Karen R Kelly

Summary

Affiliation: Naval Medical Center
Country: USA

Publications

  1. pmc A low-glycemic index diet and exercise intervention reduces TNF(alpha) in isolated mononuclear cells of older, obese adults
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Nutr 141:1089-94. 2011
  2. pmc Exercise training with weight loss and either a high- or low-glycemic index diet reduces metabolic syndrome severity in older adults
    Steven K Malin
    Department of Pathobiology, Cleveland Clinic, and Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Ann Nutr Metab 61:135-41. 2012
  3. pmc Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide
    Thomas P J Solomon
    Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA
    Diabetes Care 33:1561-6. 2010
  4. doi request reprint A 7-d exercise program increases high-molecular weight adiponectin in obese adults
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Med Sci Sports Exerc 44:69-74. 2012
  5. pmc A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans
    Thomas Pj Solomon
    Department of Pathobiology, Lerner Research Institute and Nutrition, Case Western Reserve University, Cleveland, OH, USA
    Am J Clin Nutr 92:1359-68. 2010
  6. pmc Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans
    Thomas P J Solomon
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH44195, USA
    Am J Clin Nutr 90:1222-9. 2009
  7. pmc Retinol-binding protein 4 (RBP4) protein expression is increased in omental adipose tissue of severely obese patients
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Obesity (Silver Spring) 18:663-6. 2010
  8. pmc Urinary albumin excretion, HMW adiponectin, and insulin sensitivity in type 2 diabetic patients undergoing bariatric surgery
    Sankar D Navaneethan
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Ave, Q7, Cleveland, OH 44195, USA
    Obes Surg 20:308-15. 2010
  9. pmc Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Diabetes 58:337-43. 2009
  10. pmc Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Metabolism 59:200-5. 2010

Collaborators

Detail Information

Publications13

  1. pmc A low-glycemic index diet and exercise intervention reduces TNF(alpha) in isolated mononuclear cells of older, obese adults
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Nutr 141:1089-94. 2011
    ..A low-glycemic index diet has antiinflammatory and antidiabetogenic effects when combined with exercise in older, obese prediabetics...
  2. pmc Exercise training with weight loss and either a high- or low-glycemic index diet reduces metabolic syndrome severity in older adults
    Steven K Malin
    Department of Pathobiology, Cleveland Clinic, and Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Ann Nutr Metab 61:135-41. 2012
    ..Thus, we determined the effects of exercise training with a low (LoGIx)- or high (HiGIx)-glycemic index diet on the severity of the metabolic syndrome (Z-score)...
  3. pmc Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide
    Thomas P J Solomon
    Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA
    Diabetes Care 33:1561-6. 2010
    ..The mechanisms by which lifestyle intervention may modify insulin secretion in type 2 diabetes have also not been examined but may involve the incretin axis...
  4. doi request reprint A 7-d exercise program increases high-molecular weight adiponectin in obese adults
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Med Sci Sports Exerc 44:69-74. 2012
    ..Previously, we found that 7 d of exercise improves insulin sensitivity in obese subjects; however, whether short-term exercise training affects HMW adiponectin in obese persons is unknown...
  5. pmc A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans
    Thomas Pj Solomon
    Department of Pathobiology, Lerner Research Institute and Nutrition, Case Western Reserve University, Cleveland, OH, USA
    Am J Clin Nutr 92:1359-68. 2010
    ..The optimal lifestyle intervention that reverses diabetes risk factors is not known...
  6. pmc Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans
    Thomas P J Solomon
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH44195, USA
    Am J Clin Nutr 90:1222-9. 2009
    ..The optimal combination of diet and exercise that produces the greatest reversal of obesity-related insulin resistance is unknown...
  7. pmc Retinol-binding protein 4 (RBP4) protein expression is increased in omental adipose tissue of severely obese patients
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Obesity (Silver Spring) 18:663-6. 2010
    ..55, P = 0.06). These data suggest that RBP4 may regulate adiposity, and p85 expression in obese-T2DM, thus providing a link to impaired insulin signaling and diabetes in severely obese patients...
  8. pmc Urinary albumin excretion, HMW adiponectin, and insulin sensitivity in type 2 diabetic patients undergoing bariatric surgery
    Sankar D Navaneethan
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Ave, Q7, Cleveland, OH 44195, USA
    Obes Surg 20:308-15. 2010
    ..In this pilot study, we determined the effect of weight loss induced by different types of bariatric surgery on albuminuria in severely obese type 2 diabetic (T2DM) subjects...
  9. pmc Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Diabetes 58:337-43. 2009
    ..Ceramides are a putative mediator of insulin resistance and lipotoxicity, and accumulation of ceramides within tissues in obese and diabetic subjects has been well described...
  10. pmc Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Metabolism 59:200-5. 2010
    ..We conclude that, during acute altitude exposure, there is a rapid metabolic response that is accompanied by a shift in the hormonal milieu that appears to favor increased glucose utilization...
  11. pmc Reduced cardiovascular risk following bariatric surgeries is related to a partial recovery from "adiposopathy"
    Swathi Appachi
    Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
    Obes Surg 21:1928-36. 2011
    ..We hypothesized that bariatric surgery reduces CVD risk by favorably altering the pro-inflammatory profile of adipose tissue as a result of weight loss...
  12. pmc The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland, OH 44195, USA
    Am J Physiol Endocrinol Metab 296:E1269-74. 2009
    ....
  13. pmc Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 98:E1181-8. 2013
    ..Hepatic steatosis, insulin resistance, inflammation, low levels of polyunsaturated lipids, and adiponectin are implicated in the development and progression of nonalcoholic fatty liver disease (NAFLD)...