Research Topics
| Veronica J VielandSummaryAffiliation: Nationwide Children's Hospital Country: USA Publications
| Collaborators
|
Detail Information
Publications
KELVIN: a software package for rigorous measurement of statistical evidence in human geneticsVeronica J Vieland
Battelle Center for Mathematical Medicine, Research Institute at Nationwide Children s Hospital, Ohio State University, 700 Children s Drive, Columbus, OH 43205, USA
Hum Hered 72:276-88. 2011....- MLIP: using multiple processors to compute the posterior probability of linkageManika Govil
Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
BMC Bioinformatics 9:S2. 2008..This paper describes MLIP, a multiprocessor two-point genetic linkage analysis system that supports statistical calculations, such as the PPL, based on the full parameter space implicit in the linkage likelihood... - Where's the evidence?Veronica J Vieland
Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
Hum Hered 71:59-66. 2011..Here I begin to sketch out what such an endeavor might look like... - A multilocus model of the genetic architecture of autoimmune thyroid disorder, with clinical implicationsVeronica J Vieland
Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
Am J Hum Genet 82:1349-56. 2008..This model has several clinical implications, which we believe will prove relevant to other complex diseases as well... 
Association statistics under the PPL frameworkYungui Huang
The Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
Genet Epidemiol 34:835-45. 2010..Here we examine the performance of the proposed LD statistics using simulated data, as well as assessing the effects of key modeling violations on this performance...- Fast and accurate calculation of a computationally intensive statistic for mapping disease genesSang Cheol Seok
Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
J Comput Biol 16:659-76. 2009..The savings in evaluations is sufficiently large that previously intractable problems are now feasible in real time... 
Discussing gene-gene interaction: warning--translating equations to English may result in jabberwockyChristopher W Bartlett
Center for Quantitative and Computational Biology and Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA
Genet Epidemiol 31:S61-7. 2007..The difficulty of using (primarily) affected sib pair data in a gene x gene interaction analysis is explored...- Exploiting gene x gene interaction in linkage analysisYungui Huang
Center for Quantitative and Computational Biology, Columbus Children s Research Institute, 700 Children s Drive, Columbus, Ohio 43205, USA
BMC Proc 1:S64. 2007..This suggests that gene x gene interactions could be effectively used in quantitative trait analyses even when families have been ascertained as ASPs for a related dichotomous trait... - Mapping autism risk loci using genetic linkage and chromosomal rearrangementsPeter Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
Nat Genet 39:319-28. 2007..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs... - Accumulating quantitative trait linkage evidence across multiple datasets using the posterior probability of linkageChristopher W Bartlett
Center for Statistical Genetics Research, College of Public Health and Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA, USA
Genet Epidemiol 31:91-102. 2007.... - Thermometers: something for statistical geneticists to think aboutVeronica J Vieland
College of Public Health and Carver College of Medicine, 2190 Westlawn Building, University of Iowa, Iowa City, IA 52242, USA
Hum Hered 61:144-56. 2006..I speculate that measures of evidence that come closer to meeting these requirements will do a better job of finding and characterizing genes, and I propose an alternative evidence metric as a step in this direction... - The incorporation of prior genomic information does not necessarily improve the performance of Bayesian linkage methods: an example involving sex-specific recombination and the two-point PPLMark W Logue
Program in Public Health Genetics, College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA
Hum Hered 60:196-205. 2005..We present a two-point PPL allowing for unequal male and female recombination fractions, thetaM and thetaF, and consider alternative priors on thetaM, thetaF... - Heterogeneity: GAW Group 15Veronica J Vieland
Program in Public Health Genetics and Center for Statistical Genetics Research, University of Iowa Colleges of Public Health and Medicine, Iowa City, Iowa 52245, USA
Genet Epidemiol 29:S110-5. 2005.... - The posterior probability of linkage allowing for linkage disequilibrium and a new estimate of disequilibrium between a trait and a markerXinqun Yang
Center for Statistical Genetics Research, The University of Iowa, Iowa City, Iowa 52242, USA
Hum Hered 59:210-9. 2005..The estimate of D' also behaves well even in relatively small, heterogeneous samples... - Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility geneThomas H Wassink
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, 52242, USA
Am J Med Genet B Neuropsychiatr Genet 136:36-44. 2005..We conclude, therefore, that 2q37.3 continues to be a region of interest for autism susceptibility, and that CENTG2 is an intriguing candidate gene that merits further scrutiny for its role in autism... - A case of autism and uniparental disomy of chromosome 1Thomas H Wassink
Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Hum Genet 117:200-6. 2005..In agreement with this, one of the regions of isodisomy overlaps an emerging chromosome 1 region of interest in autism located at 150-160 Mb... - HLODs, trait models, and ascertainment: implications of admixture for parameter estimation and linkage detectionVeronica J Vieland
Department of Biostatistics, Division of Statistical Genetics, Center for Statistical Genetics Research, University of Iowa, Iowa City 52240, USA
Hum Hered 53:23-35. 2002..These findings have important implications for the optimal handling of nuisance parameters in linkage analysis, particularly when evaluating the evidence for or against linkage based on multiple independent heterogeneous sets of data... - A major susceptibility locus for specific language impairment is located on 13q21Christopher W Bartlett
Center for Molecular and Behavioral Neuroscience, Rutgers University, Piscataway, NJ 08854 8095, USA
Am J Hum Genet 71:45-55. 2002..86, genomic P value <.06 under the recessive language impairment model). Our findings underscore the utility of traditional LOD-score-based methods in finding genes for complex diseases, specifically, SLI... - Evaluation of FOXP2 as an autism susceptibility geneThomas H Wassink
Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
Am J Med Genet 114:566-9. 2002..We conclude that FOXP2 is unlikely to contribute significantly to autism susceptibility... - Is schizophrenia linked to chromosome 1q?Anne S Bassett
Department of Psychiatry, University of Torontoand Clinical Genetics Research Program, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario M6J 1H4, Canada
Science 298:2277; author reply 2277. 2002 - The emperor's new methodsM Anne Spence
Am J Hum Genet 72:1084-7. 2003 - Two-locus heterogeneity cannot be distinguished from two-locus epistasis on the basis of affected-sib-pair dataVeronica J Vieland
Division of Statistical Genetics, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, 52242 1008, USA
Am J Hum Genet 73:223-32. 2003.... - A model-integrated multipoint Bayesian analysis of hypertension in the Framingham Heart Study data finds little evidence of linkageMark W Logue
Division of Statistical Genetics, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA
BMC Genet 4:S75. 2003..While the PPL analysis of this data remains inconclusive, Bayesian methodology gives us a clear mechanism for using the information gained here in further studies... - Genome-wide linkage analysis of blood pressure under locus heterogeneityXinqun Yang
Department of Biostatistics, Division of Statistical Genetics, The University of Iowa, Iowa City, USA
BMC Genet 4:S78. 2003..01. Two of them (GATA14E09 and 049xd2) seem to overlap with linkage signals reported previously, while the other two are not linked to any known signals... - Examination of potential overlap in autism and language loci on chromosomes 2, 7, and 13 in two independent samples ascertained for specific language impairmentChristopher W Bartlett
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA
Hum Hered 57:10-20. 2004..2003). Our results indicate that using samples selected for components of the autism phenotype may be a useful adjunct to autism genetics... - A new method for computing the multipoint posterior probability of linkageMark W Logue
Program in Public Health Genetics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
Hum Hered 57:90-9. 2004..This version, which we call the imputed PPL, is shown to be superior to previously developed versions... - Ascertainment bias in linkage analysis: comments on Ginsburg et alVeronica J Vieland
Genet Epidemiol 28:283-5; author reply 286-7. 2005 - Effects of updating linkage evidence across subsets of data: reanalysis of the autism genetic resource exchange data setChristopher W Bartlett
Center for Statistical Genetics Research, College of Public Health, and Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
Am J Hum Genet 76:688-95. 2005..This analysis illustrates that the way in which heterogeneity is addressed in linkage analysis can dramatically affect the overall conclusions of a linkage study... - HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneitySusan E Hodge
Am J Hum Genet 70:556-9. 2002