Research Topics
Genomes and Genes | Xaiolin ZhengSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
An essential role of p27 downregulation in fenvalerate-induced cell growth in human uterine leiomyoma and smooth muscle cellsXiaohua Gao
Molecular Pathogenesis Group, National Toxicology Program NTP Laboratory Branch, NTP, National Institute ofEnvironmental Health Sciences, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27709, USA
Am J Physiol Endocrinol Metab 303:E1025-35. 2012..Fen treatment in the presence of p27 silencing enhanced the increased cell counts and BrdU labeling in UtLM cells and UtSMCs. Taken together, these results indicate that p27 downregulation is critical for Fen-induced cell proliferation...- Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assayDarlene Dixon
National Toxicology Program NTP Laboratories Branch, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Reprod Toxicol 33:506-12. 2012..01 PFOA only mice. These data suggest that at a low dose PFOA produces minimal histopathologic changes in the reproductive tract of immature female mice, and does not antagonize the histopathologic effects of E(2)... 
Cell proliferation and apoptosis in human uterine leiomyomas and myometriaDarlene Dixon
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MDC2 09, Research Triangle Park, NC 27709, USA
Virchows Arch 441:53-62. 2002..We conclude that increased cell proliferation is the most significant contributor to growth and that the proliferative state is autonomous for each tumor in a given patient and is independent of tumor size...- Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in cocultureAlicia B Moore
Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park RTP, NC 27709, USA
Cell Commun Signal 8:10. 2010..In the present study, we investigated the interactions between human uterine leiomyoma (UtLM) cells and uterine leiomyoma-derived fibroblasts (FB), and their importance in cell growth and ECM protein production using a coculture system... - Immunohistochemical localization of growth factors and their receptors in uterine leiomyomas and matched myometriumD Dixon
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 108:795-802. 2000..In addition, decreased EGF may be secondary to the predominant estrogenic milieu present at time of sampling, as it has been proposed that progesterone, and not estrogen, may regulate EGF... - Summary of chemically induced pulmonary lesions in the National Toxicology Program (NTP) toxicology and carcinogenesis studiesDarlene Dixon
Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 36:428-39. 2008.... - A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cellsX Di
Comparative Pathobiology Group, Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Hum Reprod 23:1873-83. 2008..The aim of this study was to understand the molecular mechanism whereby genistein causes hyperproliferation of LM cells... - Effects of neonatal diethylstilbestrol (DES) exposure on morphology and growth patterns of endometrial epithelial cells in CD-1 miceA Yoshida
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 27:325-33. 1999..The data show that cell cycle kinetics, in addition to changes in morphology, are altered in the developing mouse uterus following neonatal exposure to DES... - Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethaneHiroaki Aoyama
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, P.O. Box 12233, MD C2-09, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 209:226-35. 2005..These data suggest that upregulated expression of ERalpha may be important in the induction of endometrial neoplasms in BE-treated mice... - Abnormal cell differentiation and p21 expression of endometrial epithelial cells following developmental exposure to diethylstilbestrol (DES)A Yoshida
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 28:237-45. 2000.... - Transforming growth factor-alpha, epidermal growth factor receptor, and PCNA immunoexpression in uterine leiomyosarcomas and leiomyomas in B6C3F1 miceA B Moore
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Exp Toxicol Pathol 52:195-200. 2000.... - Histomorphologic features of spontaneous and chemically-induced pulmonary neoplasms in B6C3F1 mice and Fischer 344 ratsD Dixon
National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709
Toxicol Pathol 19:540-56. 1991..Other less frequently occurring spontaneous and chemically-induced neoplasms included squamous cell carcinomas, bronchial adenomas and carcinomas, and sarcomas... - Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentrationA B Moore
Comparative Pathobiology Group, Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, NC 27709, USA
Hum Reprod 22:2623-31. 2007..001-50 microg/ml) on human uterine leiomyoma (UtLM) cells versus uterine smooth muscle cells (UtSMCs) in vitro... - Characterization of the expression of the retinoid-related, testis-associated receptor (RTR) in trophoblastsD V Mehta
Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Placenta 23:281-7. 2002..These results suggest the possibility of cross-talk between RTR and ERR alpha receptor signalling pathways in trophoblasts... - Characterization of uterine leiomyomas in CD-1 mice following developmental exposure to diethylstilbestrol (DES)Retha R Newbold
Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 30:611-6. 2002.... - Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesisAlison K Bauer
Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Natl Cancer Inst 97:1778-81. 2005..To our knowledge, this is the first model to demonstrate a modulatory role for Tlr4 in chronic lung inflammation and tumorigenesis... - Incidence of nonneoplastic lesions in historical control male and female Fischer-344 rats from 90-day toxicity studiesD Dixon
Experimental Carcinogenesis Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 23:338-48. 1995..These findings were included and discussed due to potential treatment effects that may result in an increase or decrease in these changes compared to controls. Neoplasms were not observed in rats from the prechronic studies evaluated... - Estrogen-induced changes in IGF-I, Myb family and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell linesC D Swartz
Laboratory of Experimental Pathology and Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Mol Hum Reprod 11:441-50. 2005.... - Histomorphology and ultrastructure of spontaneous pulmonary neoplasms in strain A miceD Dixon
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
Exp Lung Res 17:131-55. 1991.... - Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tractJ F Couse
Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Dev Biol 238:224-38. 2001.... - Estrogen receptor alpha (ERalpha) phospho-serine-118 is highly expressed in human uterine leiomyomas compared to matched myometriumTonia L Hermon
Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences NIEHS, National Toxicology Program NTP, National Institutes of Health NIH, Department of Health and Human Services DHHS, NC 27709, USA
Virchows Arch 453:557-69. 2008..These data suggest that ERalpha-phospho-Ser118 may be important in leiomyoma growth and is possibly phosphorylated by phospho-p44/42 MAPK... - Magnetic resonance imaging (MRI): a new tool in experimental toxicologic pathologyD Dixon
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
Toxicol Pathol 16:386-91. 1988.... - Characterization of uterine granular cell tumors in B6C3F1 mice: a histomorphologic, immunohistochemical, and ultrastructural studyA C Veit
Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, PO Box 12233, MD C2 09, 111 T W Alexander Drive, Bldg 101, Research Triangle Park, NC 27709 USA
Vet Pathol 45:654-62. 2008..The characteristics of these uterine granular cell tumors were suggestive of a myogenic origin... - Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: molecular and phenotypic characteristicsSara A Carney
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Lab Invest 82:719-28. 2002..Answers to these questions will undoubtedly lead to the development of more effective treatment and intervention regimens for clinical cases of uterine leiomyoma... - Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomasLinda Yu
Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina, United States of America
Mol Med 14:264-75. 2008..These data may provide new anti-tumor targets for noninvasive treatment of fibroids... - The second National Institutes of Health International Congress on advances in uterine leiomyoma research: conference summary and future recommendationsDarlene Dixon
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
Fertil Steril 86:800-6. 2006..This document summarizes this exchange and outlines research needs and recommendations for future research directions... - Association of race, age and body mass index with gross pathology of uterine fibroidsAlicia B Moore
Laboratory of Experimental Pathology and Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
J Reprod Med 53:90-6. 2008..To determine the associations of race, age and body mass index (BMI) with the gross pathology parameters of uterine leiomyomas in premenopausal women undergoing hysterectomy or myomectomy... - An endocrine-disrupting chemical, fenvalerate, induces cell cycle progression and collagen type I expression in human uterine leiomyoma and myometrial cellsXiaohua Gao
Comparative Pathobiology Group, Cellular and Molecular Pathology Branch, NTP, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
Toxicol Lett 196:133-41. 2010..Our results indicate that Fen exposure could be considered a novel risk factor for uterine fibroids through molecular mechanisms that do not directly involve the ERs... - Receptor tyrosine kinases and their hormonal regulation in uterine leiomyomaLinda Yu
Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Semin Reprod Med 28:250-9. 2010..It also presents data on specific signaling pathways activated in uterine leiomyomas and the "cross talk" between the estrogen receptor alpha and RTK signaling pathways... - Etiology and pathogenesis of uterine leiomyomas: a reviewGordon P Flake
Comparative Pathobiology Group, Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Environ Health Perspect 111:1037-54. 2003..These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review... - Enhanced susceptibility of staggerer (RORalphasg/sg) mice to lipopolysaccharide-induced lung inflammationCliona M Stapleton
Division of Intramural Research, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Am J Physiol Lung Cell Mol Physiol 289:L144-52. 2005..Our observations indicate that RORalpha(sg/sg) mice are more susceptible to LPS-induced airway inflammation and are in agreement with the hypothesis that RORalpha functions as a negative regulator of LPS-induced inflammatory responses... - Uterine smooth muscle tumors in potbellied pigs (Sus scrofa) resemble human fibroids: a potential animal modelKristie Mozzachio
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
Toxicol Pathol 32:402-7. 2004..These results support further investigation of uterine leiomyomas in potbellied pigs as a potentially valuable animal model for studying human fibroids... - Bromoethane, chloroethane and ethylene oxide induced uterine neoplasms in B6C3F1 mice from 2-year NTP inhalation bioassays: pathology and incidence data revisitedCatherine A Picut
Biotechnics, Inc, Hillsborough, North Carolina, USA
Exp Toxicol Pathol 55:1-9. 2003..The earlier results were confirmed. The mechanism of uterine carcinogenesis by chloroethane, bromoethane and ethylene oxide is unclear... - Assessment of hyperplastic lesions in rodent carcinogenicity studiesGary Boorman
Toxicol Pathol 31:709-10. 2003 - Society of toxicologic pathology position on assessment of hyperplastic lesions in rodent carcinogenicity studiesGary Boorman
Toxicol Pathol 32:124-5. 2004 - Karyotypic characteristics of human uterine leiomyoma and myometrial cell lines following telomerase inductionMarileila Varella-Garcia
Department of Medicine, Division of Medical Oncology, University of Colorado Health Sciences Center, Aurora, 80045, USA
Cancer Genet Cytogenet 170:71-5. 2006..This phenomenon was not observed in the UtSMC cells... - Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathwayVishal S Vaidya
Department of Toxicology, School of Pharmacy, The University of Louisiana at Monroe, Louisiana 71209-0470, USA
Toxicol Pathol 31:604-18. 2003.... - Inhibition of urethane-induced genotoxicity and cell proliferation in CYP2E1-null miceUndi Hoffler
Department of Pharmacology, Meharry Medical College, Nashville, TN, USA
Mutat Res 572:58-72. 2005..In conclusion, these data demonstrated that CYP2E1-mediated metabolism of urethane, presumably via epoxide formation, is necessary for the induction of genotoxicity, and cell proliferation in the liver and lung of wild-type mice... - Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortiumAlexander Yu Nikitin
Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
Cancer Res 64:2307-16. 2004....