J Zimmerberg

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Membrane transformation during malaria parasite release from human red blood cells
    Svetlana Glushakova
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Biol 15:1645-50. 2005
  2. ncbi request reprint Membrane biophysics
    Joshua Zimmerberg
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1855, USA
    Curr Biol 16:R272-6. 2006
  3. pmc Membranes of the world unite!
    Leonid V Chernomordik
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 175:201-7. 2006
  4. ncbi request reprint Lateral tension increases the line tension between two domains in a lipid bilayer membrane
    Sergey A Akimov
    Laboratory of Bioelectrochemistry, Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow, Russia 119991
    Phys Rev E Stat Nonlin Soft Matter Phys 75:011919. 2007
  5. pmc Quantification of malaria parasite release from infected erythrocytes: inhibition by protein-free media
    Svetlana Glushakova
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Malar J 6:61. 2007
  6. pmc Insulin stimulates the halting, tethering, and fusion of mobile GLUT4 vesicles in rat adipose cells
    Vladimir A Lizunov
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 169:481-9. 2005
  7. pmc Cholesterol promotes hemifusion and pore widening in membrane fusion induced by influenza hemagglutinin
    Subrata Biswas
    Laboratory of Cellular and Molecular Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Gen Physiol 131:503-13. 2008
  8. pmc Quantitative electron microscopy and fluorescence spectroscopy of the membrane distribution of influenza hemagglutinin
    Samuel T Hess
    Laboratory for Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 169:965-76. 2005
  9. pmc A quantitative model for membrane fusion based on low-energy intermediates
    P I Kuzmin
    Frumkin Institute of Electrochemistry, Moscow, Russia 117071
    Proc Natl Acad Sci U S A 98:7235-40. 2001
  10. pmc Membrane permeability changes at early stages of influenza hemagglutinin-mediated fusion
    V A Frolov
    A N Frumkin Institute of Electrochemistry, Russian Academy of Sciences, Moscow, Russia
    Biophys J 85:1725-33. 2003

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Membrane transformation during malaria parasite release from human red blood cells
    Svetlana Glushakova
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Biol 15:1645-50. 2005
    ..These results, together with the modulation of release by osmotic stress, suggest a pathway of parasite release that features a biochemically altered erythrocyte membrane that folds after pressure-driven rupture of membranes...
  2. ncbi request reprint Membrane biophysics
    Joshua Zimmerberg
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1855, USA
    Curr Biol 16:R272-6. 2006
  3. pmc Membranes of the world unite!
    Leonid V Chernomordik
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 175:201-7. 2006
    ..In this mini-review, we discuss how proteins can mediate each of the three major stages in the fusion pathway: contact, hemifusion, and the opening of an expanding fusion pore...
  4. ncbi request reprint Lateral tension increases the line tension between two domains in a lipid bilayer membrane
    Sergey A Akimov
    Laboratory of Bioelectrochemistry, Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow, Russia 119991
    Phys Rev E Stat Nonlin Soft Matter Phys 75:011919. 2007
    ....
  5. pmc Quantification of malaria parasite release from infected erythrocytes: inhibition by protein-free media
    Svetlana Glushakova
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Malar J 6:61. 2007
    ..Intracellular malaria parasites leave their host erythrocytes to infect neighbouring cells after each cycle of asexual replication. No method is currently available for the direct quantification of parasite release...
  6. pmc Insulin stimulates the halting, tethering, and fusion of mobile GLUT4 vesicles in rat adipose cells
    Vladimir A Lizunov
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 169:481-9. 2005
    ..It is likely that the primary mechanism of insulin action in GLUT4 translocation is to stimulate tethering and fusion of trafficking vesicles to specific fusion sites in the PM...
  7. pmc Cholesterol promotes hemifusion and pore widening in membrane fusion induced by influenza hemagglutinin
    Subrata Biswas
    Laboratory of Cellular and Molecular Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Gen Physiol 131:503-13. 2008
    ..The results of this study support the hypothesis that host cell cholesterol acts at two stages in membrane fusion: (1) early, prior to fusion pore opening, and (2) late, during fusion pore expansion...
  8. pmc Quantitative electron microscopy and fluorescence spectroscopy of the membrane distribution of influenza hemagglutinin
    Samuel T Hess
    Laboratory for Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 169:965-76. 2005
    ..This work rules out the tested hypothesis for HA over the accessible length scales, yet shows clearly how the spatial distribution of HA depends on lipid composition...
  9. pmc A quantitative model for membrane fusion based on low-energy intermediates
    P I Kuzmin
    Frumkin Institute of Electrochemistry, Moscow, Russia 117071
    Proc Natl Acad Sci U S A 98:7235-40. 2001
    ..All membrane rearrangements occur in a discrete local region without creation of an extended hemifusion diaphragm. Importantly, all steps of the proposed pathway are energetically feasible...
  10. pmc Membrane permeability changes at early stages of influenza hemagglutinin-mediated fusion
    V A Frolov
    A N Frumkin Institute of Electrochemistry, Russian Academy of Sciences, Moscow, Russia
    Biophys J 85:1725-33. 2003
    ..Subsequent rearrangement in the fusion complex leads to the resealing of the leaky membranes and enlargement of the pore...
  11. ncbi request reprint The physical chemistry of biological membranes
    Joshua Zimmerberg
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Chem Biol 2:564-7. 2006
    ..With increasing sophistication of investigative tools, there is now a growing appreciation for lipid diversity and for the role of individual lipids and specific lipid-protein interactions in membrane structure and function...
  12. ncbi request reprint How proteins produce cellular membrane curvature
    Joshua Zimmerberg
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1855, USA
    Nat Rev Mol Cell Biol 7:9-19. 2006
    ..We describe membrane elastic properties in order to formulate the structural and energetic requirements of proteins and lipids that would enable them to work together to generate the membrane shapes seen during intracellular trafficking...
  13. ncbi request reprint Neuroscience. Synaptic membranes bend to the will of a neurotoxin
    Joshua Zimmerberg
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1855, USA
    Science 310:1626-7. 2005
  14. ncbi request reprint How can proteolipids be central players in membrane fusion?
    J Zimmerberg
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1855, USA
    Trends Cell Biol 11:233-5. 2001
    ....
  15. pmc Sea urchin egg preparations as systems for the study of calcium-triggered exocytosis
    J Zimmerberg
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1855, USA
    J Physiol 520:15-21. 1999
    ..Our data do not support the hypothesis that this particular heterotrimeric complex is by itself the biological fusogen...
  16. pmc The calcium sensitivity of individual secretory vesicles is invariant with the rate of calcium delivery
    P S Blank
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Gen Physiol 112:569-76. 1998
    ..Models that attempt to explain the cessation of fusion using changes in the distribution of calcium thresholds arising from the rate of calcium delivery and/or adaptation are not applicable to this system, and thus cannot be general...
  17. pmc An early stage of membrane fusion mediated by the low pH conformation of influenza hemagglutinin depends upon membrane lipids
    L V Chernomordik
    Laboratary of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 136:81-93. 1997
    ....
  18. pmc Biochemical and functional studies of cortical vesicle fusion: the SNARE complex and Ca2+ sensitivity
    J R Coorssen
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 143:1845-57. 1998
    ..Therefore the SNARE complex alone cannot be the universal minimal fusion machine for intracellular fusion. We suggest that this complex modulates the Ca2+ sensitivity of fusion...
  19. pmc Submaximal responses in calcium-triggered exocytosis are explained by differences in the calcium sensitivity of individual secretory vesicles
    P S Blank
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    J Gen Physiol 112:559-67. 1998
    ....
  20. ncbi request reprint Calcium can disrupt the SNARE protein complex on sea urchin egg secretory vesicles without irreversibly blocking fusion
    M Tahara
    Laboratory of Cellular and Molecular Biophysics, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:33667-73. 1998
    ..These findings rule out models of fusion in which SNARE complex formation goes to completion ("zippers-up") after Ca2+ binding removes a "fusion-clamp."..
  21. pmc Poisson-distributed active fusion complexes underlie the control of the rate and extent of exocytosis by calcium
    S S Vogel
    Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 134:329-38. 1996
    ..At high calcium concentrations, docking sites have on average nine active fusion complexes...
  22. pmc A kinetic analysis of calcium-triggered exocytosis
    P S Blank
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Gen Physiol 118:145-56. 2001
    ..Thus, the nonlinear relationship between the free calcium concentration and the rate of exocytosis can be explained solely by the calcium dependence of the distribution of fusion complexes at vesicle docking sites...
  23. pmc The pathway of membrane fusion catalyzed by influenza hemagglutinin: restriction of lipids, hemifusion, and lipidic fusion pore formation
    L V Chernomordik
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1855, USA
    J Cell Biol 140:1369-82. 1998
    ..Our results suggest that restriction of lipid flux by a ring of activated HA is necessary for successful fusion, during which a lipidic fusion pore develops in a local and transient hemifusion diaphragm...
  24. ncbi request reprint Lymphocyte trafficking and HIV infection of human lymphoid tissue in a rotating wall vessel bioreactor
    L B Margolis
    NASA NIH Center for Three Dimensional Tissue Cultures, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS Res Hum Retroviruses 13:1411-20. 1997
    ....
  25. ncbi request reprint A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite
    S A Desai
    The Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 406:1001-5. 2000
    ..The surface location of this new channel and its permeability to organic solutes needed for parasite growth indicate that it may have a primary role in a sequential diffusive pathway for parasite nutrient acquisition...
  26. pmc Synchronized activation and refolding of influenza hemagglutinin in multimeric fusion machines
    I Markovic
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 155:833-44. 2001
    ....
  27. pmc PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes
    A N Chanturiya
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 10D14, Bethesda, MD 20892 1855, USA
    J Virol 78:6304-12. 2004
    ....
  28. ncbi request reprint Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranes
    G Basanez
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1855, USA
    J Biol Chem 276:31083-91. 2001
    ..Taken together, these data are consistent with the hypothesis that Bax-like proteins oligomerize to form lipid-containing pores in the outer mitochondrial membrane, thereby releasing intermembrane apoptogenic factors into the cytosol...
  29. ncbi request reprint Synaptotagmin: fusogenic role for calcium sensor?
    Joshua Zimmerberg
    Nat Struct Mol Biol 13:301-3. 2006
  30. ncbi request reprint De novo sequencing of peptides using MALDI/TOF-TOF
    Alfred L Yergey
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    J Am Soc Mass Spectrom 13:784-91. 2002
    ..These results show both the power of the present approach and the need for using de novo methods more frequently than may be otherwise appreciated...
  31. ncbi request reprint Quantitative femto- to attomole immunodetection of regulated secretory vesicle proteins critical to exocytosis
    Jens R Coorssen
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1855, USA
    Anal Biochem 307:54-62. 2002
    ..The results indicate that sea urchin egg secretory vesicles and synaptic vesicles have markedly similar SNARE densities...
  32. pmc Domain formation in membranes caused by lipid wetting of protein
    Sergey A Akimov
    Laboratory of Bioelectrochemistry, Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow, Russia, 119991
    Phys Rev E Stat Nonlin Soft Matter Phys 77:051901. 2008
    ..Using experimentally derived values of elastic moduli and spontaneous curvatures as well as height mismatch between aggregates and bulk membrane, we obtained numerical results, which can be compared with the experimental data...
  33. pmc Initial size and dynamics of viral fusion pores are a function of the fusion protein mediating membrane fusion
    Ilya Plonsky
    Laboratory of Cellular and Molecular Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1855, U S A
    Biol Cell 100:377-86. 2008
    ....
  34. doi request reprint Progressive ordering with decreasing temperature of the phospholipids of influenza virus
    Ivan V Polozov
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, 10D14, 10 Center Drive MSC 1855, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Chem Biol 4:248-55. 2008
    ..Viral fusion appears to be uncorrelated to ordered lipid content. Lipid ordering may contribute to viral stability at lower temperatures, which has recently been found to be critical for airborne transmission...
  35. ncbi request reprint Interaction of hagfish cathelicidin antimicrobial peptides with model lipid membranes
    Gorka Basañez
    Unidad de Biofísica Centro Mixto UPV CSIC, y Departamento de Bioquímica y Biología Molecular, Universidad del Pais Vasco UPV EHU, P O Box 644, 48080 Bilbao, Spain
    FEBS Lett 532:115-20. 2002
    ..Such a membrane-permeabilizing function appears to be an evolutionarily conserved host-defense mechanism of antimicrobial peptides...
  36. ncbi request reprint Regulated secretion: SNARE density, vesicle fusion and calcium dependence
    Jens R Coorssen
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1855, USA
    J Cell Sci 116:2087-97. 2003
    ....
  37. pmc Orientation and interaction of oblique cylindrical inclusions embedded in a lipid monolayer: a theoretical model for viral fusion peptides
    Yonathan Kozlovsky
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel
    Biophys J 87:999-1012. 2004
    ..This long-range interaction is predicted to dominate the other interactions previously considered in the literature...
  38. pmc Dynamics of putative raft-associated proteins at the cell surface
    Anne K Kenworthy
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bldg 18T, Rm 101, 18 Library Dr, Bethesda, MD 20895, USA
    J Cell Biol 165:735-46. 2004
    ..Thus, raft association is not the dominant factor in determining long-range protein mobility at the cell surface...
  39. pmc Shape bistability of a membrane neck: a toggle switch to control vesicle content release
    Vadim A Frolov
    A N Frumkin Institute of Electrochemistry, Russian Academy of Science, Moscow 117071, Russia
    Proc Natl Acad Sci U S A 100:8698-703. 2003
    ..In support of this notion, bistable behavior of membrane connections between vesicles and the cell plasma membrane in macrophages is demonstrated...
  40. ncbi request reprint Membrane fusion of secretory vesicles of the sea urchin egg in the absence of NSF
    Tim Whalley
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 117:2345-56. 2004
    ..In contrast, isolated CVs, though all capable of Ca(2+)-triggered homotypic fusion, contain less than one hexamer of NSF per CV. Thus NSF is not a required component of the CV fusion machinery...
  41. doi request reprint Flexible scaffolding made of rigid BARs
    Vadim A Frolov
    Program on Physical Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1855, USA
    Cell 132:727-9. 2008
    ..In this issue, Frost et al. (2008) reveal how collective twisting of rigid F-BAR domains on a soft membrane surface may lead to different membrane curvatures...
  42. doi request reprint ER biogenesis: self-assembly of tubular topology by protein hairpins
    Anna Shnyrova
    Program on Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1855, USA
    Curr Biol 18:R474-6. 2008
    ..Two of these proteins are sufficient to form tubular membrane networks from pure phospholipid vesicles, thus revealing a new paradigm of ER morphogenesis...
  43. pmc Dynamic clustered distribution of hemagglutinin resolved at 40 nm in living cell membranes discriminates between raft theories
    Samuel T Hess
    Department of Physics and Astronomy and Institute for Molecular Biophysics, University of Maine, Orono, ME 04469, USA
    Proc Natl Acad Sci U S A 104:17370-5. 2007
    ..In live cells, the dynamics of HA molecules within clusters is observed and quantified to determine an effective diffusion coefficient. The results are interpreted in terms of several established models of biological membranes...
  44. ncbi request reprint Cellular biophysics: bacterial endospore, membranes and random fluctuation
    Vladimir Lizunov
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1855, USA
    Curr Biol 16:R1025-8. 2006
    ....
  45. pmc Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals
    Elizabeth A Jonas
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:13590-5. 2004
    ....
  46. pmc Line tension and interaction energies of membrane rafts calculated from lipid splay and tilt
    Peter I Kuzmin
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biophys J 88:1120-33. 2005
    ..This barrier can kinetically stabilize the rafts against merger. Our physical theory thus quantifies conditions that allow rafts to form, and further, defines the parameters that control raft merger...
  47. ncbi request reprint A new method for culturing Plasmodium falciparum shows replication at the highest erythrocyte densities
    Tao Li
    NASA NIH Center for Three Dimensional Tissue Culture, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 187:159-62. 2003
    ..falciparum can replicate at packed erythrocyte densities suggests that this system may be useful for study of the pathogenesis of fatal cerebral malaria, of which one feature is densely packed blood cells in brain microvasculature...
  48. pmc SNARE-mediated lipid mixing depends on the physical state of the vesicles
    Xiaocheng Chen
    Department of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Biophys J 90:2062-74. 2006
    ....
  49. ncbi request reprint Endocytosis: curvature to the ENTH degree
    Ralph Nossal
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Biol 12:R770-2. 2002
    ..Recent work has shown that the protein epsin 1 induces highly curved lipidic structures when added with clathrin to appropriate lipid mixtures. This property may be a critical factor in the 'curvature stress cycle' of membrane trafficking...
  50. ncbi request reprint Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature
    Gorka Basañez
    Laboratory of Cellular and Molecular Biophysics, NICHD National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Biol Chem 277:49360-5. 2002
    ..Altogether, these results are consistent with a model whereby Bax-type proteins change the bending propensity of the membrane to form pores comprised at least in part of lipids in a structure of net positive monolayer curvature...
  51. ncbi request reprint Membrane curvature: how BAR domains bend bilayers
    Joshua Zimmerberg
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Biol 14:R250-2. 2004
    ..BAR resembles a banana that binds membranes electrostatically through its positively charged, concave surface...
  52. pmc Paradoxical lipid dependence of pores formed by the Escherichia coli alpha-hemolysin in planar phospholipid bilayer membranes
    Laura Bakas
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biophys J 91:3748-55. 2006
    ..HlyA also appeared to thicken bilayers to which it was added. We discuss these results in terms of models for proteolipidic pores...
  53. pmc Vesicle formation by self-assembly of membrane-bound matrix proteins into a fluidlike budding domain
    Anna V Shnyrova
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 179:627-33. 2007
    ..Thus, matrix proteins implement domain-driven mechanism of budding, which suffices to control the shape of these proteolipid vesicles...