Jinfang Zhu

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:733-44. 2002
  2. pmc Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment
    Hidehiro Yamane
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:793-804. 2005
  3. pmc CD4+ T cell plasticity-Th2 cells join the crowd
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 32:11-3. 2010
  4. pmc Differentiation of effector CD4 T cell populations (*)
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    Annu Rev Immunol 28:445-89. 2010
  5. pmc The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 37:660-73. 2012
  6. pmc CD4 T cells: fates, functions, and faults
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 112:1557-69. 2008
  7. pmc Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:329-41. 2009
  8. pmc Heterogeneity and plasticity of T helper cells
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Res 20:4-12. 2010
  9. pmc Transcriptional regulation of Th2 cell differentiation
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Cell Biol 88:244-9. 2010
  10. pmc Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Immunol Rev 238:247-62. 2010

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:733-44. 2002
    ..The synergy of Gfi-1 and Gata3 provides a mechanism through which IL-4 could selectively promote Th2 cell expansion...
  2. pmc Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment
    Hidehiro Yamane
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:793-804. 2005
    ..A MEK inhibition rescued early GATA-3 expression and responsiveness to IL-2; these cells were now capable of producing early IL-4 and undergoing subsequent Th2 differentiation...
  3. pmc CD4+ T cell plasticity-Th2 cells join the crowd
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 32:11-3. 2010
    ....
  4. pmc Differentiation of effector CD4 T cell populations (*)
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    Annu Rev Immunol 28:445-89. 2010
    ....
  5. pmc The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 37:660-73. 2012
    ..Our study revealed redundancy and synergy among several Th1 cell-inducing pathways in regulating the expression of T-bet and IFN-γ, and a critical role of T-bet in suppressing an endogenous Th2 cell-associated program...
  6. pmc CD4 T cells: fates, functions, and faults
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 112:1557-69. 2008
    ....
  7. pmc Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:329-41. 2009
    ..Thus, Gfi-1 plays a critical role both in enhancing Th2 cell expansion and in repressing induction of Th17 and CD103(+) iTreg cells...
  8. pmc Heterogeneity and plasticity of T helper cells
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Res 20:4-12. 2010
    ..In this review, we summarize recent reports on heterogeneity and plasticity of Th cells, and discuss potential mechanisms and implications of such features that Th cells display...
  9. pmc Transcriptional regulation of Th2 cell differentiation
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Cell Biol 88:244-9. 2010
    ..Finally, the difference between in vitro and in vivo Th2 differentiation is discussed...
  10. pmc Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Immunol Rev 238:247-62. 2010
    ..We also discuss the interactions of key transcription factors at both genetic and protein levels and the function of the resulting network(s) in regulating the expression of effector cytokines...
  11. pmc Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:18214-9. 2006
    ..Reduced Th2 cell expansion in the absence of Gfi-1 was confirmed by the diminished frequency of IL-4-producing cells when these mice were infected with Schistosoma mansoni...
  12. ncbi request reprint GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Res 16:3-10. 2006
    ....
  13. ncbi request reprint Stat5 activation plays a critical role in Th2 differentiation
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 19:739-48. 2003
    ..Stat5A binds to HSII and HSIII sites of the Il4 gene. Coinfection with STAT5A1*6-NGFR-RV and GATA-3-GFP-RV results in optimal Th2 priming...
  14. ncbi request reprint Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 5:1157-65. 2004
    ..Thus, GATA-3 serves as a principal switch in determining T(H)1-T(H)2 responses...
  15. pmc The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research CCR, NCI, NIH, Bethesda, MD 20892 4259, USA
    Eur J Immunol 40:2385-90. 2010
    ..These findings identify the sequential activity of Gata3 and Thpok as a hallmark of CD4(+) T-cell differentiation, regardless of MHC restriction...
  16. pmc The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma
    Ryoji Yagi
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 32:507-17. 2010
    ..Thus, the Runx3-mediated pathway, actively suppressed by GATA3, induces IFN-gamma production in a STAT4- and T-bet-independent manner...
  17. pmc IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:13463-8. 2009
    ....
  18. pmc Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bldg 10, Bethesda, MD 20892, USA
    J Exp Med 200:507-17. 2004
    ..Thus, infection with a parasite that induces a "Th2-type response" resulted in accumulation of tissue basophils, and these cells, stimulated by a non-FcR cross-linking mechanism, are a principal source of in vivo IL-4 production...
  19. pmc Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types
    Gang Wei
    Laboratory of Molecular Immunology, NHLBI, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Immunity 35:299-311. 2011
    ....
  20. doi request reprint Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus
    Yumei Xiong
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda 20892 4259, MD, USA
    Eur J Immunol 43:918-28. 2013
    ..Thus, in addition to its previously documented role in promoting CD4-lineage gene-expression, Gata3 represses CD8-lineage gene expression. These findings identify Gata3 as a critical pivot of CD4-CD8 lineage differentiation...
  21. pmc Interleukin 2 plays a central role in Th2 differentiation
    Javier Cote-Sierra
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:3880-5. 2004
    ..Thus, IL-2 plays a critical role in the polarization of naive CD4 T cells to the Th2 phenotype...
  22. pmc Elevating calcium in Th2 cells activates multiple pathways to induce IL-4 transcription and mRNA stabilization
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:3984-93. 2008
    ..p38 also regulates IL-4 production by mRNA stabilization. TCR stimulation also phosphorylates p38, partially through the calcium-dependent pathway; activated p38 is required for optimal IL-4 and IFN-gamma...
  23. pmc Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells
    Lie Wang
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Nat Immunol 9:1122-30. 2008
    ..We propose that GATA-3 acts as a specification factor for the CD4(+) lineage 'upstream' of the ThPOK-controlled CD4(+) commitment checkpoint...
  24. pmc Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation
    Gangqing Hu
    1 Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA 2
    Nat Immunol 14:1190-8. 2013
    ..We found that the lincRNA LincR-Ccr2-5'AS, together with GATA-3, was an essential component of a regulatory circuit in gene expression specific to the TH2 subset of helper T cells and was important for the migration of TH2 cells. ..
  25. pmc The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1
    Maria De La Luz Sierra
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda MD, USA
    Blood 115:3970-9. 2010
    ..These results uncover a previously unknown function of Gfi1 as a regulator of RasGRP1 and link Gfi1 transcriptional control to G-CSF signaling and regulation of granulopoiesis...
  26. pmc Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    Gang Wei
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:155-67. 2009
    ..Our data suggest an epigenetic mechanism underlying the specificity and plasticity of effector and regulatory T cells and also provide a framework for understanding complexity of CD4(+) T helper cell differentiation...
  27. pmc In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Cancer Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:10623-8. 2002
    ..This finding suggests a regulation of IL-4 expression keyed to the function of this cytokine in cell/cell interactions and in the regulation of threshold responses...
  28. pmc Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
    Xiang Ping Yang
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:247-54. 2011
    ..Thus, the balance rather than the absolute magnitude of these signals determined the propensity of cells to make a key inflammatory cytokine...
  29. pmc Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells
    Maria De La Luz Sierra
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 110:2276-85. 2007
    ....
  30. pmc MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1
    Ombretta Salvucci
    Laboratory of Cellular Oncology, CCR, NCI, NIH, Bethesda, MD 20892, USA
    Haematologica 97:818-26. 2012
    ..Since hematopoietic stem/progenitor cells represent a minority of all blood cells mobilized by granulocyte colony-stimulating factor, the underlying mechanisms need to be understood in order to develop selective drugs...
  31. pmc An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation
    Ryoji Yagi
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Int Immunol 23:415-20. 2011
    ....
  32. pmc Lipid phosphatases identified by screening a mouse phosphatase shRNA library regulate T-cell differentiation and protein kinase B AKT signaling
    Liying Guo
    Cytokine Biology Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:E1849-56. 2013
    ..Thus, myotubularin-related proteins have a role in controlling in vitro and in vivo Th-cell differentiation, possibly through regulation of phosphatidylinositol [3,4,5]-trisphosphate activity...
  33. doi request reprint The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells
    Ryoji Yagi
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 40:378-88. 2014
    ..Thus, GATA3 plays parallel roles in regulating the development and functions of CD4(+) T cells and IL-7Rα(+) ILCs. ..
  34. pmc GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice
    Elizabeth A Wohlfert
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 121:4503-15. 2011
    ..Overall, our work reveals what we believe to be a new facet in the complex role of GATA3 in T cells and highlights what may be a fundamental role in controlling Treg physiology during inflammation...
  35. pmc How are T(H)2-type immune responses initiated and amplified?
    William E Paul
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 10:225-35. 2010
    ....
  36. pmc KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells
    Dazhi Lai
    Laboratory of Cellular and Molecular Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 208:1093-103. 2011
    ..This work documents the impact of a small number of KLF13-dependent iNKT cells on the generation of memory-like CD8(+) T cells...
  37. ncbi request reprint Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts
    Tracy L McGaha
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Arthritis Rheum 48:2275-84. 2003
    ..We therefore examined the effect of IL-4 on collagen synthesis in primary fibroblasts isolated from normal and TSK/+ mice, which spontaneously develop a scleroderma-like syndrome characterized by diffuse cutaneous hyperplasia...
  38. pmc Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1
    Anmol Chandele
    Department of Immunobiology, Yale Medical School, New Haven, CT 06511, USA
    J Immunol 180:5309-19. 2008
    ....
  39. ncbi request reprint IL-4 selectively enhances FcgammaRIII expression and signaling on mouse mast cells
    Hey Jin Chong
    Department of Biology, Virginia Commonwealth University, Richmond, VA 23284 2012, USA
    Cell Immunol 224:65-73. 2003
    ..Selective regulation of mast cell FcgammaR by interleukin-4 could alter inflammatory IgG responses and subsequently disease severity and progression...