Genomes and Genes
Affiliation: Naval Medical Center
- Immunogenicity and protective efficacy of recombinant Campylobacter jejuni flagellum-secreted proteins in miceShahida Baqar
Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
Infect Immun 76:3170-5. 2008..jejuni CG8486 when delivered with (31.2%) or without (44.8%) LTR192G. These results suggest that FspA1 may be a good subunit vaccine candidate against C. jejuni disease...
- Campylobacter jejuni strain CG8421: a refined model for the study of Campylobacteriosis and evaluation of Campylobacter vaccines in human subjectsDavid R Tribble
Department of Enteric Diseases, Naval Medical Research Center, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Clin Infect Dis 49:1512-9. 2009..This work establishes a new C. jejuni human challenge model that uses a strain (CG8421) without ganglioside mimicry and that applies Campylobacter-specific cellular immunity screening to achieve high attack rates at lower inoculum doses...
- Assessment of the duration of protection in Campylobacter jejuni experimental infection in humansDavid R Tribble
Naval Medical Research Center, Silver Spring, Maryland, USA
Infect Immun 78:1750-9. 2010..jejuni. This study revealed a C. jejuni dose-related increase in campylobacteriosis rates, evidence of complete short-term protection that waned with time, and immune response patterns associated with protection...
- Genome sequence of a clinical isolate of Campylobacter jejuni from ThailandFrederic Poly
Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20906, USA
Infect Immun 75:3425-33. 2007....
- Safety and immunogenicity of an intranasal Shigella flexneri 2a Invaplex 50 vaccineMark S Riddle
Naval Medical Research Center, Silver Spring, MD, USA
Vaccine 29:7009-19. 2011..The current study examined vaccine safety and immunogenicity across a dose range and the clinical performance of a new intranasal delivery device...
- Immune response to and histopathology of Campylobacter jejuni infection in ferrets (Mustela putorius furo)Kevin W Nemelka
Division of Veterinary Medicine, Naval Medical Research Center, Silver Spring, Maryland, USA
Comp Med 59:363-71. 2009..The data presented contribute to the current knowledge of the pathogenicity of and immunologic response to C. jejuni CG8421 in ferrets and better understanding of this model...
- Characterization of two Campylobacter jejuni strains for use in volunteer experimental-infection studiesFrederic Poly
Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Infect Immun 76:5655-67. 2008..jejuni RM1221. The genomes of both strains shared a high degree of similarity to each other and, with the exception of the capsule locus of CG8421, to the type strain of the HS3 serotype, TGH9011...
- Safety and colonization of two novel VirG(IcsA)-based live Shigella sonnei vaccine strains in rhesus macaques (Macaca mulatta)Todd A Collins
The Walter Reed Army Institute of Research, Naval Medical Research Center, Silver Spring, MD, USA
Comp Med 58:88-94. 2008....
- Traveler's diarrhea in Thailand: randomized, double-blind trial comparing single-dose and 3-day azithromycin-based regimens with a 3-day levofloxacin regimenDavid R Tribble
Enteric Diseases Department, Naval Medical Research Center, Silver Spring, MD 20910, USA
Clin Infect Dis 44:338-46. 2007..Traveler's diarrhea in Thailand is frequently caused by Campylobacter jejuni. Rates of fluoroquinolone (FQ) resistance in Campylobacter organisms have exceeded 85% in recent years, and reduced fluoroquinolone efficacy has been observed...
- New World monkey Aotus nancymae as a model for Campylobacter jejuni infection and immunityFranca R Jones
Naval Medical Research Center, Biological Defense Research Directorate, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Infect Immun 74:790-3. 2006..Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti-Campylobacter vaccine efficacy...
- Neurologic symptoms and neuropathologic antibodies in poultry workers exposed to Campylobacter jejuniLance B Price
The Johns Hopkins University School of Medicine, Baltimore, MD21224 2780, USA
J Occup Environ Med 49:748-55. 2007..To examine associations between occupational exposure to live poultry with Campylobacter exposure, Campylobacter-associated neurologic symptoms, and neuropathologic antibodies...
- Diagnostic approach to acute diarrheal illness in a military population on training exercises in Thailand, a region of campylobacter hyperendemicityDavid R Tribble
Infectious Disease Clinical Research Program, Preventive Medicine and Biometrics Department, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 5119, USA
J Clin Microbiol 46:1418-25. 2008..Compared to the other tests evaluated, the Campylobacter EIA is a sensitive and specific rapid diagnostic test that may assist with diagnostic evaluation, with consideration of the epidemiological setting, logistics, and cost...
- Establishment of a non-human primate Campylobacter disease model for the pre-clinical evaluation of Campylobacter vaccine formulationsDilara Islam
Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences AFRIMS, 315 6 Rajvithi Road, Bangkok 10400, Thailand
Vaccine 24:3762-71. 2006....
- In vivo phase variation and serologic response to lipooligosaccharide of Campylobacter jejuni in experimental human infectionMartina M Prendergast
Department of Microbiology, National University of Ireland, Galway, Ireland
Infect Immun 72:916-22. 2004..jejuni or following administration of a killed C. jejuni whole-cell oral vaccine, although LOS phase variation occurred...