Research Topics
| Thomas A DavisSummaryAffiliation: Naval Medical Center Country: USA Publications
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Detail Information
Publications
Inflammatory biomarkers in combat wound healingJason S Hawksworth
Department of Regenerative Medicine, Combat Casualty Care, Naval Medical Research Center, Silver Spring, MD 20910, USA
Ann Surg 250:1002-7. 2009..Despite advances in complex wound management, appropriate timing of war wound closure remains subjective. In addition, the pathophysiology of acute wound failure is poorly defined...
Wound trauma mediated inflammatory signaling attenuates a tissue regenerative response in MRL/MpJ miceStephen R Zins
Regenerative Medicine Department, Operational and Undersea Medicine Directorate at the Naval Medical Research Center Silver Spring, MD 20910 7500, USA
J Inflamm (Lond) 7:25. 2010..The development of systemic inflammation following severe thermal injury has been implicated in immune dysfunction, delayed wound healing, multi-system organ failure and increased mortality...
Heterotopic ossification in complex orthopaedic combat wounds: quantification and characterization of osteogenic precursor cell activity in traumatized muscleThomas A Davis
Regenerative Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
J Bone Joint Surg Am 93:1122-31. 2011..We hypothesized that differences in the population of progenitor cells present in a wound would correlate with the subsequent formation of heterotopic ossification...
Genistein induces radioprotection by hematopoietic stem cell quiescenceThomas A Davis
Regenerative Medicine Department, Combat Casualty Care Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA
Int J Radiat Biol 84:713-26. 2008..In this study we addressed whether genistein-induced radioprotection in mice is associated with alterations of the cell cycle of hematopoietic stem and progenitor cells...
Extracorporeal shock wave therapy suppresses the early proinflammatory immune response to a severe cutaneous burn injuryThomas A Davis
Combat Casualty Care, Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD 20910, USA
Int Wound J 6:11-21. 2009....
Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiationThomas A Davis
Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD, USA
Exp Hematol 38:270-81. 2010..We investigated the consequences of different regimens of the ACE inhibitor captopril on radiation-induced hematopoietic injury...
Differential cutaneous wound healing in thermally injured MRL/MPJ miceThomas A Davis
Naval Medical Research Center, Silver Spring, MD 20910, USA
Wound Repair Regen 15:577-88. 2007..Our results convincingly demonstrate that MRL/MpJ skin burn wounds heal with scar formation with delays in two critical wound healing events: wound closure, and myofibroblast development...
Lymphocyte depletion in experimental hemorrhagic shock in SwineJason S Hawksworth
Regenerative Medicine Department, Operational and Undersea Medicine Directorate, Naval Medical Research Center, Silver Spring, MD 20910, USA
J Inflamm (Lond) 9:34. 2012..abstract:..
Lymphocyte modulation with FTY720 improves hemorrhagic shock survival in swineJason S Hawksworth
Regenerative Medicine Department, Operational and Undersea Medicine Directorate, Naval Medical Research Center, Silver Spring, Maryland, United States of America
PLoS ONE 7:e34224. 2012..These results support a novel and clinically relevant lymphocyte immunomodulation strategy to ameliorate secondary immune injury in hemorrhagic shock...
Comparative analysis of angiogenic gene expression in normal and impaired wound healing in diabetic mice: effects of extracorporeal shock wave therapyStephen R Zins
Regenerative Medicine Department, Operational and Undersea Medicine Directorate, Naval Medical Research Center, Room 2W06, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Angiogenesis 13:293-304. 2010..These data provide a more complete picture of impaired wound healing, and a way to evaluate various promising treatments...
Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survivalThomas A Davis
Naval Medical Research Center, Silver Spring, Maryland, USA
Int J Radiat Biol 83:141-51. 2007..In this study we investigated the mechanism for genistein-induced radioprotection by evaluating the recovery of bone marrow cells and peripheral blood hematology in lethally irradiated mice...
Infusion of Lin- bone marrow cells results in multilineage macrochimerism and skin allograft tolerance in minimally conditioned recipient miceKhairul Anam
Regenerative Medicine Department, Operational and Undersea Medicine Directorate at the Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
Transpl Immunol 24:69-75. 2010....
The majority of US combat casualty soft-tissue wounds are not infected or colonized upon arrival or during treatment at a continental US military medical facilityForest R Sheppard
Department of Surgery, National Naval Medical Center, Bethesda, MD, USA
Am J Surg 200:489-95. 2010..This study was designed to determine the microbial flora and bacterial quantification of present-day war wounds in US troops from Iraq and Afghanistan upon arrival at the National Naval Medical Center (NNMC)...
Prior injury accelerates subsequent wound closure in a mouse model of regenerationThomas A Davis
Endogeny Bio Corporation, 9700 Great Seneca Highway, Rockville, MD 20850, USA
Cell Tissue Res 320:417-26. 2005....
Mice with a regenerative wound healing capacity and an SLE autoimmune phenotype contain elevated numbers of circulating and marrow-derived macrophage progenitor cellsThomas A Davis
Endogeny Bio Corporation, 9700 Great Seneca Highway, Rockville, MD 20850, USA
Blood Cells Mol Dis 34:17-25. 2005....
Trauma is dangerPaul F Hwang
Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, USA
J Transl Med 9:92. 2011..Herein, we attempt to describe the immunologic response to systemic trauma in the context of the Danger model...
