Y J Zhou

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity
    Y J Zhou
    Lymphocyte Cell Biology Section, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:13850-5. 1997
  2. ncbi Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains
    M Chen
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:947-56. 2000
  3. ncbi Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation
    Y J Zhou
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:4371-80. 2000
  4. ncbi The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines
    M Gadina
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:26959-66. 2000
  5. ncbi Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases
    Y J Zhou
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Mol Cell 8:959-69. 2001
  6. ncbi Janus kinases and their role in growth and disease
    M Aringer
    Lymphocyte Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
    Life Sci 64:2173-86. 1999
  7. ncbi Signaling by type I and II cytokine receptors: ten years after
    M Gadina
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 20892, Bethesda, MD, USA
    Curr Opin Immunol 13:363-73. 2001
  8. ncbi Roles of mitogen-activated protein kinase pathways during Escherichia coli-induced apoptosis in U937 cells
    J H Wang
    Department of Geriatrics, The Second Affiliated Hospital, China Medical University, Shenyang, P R China
    Apoptosis 12:375-85. 2007
  9. ncbi Effect of the antioxidant alpha-lipoic acid on apoptosis in human umbilical vein endothelial cells induced by high glucose
    X Meng
    Department of Endocrinology and Metabolism, The First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Clin Exp Med 8:43-9. 2008

Detail Information

Publications9

  1. ncbi Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity
    Y J Zhou
    Lymphocyte Cell Biology Section, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:13850-5. 1997
    ..Given the importance of JAKs and particularly JAK3, it will be critical to fully dissect the positive and negative regulatory function of these and other tyrosine residues in the control of kinase activity and hence cytokine signaling...
  2. ncbi Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains
    M Chen
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:947-56. 2000
    ....
  3. ncbi Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation
    Y J Zhou
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:4371-80. 2000
    ..While the essential roles of Jak1 and Jak3 in signaling by gammac-utilizing cytokines are clear, it will be important to dissect the exact contributions of Lck and Syk in mediating the effects of IL-2 and related cytokines...
  4. ncbi The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines
    M Gadina
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:26959-66. 2000
    ..Therefore, up-regulation and activation of Gab2 may be important in linking the IL-2 receptor to activation of MAPK and may be an important means of achieving specificity in cytokine signaling...
  5. ncbi Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases
    Y J Zhou
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Mol Cell 8:959-69. 2001
    ..Thus, the Jak FERM domain appears to have two critical functions: receptor interaction and maintenance of kinase integrity...
  6. ncbi Janus kinases and their role in growth and disease
    M Aringer
    Lymphocyte Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
    Life Sci 64:2173-86. 1999
    ..This review on the rapidly growing field focuses on JAK function and regulation, and on their emerging role in development and human disease...
  7. ncbi Signaling by type I and II cytokine receptors: ten years after
    M Gadina
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 20892, Bethesda, MD, USA
    Curr Opin Immunol 13:363-73. 2001
    ..The phenotypes of mice deficient in these molecules are also striking, underscoring the importance of negative regulation in cytokine signaling...
  8. ncbi Roles of mitogen-activated protein kinase pathways during Escherichia coli-induced apoptosis in U937 cells
    J H Wang
    Department of Geriatrics, The Second Affiliated Hospital, China Medical University, Shenyang, P R China
    Apoptosis 12:375-85. 2007
    ..coli-induced U937 apoptosis. Taken together, we have shown that E. coli increase p38 MAPK and JNK and decrease ERK1/2 phosphorylation and increase caspase-3 and 9 activity in U937 cells...
  9. ncbi Effect of the antioxidant alpha-lipoic acid on apoptosis in human umbilical vein endothelial cells induced by high glucose
    X Meng
    Department of Endocrinology and Metabolism, The First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Clin Exp Med 8:43-9. 2008
    ..alpha-Lipoic acid effectively attenuates high glucose-induced endothelial cell apoptosis. These findings provide new perspectives on the role of alpha-lipoic acid in cardiovascular disease...