Mikulas Chavko

Summary

Affiliation: Naval Medical Center
Country: USA

Publications

  1. ncbi Activation of BDNF mRNA and protein after seizures in hyperbaric oxygen: implications for sensitization to seizures in re-exposures
    Mikulas Chavko
    Naval Medical Research Center, Environmental Physiology Department, Silver Spring, Maryland 20910, USA
    Neurochem Res 27:1649-53. 2002
  2. ncbi Relationship between protein nitration and oxidation and development of hyperoxic seizures
    Mikulas Chavko
    Operational and Undersea Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Nitric Oxide 9:18-23. 2003
  3. ncbi Measurement of blast wave by a miniature fiber optic pressure transducer in the rat brain
    Mikulas Chavko
    Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910, United States
    J Neurosci Methods 159:277-81. 2007
  4. ncbi Lung injury and recovery after exposure to blast overpressure
    Mikulas Chavko
    Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
    J Trauma 61:933-42. 2006
  5. ncbi Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depression
    Guoqiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Schizophr Res 58:21-30. 2002
  6. ncbi Increased sensitivity to seizures in repeated exposures to hyperbaric oxygen: role of NOS activation
    M Chavko
    Environmental Physiology Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Brain Res 900:227-33. 2001
  7. ncbi Extension of brain tolerance to hyperbaric O2 by intermittent air breaks is related to the time of CBF increase
    Mikulas Chavko
    Operational and Hyperbaric Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Brain Res 1084:196-201. 2006
  8. ncbi Mechanisms of protection against pulmonary hyperbaric O(2) toxicity by intermittent air breaks
    Mikulas Chavko
    Trauma and Resuscitative Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Eur J Appl Physiol 102:525-32. 2008
  9. doi Microarray analysis of gene expression in rat cortical neurons exposed to hyperbaric air and oxygen
    Ye Chen
    Undersea Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Neurochem Res 34:1047-56. 2009
  10. doi Protection against blast-induced mortality in rats by hemin
    Mikulas Chavko
    Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, Maryland, USA
    J Trauma 65:1140-5; discussion 1145. 2008

Detail Information

Publications13

  1. ncbi Activation of BDNF mRNA and protein after seizures in hyperbaric oxygen: implications for sensitization to seizures in re-exposures
    Mikulas Chavko
    Naval Medical Research Center, Environmental Physiology Department, Silver Spring, Maryland 20910, USA
    Neurochem Res 27:1649-53. 2002
    ..Administration of exogenous BDNF significantly shortened latent time to seizures in HBO exposures. We propose that upregulation of BDNF expression in the brain after seizures may contribute to sensitization to HBO toxicity...
  2. ncbi Relationship between protein nitration and oxidation and development of hyperoxic seizures
    Mikulas Chavko
    Operational and Undersea Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Nitric Oxide 9:18-23. 2003
    ..Pre-seizure increases in protein NT might indicate its role in the mechanism of HBO2-induced brain toxicity. This is supported by the observed capacity of 7-NI to inhibit tyrosine nitration and increase time to seizure...
  3. ncbi Measurement of blast wave by a miniature fiber optic pressure transducer in the rat brain
    Mikulas Chavko
    Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910, United States
    J Neurosci Methods 159:277-81. 2007
    ..Short pressure waves lasting several ms were detected inside the brain with the magnitude that might result in nervous tissue damage...
  4. ncbi Lung injury and recovery after exposure to blast overpressure
    Mikulas Chavko
    Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
    J Trauma 61:933-42. 2006
    ..The objective of this study was to characterize the progression of oxidative and inflammatory responses in lungs as well as the activation of consequent protective mechanisms after exposure to medium intensity BOP...
  5. ncbi Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depression
    Guoqiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Schizophr Res 58:21-30. 2002
    ..28, P < 0.05, n = 60) and in the PMI controlled subgroup (r = 0.43, P < 0.01, n = 38). Our data provide evidence of reduced cNOS activity in the postmortem brains of patients with schizophrenia and depression...
  6. ncbi Increased sensitivity to seizures in repeated exposures to hyperbaric oxygen: role of NOS activation
    M Chavko
    Environmental Physiology Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Brain Res 900:227-33. 2001
    ..nNOS upregulation 1 and 2 days after seizures and protection against HBO(2) seizures by nNOS-specific inhibitor 7-nitroindazole (7-NI) suggest possible involvement of NO in the mechanism of increased sensitivity to HBO(2) in reexposures...
  7. ncbi Extension of brain tolerance to hyperbaric O2 by intermittent air breaks is related to the time of CBF increase
    Mikulas Chavko
    Operational and Hyperbaric Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Brain Res 1084:196-201. 2006
    ..Results show that an "optimal window" of HBO2 exposure is required for benefits by intermittent exposure to air...
  8. ncbi Mechanisms of protection against pulmonary hyperbaric O(2) toxicity by intermittent air breaks
    Mikulas Chavko
    Trauma and Resuscitative Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Eur J Appl Physiol 102:525-32. 2008
    ..The mechanism of inhibition may involve the antiinflammatory and antioxidative effect of HO-1 but some other mechanisms may also be involved in protection by intermittent air breaks...
  9. doi Microarray analysis of gene expression in rat cortical neurons exposed to hyperbaric air and oxygen
    Ye Chen
    Undersea Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Neurochem Res 34:1047-56. 2009
    ....
  10. doi Protection against blast-induced mortality in rats by hemin
    Mikulas Chavko
    Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, Maryland, USA
    J Trauma 65:1140-5; discussion 1145. 2008
    ..Heme oxygenase-1 (HO-1) is activated by hemin, a product of Hb degradation and may confer protection against hemoglobin-mediated oxidative cell and tissue damage...
  11. doi Relationship between orientation to a blast and pressure wave propagation inside the rat brain
    Mikulas Chavko
    Neurotrauma Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    J Neurosci Methods 195:61-6. 2011
    ..The pattern of the pressure wave inside the brain in the head facing away from blast exposures assumes contribution of the static pressure, similar to hydrodynamic pressure to the pressure wave inside the brain...
  12. ncbi Role of cerebral blood flow in seizures from hyperbaric oxygen exposure
    M Chavko
    Naval Medical Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5607, USA
    Brain Res 791:75-82. 1998
    ..It also appears that the effect of drugs on seizure latency can be explained, at least in part, by their effect on CBF...
  13. doi Attenuation of pulmonary inflammation after exposure to blast overpressure by N-acetylcysteine amide
    Mikulas Chavko
    Trauma and Resuscitative Medicine Department, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Shock 32:325-31. 2009
    ..The inhibition of HO-1 mRNA activation after blast was likely also related to the drug antioxidant effect...