Veronica J Vieland

Summary

Affiliation: Nationwide Children's Hospital
Country: USA

Publications

  1. pmc Measurement of statistical evidence on an absolute scale following thermodynamic principles
    V J Vieland
    Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital and The Ohio State University, 575 Children s Crossroad, Columbus, OH 43215, USA
    Theory Biosci 132:181-94. 2013
  2. pmc KELVIN: a software package for rigorous measurement of statistical evidence in human genetics
    Veronica J Vieland
    Battelle Center for Mathematical Medicine, Research Institute at Nationwide Children s Hospital, Ohio State University, 700 Children s Drive, Columbus, OH 43205, USA
    Hum Hered 72:276-88. 2011
  3. pmc MLIP: using multiple processors to compute the posterior probability of linkage
    Manika Govil
    Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    BMC Bioinformatics 9:S2. 2008
  4. pmc Where's the evidence?
    Veronica J Vieland
    Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Hum Hered 71:59-66. 2011
  5. pmc A multilocus model of the genetic architecture of autoimmune thyroid disorder, with clinical implications
    Veronica J Vieland
    Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Am J Hum Genet 82:1349-56. 2008
  6. doi request reprint Association statistics under the PPL framework
    Yungui Huang
    The Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Genet Epidemiol 34:835-45. 2010
  7. doi request reprint Data-driven quantification of the robustness and sensitivity of cell signaling networks
    Sayak Mukherjee
    Battelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children s Hospital, The Ohio State University, 700 Children s Drive, Columbus, OH 43205, USA Department of Pediatrics, The Ohio State University, 700 Children s Drive, Columbus, OH 43205, USA
    Phys Biol 10:066002. 2013
  8. pmc Cell responses only partially shape cell-to-cell variations in protein abundances in Escherichia coli chemotaxis
    Sayak Mukherjee
    Battelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children s Hospital, and Departments of Pediatrics, Physics, Statistics, and Biophysics Graduate Program, The Ohio State University, Columbus, OH 43205
    Proc Natl Acad Sci U S A 110:18531-6. 2013
  9. pmc SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility
    Huiling He
    Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 98:E973-80. 2013
  10. pmc Fast and accurate calculation of a computationally intensive statistic for mapping disease genes
    Sang Cheol Seok
    Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    J Comput Biol 16:659-76. 2009

Collaborators

Detail Information

Publications36

  1. pmc Measurement of statistical evidence on an absolute scale following thermodynamic principles
    V J Vieland
    Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital and The Ohio State University, 575 Children s Crossroad, Columbus, OH 43215, USA
    Theory Biosci 132:181-94. 2013
    ....
  2. pmc KELVIN: a software package for rigorous measurement of statistical evidence in human genetics
    Veronica J Vieland
    Battelle Center for Mathematical Medicine, Research Institute at Nationwide Children s Hospital, Ohio State University, 700 Children s Drive, Columbus, OH 43205, USA
    Hum Hered 72:276-88. 2011
    ....
  3. pmc MLIP: using multiple processors to compute the posterior probability of linkage
    Manika Govil
    Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    BMC Bioinformatics 9:S2. 2008
    ..This paper describes MLIP, a multiprocessor two-point genetic linkage analysis system that supports statistical calculations, such as the PPL, based on the full parameter space implicit in the linkage likelihood...
  4. pmc Where's the evidence?
    Veronica J Vieland
    Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Hum Hered 71:59-66. 2011
    ..Here I begin to sketch out what such an endeavor might look like...
  5. pmc A multilocus model of the genetic architecture of autoimmune thyroid disorder, with clinical implications
    Veronica J Vieland
    Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Am J Hum Genet 82:1349-56. 2008
    ..This model has several clinical implications, which we believe will prove relevant to other complex diseases as well...
  6. doi request reprint Association statistics under the PPL framework
    Yungui Huang
    The Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Genet Epidemiol 34:835-45. 2010
    ..Here we examine the performance of the proposed LD statistics using simulated data, as well as assessing the effects of key modeling violations on this performance...
  7. doi request reprint Data-driven quantification of the robustness and sensitivity of cell signaling networks
    Sayak Mukherjee
    Battelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children s Hospital, The Ohio State University, 700 Children s Drive, Columbus, OH 43205, USA Department of Pediatrics, The Ohio State University, 700 Children s Drive, Columbus, OH 43205, USA
    Phys Biol 10:066002. 2013
    ..Our approach is general and can be used to evaluate robustness as well as generate predictions of single cell properties based on population averaged experimental data in a wide range of cell signaling systems. ..
  8. pmc Cell responses only partially shape cell-to-cell variations in protein abundances in Escherichia coli chemotaxis
    Sayak Mukherjee
    Battelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children s Hospital, and Departments of Pediatrics, Physics, Statistics, and Biophysics Graduate Program, The Ohio State University, Columbus, OH 43205
    Proc Natl Acad Sci U S A 110:18531-6. 2013
    ..These results illustrate the power of maximum entropy as a tool for the investigation of relationships between biological form and function. ..
  9. pmc SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility
    Huiling He
    Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 98:E973-80. 2013
    ..Papillary thyroid carcinoma (PTC) shows high heritability, yet efforts to find predisposing genes have been largely negative...
  10. pmc Fast and accurate calculation of a computationally intensive statistic for mapping disease genes
    Sang Cheol Seok
    Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    J Comput Biol 16:659-76. 2009
    ..The savings in evaluations is sufficiently large that previously intractable problems are now feasible in real time...
  11. ncbi request reprint Discussing gene-gene interaction: warning--translating equations to English may result in jabberwocky
    Christopher W Bartlett
    Center for Quantitative and Computational Biology and Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA
    Genet Epidemiol 31:S61-7. 2007
    ..The difficulty of using (primarily) affected sib pair data in a gene x gene interaction analysis is explored...
  12. pmc Exploiting gene x gene interaction in linkage analysis
    Yungui Huang
    Center for Quantitative and Computational Biology, Columbus Children s Research Institute, 700 Children s Drive, Columbus, Ohio 43205, USA
    BMC Proc 1:S64. 2007
    ..This suggests that gene x gene interactions could be effectively used in quantitative trait analyses even when families have been ascertained as ASPs for a related dichotomous trait...
  13. doi request reprint Meta-analysis of repository data: impact of data regularization on NIMH schizophrenia linkage results
    Kimberly A Walters
    Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio, United States of America
    PLoS ONE 9:e84696. 2014
    ..These results have implications for analyses based on other types of data (e.g., case-control GWAS or sequencing data) as well as data obtained from other repositories. ..
  14. pmc In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness
    Sayak Mukherjee
    Battelle Center for Mathematical Medicine, The Research Institute at the Nationwide Children s Hospital, Columbus, Ohio, United States of America
    PLoS ONE 8:e73937. 2013
    ..This identifies MaxEnt as an excellent tool for quantifying robustness for complex TCR signaling circuits and provides testable predictions to further elucidate a controversial mechanism of PIP3 signaling. ..
  15. pmc Employing MCMC under the PPL framework to analyze sequence data in large pedigrees
    Yungui Huang
    Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital Columbus, OH, USA
    Front Genet 4:59. 2013
    ..We illustrate both the positional mapping template, as well as the efficacy of the hybrid algorithm, in application to a single large pedigree with phenotypes simulated under a two-locus trait model...
  16. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
  17. ncbi request reprint Accumulating quantitative trait linkage evidence across multiple datasets using the posterior probability of linkage
    Christopher W Bartlett
    Center for Statistical Genetics Research, College of Public Health and Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Genet Epidemiol 31:91-102. 2007
    ....
  18. ncbi request reprint Thermometers: something for statistical geneticists to think about
    Veronica J Vieland
    College of Public Health and Carver College of Medicine, 2190 Westlawn Building, University of Iowa, Iowa City, IA 52242, USA
    Hum Hered 61:144-56. 2006
    ..I speculate that measures of evidence that come closer to meeting these requirements will do a better job of finding and characterizing genes, and I propose an alternative evidence metric as a step in this direction...
  19. ncbi request reprint The incorporation of prior genomic information does not necessarily improve the performance of Bayesian linkage methods: an example involving sex-specific recombination and the two-point PPL
    Mark W Logue
    Program in Public Health Genetics, College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA
    Hum Hered 60:196-205. 2005
    ..We present a two-point PPL allowing for unequal male and female recombination fractions, thetaM and thetaF, and consider alternative priors on thetaM, thetaF...
  20. ncbi request reprint HLODs, trait models, and ascertainment: implications of admixture for parameter estimation and linkage detection
    Veronica J Vieland
    Department of Biostatistics, Division of Statistical Genetics, Center for Statistical Genetics Research, University of Iowa, Iowa City 52240, USA
    Hum Hered 53:23-35. 2002
    ..These findings have important implications for the optimal handling of nuisance parameters in linkage analysis, particularly when evaluating the evidence for or against linkage based on multiple independent heterogeneous sets of data...
  21. pmc A major susceptibility locus for specific language impairment is located on 13q21
    Christopher W Bartlett
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Piscataway, NJ 08854 8095, USA
    Am J Hum Genet 71:45-55. 2002
    ..86, genomic P value <.06 under the recessive language impairment model). Our findings underscore the utility of traditional LOD-score-based methods in finding genes for complex diseases, specifically, SLI...
  22. ncbi request reprint Evaluation of FOXP2 as an autism susceptibility gene
    Thomas H Wassink
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Med Genet 114:566-9. 2002
    ..We conclude that FOXP2 is unlikely to contribute significantly to autism susceptibility...
  23. pmc Is schizophrenia linked to chromosome 1q?
    Anne S Bassett
    Department of Psychiatry, University of Torontoand Clinical Genetics Research Program, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario M6J 1H4, Canada
    Science 298:2277; author reply 2277. 2002
  24. pmc The emperor's new methods
    M Anne Spence
    Am J Hum Genet 72:1084-7. 2003
  25. pmc Two-locus heterogeneity cannot be distinguished from two-locus epistasis on the basis of affected-sib-pair data
    Veronica J Vieland
    Division of Statistical Genetics, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, 52242 1008, USA
    Am J Hum Genet 73:223-32. 2003
    ....
  26. pmc A model-integrated multipoint Bayesian analysis of hypertension in the Framingham Heart Study data finds little evidence of linkage
    Mark W Logue
    Division of Statistical Genetics, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA
    BMC Genet 4:S75. 2003
    ..While the PPL analysis of this data remains inconclusive, Bayesian methodology gives us a clear mechanism for using the information gained here in further studies...
  27. pmc Genome-wide linkage analysis of blood pressure under locus heterogeneity
    Xinqun Yang
    Department of Biostatistics, Division of Statistical Genetics, The University of Iowa, Iowa City, USA
    BMC Genet 4:S78. 2003
    ..01. Two of them (GATA14E09 and 049xd2) seem to overlap with linkage signals reported previously, while the other two are not linked to any known signals...
  28. pmc Examination of potential overlap in autism and language loci on chromosomes 2, 7, and 13 in two independent samples ascertained for specific language impairment
    Christopher W Bartlett
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA
    Hum Hered 57:10-20. 2004
    ..2003). Our results indicate that using samples selected for components of the autism phenotype may be a useful adjunct to autism genetics...
  29. ncbi request reprint A new method for computing the multipoint posterior probability of linkage
    Mark W Logue
    Program in Public Health Genetics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Hum Hered 57:90-9. 2004
    ..This version, which we call the imputed PPL, is shown to be superior to previously developed versions...
  30. ncbi request reprint Ascertainment bias in linkage analysis: comments on Ginsburg et al
    Veronica J Vieland
    Genet Epidemiol 28:283-5; author reply 286-7. 2005
  31. pmc Effects of updating linkage evidence across subsets of data: reanalysis of the autism genetic resource exchange data set
    Christopher W Bartlett
    Center for Statistical Genetics Research, College of Public Health, and Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Am J Hum Genet 76:688-95. 2005
    ..This analysis illustrates that the way in which heterogeneity is addressed in linkage analysis can dramatically affect the overall conclusions of a linkage study...
  32. ncbi request reprint A case of autism and uniparental disomy of chromosome 1
    Thomas H Wassink
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hum Genet 117:200-6. 2005
    ..In agreement with this, one of the regions of isodisomy overlaps an emerging chromosome 1 region of interest in autism located at 150-160 Mb...
  33. ncbi request reprint Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility gene
    Thomas H Wassink
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 136:36-44. 2005
    ..We conclude, therefore, that 2q37.3 continues to be a region of interest for autism susceptibility, and that CENTG2 is an intriguing candidate gene that merits further scrutiny for its role in autism...
  34. ncbi request reprint The posterior probability of linkage allowing for linkage disequilibrium and a new estimate of disequilibrium between a trait and a marker
    Xinqun Yang
    Center for Statistical Genetics Research, The University of Iowa, Iowa City, Iowa 52242, USA
    Hum Hered 59:210-9. 2005
    ..The estimate of D' also behaves well even in relatively small, heterogeneous samples...
  35. ncbi request reprint Heterogeneity: GAW Group 15
    Veronica J Vieland
    Program in Public Health Genetics and Center for Statistical Genetics Research, University of Iowa Colleges of Public Health and Medicine, Iowa City, Iowa 52245, USA
    Genet Epidemiol 29:S110-5. 2005
    ....
  36. pmc HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneity
    Susan E Hodge
    Am J Hum Genet 70:556-9. 2002