D L Doolan

Summary

Affiliation: Naval Medical Center
Country: USA

Publications

  1. ncbi request reprint The complexity of protective immunity against liver-stage malaria
    D L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 165:1453-62. 2000
  2. ncbi request reprint HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles
    D L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 165:1123-37. 2000
  3. ncbi request reprint Strategy for development of a pre-erythrocytic Plasmodium falciparum DNA vaccine for human use
    S L Hoffman
    Malaria Program, Naval Medical Research Institute, Bethesda, MD 20889 5607, USA
    Vaccine 15:842-5. 1997
  4. ncbi request reprint Toward clinical trials of DNA vaccines against malaria
    S L Hoffman
    Malaria Program, Naval Medical Research Institute, Bethesda, Maryland 20852, USA
    Immunol Cell Biol 75:376-81. 1997
  5. ncbi request reprint Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17kDa
    C Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Mol Immunol 44:3037-48. 2007
  6. pmc CD4(+) T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein
    Y Charoenvit
    Malaria Program, Naval Medical Research Center, Bethesda, Maryland 20814 5055, USA
    Infect Immun 67:5604-14. 1999
  7. ncbi request reprint Determining liver stage parasite burden by real time quantitative PCR as a method for evaluating pre-erythrocytic malaria vaccine efficacy
    A A Witney
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Room 3A4O, Silver Spring, MD 20910-7500, USA
    Mol Biochem Parasitol 118:233-45. 2001
  8. ncbi request reprint IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model
    D L Doolan
    Malaria Program, Naval Medical Research Center, Bethesda, MD 20889, USA
    J Immunol 163:884-92. 1999
  9. pmc Induction of CD4(+) T cell-dependent CD8(+) type 1 responses in humans by a malaria DNA vaccine
    R Wang
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Proc Natl Acad Sci U S A 98:10817-22. 2001
  10. pmc Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice
    R A Gramzinski
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910-7500, USA
    Infect Immun 69:1643-9. 2001

Detail Information

Publications15

  1. ncbi request reprint The complexity of protective immunity against liver-stage malaria
    D L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 165:1453-62. 2000
    ....
  2. ncbi request reprint HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles
    D L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 165:1123-37. 2000
    ..falciparum validates our predictive strategy in a biologically relevant system and supports the potential for developing a broadly efficacious epitope-based vaccine against malaria focused on a limited number of peptide specificities...
  3. ncbi request reprint Strategy for development of a pre-erythrocytic Plasmodium falciparum DNA vaccine for human use
    S L Hoffman
    Malaria Program, Naval Medical Research Institute, Bethesda, MD 20889 5607, USA
    Vaccine 15:842-5. 1997
    ..We anticipate that optimization of multi-gene P. falciparum DNA vaccines designed to protect against malaria by inducing CD8+ T cells that target infected hepatocytes will require extensive clinical trials during the coming years...
  4. ncbi request reprint Toward clinical trials of DNA vaccines against malaria
    S L Hoffman
    Malaria Program, Naval Medical Research Institute, Bethesda, Maryland 20852, USA
    Immunol Cell Biol 75:376-81. 1997
    ..Herein, we review the rationale and experimental foundation for the anticipated P. falciparum DNA vaccine trials...
  5. ncbi request reprint Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17kDa
    C Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Mol Immunol 44:3037-48. 2007
    ..The identification of these epitopes will allow the evaluation of delivery systems for malaria vaccine candidates as well as the delineation of protective immune mechanisms...
  6. pmc CD4(+) T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein
    Y Charoenvit
    Malaria Program, Naval Medical Research Center, Bethesda, Maryland 20814 5055, USA
    Infect Immun 67:5604-14. 1999
    ....
  7. ncbi request reprint Determining liver stage parasite burden by real time quantitative PCR as a method for evaluating pre-erythrocytic malaria vaccine efficacy
    A A Witney
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Room 3A4O, Silver Spring, MD 20910-7500, USA
    Mol Biochem Parasitol 118:233-45. 2001
    ..Our data establish this quantitative real-time PCR assay to be a fast and reproducible way of accurately assessing liver stage parasite burden and vaccine efficacy in rodent malaria models...
  8. ncbi request reprint IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model
    D L Doolan
    Malaria Program, Naval Medical Research Center, Bethesda, MD 20889, USA
    J Immunol 163:884-92. 1999
    ....
  9. pmc Induction of CD4(+) T cell-dependent CD8(+) type 1 responses in humans by a malaria DNA vaccine
    R Wang
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Proc Natl Acad Sci U S A 98:10817-22. 2001
    ..Demonstration in humans of elicitation of the class I restricted IFN-gamma responses we believe necessary for protection against the liver stage of malaria parasites brings us closer to an effective malaria vaccine...
  10. pmc Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice
    R A Gramzinski
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910-7500, USA
    Infect Immun 69:1643-9. 2001
    ..This is the first report that stimulation of the innate immune system by CpG immunostimulatory motifs can confer sterile protection against malaria...
  11. ncbi request reprint Immune response to pre-erythrocytic stages of malaria parasites
    D L Doolan
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Curr Mol Med 6:169-85. 2006
    ..Herein, we review our current understanding of the molecular and cellular aspects of pre-erythrocytic stage immunity...
  12. ncbi request reprint Mutating the anchor residues associated with MHC binding inhibits and deviates CD8+ T cell mediated protective immunity against malaria
    C Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Mol Immunol 44:2235-48. 2007
    ....
  13. ncbi request reprint DNA-based vaccines against malaria: status and promise of the Multi-Stage Malaria DNA Vaccine Operation
    D L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Int J Parasitol 31:753-62. 2001
    ....
  14. ncbi request reprint Expression of the chemokine MIG is a sensitive and predictive marker for antigen-specific, genetically restricted IFN-gamma production and IFN-gamma-secreting cells
    G T Brice
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910-7500, USA
    J Immunol Methods 257:55-69. 2001
    ..Our data validate this novel method for the detection of low as well as high levels of antigen-specific and genetically restricted IFN-gamma activity...
  15. ncbi request reprint Utilization of genomic sequence information to develop malaria vaccines
    D L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    J Exp Biol 206:3789-802. 2003
    ..Here, we present our strategy to exploit the genomic sequence of P. falciparum for malaria vaccine development...