Chun Liang Chen

Summary

Affiliation: Nationwide Children's Hospital
Country: USA

Publications

  1. pmc Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival
    Chun Liang Chen
    Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Mol Cancer 7:78. 2008
  2. pmc Heparin-binding EGF-like growth factor protects intestinal stem cells from injury in a rat model of necrotizing enterocolitis
    Chun Liang Chen
    Department of Pediatric Surgery, The Research Institute at Nationwide Children s Hospital, Center for Perinatal Research, Nationwide Children s Hospital, The Ohio State University College of Medicine, Columbus, OH 43205, USA
    Lab Invest 92:331-44. 2012
  3. pmc Heparin-binding epidermal growth factor-like growth factor improves intestinal barrier function and reduces mortality in a murine model of peritonitis
    Jixin Yang
    Department of Pediatric Surgery, Nationwide Children s Hospital, Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, and The Ohio State University College of Medicine, Columbus, OH, USA
    Surgery 153:52-62. 2013
  4. pmc Heparin-binding EGF-like growth factor promotes intestinal anastomotic healing
    Andrei Radulescu
    Center for Perinatal Research, Department of Pediatric Surgery, The Research Institute at Nationwide Children s Hospital, and The Ohio State University College of Medicine, Columbus, Ohio 43205, USA
    J Surg Res 171:540-50. 2011
  5. pmc Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells
    Chun Liang Chen
    Center for Childhood Cancer, Columbus Children s Research Institute and Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    BMC Cancer 7:111. 2007
  6. doi A technique for systemic mesenchymal stem cell transplantation in newborn rat pups
    Jixin Yang
    Department of Pediatric Surgery, College of Medicine, The Research Institute at Nationwide Children s Hospital, Center for Perinatal Research, Nationwide Children s Hospital, The Ohio State University, Columbus, OH 43205, USA
    J Invest Surg 25:405-14. 2012
  7. pmc Heparin-binding EGF-like growth factor protects pericytes from injury
    Xiaoyi Yu
    Department of Pediatric Surgery, Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, The Ohio State University College of Medicine, Columbus, Ohio, USA
    J Surg Res 172:165-76. 2012
  8. pmc Heparin-binding epidermal growth factor-like growth factor attenuates acute lung injury and multiorgan dysfunction after scald burn
    Jeffrey Lutmer
    Division of Pediatric Critical Care Medicine, Nationwide Children s Hospital, Columbus, Ohio Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio Electronic address
    J Surg Res 185:329-37. 2013
  9. pmc Mice overexpressing the gene for heparin-binding epidermal growth factor-like growth factor (HB-EGF) have increased resistance to hemorrhagic shock and resuscitation
    Hong Yi Zhang
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Department of Pediatric Surgery, Nationwide Children s Hospital, The Ohio State University College of Medicine, Columbus, OH, USA
    Surgery 149:276-83. 2011
  10. pmc Heparin-binding epidermal growth factor-like growth factor protects mesenchymal stem cells
    Daniel J Watkins
    Department of Pediatric Surgery, Research Institute at Nationwide Children s Hospital, Nationwide Children s Hospital, Center for Perinatal Research, Ohio State University College of Medicine, Columbus, Ohio, USA
    J Surg Res 177:359-64. 2012

Collaborators

Detail Information

Publications17

  1. pmc Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival
    Chun Liang Chen
    Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Mol Cancer 7:78. 2008
    ..It remains unclear whether oncogenic Stat3 signaling pathway is involved in the oncogenesis of bladder cancer...
  2. pmc Heparin-binding EGF-like growth factor protects intestinal stem cells from injury in a rat model of necrotizing enterocolitis
    Chun Liang Chen
    Department of Pediatric Surgery, The Research Institute at Nationwide Children s Hospital, Center for Perinatal Research, Nationwide Children s Hospital, The Ohio State University College of Medicine, Columbus, OH 43205, USA
    Lab Invest 92:331-44. 2012
    ..These results show that the intestinal cytoprotective effects of HB-EGF are mediated, at least in part, through its ability to protect ISCs from injury...
  3. pmc Heparin-binding epidermal growth factor-like growth factor improves intestinal barrier function and reduces mortality in a murine model of peritonitis
    Jixin Yang
    Department of Pediatric Surgery, Nationwide Children s Hospital, Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, and The Ohio State University College of Medicine, Columbus, OH, USA
    Surgery 153:52-62. 2013
    ..Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a potent intestinal cytoprotective agent. The aim of this study was to evaluate the effect of HB-EGF in a model of murine peritonitis...
  4. pmc Heparin-binding EGF-like growth factor promotes intestinal anastomotic healing
    Andrei Radulescu
    Center for Perinatal Research, Department of Pediatric Surgery, The Research Institute at Nationwide Children s Hospital, and The Ohio State University College of Medicine, Columbus, Ohio 43205, USA
    J Surg Res 171:540-50. 2011
    ..The aim of the current study was to investigate the role of heparin-binding EGF-like growth factor (HB-EGF) in intestinal anastomotic wound healing...
  5. pmc Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells
    Chun Liang Chen
    Center for Childhood Cancer, Columbus Children s Research Institute and Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    BMC Cancer 7:111. 2007
    ..However, whether constitutive Stat3 signaling plays a role in the survival and growth of osteosarcomas, rhabdomyosarcomas, and soft-tissue sarcomas is still unclear...
  6. doi A technique for systemic mesenchymal stem cell transplantation in newborn rat pups
    Jixin Yang
    Department of Pediatric Surgery, College of Medicine, The Research Institute at Nationwide Children s Hospital, Center for Perinatal Research, Nationwide Children s Hospital, The Ohio State University, Columbus, OH 43205, USA
    J Invest Surg 25:405-14. 2012
    ..9 ± 1.2 CPVF in the heart, and 19.8 ± 5.0 CPVF in the intestines. We conclude that IV MSC infusion through the UV is a convenient, safe, and effective method for systemic MSC transplantation in prematurely delivered newborn rats...
  7. pmc Heparin-binding EGF-like growth factor protects pericytes from injury
    Xiaoyi Yu
    Department of Pediatric Surgery, Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, The Ohio State University College of Medicine, Columbus, Ohio, USA
    J Surg Res 172:165-76. 2012
    ..The current study was designed to evaluate the effect of HB-EGF on pericytes, since these cells function to regulate capillary blood flow and new capillary growth...
  8. pmc Heparin-binding epidermal growth factor-like growth factor attenuates acute lung injury and multiorgan dysfunction after scald burn
    Jeffrey Lutmer
    Division of Pediatric Critical Care Medicine, Nationwide Children s Hospital, Columbus, Ohio Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio Electronic address
    J Surg Res 185:329-37. 2013
    ..The present studies were based on the hypothesis that HB-EGF would reduce the severity of ALI and multiorgan dysfunction after scald burns in mice...
  9. pmc Mice overexpressing the gene for heparin-binding epidermal growth factor-like growth factor (HB-EGF) have increased resistance to hemorrhagic shock and resuscitation
    Hong Yi Zhang
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Department of Pediatric Surgery, Nationwide Children s Hospital, The Ohio State University College of Medicine, Columbus, OH, USA
    Surgery 149:276-83. 2011
    ..The aim of the current study was to determine whether overexpression of heparin-binding epidermal growth factor-like growth factor (HB-EGF) could protect the intestines from injury after hemorrhagic shock and resuscitation in mice...
  10. pmc Heparin-binding epidermal growth factor-like growth factor protects mesenchymal stem cells
    Daniel J Watkins
    Department of Pediatric Surgery, Research Institute at Nationwide Children s Hospital, Nationwide Children s Hospital, Center for Perinatal Research, Ohio State University College of Medicine, Columbus, Ohio, USA
    J Surg Res 177:359-64. 2012
    ..The goal of the present study was to examine the effects of HB-EGF on both amniotic fluid (AF)- and bone marrow (BM)-derived MSCs in vitro...
  11. pmc Heparin-binding epidermal growth factor-like growth factor and mesenchymal stem cells act synergistically to prevent experimental necrotizing enterocolitis
    Jixin Yang
    The Research Institute at Nationwide Children s Hospital, Center for Perinatal Research, Department of Pediatric Surgery, Nationwide Children s Hospital, and The Ohio State University College of Medicine, Columbus, OH, USA
    J Am Coll Surg 215:534-45. 2012
    ..This study investigated the effects of HB-EGF on MSC in vitro, and whether MSC and HB-EGF can act synergistically to prevent NEC in vivo...
  12. pmc Heparin-binding epidermal growth factor-like growth factor (HB-EGF) preserves gut barrier function by blocking neutrophil-endothelial cell adhesion after hemorrhagic shock and resuscitation in mice
    Hong Yi Zhang
    Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Surgery 151:594-605. 2012
    ..The current study was designed to explore the mechanisms underlying the anti-inflammatory role of HB-EGF in preservation of gut barrier function after injury...
  13. pmc New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells
    Ling Cen
    Department of Pediatrics, The Ohio State University, Columbus, Ohio, 43210, USA
    BMC Cancer 9:99. 2009
    ..Clinical trials have suggested that curcumin may serve as a potential preventive or therapeutic agent for colorectal cancer...
  14. ncbi Systemic evaluation of total Stat3 and Stat3 tyrosine phosphorylation in normal human tissues
    Chun Liang Chen
    Center for Childhood Cancer, Columbus Children s Research Institute, Columbus, OH 43205, USA
    Exp Mol Pathol 80:295-305. 2006
    ..Based on the cell types, the p-Stat3 was also expressed in glandular, secretory, mucosal epithelial, circulatory endothelial, lymphoid, proliferative, and reabsorption-active cells...
  15. pmc HB-EGF protects the lungs after intestinal ischemia/reperfusion injury
    Iyore A O James
    Department of Pediatric Surgery, Nationwide Children s Hospital and the Ohio State University College of Medicine, Columbus, Ohio, USA
    J Surg Res 163:86-95. 2010
    ..In the current study, we investigated the ability of HB-EGF to protect the lungs from remote organ injury after intestinal ischemia/reperfusion (I/R)...
  16. pmc Characterization of adeno-associated virus genomes isolated from human tissues
    Bruce C Schnepp
    Center for Gene Therapy, Columbus Children s Research Institute, Columbus, OH 43205, USA
    J Virol 79:14793-803. 2005
    ..These findings are consistent with the circular episomal forms of recombinant AAV vectors that have been isolated and characterized from in vivo transduced tissues...
  17. pmc Intestinal phenotype in mice overexpressing a heparin-binding EGF-like growth factor transgene in enterocytes
    Chun Liang Chen
    Department of Pediatric Surgery, The Research Institute at Nationwide Children s Hospital, Center for Perinatal Research, Nationwide Children s Hospital, The Ohio State University College of Medicine, Columbus, OH, USA
    Growth Factors 28:82-97. 2010
    ..Since HB-EGF activates EGF receptors which have been implicated in tumor development, we examined the effects of HB-EGF overexpression in the intestine...