Research Topics
| Igor L MedintzSummaryAffiliation: Naval Medical Center Country: USA Publications
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Detail Information
Publications
Potential clinical applications of quantum dotsIgor L Medintz
Center for Bio Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC, USA
Int J Nanomedicine 3:151-67. 2008..We also explore toxicity issues surrounding these materials and speculate about the future uses of quantum dots in a clinical setting...
Luminescent quantum dots in immunoassaysEllen R Goldman
U.S. Naval Research Laboratory, Center for Bio/Molecular Science and Engineering, Code 6900, Washington, DC 20375, USA
Anal Bioanal Chem 384:560-3. 2006- Quantum dot bioconjugates for imaging, labelling and sensingIgor L Medintz
Center for Bio Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC 20375, USA
Nat Mater 4:435-46. 2005..The potential of QDs in biology has just begun to be realized and new avenues will arise as our ability to manipulate these materials improves... - Self-assembled TNT biosensor based on modular multifunctional surface-tethered componentsIgor L Medintz
Center for Bio Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington DC 20375, USA
Anal Chem 77:365-72. 2005..The modular design of the sensor demonstrates that it can be easily adapted to detect a variety of different analytes... - General strategy for biosensor design and construction employing multifunctional surface-tethered componentsIgor L Medintz
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington, D C 20375, USA
Anal Chem 76:5620-9. 2004..A complex set of interactions apparently exists on the sensing surface that may contribute to sensor behavior and range. This approach may represent a general way to assemble a wide range of useful biosensors... - Quantum-dot/dopamine bioconjugates function as redox coupled assemblies for in vitro and intracellular pH sensingIgor L Medintz
Center for Bio Molecular Science and Engineering Code 6900, US Naval Research Laboratory, Washington, District of Columbia 20375, USA
Nat Mater 9:676-84. 2010..A detailed mechanism describing the QD quenching processes that is consistent with dopamine's inherent redox chemistry is presented... - Interactions between redox complexes and semiconductor quantum dots coupled via a peptide bridgeIgor L Medintz
Center for Bio Molecular Science and Engineering and Division of Optical Sciences, U S Naval Research Laboratory, Washington, DC 20375, USA
J Am Chem Soc 130:16745-56. 2008..In addition, partial bleaching of the absorption was measured for the QD-metal complex assemblies. These proximity driven interactions were further used to construct sensing assemblies to detect proteolytic enzyme activity... - Multifunctional compact zwitterionic ligands for preparing robust biocompatible semiconductor quantum dots and gold nanoparticlesKimihiro Susumu
Optical Sciences Division, Code 5611, U S Naval Research Laboratory, Washington, D C 20375, USA
J Am Chem Soc 133:9480-96. 2011..The strong potential of these ligands to expand NP capabilities in many biological applications is highlighted... 
Single-molecule colocalization studies shed light on the idea of fully emitting versus dark single quantum dotsThomas Pons
US Naval Research Laboratory, Division of Optical Sciences, Washington, DC 20375, USA
Small 7:2101-8. 2011....- Combining chemoselective ligation with polyhistidine-driven self-assembly for the modular display of biomolecules on quantum dotsDuane E Prasuhn
Center for Bio Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC 20375, USA
ACS Nano 4:267-78. 2010..This modular approach for displaying peptides or DNA on QDs may be extended to other more complex biomolecules such as proteins or utilized with different types of nanoparticle materials... - Spatiotemporal multicolor labeling of individual cells using peptide-functionalized quantum dots and mixed delivery techniquesJames B Delehanty
Center for Bio Molecular Science and Engineering, U S Naval Research Laboratory, Washington, DC 20375, USA
J Am Chem Soc 133:10482-9. 2011..Using this overall approach, QDs were targeted to both early and late endosomes, the cellular cytosol, and the plasma membrane in live cells, ultimately allowing for simultaneous five-color fluorescent imaging... - Quantum dots and fluorescent protein FRET-based biosensorsKelly Boeneman
Center for Biomolecular Science and Engineering, Washington, DC 20375, USA
Adv Exp Med Biol 733:63-74. 2012..We further show that QDs and fluorescent proteins can be conjugated together intracellularly with strong potential for live-cell imaging and biosensing applications... - Quantum dot DNA bioconjugates: attachment chemistry strongly influences the resulting composite architectureKelly Boeneman
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington D C 20375, USA
ACS Nano 4:7253-66. 2010..These results suggest that if a particular QD biocomposite structure is desired, for example, random versus oriented, the type of bioconjugation chemistry utilized will be a key influencing factor... - Self-assembled quantum dot-sensitized multivalent DNA photonic wiresKelly Boeneman
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington, DC 20375, USA
J Am Chem Soc 132:18177-90. 2010..Integrating such DNA-based photonic structures with QDs can help create a new generation of biophotonic wire assemblies with widespread potential in nanotechnology... - Multimodal Characterization of a Linear DNA-Based NanostructureSusan Buckhout-White
Center for Bio Molecular Science and Engineering, Code 6900, Optical Sciences Division, Code 5611, and Electronic Science and Technology Division, Code 6876, U S Naval Research Laboratory, Washington, D C 20375, United States
ACS Nano 6:1026-43. 2012.... - A hybrid quantum dot-antibody fragment fluorescence resonance energy transfer-based TNT sensorEllen R Goldman
Center for Bio Molecular Science and Engineering, U S Naval Research Laboratory, Washington, D C 20375, USA
J Am Chem Soc 127:6744-51. 2005..Addition of soluble TNT displaces the dye-labeled analogue, eliminating FRET and resulting in a concentration-dependent recovery of QD photoluminescence. Sensor performance and specificity were evaluated... - Delivering quantum dot-peptide bioconjugates to the cellular cytosol: escaping from the endolysosomal systemJames B Delehanty
Center for Bio Molecular Science and Engineering, U S Naval Research Laboratory, Washington, DC 20375, USA
Integr Biol (Camb) 2:265-77. 2010..Importantly, this QD-peptide bioconjugate elicited minimal cytotoxicity in the cell lines tested... - Cellular uptake and fate of PEGylated gold nanoparticles is dependent on both cell-penetration peptides and particle sizeEunkeu Oh
Optical Sciences Division, Code 5611, U S Naval Research Laboratory, Washington, DC 20375, USA
ACS Nano 5:6434-48. 2011..The 16 nm and larger AuNPs did not enter the cells and were located at the cellular periphery. A preliminary assessment of cytotoxicity demonstrated minimal effects on cellular viability following peptide-mediated uptake... - On the quenching of semiconductor quantum dot photoluminescence by proximal gold nanoparticlesThomas Pons
U S Naval Research Laboratory, Division of Optical Sciences, Washington, DC 20375, USA
Nano Lett 7:3157-64. 2007.... - Intracellular delivery of quantum dot-protein cargos mediated by cell penetrating peptidesIgor L Medintz
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington, DC 20375, USA
Bioconjug Chem 19:1785-95. 2008..Use of QD-peptide/fluorescent protein vectors may make powerful tools for understanding the mechanisms of nanoparticle-mediated drug delivery... - Intracellular bioconjugation of targeted proteins with semiconductor quantum dotsKelly Boeneman
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, 4555 Overlook Avenue, S W, Washington, DC 20375, USA
J Am Chem Soc 132:5975-7. 2010..This approach can facilitate long-term monitoring of their spatio-temporal activity or, alternatively, allow engineering and in situ assembly of designer chimeric QD-fluorescent protein sensors... - Quantum dots as simultaneous acceptors and donors in time-gated Förster resonance energy transfer relays: characterization and biosensingW Russ Algar
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington DC 20375, USA
J Am Chem Soc 134:1876-91. 2012.... - Semiconductor quantum dots in bioanalysis: crossing the valley of deathW Russ Algar
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, 4555 Overlook Avenue, South West, Washington, DC 20375, USA
Anal Chem 83:8826-37. 2011..We describe the burgeoning role of QDs in many different fields of bioanalyses and highlight the advantages afforded by their unique physical and optical properties... - Solution-phase single quantum dot fluorescence resonance energy transferThomas Pons
Optical Sciences Division, Code 5611, Center for Bio/Molecular Science and Engineering, Code 6900, Naval Research Laboratory, Washington, D.C. 20375, USA
J Am Chem Soc 128:15324-31. 2006..The binding constant derived from spFRET is consistent with ensemble measurements... - Multiplex charge-transfer interactions between quantum dots and peptide-bridged ruthenium complexesIgor L Medintz
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington, DC 20375, USA
Anal Chem 81:4831-9. 2009.... - A reactive peptidic linker for self-assembling hybrid quantum dot-DNA bioconjugatesIgor L Medintz
U S Naval Research Laboratory, Center for Bio Molecular Science and Engineering Code 6900, Division of Optical Sciences Code 5611, Washington, DC 20375, USA
Nano Lett 7:1741-8. 2007.... - Multidentate poly(ethylene glycol) ligands provide colloidal stability to semiconductor and metallic nanocrystals in extreme conditionsMichael H Stewart
Optical Sciences Division, Naval Research Laboratory, Washington, D C 20375, USA
J Am Chem Soc 132:9804-13. 2010..The improved colloidal stability of nanocrystals afforded by the tetradentate ligands was further demonstrated via the assembly of stable QD-nuclear localization signal peptide bioconjugates that promoted intracellular uptake... - Polyethylene glycol-based bidentate ligands to enhance quantum dot and gold nanoparticle stability in biological mediaBing C Mei
Division of Optical Sciences, US Naval Research Laboratory, Washington, District of Columbia 20375, USA
Nat Protoc 4:412-23. 2009..These ligands provide a straightforward means of preparing QDs and AuNPs that exhibit greater resistance to environmental changes, facilitating their effective use in bioassays and live cell imaging... - Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligandsKimihiro Susumu
Division of Optical Sciences and Center for Bio Molecular Science and Engineering, U S Naval Research Laboratory, Washington, D C 20375, USA
J Am Chem Soc 129:13987-96. 2007..The new functional surface ligands described here provide not only stable and highly water-soluble QDs but also simple and easy access to various biological entities... - Multiplexed toxin analysis using four colors of quantum dot fluororeagentsEllen R Goldman
Center for Bio Molecular Science and Engineering and Division of Optical Sciences, U S Naval Research Laboratory, Washington, D C 20375, USA
Anal Chem 76:684-8. 2004..Using a simple linear equation-based algorithm, it was possible to deconvolute the signal from mixed toxin samples, which allowed quantitation of all four toxins simultaneously... - Multivalent conjugation of peptides, proteins, and DNA to semiconductor quantum dotsDuane E Prasuhn
Center for Bio Molecular Science and Engineering, U S Naval Research Laboratory, Washington, DC, USA
Methods Mol Biol 726:95-110. 2011..These approaches can be successfully employed in the construction of a variety of QD-biomolecule constructs utilizing synthetic peptides, recombinant proteins, peptides, and even modified DNA oligomers... - Polyvalent display and packing of peptides and proteins on semiconductor quantum dots: predicted versus experimental resultsDuane E Prasuhn
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington, DC 20375, USA
Small 6:555-64. 2010..These results can contribute towards an overall understanding of how to engineer designer bioconjugates for both QDs and other nanoparticle materials... - Quantum dot-based multiplexed fluorescence resonance energy transferAaron R Clapp
U.S. Naval Research Laboratory, Optical Sciences Division, Code 5611, Washington, DC 20375, USA
J Am Chem Soc 127:18212-21. 2005..Steady-state fluorescence results were corroborated by time-resolved measurements where selective shortening of QD lifetime was measured only for populations that were selectively engaged in nonradiative energy transfer... - Complex Förster energy transfer interactions between semiconductor quantum dots and a redox-active osmium assemblyMichael H Stewart
Optical Sciences Division, Code 5611, U S Naval Research Laboratory, Washington, DC 20375, USA
ACS Nano 6:5330-47. 2012.... - Quantum dot peptide biosensors for monitoring caspase 3 proteolysis and calcium ionsDuane E Prasuhn
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, 4555 Overlook Ave, S W, Washington, D C 20375, USA
ACS Nano 4:5487-97. 2010..These results highlight the potential for combining peptides with QDs using different chemistries to create sensors for monitoring chemical compounds and biological processes... - Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophoresH Tetsuo Uyeda
US Naval Research Laboratory, Division of Optical Sciences, Center for Bio/Molecular Science and Engineering, Washington, DC 20375, USA
J Am Chem Soc 127:3870-8. 2005..These ligands provide a straightforward means of preparing QDs that exhibit greater resistance to environmental changes, making them more amenable for use in live cell imaging and other biotechnological applications... - Can luminescent quantum dots be efficient energy acceptors with organic dye donors?Aaron R Clapp
US Naval Research Laboratory, Optical Sciences Division, Code 5611, Washington, DC 20375, USA
J Am Chem Soc 127:1242-50. 2005..This is due to the long exciton lifetime of the acceptor compared to that of the dye, combined with substantial QD direct excitation... - Fluorescence resonance energy transfer between quantum dot donors and dye-labeled protein acceptorsAaron R Clapp
Optical Sciences Division, Code 5611, U.S. Naval Research Laboratory, Washington, D.C. 20375, USA
J Am Chem Soc 126:301-10. 2004.... - Hydrodynamic dimensions, electrophoretic mobility, and stability of hydrophilic quantum dotsThomas Pons
Optical Sciences Division and Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375, USA
J Phys Chem B 110:20308-16. 2006..These properties are critical for the design of QD-based biosensing assays as well as QD bioconjugate diffusion in live cells... - Maltose-binding protein: a versatile platform for prototyping biosensingIgor L Medintz
Center for Bio Molecular Science and Engineering, Code 6900, Laboratory for the Structure of Matter, Code 6812, US Naval Research Laboratory, WA 20375 5320, USA
Curr Opin Biotechnol 17:17-27. 2006.... - Peptides for specific intracellular delivery and targeting of nanoparticles: implications for developing nanoparticle-mediated drug deliveryJames B Delehanty
Center for Bio Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC 20375, USA
Ther Deliv 1:411-33. 2010..The paper concludes with a brief forward-looking perspective discussing what can be expected as this field develops in the coming years... - Proteolytic activity at quantum dot-conjugates: kinetic analysis reveals enhanced enzyme activity and localized interfacial "hopping"W Russ Algar
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington, D C 20375, United States
Nano Lett 12:3793-802. 2012..A "hopping" mode of proteolysis at the nanoparticle was identified, confirming enhanced activity... - Application of a homogenous assay for the detection of 2,4,6-trinitrotoluene to environmental water samplesEllen R Goldman
U S Naval Research Laboratory, Center for Bio Molecular Science and Engineering, Washington, DC 20375, USA
ScientificWorldJournal 5:445-51. 2005..17 M) significantly improved the range over which the assay functioned in several river water samples... - The controlled display of biomolecules on nanoparticles: a challenge suited to bioorthogonal chemistryW Russ Algar
Center for Bio Molecular Science and Engineering, Optical Sciences Division, U S Naval Research Laboratory, 4555 Overlook Avenue S W, Washington, DC 20375, United States
Bioconjug Chem 22:825-58. 2011..Potential chemistries that have not yet been applied to NPs are also discussed, and an outlook on future developments in this field is given... - Surface-immobilized self-assembled protein-based quantum dot nanoassembliesKim E Sapsford
Center for Bio/Molecular Science and Engineering, Code 6900, Naval Research Laboratory, Washington, D.C. 20375, USA
Langmuir 20:7720-8. 2004..The utility of this self-assembly strategy is further demonstrated by assembling a QD-protein structure that allows the QDs to engage in FRET with a dye located on the surface-covering protein... - Fluoroimmunoassays using antibody-conjugated quantum dotsEllen R Goldman
Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC, USA
Methods Mol Biol 303:19-34. 2005.... - Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugatesIgor L Medintz
Center for Bio Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC 20375, USA
Nat Mater 5:581-9. 2006..We also screened a number of inhibitory compounds against the QD-thrombin conjugate. This technology is not limited to sensing proteases, but may be amenable to monitoring other enzymatic modifications... - Self-assembled quantum dot-peptide bioconjugates for selective intracellular deliveryJames B Delehanty
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington, D C 20375, USA
Bioconjug Chem 17:920-7. 2006..The efficacy of using peptides for selective intracellular delivery is highlighted by performing a multicolor QD labeling, where we found that the presence or absence of peptide on the QD surface controls cellular uptake... - Self-assembled nanoscale biosensors based on quantum dot FRET donorsIgor L Medintz
Center for Bio/Molecular Science and Engineering, Code 6910, US Naval Research Laboratory, Washington, DC 20375, USA
Nat Mater 2:630-8. 2003..Quantum dot-biomolecule assemblies constructed using these methods may facilitate development of new hybrid sensing materials... - Recent progress in developing FRET-based intracellular sensors for the detection of small molecule nutrients and ligandsIgor L Medintz
Center for Bio Molecular Science and Engineering, Code 6900 U S Naval Research Laboratory, 4555 Overlook Ave, SW Washington, DC 20375, USA
Trends Biotechnol 24:539-42. 2006..The insight gained from designing these sensors, along with the preliminary results gathered from their first application, serve to illustrate the impact that they can have on improving our fundamental understanding of biology... - Reversible modulation of quantum dot photoluminescence using a protein- bound photochromic fluorescence resonance energy transfer acceptorIgor L Medintz
Center for Bio Molecular Science and Engineering, Code 6900, Division of Optical Sciences, Code 5611, U S Naval Research Laboratory, Washington, DC 20375, USA
J Am Chem Soc 126:30-1. 2004..This result suggests a possible use of BIPS-labeled proteins in QD-based nanostructures as part of a threshold switch or other biosensing device... - Sensing caspase 3 activity with quantum dot-fluorescent protein assembliesKelly Boeneman
Center for Bio Molecular Science and Engineering, U S Naval Research Laboratory, Washington, DC 20375, USA
J Am Chem Soc 131:3828-9. 2009.... - Quantum dots: a powerful tool for understanding the intricacies of nanoparticle-mediated drug deliveryJames B Delehanty
Center for Bio Molecular Science and Engineering, SW Washington, DC 20375, USA
Expert Opin Drug Deliv 6:1091-112. 2009..Important related issues such as QD biofunctionalization and toxicity are also discussed. The paper concludes with a perspective of how this field can be expected to develop in the future... - TNT detection using multiplexed liquid array displacement immunoassaysGeorge P Anderson
Center for Bio Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375, USA
Anal Chem 78:2279-85. 2006..Seawater required dilution with two parts buffer to avoid loss of microspheres, while the acetone extracts were diluted 100-fold or more to minimize solvent affects... - Delivering quantum dots into cells: strategies, progress and remaining issuesJames B Delehanty
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington, DC, USA
Anal Bioanal Chem 393:1091-105. 2009..Finally, we conclude by providing a perspective of how this field can be expected to develop in the future... - Quantum dot-based resonance energy transfer and its growing application in biologyIgor L Medintz
US Naval Research Laboratory, Center for Bio Molecular Science and Engineering, Code 6910, and Division of Optical Sciences, Code 5611, 4555 Overlook Ave, S W Washington DC, 20375, USA
Phys Chem Chem Phys 11:17-45. 2009..We conclude by providing an assessment of where QD-based FRET investigations may be evolving in the near future... - A fluorescence resonance energy transfer sensor based on maltose binding proteinIgor L Medintz
Center for Bio Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington DC 20375, USA
Bioconjug Chem 14:909-18. 2003..In the use of these FRET pairs, MBP dissociation values for maltose were estimated (0.14-2.90 microM). Maltose limits of detection were in the 50-100 nm range... - Förster resonance energy transfer investigations using quantum-dot fluorophoresAaron R Clapp
US Naval Research Laboratory, Optical Sciences Division, Code 5611, Washington, DC 20375, USA
Chemphyschem 7:47-57. 2006..We also review the recent developments made in using QD bioreceptor conjugates to design FRET-based assays... - Multiplexed tracking of protease activity using a single color of quantum dot vector and a time-gated förster resonance energy transfer relayW Russ Algar
Center for Bio Molecular Science and Engineering, Code 6900, and Optical Sciences Division, Code 5611, U S Naval Research Laboratory, Washington, D C 20375, United States
Anal Chem 84:10136-46. 2012..Prospective applications in biochemical research, applied diagnostics, and drug discovery are discussed... - Materials for fluorescence resonance energy transfer analysis: beyond traditional donor-acceptor combinationsKim E Sapsford
Center for Bio/Molecular Science and Engineering, U.S. Naval Research Laboratory, Code 6910, 4555 Overlook Avenue SW, Washington, DC 20375, USA
Angew Chem Int Ed Engl 45:4562-89. 2006..We focus in particular on the benefits and limitations of these materials and their combinations, as well as the available methods of bioconjugation... - Designer variable repeat length polypeptides as scaffolds for surface immobilization of quantum dotsIgor L Medintz
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington, DC 20375, USA
J Phys Chem B 110:10683-90. 2006..The versatility of this capture strategy is highlighted by the creation of a variety of one- and two-dimensional polypeptide-QD structures as well as a self-assembled surface-immobilized FRET-based nutrient sensor... - Active cellular sensing with quantum dots: Transitioning from research tool to reality; a reviewJames B Delehanty
Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington, DC 20375, United States Electronic address
Anal Chim Acta 750:63-81. 2012..A perspective on where this field is expected to develop in both the near and long-term is also provided... - Decoration of discretely immobilized cowpea mosaic virus with luminescent quantum dotsIgor L Medintz
Center for Bio/Molecular Science and Engineering Code 6900, Laboratory for the Structure of Matter Code 6812, Washington, DC 20375, USA
Langmuir 21:5501-10. 2005..Characterization of the assembled CPMV and QD structures is presented, and the potential uses for protein-coated QDs functionalized onto this symmetrical virion nanoscaffold are discussed... - Elaborate nanoparticle-based traps for catching cytosolic players in the actJames B Delehanty
Center for Bio Molecular Science and Engineering, US Naval Research Laboratory, Code 6900, Washington DC 20375 USA
Chembiochem 13:30-3. 2012..The system uses the rapid, innate self-assembly of ferritin, expressing bait and prey molecules, into ordered nanoclusters whose morphology is tracked by using fluorescence microscopy... - Transcript and proteomic analyses of wild-type and gpa2 mutant Saccharomyces cerevisiae strains suggest a role for glycolytic carbon source sensing in pseudohyphal differentiationIgor L Medintz
Center for Bio Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC 20375, USA
Mol Biosyst 3:623-34. 2007.... - Novel energy transfer fluorescence labeling cassetteIgor L Medintz
Biotechniques 32:270, 272. 2002 - Microfabricated 384-lane capillary array electrophoresis bioanalyzer for ultrahigh-throughput genetic analysisCharles A Emrich
Department of Chemistry, University of California, Berkeley 94720, USA
Anal Chem 74:5076-83. 2002..This lab-on-a-chip device thoroughly exploits the power of microfabrication to produce high-density capillary electrophoresis arrays and to use them for high-throughput bioanalysis...