Zhi Ming Zheng

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Split genes and their expression in Kaposi's sarcoma-associated herpesvirus
    Zhi Ming Zheng
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Rev Med Virol 13:173-84. 2003
  2. ncbi Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
    Rui Hong Wang
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 14:312-23. 2008
  3. ncbi Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression
    Jeong Gu Kang
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr, Rm 6N106, Bethesda, MD 20892 1868, USA
    J Virol 85:2620-30. 2011
  4. ncbi Utilization of the bovine papillomavirus type 1 late-stage-specific nucleotide 3605 3' splice site is modulated by a novel exonic bipartite regulator but not by an intronic purine-rich element
    Z M Zheng
    Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 74:10612-22. 2000
  5. ncbi Papillomavirus genome structure, expression, and post-transcriptional regulation
    Zhi Ming Zheng
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Front Biosci 11:2286-302. 2006
  6. ncbi Development of resistance to RNAi in mammalian cells
    Zhi Ming Zheng
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Room 10S 255, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1058:105-18. 2005
  7. ncbi Regulation of cellular miRNA expression by human papillomaviruses
    Zhi Ming Zheng
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Biochim Biophys Acta 1809:668-77. 2011
  8. ncbi Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses
    Zhi Ming Zheng
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Biol Sci 6:730-55. 2010
  9. ncbi Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression
    Zhi Ming Zheng
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Biomed Sci 11:278-94. 2004
  10. ncbi Splicing of a cap-proximal human Papillomavirus 16 E6E7 intron promotes E7 expression, but can be restrained by distance of the intron from its RNA 5' cap
    Zhi Ming Zheng
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Biol 337:1091-108. 2004

Collaborators

Detail Information

Publications43

  1. ncbi Split genes and their expression in Kaposi's sarcoma-associated herpesvirus
    Zhi Ming Zheng
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Rev Med Virol 13:173-84. 2003
    ..This appears to be related to cell differentiation and stages of the virus infection, presumably involving viral cis elements and trans splicing factors...
  2. ncbi Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
    Rui Hong Wang
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 14:312-23. 2008
    ..Finally, we show that many human cancers exhibit reduced levels of SIRT1 compared to normal controls. Thus, SIRT1 may act as a tumor suppressor through its role in DNA damage response and genome integrity...
  3. ncbi Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression
    Jeong Gu Kang
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr, Rm 6N106, Bethesda, MD 20892 1868, USA
    J Virol 85:2620-30. 2011
    ..In addition, our data provide the first evidence that a tumor virus may use a viral protein to interfere with microRNA (miRNA)-mediated repression of an miRNA target to induce cell proliferation and tumorigenesis during virus infection...
  4. ncbi Utilization of the bovine papillomavirus type 1 late-stage-specific nucleotide 3605 3' splice site is modulated by a novel exonic bipartite regulator but not by an intronic purine-rich element
    Z M Zheng
    Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 74:10612-22. 2000
    ..Our data indicate that BPV-1 splicing regulation is very complex and is likely to be controlled by multiple splicing factors during keratinocyte differentiation...
  5. ncbi Papillomavirus genome structure, expression, and post-transcriptional regulation
    Zhi Ming Zheng
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Front Biosci 11:2286-302. 2006
    ..Continuing research on post-transcriptional regulation of papillomavirus infection will remain as a future focus to provide more insights into papillomavirus-host interactions, the virus life-cycle, and viral oncogenesis...
  6. ncbi Development of resistance to RNAi in mammalian cells
    Zhi Ming Zheng
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Room 10S 255, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1058:105-18. 2005
    ....
  7. ncbi Regulation of cellular miRNA expression by human papillomaviruses
    Zhi Ming Zheng
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Biochim Biophys Acta 1809:668-77. 2011
    ..This article is part of a Special Issue entitled: "MicroRNAs in viral gene regulation"...
  8. ncbi Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses
    Zhi Ming Zheng
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Biol Sci 6:730-55. 2010
    ....
  9. ncbi Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression
    Zhi Ming Zheng
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Biomed Sci 11:278-94. 2004
    ..The balance between positive and negative regulation of splice site selection likely depends on the cis-element's identity and changes in cellular splicing factors under physiological or pathological conditions...
  10. ncbi Splicing of a cap-proximal human Papillomavirus 16 E6E7 intron promotes E7 expression, but can be restrained by distance of the intron from its RNA 5' cap
    Zhi Ming Zheng
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Biol 337:1091-108. 2004
    ..HPV16 E6E7 pre-mRNA takes advantage of its small cap-proximal exon to confer efficient splicing for better E7 expression...
  11. ncbi Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59
    Vladimir Majerciak
    Tumor Virus RNA Biology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Virol 85:1528-40. 2011
    ..Collectively, our data provide novel insight elucidating a molecular mechanism by which ORF57 promotes the expression of viral intronless genes...
  12. ncbi The E7 oncoprotein is translated from spliced E6*I transcripts in high-risk human papillomavirus type 16- or type 18-positive cervical cancer cell lines via translation reinitiation
    Shuang Tang
    HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI NIH, 10 Center Dr, Rm 10 S255, MSC 1868, Bethesda, Maryland 20892 1868, USA
    J Virol 80:4249-63. 2006
    ..The data thus provide direct evidence that the E6*I mRNAs of high-risk HPVs are responsible for E7 production...
  13. ncbi Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression
    Vladimir Majerciak
    HIV and AIDS Malignancy Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:11297-307. 2010
    ..Collectively, our data provide the first compelling evidence that caspase cleavage of ORF57 may represent a cellular function against lytic KSHV infection...
  14. ncbi Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation
    Jeong Gu Kang
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    J Pathol 225:378-89. 2011
    ..Taking these factors together, our study indicates that IL-6 expression can be regulated by miRNA interactions in its ORF and provides evidence for the role of these interactions in the pathogenesis of KSHV-associated diseases...
  15. ncbi Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8alpha, and K8.1 and the production of infectious virus
    Vladimir Majerciak
    HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI NIH, 10 Center Dr, Rm 10 S255, MSC 1868, Bethesda, MD 20892 1868, USA
    J Virol 81:1062-71. 2007
    ..Altogether, our data indicate that in the context of the viral genome, KSHV ORF57 is essential for ORF59, K8alpha, and K8.1 expression and infectious virus production...
  16. ncbi Construction of a full transcription map of human papillomavirus type 18 during productive viral infection
    Xiaohong Wang
    Tumor Virus RNA Biology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 85:8080-92. 2011
    ..Collectively, a full HPV18 transcription map constructed from this report will lead us to further understand HPV18 gene expression and virus oncogenesis...
  17. ncbi Requirement of UAP56, URH49, RBM15, and OTT3 in the expression of Kaposi sarcoma-associated herpesvirus ORF57
    Vladimir Majerciak
    Tumor Virus RNA Biology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1868, USA
    Virology 407:206-12. 2010
    ..Collectively, our data indicate that the expression of KSHV ORF57 is regulated by cellular RNA export factors and cofactors at the posttranscriptional level...
  18. ncbi Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility
    Motoko Unoki
    Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:34677-86. 2006
    ..Understanding the functions of the four splice variants may aid in defining their roles in human carcinogenesis...
  19. ncbi SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance
    Rong Jia
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Biol Sci 6:806-26. 2010
    ..Collectively, these results suggest that increased SRp20 expression in tumor cells is a critical step for tumor initiation, progression, and maintenance...
  20. ncbi Kaposi's sarcoma-associated herpesvirus ORF57 is not a bona fide export factor
    Guy R Pilkington
    Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
    J Virol 86:13089-94. 2012
    ..In this study, we show that although ORF57 promotes expression of a selection of KSHV viral intronless RNAs, it is not a bona fide export factor...
  21. ncbi Stability of a long noncoding viral RNA depends on a 9-nt core element at the RNA 5' end to interact with viral ORF57 and cellular PABPC1
    Maria J Massimelli
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1868, USA
    Int J Biol Sci 7:1145-60. 2011
    ..In addition, we found that PAN RNA is partially exportable in the presence of ORF57. Together, our data provide compelling evidence as to how ORF57 functions to accumulate a non-coding viral RNA in the course of virus lytic infection...
  22. ncbi XPC branch-point sequence mutations disrupt U2 snRNP binding, resulting in abnormal pre-mRNA splicing in xeroderma pigmentosum patients
    Sikandar G Khan
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Hum Mutat 31:167-75. 2010
    ..At the cellular level these changes were associated with features of reduced DNA repair including diminished NER protein recruitment, reduced post-UV survival and impaired photoproduct removal...
  23. ncbi Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6
    Xiaohong Wang
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    RNA 15:637-47. 2009
    ..Together, this is the first time a viral oncoprotein has been shown to regulate cellular miRNA expression. Our data have provided new insights into mechanisms by which high-risk HPVs contribute to the development of cervical cancer...
  24. ncbi Kaposi's sarcoma-associated herpesvirus ORF57 in viral RNA processing
    Vladimir Majerciak
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1868, USA
    Front Biosci 14:1516-28. 2009
    ..Thus, some functions of ORF57 have been conserved while others have diverged from its homologues as ORF57 adapted over evolution to KSHV biology and pathogenesis...
  25. ncbi Exonic splicing enhancer-dependent selection of the bovine papillomavirus type 1 nucleotide 3225 3' splice site can be rescued in a cell lacking splicing factor ASF/SF2 through activation of the phosphatidylinositol 3-kinase/Akt pathway
    Xuefeng Liu
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:2105-15. 2003
    ....
  26. ncbi Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing
    Vladimir Majerciak
    HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI NIH, 10 Center Dr, Rm 6N106, MSC 1868, Bethesda, MD 20892 1868, USA
    J Virol 82:2792-801. 2008
    ..Collectively our data indicate that KSHV ORF57 functions as a novel splicing factor in the spliceosome-mediated splicing of viral RNA transcripts...
  27. ncbi Upregulation of p18Ink4c expression by oncogenic HPV E6 via p53-miR-34a pathway
    Xiaohong Wang
    Tumor Virus RNA Biology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 129:1362-72. 2011
    ..In summary, our study demonstrates an intimate connection among oncogenic HPV E6, p53, miR-34a and p18Ink4c and identifies p18Ink4c as a possible biomarker for cervical cancer...
  28. ncbi Human papillomavirus type 16 E2 and E6 are RNA-binding proteins and inhibit in vitro splicing of pre-mRNAs with suboptimal splice sites
    Sohrab Bodaghi
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Virology 386:32-43. 2009
    ..Together, these findings suggest that HPV16 E2 and E6 are RNA binding proteins and might play roles in posttranscriptional regulation during virus infection...
  29. ncbi Control of the papillomavirus early-to-late switch by differentially expressed SRp20
    Rong Jia
    HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr 6N106, Bethesda, MD 20892 1868, USA
    J Virol 83:167-80. 2009
    ....
  30. ncbi Could human papillomaviruses be spread through blood?
    Sohrab Bodaghi
    HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI NIH, 10 Center Dr, Rm 10 S255, MSC 1868, Bethesda, MD 20892 1868, USA
    J Clin Microbiol 43:5428-34. 2005
    ..Our data suggest that PBMCs may be HPV carriers and might spread the virus through blood...
  31. ncbi Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth
    Xiaohong Wang
    HIV and AIDS Malignancy Branch, Center for Cancer Research, Nation Cancer Institute National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2557. 2008
    ..When introduced into cell lines, miR-146a was found to promote cell proliferation. Collectively, our data indicate that downregulation of miR-143 and miR-145 and upregulation of miR-146a play a role in cervical carcinogenesis...
  32. ncbi Kaposi's sarcoma-associated herpesvirus K8 exon 3 contains three 5'-splice sites and harbors a K8.1 transcription start site
    Shuang Tang
    HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:14547-56. 2002
    ..1 mRNAs translated a little K8 and no detectable K8.1 proteins in 293 cells. Data suggest that production of the K8/K8.1 mRNAs may be an essential way to control K8 mRNAs, especially K8alpha, to a threshold at RNA processing level...
  33. ncbi Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA
    Maria J Massimelli
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:243-56. 2013
    ....
  34. ncbi Regulation of bovine papillomavirus type 1 gene expression by RNA processing
    Rong Jia
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Front Biosci 14:1270-82. 2009
    ....
  35. ncbi Kaposi's sarcoma-associated herpesvirus K8beta is derived from a spliced intermediate of K8 pre-mRNA and antagonizes K8alpha (K-bZIP) to induce p21 and p53 and blocks K8alpha-CDK2 interaction
    Koji Yamanegi
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1868, USA
    J Virol 79:14207-21. 2005
    ....
  36. ncbi Genetic organization and hypoxic activation of the Kaposi's sarcoma-associated herpesvirus ORF34-37 gene cluster
    Muzammel Haque
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1868, USA
    J Virol 80:7037-51. 2006
    ..Moreover, the activation of ORF36 by hypoxia might be exploited to develop targeted therapy for PEL, which arises in a hypoxic environment (pleural effusions)...
  37. ncbi A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis
    Motoko Unoki
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Dr, Bldg 37, Rm 3068, Bethesda, MD 20892, USA
    FEBS Lett 582:3868-74. 2008
    ..ING2a and ING2b have compensatory roles that protect cells from cell cycle arrest and apoptosis and may be involved in development of chemotherapeutic resistance...
  38. ncbi Structural and functional analyses of Kaposi sarcoma-associated herpesvirus ORF57 nuclear localization signals in living cells
    Vladimir Majerciak
    HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:28365-78. 2006
    ..Thus, the three NLSs identified in ORF57 provide at least two functions, nuclear localization of ORF57 and up-regulation of ORF59 expression...
  39. ncbi Intron definition and a branch site adenosine at nt 385 control RNA splicing of HPV16 E6*I and E7 expression
    Masahiko Ajiro
    Tumor Virus RNA Biology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA
    PLoS ONE 7:e46412. 2012
    ..This study elucidates for the first time a mapped branch point in HPV16 genome involved in viral oncogene expression...
  40. ncbi Signals that dictate nuclear localization of human papillomavirus type 16 oncoprotein E6 in living cells
    Mingfang Tao
    HIV and AIDS Malignancy Branch. Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:13232-47. 2003
    ..The discovery of three unique NLS sequences in 16E6 provides new insights into the nuclear association of 16E6 which may reveal other novel activities of this important oncogenic protein...
  41. ncbi Colorectal papillomavirus infection in patients with colorectal cancer
    Sohrab Bodaghi
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:2862-7. 2005
    ..HPV infection may play a role in colorectal carcinogenesis...
  42. ncbi Gene structure and expression of Kaposi's sarcoma-associated herpesvirus ORF56, ORF57, ORF58, and ORF59
    Vladimir Majerciak
    HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI/NIH, 10 Center Dr, Rm. 10 S255, MSC-1868, Bethesda, MD 20892-1868, USA
    J Virol 80:11968-81. 2006
    ..Both ORF56 and ORF59 are targets of ORF57 and were up-regulated significantly in the presence of ORF57, a posttranscriptional regulator...
  43. ncbi Requirement of a 12-base-pair TATT-containing sequence and viral lytic DNA replication in activation of the Kaposi's sarcoma-associated herpesvirus K8.1 late promoter
    Shuang Tang
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 78:2609-14. 2004
    ..1 promoter on the reporter is involved in KSHV lytic DNA replication largely by trans...