Leif D Nelin


Affiliation: Nationwide Children's Hospital
Country: USA


  1. Nelin L, Potenziano J. Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response. BMC Pediatr. 2019;19:17 pubmed publisher
    ..Thus, reliable, objective, early criteria for iNO response still need to be established, and initial PaO2/OI responses should be interpreted with caution, particularly when considering discontinuing iNO therapy. ..
  2. Li J, Wang X, Ackerman W, Batty A, Kirk S, White W, et al. Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis. Int J Mol Sci. 2018;19: pubmed publisher
    ..Taken together, our studies indicate that sepsis leads to a substantial change in triglyceride metabolic gene expression programs and Mkp-1 plays an important role in this process. ..
  3. Sood B, Keszler M, Garg M, Klein J, OHLS R, Ambalavanan N, et al. Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials. Trials. 2014;15:486 pubmed publisher
    ..CLINICALTRIALS.GOV: Pilot one: NCT number: 00598429 registered on 10 January 2008. Last updated: 3 February 2011. Pilot two: NCT number: 01467076 17 October 2011. Last updated: 13 February 2013. ..
  4. Shepherd E, Clouse B, Hasenstab K, Sitaram S, Malleske D, Nelin L, et al. Infant Pulmonary Function Testing and Phenotypes in Severe Bronchopulmonary Dysplasia. Pediatrics. 2018;141: pubmed publisher
  5. Nelin L, White H, Jin Y, Trittmann J, Chen B, Liu Y. The Src family tyrosine kinases src and yes have differential effects on inflammation-induced apoptosis in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2016;310:L880-8 pubmed publisher
  6. Jin Y, Jin Y, Chen B, Tipple T, Nelin L. Arginase II is a target of miR-17-5p and regulates miR-17-5p expression in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2014;307:L197-204 pubmed publisher
    ..We also found that l-arginine, the substrate for arginase II, and l-ornithine, the amino acid product of arginase II, were not involved in the regulation of miR-17-5p expression. ..
  7. Jin Y, Liu Y, Nelin L. Extracellular signal-regulated kinase mediates expression of arginase II but not inducible nitric-oxide synthase in lipopolysaccharide-stimulated macrophages. J Biol Chem. 2015;290:2099-111 pubmed publisher
    ..These results suggest that differential inhibition of the MAPK pathway may be a potential therapeutic strategy to regulate macrophage phenotype. ..
  8. White H, Jin Y, Chicoine L, Chen B, Liu Y, Nelin L. Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2017;312:L649-L656 pubmed publisher
    ..Our findings suggest that hypoxic activation of EGFR results in phosphorylation of ERK, which is required for hypoxic induction of arginase II and cellular proliferation. ..
  9. Setty B, Pillay Smiley N, Pool C, Jin Y, Liu Y, Nelin L. Hypoxia-induced proliferation of HeLa cells depends on epidermal growth factor receptor-mediated arginase II induction. Physiol Rep. 2017;5: pubmed publisher
    ..These results demonstrate an EGF/EGFR/arginase II pathway that is necessary for hypoxic proliferation in HeLa cells. ..

More Information


  1. Nelin L, Logan J. The use of inhaled corticosteroids in chronically ventilated preterm infants. Semin Fetal Neonatal Med. 2017;22:296-301 pubmed publisher
    ..Thus, there is a real need for well-powered randomized controlled trials examining short- and long-term outcomes of ICS use in this population. ..