D L Doolan

Summary

Affiliation: Naval Medical Center
Country: USA

Publications

  1. ncbi The complexity of protective immunity against liver-stage malaria
    D L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 165:1453-62. 2000
  2. ncbi HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles
    D L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 165:1123-37. 2000
  3. ncbi Strategy for development of a pre-erythrocytic Plasmodium falciparum DNA vaccine for human use
    S L Hoffman
    Malaria Program, Naval Medical Research Institute, Bethesda, MD 20889 5607, USA
    Vaccine 15:842-5. 1997
  4. ncbi Toward clinical trials of DNA vaccines against malaria
    S L Hoffman
    Malaria Program, Naval Medical Research Institute, Bethesda, Maryland 20852, USA
    Immunol Cell Biol 75:376-81. 1997
  5. ncbi Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17kDa
    C Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Mol Immunol 44:3037-48. 2007
  6. ncbi CD4(+) T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein
    Y Charoenvit
    Malaria Program, Naval Medical Research Center, Bethesda, Maryland 20814 5055, USA
    Infect Immun 67:5604-14. 1999
  7. ncbi Determining liver stage parasite burden by real time quantitative PCR as a method for evaluating pre-erythrocytic malaria vaccine efficacy
    A A Witney
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Room 3A4O, Silver Spring, MD 20910-7500, USA
    Mol Biochem Parasitol 118:233-45. 2001
  8. ncbi IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model
    D L Doolan
    Malaria Program, Naval Medical Research Center, Bethesda, MD 20889, USA
    J Immunol 163:884-92. 1999
  9. ncbi Induction of CD4(+) T cell-dependent CD8(+) type 1 responses in humans by a malaria DNA vaccine
    R Wang
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Proc Natl Acad Sci U S A 98:10817-22. 2001
  10. ncbi Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice
    R A Gramzinski
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910-7500, USA
    Infect Immun 69:1643-9. 2001

Detail Information

Publications15

  1. ncbi The complexity of protective immunity against liver-stage malaria
    D L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 165:1453-62. 2000
    ....
  2. ncbi HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles
    D L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 165:1123-37. 2000
    ..falciparum validates our predictive strategy in a biologically relevant system and supports the potential for developing a broadly efficacious epitope-based vaccine against malaria focused on a limited number of peptide specificities...
  3. ncbi Strategy for development of a pre-erythrocytic Plasmodium falciparum DNA vaccine for human use
    S L Hoffman
    Malaria Program, Naval Medical Research Institute, Bethesda, MD 20889 5607, USA
    Vaccine 15:842-5. 1997
    ..We anticipate that optimization of multi-gene P. falciparum DNA vaccines designed to protect against malaria by inducing CD8+ T cells that target infected hepatocytes will require extensive clinical trials during the coming years...
  4. ncbi Toward clinical trials of DNA vaccines against malaria
    S L Hoffman
    Malaria Program, Naval Medical Research Institute, Bethesda, Maryland 20852, USA
    Immunol Cell Biol 75:376-81. 1997
    ..Herein, we review the rationale and experimental foundation for the anticipated P. falciparum DNA vaccine trials...
  5. ncbi Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17kDa
    C Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Mol Immunol 44:3037-48. 2007
    ..The identification of these epitopes will allow the evaluation of delivery systems for malaria vaccine candidates as well as the delineation of protective immune mechanisms...
  6. ncbi CD4(+) T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein
    Y Charoenvit
    Malaria Program, Naval Medical Research Center, Bethesda, Maryland 20814 5055, USA
    Infect Immun 67:5604-14. 1999
    ....
  7. ncbi Determining liver stage parasite burden by real time quantitative PCR as a method for evaluating pre-erythrocytic malaria vaccine efficacy
    A A Witney
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Room 3A4O, Silver Spring, MD 20910-7500, USA
    Mol Biochem Parasitol 118:233-45. 2001
    ..Our data establish this quantitative real-time PCR assay to be a fast and reproducible way of accurately assessing liver stage parasite burden and vaccine efficacy in rodent malaria models...
  8. ncbi IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model
    D L Doolan
    Malaria Program, Naval Medical Research Center, Bethesda, MD 20889, USA
    J Immunol 163:884-92. 1999
    ....
  9. ncbi Induction of CD4(+) T cell-dependent CD8(+) type 1 responses in humans by a malaria DNA vaccine
    R Wang
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Proc Natl Acad Sci U S A 98:10817-22. 2001
    ..Demonstration in humans of elicitation of the class I restricted IFN-gamma responses we believe necessary for protection against the liver stage of malaria parasites brings us closer to an effective malaria vaccine...
  10. ncbi Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice
    R A Gramzinski
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910-7500, USA
    Infect Immun 69:1643-9. 2001
    ..This is the first report that stimulation of the innate immune system by CpG immunostimulatory motifs can confer sterile protection against malaria...
  11. ncbi Immune response to pre-erythrocytic stages of malaria parasites
    D L Doolan
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Curr Mol Med 6:169-85. 2006
    ..Herein, we review our current understanding of the molecular and cellular aspects of pre-erythrocytic stage immunity...
  12. ncbi Mutating the anchor residues associated with MHC binding inhibits and deviates CD8+ T cell mediated protective immunity against malaria
    C Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Mol Immunol 44:2235-48. 2007
    ....
  13. ncbi DNA-based vaccines against malaria: status and promise of the Multi-Stage Malaria DNA Vaccine Operation
    D L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Int J Parasitol 31:753-62. 2001
    ....
  14. ncbi Expression of the chemokine MIG is a sensitive and predictive marker for antigen-specific, genetically restricted IFN-gamma production and IFN-gamma-secreting cells
    G T Brice
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910-7500, USA
    J Immunol Methods 257:55-69. 2001
    ..Our data validate this novel method for the detection of low as well as high levels of antigen-specific and genetically restricted IFN-gamma activity...
  15. ncbi Utilization of genomic sequence information to develop malaria vaccines
    D L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    J Exp Biol 206:3789-802. 2003
    ..Here, we present our strategy to exploit the genomic sequence of P. falciparum for malaria vaccine development...