Robert P Hoffman

Summary

Affiliation: Nationwide Children's Hospital
Country: USA

Publications

  1. pmc Ascorbic acid blocks hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes
    Robert P Hoffman
    Division of Pediatric Endocrinology, Metabolism and Diabetes, Department of Pediatrics, The Clinical Research Center of The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA
    Pediatr Diabetes 13:607-10. 2012
  2. doi request reprint Indices of insulin action calculated from fasting glucose and insulin reflect hepatic, not peripheral, insulin sensitivity in African-American and Caucasian adolescents
    Robert P Hoffman
    Division of Pediatric Endocrinology, Department of Pediatrics, The Clinical Research Center, The Ohio State University College of Medicine and Public Health, Columbus, OH, USA
    Pediatr Diabetes 9:57-61. 2008
  3. pmc Hyperglycemia increases muscle blood flow and alters endothelial function in adolescents with type 1 diabetes
    Amanda S Dye
    Department of Pediatrics, West Virginia University, Charleston, WV 25302, USA
    Exp Diabetes Res 2012:170380. 2012
  4. ncbi request reprint Pubertal changes in HOMA and QUICKI: relationship to hepatic and peripheral insulin sensitivity
    Robert P Hoffman
    Department of Pediatrics, The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA
    Pediatr Diabetes 5:122-5. 2004
  5. doi request reprint Young children (<5 yr) and adolescents (>12 yr) with type 1 diabetes mellitus have low rate of partial remission: diabetic ketoacidosis is an important risk factor
    Sasigarn A Bowden
    Division of Endocrinology, Department of Pediatrics, Columbus Children s Hospital, The Ohio State University College of Medicine, Columbus, OH, USA
    Pediatr Diabetes 9:197-201. 2008
  6. pmc Impaired endothelial function in healthy African-American adolescents compared with Caucasians
    Mary M Duck
    University of Cincinnati College of Medicine, Columbus, Ohio, USA
    J Pediatr 150:400-6. 2007
  7. ncbi request reprint Antecedent hypoglycemia does not alter increased epinephrine-induced lipolysis in type 1 diabetes mellitus
    Robert P Hoffman
    Division of Pediatric Endocrinology, Department of Pediatrics, The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA
    Metabolism 55:371-80. 2006
  8. ncbi request reprint Metabolic syndrome racial differences in adolescents
    Robert P Hoffman
    Department of Pediatrics, The Ohio State University College of Medicine and Public Health, The Research Institute of Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Curr Diabetes Rev 5:259-65. 2009
  9. ncbi request reprint Sympathetic mechanisms of hypoglycemic counterregulation
    Robert P Hoffman
    Department of Pediatrics, Children s Research Institute, Columbus, OH 43205, USA
    Curr Diabetes Rev 3:185-93. 2007
  10. ncbi request reprint Increased fasting triglyceride levels are associated with hepatic insulin resistance in Caucasian but not African-American adolescents
    Robert P Hoffman
    Division of Pediatric Endocrinology, Clinical Research Center of the Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA
    Diabetes Care 29:1402-4. 2006

Collaborators

Detail Information

Publications16

  1. pmc Ascorbic acid blocks hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes
    Robert P Hoffman
    Division of Pediatric Endocrinology, Metabolism and Diabetes, Department of Pediatrics, The Clinical Research Center of The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA
    Pediatr Diabetes 13:607-10. 2012
    ..To determine whether acute ascorbic acid infusions alter the effect of hyperglycemia on endothelial function in adolescents with type 1 diabetes...
  2. doi request reprint Indices of insulin action calculated from fasting glucose and insulin reflect hepatic, not peripheral, insulin sensitivity in African-American and Caucasian adolescents
    Robert P Hoffman
    Division of Pediatric Endocrinology, Department of Pediatrics, The Clinical Research Center, The Ohio State University College of Medicine and Public Health, Columbus, OH, USA
    Pediatr Diabetes 9:57-61. 2008
    ..001; QUICKI, p < 0.001). The relationships were similar in African-American and Caucasian subjects. These results demonstrate that in adolescents, HOMA(IR) and QUICKI assess hepatic but not peripheral insulin action...
  3. pmc Hyperglycemia increases muscle blood flow and alters endothelial function in adolescents with type 1 diabetes
    Amanda S Dye
    Department of Pediatrics, West Virginia University, Charleston, WV 25302, USA
    Exp Diabetes Res 2012:170380. 2012
    ..In addition they have implications for future studies of endothelial function in type 1 diabetes and provide insight into the etiology of macrovascular and microvascular complications of type 1 diabetes...
  4. ncbi request reprint Pubertal changes in HOMA and QUICKI: relationship to hepatic and peripheral insulin sensitivity
    Robert P Hoffman
    Department of Pediatrics, The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA
    Pediatr Diabetes 5:122-5. 2004
    ..They thus should reflect, in principle, insulin action on both the liver and the periphery...
  5. doi request reprint Young children (<5 yr) and adolescents (>12 yr) with type 1 diabetes mellitus have low rate of partial remission: diabetic ketoacidosis is an important risk factor
    Sasigarn A Bowden
    Division of Endocrinology, Department of Pediatrics, Columbus Children s Hospital, The Ohio State University College of Medicine, Columbus, OH, USA
    Pediatr Diabetes 9:197-201. 2008
    ....
  6. pmc Impaired endothelial function in healthy African-American adolescents compared with Caucasians
    Mary M Duck
    University of Cincinnati College of Medicine, Columbus, Ohio, USA
    J Pediatr 150:400-6. 2007
    ..To determine whether African-American adolescents have endothelial dysfunction compared with Caucasians and whether differences are a result of differences in insulin sensitivity calculated from total glucose (S(I)) or secretion...
  7. ncbi request reprint Antecedent hypoglycemia does not alter increased epinephrine-induced lipolysis in type 1 diabetes mellitus
    Robert P Hoffman
    Division of Pediatric Endocrinology, Department of Pediatrics, The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA
    Metabolism 55:371-80. 2006
    ..These results demonstrate that type 1 diabetic subjects have increased lipolysis and decreased glucose utilization in response to epinephrine. These effects are not altered by antecedent hypoglycemia...
  8. ncbi request reprint Metabolic syndrome racial differences in adolescents
    Robert P Hoffman
    Department of Pediatrics, The Ohio State University College of Medicine and Public Health, The Research Institute of Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Curr Diabetes Rev 5:259-65. 2009
    ..Future research should focus on the mechanisms of these abnormalities and ways to prevent their development in this age group...
  9. ncbi request reprint Sympathetic mechanisms of hypoglycemic counterregulation
    Robert P Hoffman
    Department of Pediatrics, Children s Research Institute, Columbus, OH 43205, USA
    Curr Diabetes Rev 3:185-93. 2007
    ..It is hoped that this information can be used in the future to help develop ways to protect patients with type 1 diabetes from hypoglycemia and its adverse effects...
  10. ncbi request reprint Increased fasting triglyceride levels are associated with hepatic insulin resistance in Caucasian but not African-American adolescents
    Robert P Hoffman
    Division of Pediatric Endocrinology, Clinical Research Center of the Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA
    Diabetes Care 29:1402-4. 2006
  11. ncbi request reprint Practical management of type 1 diabetes mellitus in adolescent patients: challenges and goals
    Robert P Hoffman
    Department of Pediatrics, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, USA
    Treat Endocrinol 3:27-39. 2004
    ..Regular eye exams, blood pressure monitoring, and urinary microalbumin measurements are critical. In this manner, the goals of management of type 1 diabetes in adolescents can be met...
  12. ncbi request reprint Growth hormone (GH) treatment does not restore endothelial function in children with GH deficiency
    Robert P Hoffman
    Division of Pediatric Endocrinology, Department of Pediatrics, The Ohio State University College of Medicine Children s Hospital, Columbus, OH 43205, USA
    J Pediatr Endocrinol Metab 21:323-8. 2008
    ..In adults with growth hormone (GH) deficiency (GHD), GH treatment restores impaired endothelial function, a precursor of cardiovascular disease. Its effect in children with GHD is unknown...
  13. doi request reprint Triple diabetes: coexistence of type 1 diabetes mellitus and a novel mutation in the gene responsible for MODY3 in an overweight adolescent
    Sasigarn A Bowden
    Division of Endocrinology, Department of Pediatrics, Columbus Children s Hospital, The Ohio State University, Columbus, OH 43205, USA
    Pediatr Diabetes 9:162-4. 2008
    ....
  14. ncbi request reprint Systemic and local adrenergic regulation of muscle glucose utilization during hypoglycemia in healthy subjects
    Robert P Hoffman
    Department of Pediatrics, Columbus Children s Hospital, Columbus, Ohio 43205, USA
    Diabetes 51:734-42. 2002
    ..alpha-Adrenergic activation inhibits vasodilation and helps maintain brain glucose delivery...
  15. ncbi request reprint Comparison of insulin sensitivity and glucose effectiveness determined by the one- and two-compartment-labeled minimal model in late prepubertal children and early adolescents
    Robert P Hoffman
    Department of Pediatrics, Ohio State University College of Medicine and Public Health, Columbus, OH, USA
    Metabolism 51:1582-6. 2002
    ..Thus, when insulin sensitivity is the primary interest, the 1CMM is more robust because its parameters are more reliably estimated than those of 2CMM and is the logical choice in pediatric population-based studies...
  16. doi request reprint Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients
    Suzanne E Kingery
    Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Pediatr Diabetes 13:408-18. 2012
    ..To determine the roles of complement C4A and C4B gene copy-number variations and their plasma protein concentrations in residual insulin secretion and loss of pancreatic β-cell function in new-onset type 1 diabetes (T1D) patients...