Karen R Kelly

Summary

Affiliation: Naval Medical Center
Country: USA

Publications

  1. pmc A low-glycemic index diet and exercise intervention reduces TNF(alpha) in isolated mononuclear cells of older, obese adults
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Nutr 141:1089-94. 2011
  2. pmc Exercise training with weight loss and either a high- or low-glycemic index diet reduces metabolic syndrome severity in older adults
    Steven K Malin
    Department of Pathobiology, Cleveland Clinic, and Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Ann Nutr Metab 61:135-41. 2012
  3. pmc Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide
    Thomas P J Solomon
    Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA
    Diabetes Care 33:1561-6. 2010
  4. doi request reprint A 7-d exercise program increases high-molecular weight adiponectin in obese adults
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Med Sci Sports Exerc 44:69-74. 2012
  5. pmc A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans
    Thomas Pj Solomon
    Department of Pathobiology, Lerner Research Institute and Nutrition, Case Western Reserve University, Cleveland, OH, USA
    Am J Clin Nutr 92:1359-68. 2010
  6. pmc Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans
    Thomas P J Solomon
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH44195, USA
    Am J Clin Nutr 90:1222-9. 2009
  7. pmc Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 98:E1181-8. 2013
  8. pmc Retinol-binding protein 4 (RBP4) protein expression is increased in omental adipose tissue of severely obese patients
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Obesity (Silver Spring) 18:663-6. 2010
  9. pmc Urinary albumin excretion, HMW adiponectin, and insulin sensitivity in type 2 diabetic patients undergoing bariatric surgery
    Sankar D Navaneethan
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Ave, Q7, Cleveland, OH 44195, USA
    Obes Surg 20:308-15. 2010
  10. pmc Lifestyle-induced decrease in fat mass improves adiponectin secretion in obese adults
    Karen R Kelly
    1Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 2Department of Nutrition, Case Western Reserve University, School of Medicine, Cleveland, OH 3Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH 4Department of Physiology, Case Western Reserve University, School of Medicine, Cleveland, OH and 5Metabolic Translational Research Center, Cleveland Clinic, Cleveland, OH
    Med Sci Sports Exerc 46:920-6. 2014

Collaborators

Detail Information

Publications14

  1. pmc A low-glycemic index diet and exercise intervention reduces TNF(alpha) in isolated mononuclear cells of older, obese adults
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Nutr 141:1089-94. 2011
    ..A low-glycemic index diet has antiinflammatory and antidiabetogenic effects when combined with exercise in older, obese prediabetics...
  2. pmc Exercise training with weight loss and either a high- or low-glycemic index diet reduces metabolic syndrome severity in older adults
    Steven K Malin
    Department of Pathobiology, Cleveland Clinic, and Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Ann Nutr Metab 61:135-41. 2012
    ..Thus, we determined the effects of exercise training with a low (LoGIx)- or high (HiGIx)-glycemic index diet on the severity of the metabolic syndrome (Z-score)...
  3. pmc Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide
    Thomas P J Solomon
    Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA
    Diabetes Care 33:1561-6. 2010
    ..The mechanisms by which lifestyle intervention may modify insulin secretion in type 2 diabetes have also not been examined but may involve the incretin axis...
  4. doi request reprint A 7-d exercise program increases high-molecular weight adiponectin in obese adults
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Med Sci Sports Exerc 44:69-74. 2012
    ..Previously, we found that 7 d of exercise improves insulin sensitivity in obese subjects; however, whether short-term exercise training affects HMW adiponectin in obese persons is unknown...
  5. pmc A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans
    Thomas Pj Solomon
    Department of Pathobiology, Lerner Research Institute and Nutrition, Case Western Reserve University, Cleveland, OH, USA
    Am J Clin Nutr 92:1359-68. 2010
    ..The optimal lifestyle intervention that reverses diabetes risk factors is not known...
  6. pmc Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans
    Thomas P J Solomon
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH44195, USA
    Am J Clin Nutr 90:1222-9. 2009
    ..The optimal combination of diet and exercise that produces the greatest reversal of obesity-related insulin resistance is unknown...
  7. pmc Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 98:E1181-8. 2013
    ..Hepatic steatosis, insulin resistance, inflammation, low levels of polyunsaturated lipids, and adiponectin are implicated in the development and progression of nonalcoholic fatty liver disease (NAFLD)...
  8. pmc Retinol-binding protein 4 (RBP4) protein expression is increased in omental adipose tissue of severely obese patients
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Obesity (Silver Spring) 18:663-6. 2010
    ..55, P = 0.06). These data suggest that RBP4 may regulate adiposity, and p85 expression in obese-T2DM, thus providing a link to impaired insulin signaling and diabetes in severely obese patients...
  9. pmc Urinary albumin excretion, HMW adiponectin, and insulin sensitivity in type 2 diabetic patients undergoing bariatric surgery
    Sankar D Navaneethan
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Ave, Q7, Cleveland, OH 44195, USA
    Obes Surg 20:308-15. 2010
    ..In this pilot study, we determined the effect of weight loss induced by different types of bariatric surgery on albuminuria in severely obese type 2 diabetic (T2DM) subjects...
  10. pmc Lifestyle-induced decrease in fat mass improves adiponectin secretion in obese adults
    Karen R Kelly
    1Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 2Department of Nutrition, Case Western Reserve University, School of Medicine, Cleveland, OH 3Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH 4Department of Physiology, Case Western Reserve University, School of Medicine, Cleveland, OH and 5Metabolic Translational Research Center, Cleveland Clinic, Cleveland, OH
    Med Sci Sports Exerc 46:920-6. 2014
    ..5 yr, body mass index = 34.5 ± 0.7 kg·m)...
  11. pmc Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Metabolism 59:200-5. 2010
    ..We conclude that, during acute altitude exposure, there is a rapid metabolic response that is accompanied by a shift in the hormonal milieu that appears to favor increased glucose utilization...
  12. pmc Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Diabetes 58:337-43. 2009
    ..Ceramides are a putative mediator of insulin resistance and lipotoxicity, and accumulation of ceramides within tissues in obese and diabetic subjects has been well described...
  13. pmc Reduced cardiovascular risk following bariatric surgeries is related to a partial recovery from "adiposopathy"
    Swathi Appachi
    Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
    Obes Surg 21:1928-36. 2011
    ..We hypothesized that bariatric surgery reduces CVD risk by favorably altering the pro-inflammatory profile of adipose tissue as a result of weight loss...
  14. pmc The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland, OH 44195, USA
    Am J Physiol Endocrinol Metab 296:E1269-74. 2009
    ....