Research Topics
| Mikulas ChavkoSummaryAffiliation: Naval Medical Center Country: USA Publications
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Detail Information
Publications
Activation of BDNF mRNA and protein after seizures in hyperbaric oxygen: implications for sensitization to seizures in re-exposuresMikulas Chavko
Naval Medical Research Center, Environmental Physiology Department, Silver Spring, Maryland 20910, USA
Neurochem Res 27:1649-53. 2002..Administration of exogenous BDNF significantly shortened latent time to seizures in HBO exposures. We propose that upregulation of BDNF expression in the brain after seizures may contribute to sensitization to HBO toxicity...- Relationship between protein nitration and oxidation and development of hyperoxic seizuresMikulas Chavko
Operational and Undersea Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
Nitric Oxide 9:18-23. 2003..Pre-seizure increases in protein NT might indicate its role in the mechanism of HBO2-induced brain toxicity. This is supported by the observed capacity of 7-NI to inhibit tyrosine nitration and increase time to seizure... - Measurement of blast wave by a miniature fiber optic pressure transducer in the rat brainMikulas Chavko
Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910, United States
J Neurosci Methods 159:277-81. 2007..Short pressure waves lasting several ms were detected inside the brain with the magnitude that might result in nervous tissue damage... - Lung injury and recovery after exposure to blast overpressureMikulas Chavko
Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
J Trauma 61:933-42. 2006..The objective of this study was to characterize the progression of oxidative and inflammatory responses in lungs as well as the activation of consequent protective mechanisms after exposure to medium intensity BOP... - Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depressionGuoqiang Xing
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
Schizophr Res 58:21-30. 2002..28, P < 0.05, n = 60) and in the PMI controlled subgroup (r = 0.43, P < 0.01, n = 38). Our data provide evidence of reduced cNOS activity in the postmortem brains of patients with schizophrenia and depression... - Increased sensitivity to seizures in repeated exposures to hyperbaric oxygen: role of NOS activationM Chavko
Environmental Physiology Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Brain Res 900:227-33. 2001..nNOS upregulation 1 and 2 days after seizures and protection against HBO(2) seizures by nNOS-specific inhibitor 7-nitroindazole (7-NI) suggest possible involvement of NO in the mechanism of increased sensitivity to HBO(2) in reexposures... - Extension of brain tolerance to hyperbaric O2 by intermittent air breaks is related to the time of CBF increaseMikulas Chavko
Operational and Hyperbaric Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Brain Res 1084:196-201. 2006..Results show that an "optimal window" of HBO2 exposure is required for benefits by intermittent exposure to air... - Mechanisms of protection against pulmonary hyperbaric O(2) toxicity by intermittent air breaksMikulas Chavko
Trauma and Resuscitative Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Eur J Appl Physiol 102:525-32. 2008..The mechanism of inhibition may involve the antiinflammatory and antioxidative effect of HO-1 but some other mechanisms may also be involved in protection by intermittent air breaks... 
Microarray analysis of gene expression in rat cortical neurons exposed to hyperbaric air and oxygenYe Chen
Undersea Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910, USA
Neurochem Res 34:1047-56. 2009....- Protection against blast-induced mortality in rats by heminMikulas Chavko
Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, Maryland, USA
J Trauma 65:1140-5; discussion 1145. 2008..Heme oxygenase-1 (HO-1) is activated by hemin, a product of Hb degradation and may confer protection against hemoglobin-mediated oxidative cell and tissue damage... - Relationship between orientation to a blast and pressure wave propagation inside the rat brainMikulas Chavko
Neurotrauma Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
J Neurosci Methods 195:61-6. 2011..The pattern of the pressure wave inside the brain in the head facing away from blast exposures assumes contribution of the static pressure, similar to hydrodynamic pressure to the pressure wave inside the brain... - Role of cerebral blood flow in seizures from hyperbaric oxygen exposureM Chavko
Naval Medical Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5607, USA
Brain Res 791:75-82. 1998..It also appears that the effect of drugs on seizure latency can be explained, at least in part, by their effect on CBF... - Attenuation of pulmonary inflammation after exposure to blast overpressure by N-acetylcysteine amideMikulas Chavko
Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
Shock 32:325-31. 2009..The inhibition of HO-1 mRNA activation after blast was likely also related to the drug antioxidant effect...