R D Kopke

Summary

Affiliation: Naval Medical Center
Country: USA

Publications

  1. ncbi Reduction of noise-induced hearing loss using L-NAC and salicylate in the chinchilla
    R D Kopke
    Department of Defense Spatial Orientation Center, Naval Medical Center San Diego, San Diego, CA 92134 2200, USA
    Hear Res 149:138-46. 2000
  2. ncbi Microdose gentamicin administration via the round window microcatheter: results in patients with Meniere's disease
    M E Hoffer
    The Department of Defense Spatial Orientation Center, Naval Medical Center San Diego, California 93124 2200, USA
    Ann N Y Acad Sci 942:46-51. 2001
  3. ncbi Use of the round window microcatheter in the treatment of Meniere's disease
    M E Hoffer
    Department of Defense Spatial Orientation Center, Naval Medical Center San Diego, San Diego, California 92134 2200, USA
    Laryngoscope 111:2046-9. 2001
  4. ncbi Morphologic changes in the inner ear of Chinchilla laniger after middle ear administration of gentamicin in a sustained-release vehicle
    M E Hoffer
    Department of Defense Spatial Orientation Center, Naval Medical Center San Diego, CA 92134 5000, USA
    Otolaryngol Head Neck Surg 120:643-8. 1999
  5. ncbi Growth factor treatment enhances vestibular hair cell renewal and results in improved vestibular function
    R D Kopke
    Departments of Defense Spatial Orientation Center and Otolaryngology, Naval Medical Center, San Diego, CA 92134, USA
    Proc Natl Acad Sci U S A 98:5886-91. 2001
  6. ncbi Pharmacological rescue of noise induced hearing loss using N-acetylcysteine and acetyl-L-carnitine
    J K M Coleman
    Department of Defense Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center, San Diego, CA 92134, USA
    Hear Res 226:104-13. 2007
  7. ncbi Targeted topical steroid therapy in sudden sensorineural hearing loss
    R D Kopke
    The Department of Defense Spatial Orientation Center, Naval Medical Center, San Diego, California 92134-2200, USA
    Otol Neurotol 22:475-9. 2001
  8. ncbi Transtympanic versus sustained-release administration of gentamicin: kinetics, morphology, and function
    M E Hoffer
    Department of Defense Spatial Orientation Center, Naval Medical Center San Diego, San Diego, CA 92134-2200
    Laryngoscope 111:1343-57. 2001

Collaborators

Detail Information

Publications8

  1. ncbi Reduction of noise-induced hearing loss using L-NAC and salicylate in the chinchilla
    R D Kopke
    Department of Defense Spatial Orientation Center, Naval Medical Center San Diego, San Diego, CA 92134 2200, USA
    Hear Res 149:138-46. 2000
    ..These findings demonstrate the feasibility of reduction of noise-induced hearing loss using clinically available antioxidant compounds...
  2. ncbi Microdose gentamicin administration via the round window microcatheter: results in patients with Meniere's disease
    M E Hoffer
    The Department of Defense Spatial Orientation Center, Naval Medical Center San Diego, California 93124 2200, USA
    Ann N Y Acad Sci 942:46-51. 2001
    ..Our results are compared to the published literature examining transtympanic injection. In addition, the underlying science supporting this type of treatment is examined...
  3. ncbi Use of the round window microcatheter in the treatment of Meniere's disease
    M E Hoffer
    Department of Defense Spatial Orientation Center, Naval Medical Center San Diego, San Diego, California 92134 2200, USA
    Laryngoscope 111:2046-9. 2001
    ..We applied the 1995 American Academy of Otolaryngology-Head and Neck Surgery criteria to this patient group to analyze the results of treatment...
  4. ncbi Morphologic changes in the inner ear of Chinchilla laniger after middle ear administration of gentamicin in a sustained-release vehicle
    M E Hoffer
    Department of Defense Spatial Orientation Center, Naval Medical Center San Diego, CA 92134 5000, USA
    Otolaryngol Head Neck Surg 120:643-8. 1999
    ..We also examine measurement of hair cell damage with heat shock protein levels. By better understanding the actions of gentamicin in this animal model, we hope to facilitate safer use of intratympanic medicines in our patient population...
  5. ncbi Growth factor treatment enhances vestibular hair cell renewal and results in improved vestibular function
    R D Kopke
    Departments of Defense Spatial Orientation Center and Otolaryngology, Naval Medical Center, San Diego, CA 92134, USA
    Proc Natl Acad Sci U S A 98:5886-91. 2001
    ..These results suggest that growth factor therapy may be an effective treatment for balance disorders that are the result of hair cell dysfunction and/or loss...
  6. ncbi Pharmacological rescue of noise induced hearing loss using N-acetylcysteine and acetyl-L-carnitine
    J K M Coleman
    Department of Defense Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center, San Diego, CA 92134, USA
    Hear Res 226:104-13. 2007
    ..It may be possible to obtain a greater therapeutic effect using these agents in combination or at higher doses or for a longer period of time to address the secondary oxidative events occurring 7-10 days after acute noise exposure...
  7. ncbi Targeted topical steroid therapy in sudden sensorineural hearing loss
    R D Kopke
    The Department of Defense Spatial Orientation Center, Naval Medical Center, San Diego, California 92134-2200, USA
    Otol Neurotol 22:475-9. 2001
    ....
  8. ncbi Transtympanic versus sustained-release administration of gentamicin: kinetics, morphology, and function
    M E Hoffer
    Department of Defense Spatial Orientation Center, Naval Medical Center San Diego, San Diego, CA 92134-2200
    Laryngoscope 111:1343-57. 2001
    ..Sustained delivery of gentamicin produces universal HL at 72 hours. The reliability of sustained-release delivery to the ear reduces functional and morphological variations between animals...