David S Hains

Summary

Affiliation: Nationwide Children's Hospital
Country: USA

Publications

  1. doi request reprint Do declining private insurance coverage rates influence pediatric hospital charging practices?
    David S Hains
    The Research Institute at Nationwide Children s Hospital, 700 Children s Drive, Columbus, OH 43205, USA
    Clin Pediatr (Phila) 50:417-23. 2011
  2. pmc Human alpha defensin 5 expression in the human kidney and urinary tract
    John David Spencer
    Pediatric Nephrology Fellowship Program, Nationwide Children s Hospital, Columbus, Ohio, United States of America
    PLoS ONE 7:e31712. 2012
  3. pmc Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract
    John David Spencer
    Department of Pediatrics, Division of Nephrology, Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Kidney Int 83:615-25. 2013
  4. doi request reprint The demographics and costs of inpatient vesicoureteral reflux management in the USA
    John David Spencer
    Pediatric Nephrology Fellowship Program, Nationwide Children s Hospital, The Ohio State University, Columbus, OH, USA
    Pediatr Nephrol 26:1995-2001. 2011
  5. pmc Molecular basis of renal adaptation in a murine model of congenital obstructive nephropathy
    Brian Becknell
    Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America Division of Pediatric Nephrology, Nationwide Children s Hospital, Columbus, Ohio, United States of America
    PLoS ONE 8:e72762. 2013
  6. doi request reprint Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract
    John D Spencer
    Pediatric Nephrology Fellowship Program, Nationwide Children s Hospital, The Ohio State University, Columbus, Ohio, USA
    Kidney Int 80:174-80. 2011
  7. pmc Struvite urolithiasis and chronic urinary tract infection in a murine model of urinary diversion
    Brian Becknell
    Division of Nephrology, Department of Pediatrics, Nationwide Children s Hospital, Columbus, OH 43205, USA
    Urology 81:943-8. 2013
  8. pmc An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract
    John D Spencer
    1 Division of Nephrology, Department of Pediatrics, Nationwide Children s Hospital, Columbus, Ohio, USA 2 Center for Clinical and Translational Research, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio, USA 3 Kidney Innate Immunity Research Group, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio, USA
    Kidney Int 85:1179-91. 2014
  9. doi request reprint Pediatric urinary tract infections: an analysis of hospitalizations, charges, and costs in the USA
    John David Spencer
    Department of Pediatrics, Ohio State University, Columbus, OH 43205, USA
    Pediatr Nephrol 25:2469-75. 2010
  10. pmc The accuracy and health risks of a voiding cystourethrogram after a febrile urinary tract infection
    John David Spencer
    Nationwide Children s Hospital, Department of Pediatrics, Division of Nephrology, 700 Children s Drive, Columbus, OH 43205, USA
    J Pediatr Urol 8:72-6. 2012

Detail Information

Publications20

  1. doi request reprint Do declining private insurance coverage rates influence pediatric hospital charging practices?
    David S Hains
    The Research Institute at Nationwide Children s Hospital, 700 Children s Drive, Columbus, OH 43205, USA
    Clin Pediatr (Phila) 50:417-23. 2011
    ..To analyze trends in primary payer composition for pediatric hospitalizations and insurance coverage rates from 2000 to 2006 and possible effects on hospital charging practices...
  2. pmc Human alpha defensin 5 expression in the human kidney and urinary tract
    John David Spencer
    Pediatric Nephrology Fellowship Program, Nationwide Children s Hospital, Columbus, Ohio, United States of America
    PLoS ONE 7:e31712. 2012
    ..Here, we characterize the expression and relevance of the AMP human alpha-defensin 5 (HD5) in the human kidney and urinary tract in normal and infected subjects...
  3. pmc Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract
    John David Spencer
    Department of Pediatrics, Division of Nephrology, Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Kidney Int 83:615-25. 2013
    ..Thus, RNase 7 expression is increased in the urinary tract with infection and has antibacterial activity against uropathogens at micromolar concentrations...
  4. doi request reprint The demographics and costs of inpatient vesicoureteral reflux management in the USA
    John David Spencer
    Pediatric Nephrology Fellowship Program, Nationwide Children s Hospital, The Ohio State University, Columbus, OH, USA
    Pediatr Nephrol 26:1995-2001. 2011
    ..Since 2000, hospital charges for inpatient VUR management have increased. More efforts are needed to evaluate cost-effective strategies for the evaluation and management of VUR...
  5. pmc Molecular basis of renal adaptation in a murine model of congenital obstructive nephropathy
    Brian Becknell
    Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America Division of Pediatric Nephrology, Nationwide Children s Hospital, Columbus, Ohio, United States of America
    PLoS ONE 8:e72762. 2013
    ..These observations will permit the development of novel biomarkers and therapeutic approaches to progressive renal injury in the context of congenital obstruction. ..
  6. doi request reprint Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract
    John D Spencer
    Pediatric Nephrology Fellowship Program, Nationwide Children s Hospital, The Ohio State University, Columbus, Ohio, USA
    Kidney Int 80:174-80. 2011
    ..Thus, RNase 7 is expressed in the human kidney and urinary tract and it may have an important antimicrobial role in maintaining tract sterility...
  7. pmc Struvite urolithiasis and chronic urinary tract infection in a murine model of urinary diversion
    Brian Becknell
    Division of Nephrology, Department of Pediatrics, Nationwide Children s Hospital, Columbus, OH 43205, USA
    Urology 81:943-8. 2013
    ..To characterize the clinical course after cutaneous vesicostomy (CV) in megabladder (mgb(-/-)) mice with functional urinary bladder obstruction...
  8. pmc An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract
    John D Spencer
    1 Division of Nephrology, Department of Pediatrics, Nationwide Children s Hospital, Columbus, Ohio, USA 2 Center for Clinical and Translational Research, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio, USA 3 Kidney Innate Immunity Research Group, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio, USA
    Kidney Int 85:1179-91. 2014
    ..Thus, these results demonstrate a new immunomodulatory role for RI and identified a unique regulatory pathway that may affect how RNase 7 maintains urinary tract sterility. ..
  9. doi request reprint Pediatric urinary tract infections: an analysis of hospitalizations, charges, and costs in the USA
    John David Spencer
    Department of Pediatrics, Ohio State University, Columbus, OH 43205, USA
    Pediatr Nephrol 25:2469-75. 2010
    ..Over time, more children hospitalized with a UTI depend on public agencies to cover healthcare expense. More efforts are needed to evaluate cost-effective strategies for evaluation and treatment of UTIs...
  10. pmc The accuracy and health risks of a voiding cystourethrogram after a febrile urinary tract infection
    John David Spencer
    Nationwide Children s Hospital, Department of Pediatrics, Division of Nephrology, 700 Children s Drive, Columbus, OH 43205, USA
    J Pediatr Urol 8:72-6. 2012
    ..This study examines the health risks and accuracy of VCUG testing after diagnosis of a febrile UTI...
  11. pmc The innate immune response during urinary tract infection and pyelonephritis
    John David Spencer
    Department of Pediatrics, Division of Nephrology, Nationwide Children s Hospital, 700 Children s Drive, Columbus, OH, 43205, USA
    Pediatr Nephrol 29:1139-49. 2014
    ..In doing so, we focus on the role of antimicrobial peptides-a ubiquitous component of the innate immune response. ..
  12. pmc High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma
    David S Hains
    Division of Nephrology, Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio, USA
    J Urol 183:2077-84. 2010
    ..We determined whether Fgfr2(Mes-/-) mutants developed abnormally positioned ureters predisposing to vesicoureteral reflux...
  13. doi request reprint Hepatoblastoma and prune belly syndrome: a potential association
    Brian Becknell
    Department of Pediatrics, Ohio State University College of Medicine, Columbus, OH 43205, USA
    Pediatr Nephrol 26:1269-73. 2011
    ..All individuals were born after 2002. These subjects lacked genetic, natal, or environmental factors known to confer risk of HBL. The occurrence of PBS and HBL in these patients constitutes a novel potential association...
  14. pmc Expression and antimicrobial function of beta-defensin 1 in the lower urinary tract
    Brian Becknell
    Section of Nephrology, Nationwide Children s Hospital, Columbus, Ohio, United States of America Center for Clinical and Translational Research, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio, United States of America
    PLoS ONE 8:e77714. 2013
    ..Thus, whereas mBD-1 deficiency does not alter bladder UPEC burden in vivo, we have identified mBD-3 and mBD-14 as potential mediators of mucosal immunity in the lower urinary tract...
  15. pmc Contribution of structural domains to the activity of ribonuclease 7 against uropathogenic bacteria
    Huanyu Wang
    Center for Clinical and Translational Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio, USA
    Antimicrob Agents Chemother 57:766-74. 2013
    ..Our results suggest that distinct mechanisms are responsible for RNase 7's antimicrobial activity against various uropathogens...
  16. ncbi request reprint Trends in hospitalization characteristics for pediatric nephrotic syndrome in the USA
    Rose M Ayoob
    Center for Clinical and Translational Research, Nationwide Children s Hospital, The Ohio State University, Columbus, OH, USA
    Clin Nephrol 78:106-11. 2012
    ..The overall aim of the current study was to analyze trends in hospital charges, length of stay (LOS), and mortality for children hospitalized with nephrotic syndrome (NS) in the US...
  17. ncbi request reprint Impact of urinary tract infection on inpatient healthcare for congenital obstructive uropathy
    Brian Becknell
    Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH 43201, USA
    J Pediatr Urol 8:470-6. 2012
    ..Urinary tract infections (UTIs) pose a risk for ascending infections and CKD in patients with COU. We evaluated the impact of comorbid UTIs on hospital charges and length of stay (LOS) for pediatric COU discharges...
  18. pmc The effects of hypertension on cognitive function in children and adolescents
    Stephen D Cha
    Pediatric Nephrology, Nationwide Children s Hospital, Columbus, OH 43205, USA
    Int J Pediatr 2012:891094. 2012
    ..More research is needed in the area, and the results of future studies could have far reaching implications for long-term outcomes in hypertensive children and adolescents...
  19. pmc Novel X-linked glomerulopathy is associated with a COL4A5 missense mutation in a non-collagenous interruption
    Brian Becknell
    Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43205, USA
    Kidney Int 79:120-7. 2011
    ..Hence, COL4A5 mutation analysis should be considered when glomerulonephritis presents in an X-linked inheritance pattern, even with a presentation distinct from Alport syndrome...
  20. doi request reprint Management and etiology of the unilateral multicystic dysplastic kidney: a review
    David S Hains
    Department of Pediatrics, Division of Pediatric Nephrology, The Ohio State University College of Medicine, 700 Children s Drive, Columbus, OH 43205, USA
    Pediatr Nephrol 24:233-41. 2009
    ..Finally, the body of literature does not support the routine surgical removal of MCDKs...