33:70-8. 2009
    ..We hypothesized that such effects would persist into long-term abstinence, and evaluated them in middle-aged long-term abstinent alcoholics (LTAA) compared with age and gender comparable nonalcoholic controls (NAC)...
  13. pmc Parietal gray matter volume loss is related to spatial processing deficits in long-term abstinent alcoholic men
    George Fein
    Neurobehavioral Research, Inc, Honolulu, Hawaii 96814, USA
    Alcohol Clin Exp Res 33:1806-14. 2009
    ..2006)...
  14. pmc Sensation seeking in long-term abstinent alcoholics, treatment-naïve active alcoholics, and nonalcoholic controls
    George Fein
    Neurobehavioral Research, Inc, Honolulu, Hawaii 96814, USA
    Alcohol Clin Exp Res 34:1045-51. 2010
    ..In the current study, we examine sensation seeking in middle-aged long-term abstinent alcoholics (LTAA) and in younger actively drinking treatment-naïve alcoholics (TxN)...
  15. pmc Event-related potentials during visual target detection in treatment-naïve active alcoholics
    George Fein
    Neurobehavioral Research Inc, 1585 Kapiolani Blvd, Honolulu, HI 96814, USA
    Alcohol Clin Exp Res 35:1171-9. 2011
    ..We studied visual target detection in a treatment-naïve alcohol-dependent sample (TNAD) versus age and gender comparable nonalcoholic controls (NAC) to investigate whether reduced P3 amplitudes generalize to TNAD...
  16. pmc Impairment on a simulated gambling task in long-term abstinent alcoholics
    G Fein
    Neurobehavioral Research, Inc, Corte Madera, California 94925, USA
    Alcohol Clin Exp Res 28:1487-91. 2004
    ..This study expands on the current literature by using the SGT to examine decision making in long-term abstinent alcoholics (mean of 6.6 years' abstinence) who do not have antisocial personality disorder or a history of conduct disorder...
  17. pmc ERP and RT delays in long-term abstinent alcoholics in processing of emotional facial expressions during gender and emotion categorization tasks
    George Fein
    Neurobehavioral Research Inc, Berkeley, California, USA
    Alcohol Clin Exp Res 34:1127-39. 2010
    ..There is considerable evidence that alcoholics differ from nonalcoholics in the processing of stimuli that have emotional content. The current study examines those differences that are present in multi-year abstinent individuals...
  18. pmc Visual P300s in long-term abstinent chronic alcoholics
    George Fein
    Neurobehavioral Research Inc, Corte Madera, California 94925, USA
    Alcohol Clin Exp Res 30:2000-7. 2006
    ..This study examines the amplitude and latency of the P3b and P3a event-related brain electrical components in LTAAs compared with normal controls (NCs) and whether these measures are related to alcohol use and other subject variables...
  19. pmc Normal performance on a simulated gambling task in treatment-naive alcohol-dependent individuals
    George Fein
    Neurobehavioral Research, Inc, Corte Madera, California 94925, USA
    Alcohol Clin Exp Res 30:959-66. 2006
    ..This study examines decision making on the SGT in young adults with alcohol dependence who are treatment-naive (TxN)...
  20. pmc Prefrontal cortical volume reduction associated with frontal cortex function deficit in 6-week abstinent crack-cocaine dependent men
    George Fein
    Neurobehavioral Research Inc, 201 Tamal Vista Boulevard, Corte Madera, CA 94925, USA
    Drug Alcohol Depend 68:87-93. 2002
    ..Our goal was to test the a priori hypothesis of prefrontal cortical volume reduction, along with associated impairments in frontal mediated functions, and to look for differences between the Cr and CrA groups...
  21. pmc Mismatch negativity: no difference between controls and abstinent alcoholics
    George Fein
    Neurobehavioral Research, Inc, Corte Madera, CA, USA
    Alcohol Clin Exp Res 28:137-42. 2004
    ..This study examined the association of MMN with alcoholism family history density, with indices of the presence and severity of externalizing disorders (a risk-factor for alcoholism), and with alcohol use variables...
  22. ncbi request reprint Cerebral reserve capacity: implications for alcohol and drug abuse
    George Fein
    Neurobehavioral Research Inc, 201 Tamal Vista Boulevard, Corte Madera, CA 94925, USA
    Alcohol 32:63-7. 2004
    ..Finally, we comment on the most important public health implication of the cerebral reserve capacity model (vis-à-vis addiction)...
  23. ncbi request reprint Controlling for premorbid brain size in imaging studies: T1-derived cranium scaling factor vs. T2-derived intracranial vault volume
    George Fein
    Neurobehavioral Research, Inc, 201 Tamal Vista Boulevard, Corte Madera, CA 94925, USA
    Psychiatry Res 131:169-76. 2004
    ..Furthermore, neither race, sex, nor age accounted for any additional variance in ICV, indicating that neither race-, gender-, nor age-associated cranial bone thickness effects were present in this data set...
  24. pmc Mismatch negativity: no difference between treatment-naive alcoholics and controls
    George Fein
    Neurobehavioral Research, Inc, 201 Tamal Vista Blvd, Corte Madera, CA 94925, USA
    Alcohol Clin Exp Res 28:1861-6. 2004
    ..This study examined MMN in actively drinking treatment-naive alcohol-dependent individuals. This study examined the association of MMN with risk factors for alcoholism, postalcohol withdrawal hyperexcitability, and alcohol use variables...
  25. pmc EEG spectral changes in treatment-naive, actively drinking alcoholics
    George Fein
    Neurobehavioral Research, Inc, Corte Madera, California 94925, USA
    Alcohol Clin Exp Res 29:538-46. 2005
    ..The current study examines the EEG spectra of actively drinking, treatment-naive alcoholics (TxNAs)...
  26. ncbi request reprint Treated and treatment-naive alcoholics come from different populations
    George Fein
    Neurobehavioral Research, Inc, Corte Madera, CA 94925, USA
    Alcohol 35:19-26. 2005
    ..This finding supports the suggestion that results from studies of alcoholics in treatment or after treatment (i.e., most studies of alcoholics) cannot be generalized to untreated individuals (who make up the majority of alcoholics)...
  27. pmc Brain atrophy in long-term abstinent alcoholics who demonstrate impairment on a simulated gambling task
    George Fein
    Neurobehavioral Research Inc, 201 Tamal Vista Boulevard, Corte Madera, CA 94925, USA
    Neuroimage 32:1465-71. 2006
    ..Without both of these methodological advances, no statistically significant finding would have been forthcoming from this work...
  28. pmc Cognitive performance in long-term abstinent alcoholic individuals
    George Fein
    Neurobehavioral Research Inc, Corte Madera, California 94925, USA
    Alcohol Clin Exp Res 30:1538-44. 2006
    ..We examined the association of neurocognitive variables with age, duration of abstinence, alcohol use measures, and the density of a family history of problem drinking...
  29. pmc Sub-diagnostic psychiatric comorbidity in alcoholics
    George Fein
    Neurobehavioral Research, Inc, 201 Tamal Vista Boulevard, Corte Madera, CA 94925 1110, USA
    Drug Alcohol Depend 87:139-45. 2007
    ....
  30. pmc Treated and treatment-naive alcoholics come from different populations
    George Fein
    Neurobehavioral Research, Inc, Corte Madera, CA 94925, USA
    Alcohol 36:19-26. 2005
    ..This finding supports the suggestion that results from studies of alcoholics in treatment or after treatment (i.e., most studies of alcoholics) cannot be generalized to untreated individuals (who make up the majority of alcoholics)...
  31. pmc Statistical parametric mapping of brain morphology: sensitivity is dramatically increased by using brain-extracted images as inputs
    George Fein
    Neurobehavioral Research, Inc, 201 Tamal Vista Blvd, Corte Madera, CA 94925, USA
    Neuroimage 30:1187-95. 2006
    ..We show how this reduction in the RMSEs profoundly affects power analyses. SPM2 analyses of brain-extracted images may require sample sizes only half as great as analyses of non-brain-extracted images...
  32. pmc Psychiatric comorbidity in long-term abstinent alcoholic individuals
    Victoria Di Sclafani
    Neurobehavioral Research Inc, Corte Madera, California 94925, USA
    Alcohol Clin Exp Res 31:795-803. 2007
    ..e., comparable with NC) and (2) can ongoing abstinence be maintained in the face of a current psychiatric disorder?..
  33. pmc Neuropsychological performance of individuals dependent on crack-cocaine, or crack-cocaine and alcohol, at 6 weeks and 6 months of abstinence
    Victoria Di Sclafani
    Neurobehavioral Research Inc, 201 Tamal Vista Boulevard, Corte Madera, CA 94925, USA
    Drug Alcohol Depend 66:161-71. 2002
    ..This study examined cognitive function in abstinent crack dependent and crack and alcohol dependent individuals at 6 weeks and 6 months abstinence...
  34. pmc Treatment-naive active alcoholics have greater psychiatric comorbidity than normal controls but less than treated abstinent alcoholics
    Victoria Di Sclafani
    Neurobehavioral Research, Inc, 2800 Woodlawn Drive, Suite 129, Honolulu, HI 96822, USA
    Drug Alcohol Depend 98:115-22. 2008
    ..We compared untreated versus treated alcoholics, in order to ascertain whether both groups belonged to the same population with regard to psychiatric comorbidity...
  35. pmc Event-related oscillations versus event-related potentials in a P300 task as biomarkers for alcoholism
    Colin Andrew
    Neurobehavioral Research Inc, Honolulu, Hawaii 96814, USA
    Alcohol Clin Exp Res 34:669-80. 2010
    ..This study examines this question in a group of long-term abstinent alcoholics (LTAAs)...
  36. doi request reprint Emotion-word processing difficulties in abstinent alcoholics with and without lifetime externalizing disorders
    Michael J Endres
    Neurobehavioral Research, Inc, Honolulu, HI 96814, USA
    Alcohol Clin Exp Res 37:831-8. 2013
    ....
  37. pmc Subcortical volumes in long-term abstinent alcoholics: associations with psychiatric comorbidity
    Mohammad Sameti
    Neurobehavioral Research, Inc, 1585 Kapiolani Blvd, Honolulu, HI 96814, USA
    Alcohol Clin Exp Res 35:1067-80. 2011
    ..Most studies have focused on active or recently detoxified alcoholics, while subcortical structures in long-term abstinent alcoholics (LTAA) have remained relatively uninvestigated...
  38. pmc Resting state synchrony in long-term abstinent alcoholics with versus without comorbid drug dependence
    Jazmin Camchong
    Neurobehavioral Research, Inc, 1585 Kapiolani Blvd, Honolulu, HI 96814, USA
    Drug Alcohol Depend 131:56-65. 2013
    ..The aim of the present study was to investigate whether long-term abstinent alcoholics with comorbid stimulants dependence (LTAAS) show similar RSS mechanisms...
  39. pmc Persistent but less severe ataxia in long-term versus short-term abstinent alcoholic men and women: a cross-sectional analysis
    STAN SMITH
    Neurobehavioral Research, Inc, Honolulu, Hawaii 96814, USA
    Alcohol Clin Exp Res 35:2184-92. 2011
    ..However, abstinence durations reported have been limited, and their power and generalizability have suffered from small sample sizes...
  40. pmc Cognitive performance in treatment-naïve active alcoholics
    STAN SMITH
    Neurobehavioral Research, Inc, Honolulu, Hawaii 96814, USA
    Alcohol Clin Exp Res 34:2097-105. 2010
    ..In addition, a goal of the present study was to assess potential differential effects of alcohol dependence on cognitive performance in TNAD men and women...
  41. pmc Resting-state synchrony in short-term versus long-term abstinent alcoholics
    Jazmin Camchong
    Neurobehavioral Research, Inc, Honolulu, HI 96814, USA
    Alcohol Clin Exp Res 37:794-803. 2013
    ..In this study, we investigate whether these RSS patterns can be identified in short-term abstinent alcoholics (STAA)...
  42. pmc Age effect on subcortical structures in healthy adults
    Matt Goodro
    Neurobehavioral Research, Inc, 1585 Kapiolani Blvd, Ste 1030, Honolulu, HI 96814, USA
    Psychiatry Res 203:38-45. 2012
    ..This agreement lends support to the validity of the image-analysis tools and procedures used in the present study...
  43. pmc Methamphetamine users show greater than normal age-related cortical gray matter loss
    Helenna Nakama
    University of Hawaii, John A Burns School of Medicine, Department of Psychiatry, Honolulu, HI 96813, USA
    Addiction 106:1474-83. 2011
    ..Methamphetamine (Meth) abuse continues to be a major illicit drug of abuse. Neuroimaging findings suggest that Meth is neurotoxic and may alter various brain structures, but the effect of Meth on the aging brain has not been studied...
  44. pmc Resting-state synchrony during early alcohol abstinence can predict subsequent relapse
    Jazmin Camchong
    Neurobehavioral Research, Inc, Honolulu, HI 96814, USA
    Cereb Cortex 23:2086-99. 2013
    ..The association of lower RSS with poorer inhibitory control suggests that low RSS may constitute a faulty foundation for future responses to external cues, which can be manifested as the inability to inhibit behavior. ..
  45. pmc Resting-state synchrony in long-term abstinent alcoholics
    Jazmin Camchong
    Neurobehavioral Research, Inc, Honolulu, HI 96814, USA
    Alcohol Clin Exp Res 37:75-85. 2013
    ..Little is known, however, about whether these characteristics are present after long periods of abstinence...
  46. pmc Induced theta oscillations as biomarkers for alcoholism
    Colin Andrew
    Neurobehavioral Research Inc, Honolulu, HI 96814, USA
    Clin Neurophysiol 121:350-8. 2010
    ..This study investigates the discriminatory power of non-phase-locked oscillations in a group of long-term abstinent alcoholics (LTAAs) and non-alcoholic controls (NACs)...
  47. ncbi request reprint N400 event-related potential reduction indexes: early central nervous system impairment in HIV
    Lynn Nielsen-Bohlman
    Department of Psychiatry, Vanderbilt University, 1500 21st Avenue South, Suite 1100, Nashville, TN 37212, USA
    J NeuroAIDS 2:51-65. 2002
    ....
  48. ncbi request reprint Alpha2-noradrenergic effects on ERP and behavioral indices of auditory information processing
    Bruce I Turetsky
    Department of Cognitive Science, University of California, San Diego, La Jolla 92093 0515, USA
    Psychophysiology 39:147-57. 2002
    ..Our results offer a possible link between these two sets of findings, suggesting that some patients with schizophrenia may have dysfunctional noradrenergic systems...

Research Grants25

  1. Effects of heavy alcohol abuse on adolescent brain structure and function
    George Fein; Fiscal Year: 2007
    ..We will be uniquely able to isolate the effects of AUDs on brain structure and function in adolescence. ..
  2. Effects of heavy alcohol abuse on adolescent brain structure and function
    George Fein; Fiscal Year: 2009
    ..We will be uniquely able to isolate the effects of AUDs on brain structure and function in adolescence. ..
  3. Brain Morbidity in Treatment-Naive Alcoholics
    George Fein; Fiscal Year: 2009
    ..Since most studies of alcoholism in the U.S. use convenience samples of alcoholics in treatment (a minority of all alcoholics), the proposed studies are essential to understand the impact of AD on the US population. ..
  4. Long-Term Abstinence Clinical Issues and CNS Disinhibition
    George Fein; Fiscal Year: 2009
    ..which represent selection variables determining which individuals are able to achieve long-term abstinence. ..
  5. Effects of heavy alcohol abuse on adolescent brain structure and function
    George Fein; Fiscal Year: 2010
    ..We will be uniquely able to isolate the effects of AUDs on brain structure and function in adolescence. ..
  6. Long-Term Abstinence Clinical Issues and CNS Disinhibition
    George Fein; Fiscal Year: 2010
    ..It is only by understanding the successes in dealing with chronic alcoholism among treated samples with significant comorbidity that society will be able to make significant progress in facilitating such successes in the future. ..
  7. Brain Morbidity in Treatment-Naive Alcoholics
    George Fein; Fiscal Year: 2006
    ..abstract_text> ..
  8. EFFECTS OF ALCOHOL ABUSE ON THE AGING BRAIN
    George Fein; Fiscal Year: 2004
    ..g., brain "functional reserve," presence of the APOE-epsilon4 allele) that may modulate the effects of chronic alcohol abuse/dependence and age on brain structure and function. ..
  9. CHRONIC COCAINE ABUSE EFFECTS ON P50 AND P3A ERPS
    George Fein; Fiscal Year: 2001
    ..Finally, samples of active cocaine abusers will be studied. ..
  10. CORE--CLINICAL
    George Fein; Fiscal Year: 2002
    ..The Core will be responsible for a CSF substudy comparing viral load and anti-viral drug levels in CSF versus blood. . The Core will be responsible for data management and design and coordination of statistical analyses across the PPG. ..
  11. Brain Morbidity in Treatment-Naive Alcoholics
    George Fein; Fiscal Year: 2010
    ..Since most studies of alcoholism in the U.S. use convenience samples of alcoholics in treatment (a minority of all alcoholics), the proposed studies are essential to understand the impact of AD on the US population. ..