George Fein

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..Current antisocial symptoms were reduced to subdiagnostic levels in long-term abstinence; however, the number of current symptoms was not measured beyond its being subdiagnostic...

..We present longitudinal data on recovery of gait and balance in alcoholics 6 to 15 weeks abstinent at baseline assessment through follow-up assessment 4 to 16 months after baseline...

..In addition, few studies have addressed the associations of codependence on other drugs with alcoholic gait and balance disturbance...

..The literature suggests a negative synergy between BPD and SUDs, which may impact an individual's ability to achieve and maintain remission of either disorder in the face of the other...

..The consequences of heavy alcohol use during adolescence on nutritional status, specifically growth and weight status are largely unknown at this time...

..We compared these findings with our previously reported results in analogous middle-aged samples (MAA versus MNC)...

..However, there is still a dearth of published findings on cognitive functioning in very long-term abstinence alcoholics, especially in the elderly population...

..We recorded F-ERNs during the BART and during a BART simulation, where individuals observed the rewards and consequences of (someone else's) BART performance...

..Performance on the IGT was positively associated with auditory working memory and psychomotor function in young adults, and in immediate memory in older adults...

..We hypothesized that such effects would persist into long-term abstinence, and evaluated them in middle-aged long-term abstinent alcoholics (LTAA) compared with age and gender comparable nonalcoholic controls (NAC)...

..2006)...

..In the current study, we examine sensation seeking in middle-aged long-term abstinent alcoholics (LTAA) and in younger actively drinking treatment-naïve alcoholics (TxN)...

..There is considerable evidence that alcoholics differ from nonalcoholics in the processing of stimuli that have emotional content. The current study examines those differences that are present in multi-year abstinent individuals...

..We studied visual target detection in a treatment-naïve alcohol-dependent sample (TNAD) versus age and gender comparable nonalcoholic controls (NAC) to investigate whether reduced P3 amplitudes generalize to TNAD...

..This study examines the amplitude and latency of the P3b and P3a event-related brain electrical components in LTAAs compared with normal controls (NCs) and whether these measures are related to alcohol use and other subject variables...

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..We examined the association of neurocognitive variables with age, duration of abstinence, alcohol use measures, and the density of a family history of problem drinking...

..This finding supports the suggestion that results from studies of alcoholics in treatment or after treatment (i.e., most studies of alcoholics) cannot be generalized to untreated individuals (who make up the majority of alcoholics)...

..Our goal was to test the a priori hypothesis of prefrontal cortical volume reduction, along with associated impairments in frontal mediated functions, and to look for differences between the Cr and CrA groups...

..This study examined the association of MMN with alcoholism family history density, with indices of the presence and severity of externalizing disorders (a risk-factor for alcoholism), and with alcohol use variables...

..Finally, we comment on the most important public health implication of the cerebral reserve capacity model (vis-à-vis addiction)...

..Furthermore, neither race, sex, nor age accounted for any additional variance in ICV, indicating that neither race-, gender-, nor age-associated cranial bone thickness effects were present in this data set...

..This study expands on the current literature by using the SGT to examine decision making in long-term abstinent alcoholics (mean of 6.6 years' abstinence) who do not have antisocial personality disorder or a history of conduct disorder...

..This study examined MMN in actively drinking treatment-naive alcohol-dependent individuals. This study examined the association of MMN with risk factors for alcoholism, postalcohol withdrawal hyperexcitability, and alcohol use variables...

..The current study examines the EEG spectra of actively drinking, treatment-naive alcoholics (TxNAs)...

..This finding supports the suggestion that results from studies of alcoholics in treatment or after treatment (i.e., most studies of alcoholics) cannot be generalized to untreated individuals (who make up the majority of alcoholics)...

..This study examines decision making on the SGT in young adults with alcohol dependence who are treatment-naive (TxN)...

..Without both of these methodological advances, no statistically significant finding would have been forthcoming from this work...

..We show how this reduction in the RMSEs profoundly affects power analyses. SPM2 analyses of brain-extracted images may require sample sizes only half as great as analyses of non-brain-extracted images...

..e., comparable with NC) and (2) can ongoing abstinence be maintained in the face of a current psychiatric disorder?..

..The strongest predictor of brain damage associated with substance dependence in this sample was dose (particularly quantity and duration of peak dose)...

..We compared untreated versus treated alcoholics, in order to ascertain whether both groups belonged to the same population with regard to psychiatric comorbidity...

..This study examines this question in a group of long-term abstinent alcoholics (LTAAs)...

..However, abstinence durations reported have been limited, and their power and generalizability have suffered from small sample sizes...

..In addition, a goal of the present study was to assess potential differential effects of alcohol dependence on cognitive performance in TNAD men and women...

..Most studies have focused on active or recently detoxified alcoholics, while subcortical structures in long-term abstinent alcoholics (LTAA) have remained relatively uninvestigated...

..Methamphetamine (Meth) abuse continues to be a major illicit drug of abuse. Neuroimaging findings suggest that Meth is neurotoxic and may alter various brain structures, but the effect of Meth on the aging brain has not been studied...

..This agreement lends support to the validity of the image-analysis tools and procedures used in the present study...

..This study investigates the discriminatory power of non-phase-locked oscillations in a group of long-term abstinent alcoholics (LTAAs) and non-alcoholic controls (NACs)...

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..Our results offer a possible link between these two sets of findings, suggesting that some patients with schizophrenia may have dysfunctional noradrenergic systems...

..We will be uniquely able to isolate the effects of AUDs on brain structure and function in adolescence. ..

..We will be uniquely able to isolate the effects of AUDs on brain structure and function in adolescence. ..

..Since most studies of alcoholism in the U.S. use convenience samples of alcoholics in treatment (a minority of all alcoholics), the proposed studies are essential to understand the impact of AD on the US population. ..

..which represent selection variables determining which individuals are able to achieve long-term abstinence. ..

..We will be uniquely able to isolate the effects of AUDs on brain structure and function in adolescence. ..

..It is only by understanding the successes in dealing with chronic alcoholism among treated samples with significant comorbidity that society will be able to make significant progress in facilitating such successes in the future. ..

..abstract_text> ..

..g., brain "functional reserve," presence of the APOE-epsilon4 allele) that may modulate the effects of chronic alcohol abuse/dependence and age on brain structure and function. ..

..Finally, samples of active cocaine abusers will be studied. ..

..The Core will be responsible for a CSF substudy comparing viral load and anti-viral drug levels in CSF versus blood. . The Core will be responsible for data management and design and coordination of statistical analyses across the PPG. ..

..Since most studies of alcoholism in the U.S. use convenience samples of alcoholics in treatment (a minority of all alcoholics), the proposed studies are essential to understand the impact of AD on the US population. ..