E Zudaire

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Adrenomedullin functions as an important tumor survival factor in human carcinogenesis
    Frank Cuttitta
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Microsc Res Tech 57:110-9. 2002
  2. pmc Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis
    Enrique Zudaire
    CCBB, CCR, National Cancer Institute, Bldg 10, RM, 12N226, Bethesda, MD 20892, USA
    Am J Pathol 168:280-91. 2006
  3. pmc A computational tool for quantitative analysis of vascular networks
    Enrique Zudaire
    Angiogenesis Core Facility, Radiation Oncology Branch, National Institute of Health National Cancer Institute, Gaithersburg, Maryland, United States of America
    PLoS ONE 6:e27385. 2011
  4. ncbi request reprint The central role of adrenomedullin in host defense
    Enrique Zudaire
    Cell and Cancer Biology, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    J Leukoc Biol 80:237-44. 2006
  5. pmc The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers
    Enrique Zudaire
    Angiogenesis Core Facility, NCI, NIH, Gaithersburg, Maryland 20892 4605, USA
    J Clin Invest 118:640-50. 2008
  6. ncbi request reprint Characterization of adrenomedullin in birds
    Enrique Zudaire
    Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Gen Comp Endocrinol 143:10-20. 2005
  7. ncbi request reprint Characterization of adrenomedullin in non-human primates
    Enrique Zudaire
    Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 321:859-69. 2004
  8. ncbi request reprint Adrenomedullin and cancer
    E Zudaire
    Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 13N262, Bethesda MD 20892, USA
    Regul Pept 112:175-83. 2003
  9. ncbi request reprint Regulation of pancreatic physiology by adrenomedullin and its binding protein
    E Zudaire
    Department of Cell and Cancer Biology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 13N262, Bethesda, MD 20892, USA
    Regul Pept 112:121-30. 2003
  10. ncbi request reprint Adrenomedullin expression and function in the rat carotid body
    A Martinez
    Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 13N262, Bethesda, Maryland 20892, USA
    J Endocrinol 176:95-102. 2003

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Adrenomedullin functions as an important tumor survival factor in human carcinogenesis
    Frank Cuttitta
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Microsc Res Tech 57:110-9. 2002
    ....
  2. pmc Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis
    Enrique Zudaire
    CCBB, CCR, National Cancer Institute, Bldg 10, RM, 12N226, Bethesda, MD 20892, USA
    Am J Pathol 168:280-91. 2006
    ..Our collective data suggest a new role for AM as a cross-talk molecule that integrates tumor and MC communication, underlying a unique promotion mechanism of human cancers...
  3. pmc A computational tool for quantitative analysis of vascular networks
    Enrique Zudaire
    Angiogenesis Core Facility, Radiation Oncology Branch, National Institute of Health National Cancer Institute, Gaithersburg, Maryland, United States of America
    PLoS ONE 6:e27385. 2011
    ..We have validated AngioTool using images of embryonic murine hindbrains, post-natal retinas and allantois explants. AngioTool is open source and can be downloaded free of charge...
  4. ncbi request reprint The central role of adrenomedullin in host defense
    Enrique Zudaire
    Cell and Cancer Biology, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    J Leukoc Biol 80:237-44. 2006
    ..Although major progress toward this end has been achieved over the past few years, our further understanding of the pleiotropic mechanisms involved with AM as a protective peptide is paramount to maximize its clinical application...
  5. pmc The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers
    Enrique Zudaire
    Angiogenesis Core Facility, NCI, NIH, Gaithersburg, Maryland 20892 4605, USA
    J Clin Invest 118:640-50. 2008
    ..These results therefore demonstrate that AHRR is a putative new tumor suppressor gene in multiple types of human cancers...
  6. ncbi request reprint Characterization of adrenomedullin in birds
    Enrique Zudaire
    Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Gen Comp Endocrinol 143:10-20. 2005
    ..These data demonstrate a high degree of homology between the cAM gene and its mammalian ortholog and evolutionary conservation of the regulatory mechanisms controlling its expression...
  7. ncbi request reprint Characterization of adrenomedullin in non-human primates
    Enrique Zudaire
    Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 321:859-69. 2004
    ..Our collective data show a high degree of homology between mAM and hAM, which renders the monkey an attractive animal model for future pharmacological and pre-clinical studies targeting AM...
  8. ncbi request reprint Adrenomedullin and cancer
    E Zudaire
    Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 13N262, Bethesda MD 20892, USA
    Regul Pept 112:175-83. 2003
    ..The collective findings brought together over the last years place AM as a major regulator of carcinogenesis-tumor progression and identifies its autocrine loop as a putative target for developing new strategies against human cancers...
  9. ncbi request reprint Regulation of pancreatic physiology by adrenomedullin and its binding protein
    E Zudaire
    Department of Cell and Cancer Biology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 13N262, Bethesda, MD 20892, USA
    Regul Pept 112:121-30. 2003
    ..Further investigation focused on the development of blocking agents for AM could result in new treatments for pancreatic AM-related disorders...
  10. ncbi request reprint Adrenomedullin expression and function in the rat carotid body
    A Martinez
    Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 13N262, Bethesda, Maryland 20892, USA
    J Endocrinol 176:95-102. 2003
    ..All these data suggest that AM is an important autocrine regulator of carotid body function...
  11. pmc Functional characterization of filamin a interacting protein 1-like, a novel candidate for antivascular cancer therapy
    Mijung Kwon
    Tumor Angiogenesis Section, Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 68:7332-41. 2008
    ..Overall, these findings suggest that the novel protein FILIP1L may be an important mediator of the effects of angiogenesis inhibitors and that FILIP1L has the potential to be an antivascular reagent for cancer therapy...
  12. pmc Intracellular proadrenomedullin-derived peptides decorate the microtubules and contribute to cytoskeleton function
    Dan L Sackett
    Laboratory of Integrative and Medical Biophysics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Endocrinology 149:2888-98. 2008
    ..These results show that PAMP is a novel MAP, whereas AM may be exerting more subtle effects in regulating cytoskeleton function...
  13. pmc Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis
    Lana E Kandalaft
    Cell and Cancer Biology Branch, National Cancer Institute, Advanced Technology Center, Gaithersburg, MD 20877, USA
    Carcinogenesis 29:1282-9. 2008
    ..Collectively, our results suggest a role for DENTT as a suppressor of the tumorigenic phenotype...
  14. ncbi request reprint Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo
    Alfredo Martinez
    Cell and Cancer Biology Branch and Vascular Biology Faculty, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 24:4106-13. 2005
    ..Our collective observations indicate that GRP is a new angiogenic peptide and that its inhibition offers an attractive tool to reduce tumor burden...
  15. ncbi request reprint Proadrenomedullin NH2-terminal 20 peptide is a potent angiogenic factor, and its inhibition results in reduction of tumor growth
    Alfredo Martinez
    Cell and Cancer Biology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 64:6489-94. 2004
    ..Together, our data demonstrate PAMP to be an extremely potent angiogenic factor and implicate this peptide as an attractive molecular target for angiogenesis-based antitumor therapy...
  16. ncbi request reprint Expression of complement factor H by lung cancer cells: effects on the activation of the alternative pathway of complement
    Daniel Ajona
    Division of Oncology, Center for Applied Medical Research, Pamplona, Spain
    Cancer Res 64:6310-8. 2004
    ..In summary, we demonstrate the expression of factor H and FHL-1 by some lung cancer cells and analyze the contribution of these proteins to the protection against complement activation...
  17. ncbi request reprint Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition
    Ingalill Avis
    Intervention Section, Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 65:4181-90. 2005
    ....
  18. pmc Molecular basis for agonist selectivity and activation of the orphan bombesin receptor subtype 3 receptor
    Nieves Gonzalez
    Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Heath, Building 10, Room 9C 103, 10 CENTER DR MSC 1804, Bethesda, MD 20892 1804, USA
    J Pharmacol Exp Ther 324:463-74. 2008
    ....
  19. ncbi request reprint Using peripheral blood mononuclear cells to determine a gene expression profile of acute ischemic stroke: a pilot investigation
    David F Moore
    Section of Neurology, University of Manitoba, Winnipeg, Manitoba, Canada
    Circulation 111:212-21. 2005
    ..Direct brain biopsy is rarely indicated during acute stroke. This study uses peripheral blood mononuclear cells (PBMCs) to determine whether a systemic gene expression profile could be demonstrated in patients with acute ischemic stroke...
  20. ncbi request reprint Identification of adrenomedullin in avian type II pneumocytes: increased expression after exposure to air pollutants
    Natalia Cuesta
    Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    J Histochem Cytochem 53:773-80. 2005
    ..Taken together, our findings support the implication of AM in the response of type II pneumocytes to air pollutants...