Thomas A Davis

Summary

Affiliation: Naval Medical Center
Country: USA

Publications

  1. ncbi request reprint Inflammatory biomarkers in combat wound healing
    Jason S Hawksworth
    Department of Regenerative Medicine, Combat Casualty Care, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Ann Surg 250:1002-7. 2009
  2. pmc Adipose-derived stromal cells promote allograft tolerance induction
    Thomas A Davis
    Regenerative Medicine Department, Operational and Undersea Medicine Directorate, Naval Medical Research Center, Silver Spring, Maryland, USA Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA Department of Medicine and Surgery Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA LaCell, LLC, New Orleans, Louisiana, USA
    Stem Cells Transl Med 3:1444-50. 2014
  3. doi request reprint Ectopic bone formation in severely combat-injured orthopedic patients -- a hematopoietic niche
    Thomas A Davis
    Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, USA
    Bone 56:119-26. 2013
  4. pmc Wound trauma mediated inflammatory signaling attenuates a tissue regenerative response in MRL/MpJ mice
    Stephen R Zins
    Regenerative Medicine Department, Operational and Undersea Medicine Directorate at the Naval Medical Research Center Silver Spring, MD 20910 7500, USA
    J Inflamm (Lond) 7:25. 2010
  5. doi request reprint Heterotopic ossification in complex orthopaedic combat wounds: quantification and characterization of osteogenic precursor cell activity in traumatized muscle
    Thomas A Davis
    Regenerative Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    J Bone Joint Surg Am 93:1122-31. 2011
  6. doi request reprint Genistein induces radioprotection by hematopoietic stem cell quiescence
    Thomas A Davis
    Regenerative Medicine Department, Combat Casualty Care Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Int J Radiat Biol 84:713-26. 2008
  7. doi request reprint Extracorporeal shock wave therapy suppresses the early proinflammatory immune response to a severe cutaneous burn injury
    Thomas A Davis
    Combat Casualty Care, Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Int Wound J 6:11-21. 2009
  8. pmc Osteogenic gene expression correlates with development of heterotopic ossification in war wounds
    Korboi N Evans
    Regenerative Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA
    Clin Orthop Relat Res 472:396-404. 2014
  9. doi request reprint Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation
    Michal Barshishat-Kupper
    Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20892, USA
    Exp Hematol 39:293-304. 2011
  10. pmc Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation
    Thomas A Davis
    Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD, USA
    Exp Hematol 38:270-81. 2010

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Inflammatory biomarkers in combat wound healing
    Jason S Hawksworth
    Department of Regenerative Medicine, Combat Casualty Care, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Ann Surg 250:1002-7. 2009
    ..Despite advances in complex wound management, appropriate timing of war wound closure remains subjective. In addition, the pathophysiology of acute wound failure is poorly defined...
  2. pmc Adipose-derived stromal cells promote allograft tolerance induction
    Thomas A Davis
    Regenerative Medicine Department, Operational and Undersea Medicine Directorate, Naval Medical Research Center, Silver Spring, Maryland, USA Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA Department of Medicine and Surgery Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA LaCell, LLC, New Orleans, Louisiana, USA
    Stem Cells Transl Med 3:1444-50. 2014
    ....
  3. doi request reprint Ectopic bone formation in severely combat-injured orthopedic patients -- a hematopoietic niche
    Thomas A Davis
    Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, USA
    Bone 56:119-26. 2013
    ..These findings begin to characterize the functional biology of ectopic bone and elucidate the interactions between HPC and non-hematopoietic cell types within the ectopic intramedullary hematopoietic microenvironmental niche identified. ..
  4. pmc Wound trauma mediated inflammatory signaling attenuates a tissue regenerative response in MRL/MpJ mice
    Stephen R Zins
    Regenerative Medicine Department, Operational and Undersea Medicine Directorate at the Naval Medical Research Center Silver Spring, MD 20910 7500, USA
    J Inflamm (Lond) 7:25. 2010
    ..The development of systemic inflammation following severe thermal injury has been implicated in immune dysfunction, delayed wound healing, multi-system organ failure and increased mortality...
  5. doi request reprint Heterotopic ossification in complex orthopaedic combat wounds: quantification and characterization of osteogenic precursor cell activity in traumatized muscle
    Thomas A Davis
    Regenerative Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    J Bone Joint Surg Am 93:1122-31. 2011
    ..We hypothesized that differences in the population of progenitor cells present in a wound would correlate with the subsequent formation of heterotopic ossification...
  6. doi request reprint Genistein induces radioprotection by hematopoietic stem cell quiescence
    Thomas A Davis
    Regenerative Medicine Department, Combat Casualty Care Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Int J Radiat Biol 84:713-26. 2008
    ..In this study we addressed whether genistein-induced radioprotection in mice is associated with alterations of the cell cycle of hematopoietic stem and progenitor cells...
  7. doi request reprint Extracorporeal shock wave therapy suppresses the early proinflammatory immune response to a severe cutaneous burn injury
    Thomas A Davis
    Combat Casualty Care, Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Int Wound J 6:11-21. 2009
    ....
  8. pmc Osteogenic gene expression correlates with development of heterotopic ossification in war wounds
    Korboi N Evans
    Regenerative Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA
    Clin Orthop Relat Res 472:396-404. 2014
    ..Heterotopic ossification (HO) is a frequent complication of modern wartime extremity injuries. The biological mechanisms responsible for the development of HO in traumatic wounds remain elusive...
  9. doi request reprint Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation
    Michal Barshishat-Kupper
    Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20892, USA
    Exp Hematol 39:293-304. 2011
    ..Here we investigate captopril and radiation regulation of erythropoietin (EPO) and thrombopoietin (TPO), key effectors of erythroid progenitor proliferation and differentiation...
  10. pmc Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation
    Thomas A Davis
    Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD, USA
    Exp Hematol 38:270-81. 2010
    ..We investigated the consequences of different regimens of the ACE inhibitor captopril on radiation-induced hematopoietic injury...
  11. pmc Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation
    Regina M Day
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    J Radiat Res 49:361-72. 2008
    ..These data suggest that genistein is protective against a range of radiation injuries...
  12. ncbi request reprint Differential cutaneous wound healing in thermally injured MRL/MPJ mice
    Thomas A Davis
    Naval Medical Research Center, Silver Spring, MD 20910, USA
    Wound Repair Regen 15:577-88. 2007
    ..Our results convincingly demonstrate that MRL/MpJ skin burn wounds heal with scar formation with delays in two critical wound healing events: wound closure, and myofibroblast development...
  13. doi request reprint Bioburden Increases Heterotopic Ossification Formation in an Established Rat Model
    Gabriel J Pavey
    Regenerative Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA
    Clin Orthop Relat Res 473:2840-7. 2015
    ..Our group has recently developed a small animal model of trauma-induced HO that incorporates many of the multifaceted injury patterns of combat trauma in the absence of bacterial contamination and subsequent wound colonization...
  14. pmc Lymphocyte depletion in experimental hemorrhagic shock in Swine
    Jason S Hawksworth
    Regenerative Medicine Department, Operational and Undersea Medicine Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Inflamm (Lond) 9:34. 2012
    ..abstract:..
  15. pmc Lymphocyte modulation with FTY720 improves hemorrhagic shock survival in swine
    Jason S Hawksworth
    Regenerative Medicine Department, Operational and Undersea Medicine Directorate, Naval Medical Research Center, Silver Spring, Maryland, United States of America
    PLoS ONE 7:e34224. 2012
    ..These results support a novel and clinically relevant lymphocyte immunomodulation strategy to ameliorate secondary immune injury in hemorrhagic shock...
  16. doi request reprint Comparative analysis of angiogenic gene expression in normal and impaired wound healing in diabetic mice: effects of extracorporeal shock wave therapy
    Stephen R Zins
    Regenerative Medicine Department, Operational and Undersea Medicine Directorate, Naval Medical Research Center, Room 2W06, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Angiogenesis 13:293-304. 2010
    ..These data provide a more complete picture of impaired wound healing, and a way to evaluate various promising treatments...
  17. doi request reprint Infusion of Lin- bone marrow cells results in multilineage macrochimerism and skin allograft tolerance in minimally conditioned recipient mice
    Khairul Anam
    Regenerative Medicine Department, Operational and Undersea Medicine Directorate at the Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Transpl Immunol 24:69-75. 2010
    ....
  18. ncbi request reprint Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival
    Thomas A Davis
    Naval Medical Research Center, Silver Spring, Maryland, USA
    Int J Radiat Biol 83:141-51. 2007
    ..In this study we investigated the mechanism for genistein-induced radioprotection by evaluating the recovery of bone marrow cells and peripheral blood hematology in lethally irradiated mice...
  19. ncbi request reprint Mice with a regenerative wound healing capacity and an SLE autoimmune phenotype contain elevated numbers of circulating and marrow-derived macrophage progenitor cells
    Thomas A Davis
    Endogeny Bio Corporation, 9700 Great Seneca Highway, Rockville, MD 20850, USA
    Blood Cells Mol Dis 34:17-25. 2005
    ....
  20. ncbi request reprint Prior injury accelerates subsequent wound closure in a mouse model of regeneration
    Thomas A Davis
    Endogeny Bio Corporation, 9700 Great Seneca Highway, Rockville, MD 20850, USA
    Cell Tissue Res 320:417-26. 2005
    ....
  21. doi request reprint An Evolving Uncontrolled Hemorrhage Model Using Cynomolgus Macaques
    Benjamin A Bograd
    Department of Surgery, Walter Reed National Military Medical Center, Bethesda and Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring Department of Surgery, Uniformed Services, University of the Health Sciences, Bethesda, Maryland
    Shock 44:123-8. 2015
    ..In this prospective study, the pathophysiology of a nonhuman primate uncontrolled hemorrhagic shock model is evaluated with the goal of creating an acute systemic inflammatory syndrome response and a reproducible hemorrhage...
  22. doi request reprint Preventing Heterotopic Ossification in Combat Casualties-Which Models Are Best Suited for Clinical Use?
    Keith A Alfieri
    Department of Orthopaedics, Walter Reed National Military Medical Center, Bethesda, MD, USA
    Clin Orthop Relat Res 473:2807-13. 2015
    ..There are no validated models to help guide clinicians in the treatment for this common and potentially disabling condition...
  23. doi request reprint Burned to the bone
    Jonathan A Forsberg
    Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Sci Transl Med 6:255fs37. 2014
    ..this issue)...
  24. pmc Trauma is danger
    Paul F Hwang
    Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, USA
    J Transl Med 9:92. 2011
    ..Herein, we attempt to describe the immunologic response to systemic trauma in the context of the Danger model...
  25. doi request reprint The majority of US combat casualty soft-tissue wounds are not infected or colonized upon arrival or during treatment at a continental US military medical facility
    Forest R Sheppard
    Department of Surgery, National Naval Medical Center, Bethesda, MD, USA
    Am J Surg 200:489-95. 2010
    ..This study was designed to determine the microbial flora and bacterial quantification of present-day war wounds in US troops from Iraq and Afghanistan upon arrival at the National Naval Medical Center (NNMC)...
  26. doi request reprint Early Characterization of Blast-related Heterotopic Ossification in a Rat Model
    Ammar T Qureshi
    Regenerative Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA
    Clin Orthop Relat Res 473:2831-9. 2015
    ..Defining the timing of early osteogenic-related genes may help identify candidate prophylactic agents and guide the timing of prophylactic therapy after blast and other combat-related extremity injuries...
  27. doi request reprint Modeling acute traumatic injury
    Apple P Valparaiso
    Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, Maryland Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland
    J Surg Res 194:220-32. 2015
    ....