Lynette K Rogers

Summary

Affiliation: Nationwide Children's Hospital
Country: USA

Publications

  1. pmc DHA supplementation: current implications in pregnancy and childhood
    Lynette K Rogers
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, 700 Children s Dr, Department of Pediatrics, The Ohio State University, Columbus, OH, United States
    Pharmacol Res 70:13-9. 2013
  2. pmc Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia
    Lynette K Rogers
    Department of Pediatrics, Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, The Ohio State University, Columbus, OH, USA
    Acta Paediatr 101:e321-6. 2012
  3. pmc Maternal docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice
    Lynette K Rogers
    Center for Perinatal Research, The Ohio State University, Columbus, OH 43205, USA
    J Nutr 141:214-22. 2011
  4. pmc Hyperoxia exposure alters hepatic eicosanoid metabolism in newborn mice
    Lynette K Rogers
    Center for Perinatal Research, Department of Pediatrics, The Research Institute at Nationwide Children s Hospital, Ohio State University, 700 Children s Dr, Columbus, Ohio 43205, USA
    Pediatr Res 67:144-9. 2010
  5. ncbi request reprint Diquat induces renal proximal tubule injury in glutathione reductase-deficient mice
    Lynette K Rogers
    Center for Developmental Pharmacology and Toxicology, Columbus Children s Research Institute, Columbus, OH 43205, USA
    Toxicol Appl Pharmacol 217:289-98. 2006
  6. pmc Maternal dietary docosahexaenoic acid supplementation attenuates fetal growth restriction and enhances pulmonary function in a newborn mouse model of perinatal inflammation
    Markus Velten
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, OH
    J Nutr 144:258-66. 2014
  7. pmc Differential responses in the lungs of newborn mouse pups exposed to 85% or >95% oxygen
    Lynette K Rogers
    The Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, Ohio State University, Columbus, Ohio 43205, USA
    Pediatr Res 65:33-8. 2009
  8. pmc Alterations of the thioredoxin system by hyperoxia: implications for alveolar development
    Trent E Tipple
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, 700 Children s Drive, Columbus, OH 43205, USA
    Am J Respir Cell Mol Biol 41:612-9. 2009
  9. pmc Deficits in lung alveolarization and function after systemic maternal inflammation and neonatal hyperoxia exposure
    Markus Velten
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, and Department of Pediatrics, The Ohio State University, 700 Children s Dr, Columbus, OH 43205, USA
    J Appl Physiol (1985) 108:1347-56. 2010
  10. pmc Thioredoxin-related mechanisms in hyperoxic lung injury in mice
    Trent E Tipple
    Columbus Children s Research Institute, Columbus Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Am J Respir Cell Mol Biol 37:405-13. 2007

Collaborators

Detail Information

Publications39

  1. pmc DHA supplementation: current implications in pregnancy and childhood
    Lynette K Rogers
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, 700 Children s Dr, Department of Pediatrics, The Ohio State University, Columbus, OH, United States
    Pharmacol Res 70:13-9. 2013
    ..However, optimal composition of the supplement and dosing and treatment strategies still need to be determined to lend support for routine supplementation...
  2. pmc Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia
    Lynette K Rogers
    Department of Pediatrics, Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, The Ohio State University, Columbus, OH, USA
    Acta Paediatr 101:e321-6. 2012
    ..The studies also tested a secondary hypothesis that plasma lipid metabolite levels were correlated with gestational age...
  3. pmc Maternal docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice
    Lynette K Rogers
    Center for Perinatal Research, The Ohio State University, Columbus, OH 43205, USA
    J Nutr 141:214-22. 2011
    ..In mice, DHA supplementation decreases leukocyte infiltration in the offspring exposed to hyperoxia, suggesting a potential role for DHA supplementation as a therapy to reduce inflammation in preterm infants...
  4. pmc Hyperoxia exposure alters hepatic eicosanoid metabolism in newborn mice
    Lynette K Rogers
    Center for Perinatal Research, Department of Pediatrics, The Research Institute at Nationwide Children s Hospital, Ohio State University, 700 Children s Dr, Columbus, Ohio 43205, USA
    Pediatr Res 67:144-9. 2010
    ..The findings of this study identify possible new mechanisms associated with hyperoxic lung injury in a newborn model of bronchopulmonary dysplasia and thus open opportunities for research...
  5. ncbi request reprint Diquat induces renal proximal tubule injury in glutathione reductase-deficient mice
    Lynette K Rogers
    Center for Developmental Pharmacology and Toxicology, Columbus Children s Research Institute, Columbus, OH 43205, USA
    Toxicol Appl Pharmacol 217:289-98. 2006
    ..8+/-4.1 vs 17.9+/-0.3 mg/dl). Diquat-induced renal injury in the GR-deficient Neu mice offers a useful model for studies of ROS-induced renal necrosis and of the contributions of GR in defense against oxidant-mediated injuries in vivo...
  6. pmc Maternal dietary docosahexaenoic acid supplementation attenuates fetal growth restriction and enhances pulmonary function in a newborn mouse model of perinatal inflammation
    Markus Velten
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, OH
    J Nutr 144:258-66. 2014
    ..In a model of severe inflammation, maternal DHA supplementation lessened inflammation and improved lung growth in the offspring. Maternal supplementation with DHA may be a therapeutic strategy to reduce neonatal inflammation. ..
  7. pmc Differential responses in the lungs of newborn mouse pups exposed to 85% or >95% oxygen
    Lynette K Rogers
    The Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, Ohio State University, Columbus, Ohio 43205, USA
    Pediatr Res 65:33-8. 2009
    ..Our data indicate that there are differences in the models of 85% or >95% O2 exposure and these differences may provide mechanistic insights into hyperoxic lung injury in an immature system...
  8. pmc Alterations of the thioredoxin system by hyperoxia: implications for alveolar development
    Trent E Tipple
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, 700 Children s Drive, Columbus, OH 43205, USA
    Am J Respir Cell Mol Biol 41:612-9. 2009
    ..The inverse correlation of Txnip with VEGF expression suggests that decreased Trx1 function contributes to the observed lung developmental abnormalities...
  9. pmc Deficits in lung alveolarization and function after systemic maternal inflammation and neonatal hyperoxia exposure
    Markus Velten
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, and Department of Pediatrics, The Ohio State University, 700 Children s Dr, Columbus, OH 43205, USA
    J Appl Physiol (1985) 108:1347-56. 2010
    ..This new model should be useful in designing studies of specific mechanisms and interventions that could ultimately be utilized to define therapies to prevent BPD in premature infants...
  10. pmc Thioredoxin-related mechanisms in hyperoxic lung injury in mice
    Trent E Tipple
    Columbus Children s Research Institute, Columbus Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Am J Respir Cell Mol Biol 37:405-13. 2007
    ..The protective effects of ATG against hyperoxic lung injury could prove to be particularly useful therapeutically...
  11. pmc Prenatal inflammation exacerbates hyperoxia-induced functional and structural changes in adult mice
    Markus Velten
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio, USA
    Am J Physiol Regul Integr Comp Physiol 303:R279-90. 2012
    ....
  12. ncbi request reprint Altered expressions of fibroblast growth factor receptors and alveolarization in neonatal mice exposed to 85% oxygen
    Min Soo Park
    Department of Pediatrics, Columbus Children s Research Institute, Columbus, Ohio 43205, USA
    Pediatr Res 62:652-7. 2007
    ..The temporally and spatially specific alterations in the expressions of FGFR-3, FGFR-4, and FGF-7 in the mice exposed to hyperoxia may contribute to aberrant lung development...
  13. pmc Neonatal hyperoxic exposure persistently alters lung secretoglobins and annexin A1
    Thomas M Raffay
    Nationwide Children s Hospital, The Ohio State University College of Medicine, Columbus, OH 43205, USA
    Biomed Res Int 2013:408485. 2013
    ..Studies to determine the mechanism(s) by which CCSP alterations affect SCGBs, ANXA1, and innate immune responses in BPD are warranted. ..
  14. ncbi request reprint Hyperoxia increases hepatic arginase expression and ornithine production in mice
    Daniel T Malleske
    Center for Developmental Pharmacology and Toxicology, Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Toxicol Appl Pharmacol 215:109-17. 2006
    ..NO production, as reflected by lower liver levels of NO(X). The resultant greater hepatic ornithine concentrations may represent a mechanism to facilitate tissue repair, by favoring the production of polyamines and/or proline...
  15. ncbi request reprint Analyses of glutathione reductase hypomorphic mice indicate a genetic knockout
    Lynette K Rogers
    Center for Developmental Pharmacology and Toxicology, Children s Research Institute, Columbus, Ohio 43205, USA
    Toxicol Sci 82:367-73. 2004
    ..The Neu mice offer live animal models with which to test hypotheses regarding oxidant mechanisms of tissue injury in vivo...
  16. pmc Perinatal inflammation results in decreased oligodendrocyte numbers in adulthood
    Amanda E Graf
    Center for Perinatal Research at Nationwide Children s Hospital, Columbus, OH, United States Department of Pediatrics, The Ohio State University, Columbus, OH, United States
    Life Sci 94:164-71. 2014
    ....
  17. pmc Glutathione reductase targeted to type II cells does not protect mice from hyperoxic lung injury
    Kathryn M Heyob
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205, USA
    Am J Respir Cell Mol Biol 39:683-8. 2008
    ....
  18. doi request reprint Riboflavin supplementation does not attenuate hyperoxic lung injury in transgenic (spc-mt)hGR mice
    Kathryn M Heyob
    The Research Institute at Nationwide Children s Hospital, The Ohio State University, Columbus, Ohio, USA
    Exp Lung Res 37:155-61. 2011
    ..The results indicated that modulation of mitochondrial GR activity in lung type II cells is not an effective therapy to minimize hyperoxic lung injury...
  19. pmc Adverse perinatal environment contributes to altered cardiac development and function
    Markus Velten
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio
    Am J Physiol Heart Circ Physiol 306:H1334-40. 2014
    ..Our data suggest that perinatal inflammation and hyperoxia exposure alter fetal development, resulting in early cardiac dysfunction. ..
  20. pmc Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury
    Lyn M Wancket
    Department of Veterinary Bioscience, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA
    Toxicol Pathol 40:1095-105. 2012
    ..The more severe phenotype exhibited by Mkp-1⁻/⁻ mice indicates that Mkp-1 plays a protective role during acute acetaminophen overdose, potentially through regulation of JNK...
  21. pmc Methods for the determination of plasma or tissue glutathione levels
    Trent E Tipple
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, OH, USA
    Methods Mol Biol 889:315-24. 2012
    ..The HPLC method is particularly useful for situations in which sample amounts are limited. Detailed instructions for performing each method as well as the advantages and disadvantages of each are discussed in this chapter...
  22. pmc Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps
    Jing Yan
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205, USA
    J Immunol 188:2316-27. 2012
    ..Thus, Gsr-mediated redox regulation is crucial for bacterial clearance during host defense against massive bacterial challenge...
  23. ncbi request reprint Compartmental inhibition of hepatic glutathione reductase activities by 1,3-bis(2-chloroethyl)-N-nitrosourea (BCNU) in Sprague-Dawley and Fischer-344 rats
    Katrina S Jopperi-Davis
    Section of Neonatology, Department of Pediatrics, Center for Developmental Pharmacology and Toxicology, Columbus Children s Research Institute, 700 Children s Drive, Rm W202, Columbus, OH 43205, USA
    Toxicol Lett 147:219-28. 2004
    ....
  24. ncbi request reprint Effects of fasting on tissue contents of coenzyme A and related intermediates in rats
    Floor A Jenniskens
    Center for Developmental Pharmacology and Toxicology, Columbus Children s Research Institute, Ohio State University, Columbus, Ohio 43205, USA
    Pediatr Res 52:437-42. 2002
    ....
  25. pmc Lipopolysaccharide-induced cyclooxygenase-2 expression in mouse transformed Clara cells
    Rodney D Britt
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, The Ohio State University, Columbus, OH 43205, USA
    Cell Physiol Biochem 29:213-22. 2012
    ..Clara cells, non-ciliated epithelial cells, are located in the distal airways in humans and conducting airways in mice. These cells actively participate in innate immune responses but their precise contributions remain poorly defined...
  26. pmc Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice
    Markus Velten
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 6:e24544. 2011
    ..In the present study, we hypothesized that systemic maternal inflammation and neonatal hyperoxia exposure compromise cardiac structure, resulting in LV dysfunction during adulthood...
  27. pmc Inhaled nitric oxide prevents 3-nitrotyrosine formation in the lungs of neonatal mice exposed to >95% oxygen
    Michael R Stenger
    Pulmonary Hypertension Group, Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, 700 Children s Drive, Columbus, OH 43205, USA
    Lung 188:217-27. 2010
    ..We speculate that the decreased protein nitration observed with the addition of NO may be a potential mechanism limiting hyperoxic lung injury...
  28. pmc Associations between maternal and infant morbidities and sRAGE within the first week of life in extremely preterm infants
    Lynette K Rogers
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio, United States of America Department of Pediatrics, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 8:e82537. 2013
    ....
  29. pmc The thioredoxin reductase-1 inhibitor aurothioglucose attenuates lung injury and improves survival in a murine model of acute respiratory distress syndrome
    Rodney D Britt
    1 Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio
    Antioxid Redox Signal 20:2681-91. 2014
    ..Using a murine ARDS model, we tested the hypothesis that aurothioglucose (ATG) treatment increases pulmonary GSH levels, attenuates lung injury, and decreases mortality in a GSH-dependent manner...
  30. pmc Glutathione reductase is essential for host defense against bacterial infection
    Jing Yan
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43205, USA State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou, People s Republic of China
    Free Radic Biol Med 61:320-332. 2013
    ..Our results indicate that the oxidative defense mechanism mediated by Gsr is required for an effective innate immune response against bacteria, probably by preventing phagocyte dysfunction due to oxidative damage...
  31. doi request reprint Maternal inflammation, growth retardation, and preterm birth: insights into adult cardiovascular disease
    Lynette K Rogers
    The Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, The Ohio State University, Columbus, Ohio, USA
    Life Sci 89:417-21. 2011
    ....
  32. ncbi request reprint CoASH and CoASSG levels in lungs of hyperoxic rats as potential biomarkers of intramitochondrial oxidant stresses
    Donough J O'Donovan
    Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Pediatr Res 51:346-53. 2002
    ....
  33. ncbi request reprint Detection of reversible protein thiol modifications in tissues
    Lynette K Rogers
    Center for Perinatal Research, Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Anal Biochem 358:171-84. 2006
    ..We demonstrated that reagents and techniques we have identified for disulfide detection in complex samples are also applicable to two-dimensional electrophoresis separations...
  34. ncbi request reprint Nuclear and nucleolar glutathione reductase, peroxidase, and transferase activities in livers of male and female Fischer-344 rats
    Lynette K Rogers
    Children s Research Institute, Center for Developmental Pharmacology and Toxicology, and Department of Pediatrics, Children s Hospital, The Ohio State University, Columbus, Ohio 43205, USA
    Toxicol Sci 69:279-85. 2002
    ..Nuclear GR, GPX, and GST probably contribute to antioxidant defense mechanisms, but the functions served by localization of GR and GPX in nucleoli are less evident...
  35. doi request reprint Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine
    Clifford L Cua
    The Heart Center, Nationwide Children s Hospital The Ohio State University, Columbus, OH, USA
    Eur J Pediatr 170:859-63. 2011
    ..5 ± 1.7 μM) versus non-PH patients (8.5 ± 7.3 μM). These results are consistent with ADMA contributing to lower NO production in DS patients with PH and suggest that ADMA levels may be a potential biomarker for PH in DS patients...
  36. ncbi request reprint Docosahexaenoic Acid and Amino Acid Contents in Pasteurized Donor Milk are Low for Preterm Infants
    Christina J Valentine
    Neonatal Nutrition Team, Ohio State University, Columbus, OH 43205, USA
    J Pediatr 157:906-10. 2010
    ..To evaluate whether pasteurized donor human milk meets the nutritional needs of preterm infants in terms of free fatty acid and amino acid contents...
  37. pmc Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity
    Michael R Farrell
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Free Radic Biol Med 49:1361-7. 2010
    ..Alterations in Txnip expression could alter lung VEGF expression in prematurely born human infants and contribute to the development of BPD...
  38. ncbi request reprint Stable transfection of Chinese hamster ovary cells with glutamate-cysteine ligase catalytic subunit cDNA confers increased resistance to tert-butyl hydroperoxide toxicity
    Caraciolo J Fernandes
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Toxicol Lett 136:107-20. 2002
    ....
  39. pmc Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury
    Morgan L Locy
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Antioxid Redox Signal 17:1407-16. 2012
    ..The present studies tested the hypothesis that TrxR1 inhibition protects against the effects of hyperoxia via nuclear factor E2-related factor 2 (Nrf2)-dependent mechanisms...