Xaiolin Zheng

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc An essential role of p27 downregulation in fenvalerate-induced cell growth in human uterine leiomyoma and smooth muscle cells
    Xiaohua Gao
    Molecular Pathogenesis Group, National Toxicology Program NTP Laboratory Branch, NTP, National Institute ofEnvironmental Health Sciences, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Endocrinol Metab 303:E1025-35. 2012
  2. pmc Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay
    Darlene Dixon
    National Toxicology Program NTP Laboratories Branch, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Reprod Toxicol 33:506-12. 2012
  3. ncbi request reprint Cell proliferation and apoptosis in human uterine leiomyomas and myometria
    Darlene Dixon
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MDC2 09, Research Triangle Park, NC 27709, USA
    Virchows Arch 441:53-62. 2002
  4. pmc Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture
    Alicia B Moore
    Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park RTP, NC 27709, USA
    Cell Commun Signal 8:10. 2010
  5. ncbi request reprint Immunohistochemical localization of growth factors and their receptors in uterine leiomyomas and matched myometrium
    D Dixon
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 108:795-802. 2000
  6. pmc Summary of chemically induced pulmonary lesions in the National Toxicology Program (NTP) toxicology and carcinogenesis studies
    Darlene Dixon
    Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:428-39. 2008
  7. pmc A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells
    X Di
    Comparative Pathobiology Group, Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Hum Reprod 23:1873-83. 2008
  8. ncbi request reprint Effects of neonatal diethylstilbestrol (DES) exposure on morphology and growth patterns of endometrial epithelial cells in CD-1 mice
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:325-33. 1999
  9. ncbi request reprint Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethane
    Hiroaki Aoyama
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, P O Box 12233, MD C2 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 209:226-35. 2005
  10. ncbi request reprint Abnormal cell differentiation and p21 expression of endometrial epithelial cells following developmental exposure to diethylstilbestrol (DES)
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:237-45. 2000

Collaborators

Detail Information

Publications39

  1. pmc An essential role of p27 downregulation in fenvalerate-induced cell growth in human uterine leiomyoma and smooth muscle cells
    Xiaohua Gao
    Molecular Pathogenesis Group, National Toxicology Program NTP Laboratory Branch, NTP, National Institute ofEnvironmental Health Sciences, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Endocrinol Metab 303:E1025-35. 2012
    ..Fen treatment in the presence of p27 silencing enhanced the increased cell counts and BrdU labeling in UtLM cells and UtSMCs. Taken together, these results indicate that p27 downregulation is critical for Fen-induced cell proliferation...
  2. pmc Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay
    Darlene Dixon
    National Toxicology Program NTP Laboratories Branch, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Reprod Toxicol 33:506-12. 2012
    ..01 PFOA only mice. These data suggest that at a low dose PFOA produces minimal histopathologic changes in the reproductive tract of immature female mice, and does not antagonize the histopathologic effects of E(2)...
  3. ncbi request reprint Cell proliferation and apoptosis in human uterine leiomyomas and myometria
    Darlene Dixon
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MDC2 09, Research Triangle Park, NC 27709, USA
    Virchows Arch 441:53-62. 2002
    ..We conclude that increased cell proliferation is the most significant contributor to growth and that the proliferative state is autonomous for each tumor in a given patient and is independent of tumor size...
  4. pmc Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture
    Alicia B Moore
    Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park RTP, NC 27709, USA
    Cell Commun Signal 8:10. 2010
    ..In the present study, we investigated the interactions between human uterine leiomyoma (UtLM) cells and uterine leiomyoma-derived fibroblasts (FB), and their importance in cell growth and ECM protein production using a coculture system...
  5. ncbi request reprint Immunohistochemical localization of growth factors and their receptors in uterine leiomyomas and matched myometrium
    D Dixon
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 108:795-802. 2000
    ..In addition, decreased EGF may be secondary to the predominant estrogenic milieu present at time of sampling, as it has been proposed that progesterone, and not estrogen, may regulate EGF...
  6. pmc Summary of chemically induced pulmonary lesions in the National Toxicology Program (NTP) toxicology and carcinogenesis studies
    Darlene Dixon
    Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 36:428-39. 2008
    ....
  7. pmc A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells
    X Di
    Comparative Pathobiology Group, Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Hum Reprod 23:1873-83. 2008
    ..The aim of this study was to understand the molecular mechanism whereby genistein causes hyperproliferation of LM cells...
  8. ncbi request reprint Effects of neonatal diethylstilbestrol (DES) exposure on morphology and growth patterns of endometrial epithelial cells in CD-1 mice
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:325-33. 1999
    ..The data show that cell cycle kinetics, in addition to changes in morphology, are altered in the developing mouse uterus following neonatal exposure to DES...
  9. ncbi request reprint Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethane
    Hiroaki Aoyama
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, P O Box 12233, MD C2 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 209:226-35. 2005
    ..These data suggest that upregulated expression of ERalpha may be important in the induction of endometrial neoplasms in BE-treated mice...
  10. ncbi request reprint Abnormal cell differentiation and p21 expression of endometrial epithelial cells following developmental exposure to diethylstilbestrol (DES)
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:237-45. 2000
    ....
  11. ncbi request reprint Transforming growth factor-alpha, epidermal growth factor receptor, and PCNA immunoexpression in uterine leiomyosarcomas and leiomyomas in B6C3F1 mice
    A B Moore
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Exp Toxicol Pathol 52:195-200. 2000
    ....
  12. ncbi request reprint Histomorphologic features of spontaneous and chemically-induced pulmonary neoplasms in B6C3F1 mice and Fischer 344 rats
    D Dixon
    National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 19:540-56. 1991
    ..Other less frequently occurring spontaneous and chemically-induced neoplasms included squamous cell carcinomas, bronchial adenomas and carcinomas, and sarcomas...
  13. pmc Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentration
    A B Moore
    Comparative Pathobiology Group, Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, NC 27709, USA
    Hum Reprod 22:2623-31. 2007
    ..001-50 microg/ml) on human uterine leiomyoma (UtLM) cells versus uterine smooth muscle cells (UtSMCs) in vitro...
  14. ncbi request reprint Characterization of the expression of the retinoid-related, testis-associated receptor (RTR) in trophoblasts
    D V Mehta
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Placenta 23:281-7. 2002
    ..These results suggest the possibility of cross-talk between RTR and ERR alpha receptor signalling pathways in trophoblasts...
  15. ncbi request reprint Characterization of uterine leiomyomas in CD-1 mice following developmental exposure to diethylstilbestrol (DES)
    Retha R Newbold
    Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:611-6. 2002
    ....
  16. ncbi request reprint Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis
    Alison K Bauer
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 97:1778-81. 2005
    ..To our knowledge, this is the first model to demonstrate a modulatory role for Tlr4 in chronic lung inflammation and tumorigenesis...
  17. ncbi request reprint Incidence of nonneoplastic lesions in historical control male and female Fischer-344 rats from 90-day toxicity studies
    D Dixon
    Experimental Carcinogenesis Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 23:338-48. 1995
    ..These findings were included and discussed due to potential treatment effects that may result in an increase or decrease in these changes compared to controls. Neoplasms were not observed in rats from the prechronic studies evaluated...
  18. ncbi request reprint Estrogen-induced changes in IGF-I, Myb family and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines
    C D Swartz
    Laboratory of Experimental Pathology and Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Hum Reprod 11:441-50. 2005
    ....
  19. ncbi request reprint Histomorphology and ultrastructure of spontaneous pulmonary neoplasms in strain A mice
    D Dixon
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Exp Lung Res 17:131-55. 1991
    ....
  20. ncbi request reprint Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract
    J F Couse
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Dev Biol 238:224-38. 2001
    ....
  21. pmc Estrogen receptor alpha (ERalpha) phospho-serine-118 is highly expressed in human uterine leiomyomas compared to matched myometrium
    Tonia L Hermon
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences NIEHS, National Toxicology Program NTP, National Institutes of Health NIH, Department of Health and Human Services DHHS, NC 27709, USA
    Virchows Arch 453:557-69. 2008
    ..These data suggest that ERalpha-phospho-Ser118 may be important in leiomyoma growth and is possibly phosphorylated by phospho-p44/42 MAPK...
  22. ncbi request reprint Magnetic resonance imaging (MRI): a new tool in experimental toxicologic pathology
    D Dixon
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Pathol 16:386-91. 1988
    ....
  23. pmc Characterization of uterine granular cell tumors in B6C3F1 mice: a histomorphologic, immunohistochemical, and ultrastructural study
    A C Veit
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, PO Box 12233, MD C2 09, 111 T W Alexander Drive, Bldg 101, Research Triangle Park, NC 27709 USA
    Vet Pathol 45:654-62. 2008
    ..The characteristics of these uterine granular cell tumors were suggestive of a myogenic origin...
  24. ncbi request reprint Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: molecular and phenotypic characteristics
    Sara A Carney
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Lab Invest 82:719-28. 2002
    ..Answers to these questions will undoubtedly lead to the development of more effective treatment and intervention regimens for clinical cases of uterine leiomyoma...
  25. pmc Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas
    Linda Yu
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina, United States of America
    Mol Med 14:264-75. 2008
    ..These data may provide new anti-tumor targets for noninvasive treatment of fibroids...
  26. ncbi request reprint The second National Institutes of Health International Congress on advances in uterine leiomyoma research: conference summary and future recommendations
    Darlene Dixon
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Fertil Steril 86:800-6. 2006
    ....
  27. ncbi request reprint Association of race, age and body mass index with gross pathology of uterine fibroids
    Alicia B Moore
    Laboratory of Experimental Pathology and Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    J Reprod Med 53:90-6. 2008
    ..To determine the associations of race, age and body mass index (BMI) with the gross pathology parameters of uterine leiomyomas in premenopausal women undergoing hysterectomy or myomectomy...
  28. pmc An endocrine-disrupting chemical, fenvalerate, induces cell cycle progression and collagen type I expression in human uterine leiomyoma and myometrial cells
    Xiaohua Gao
    Comparative Pathobiology Group, Cellular and Molecular Pathology Branch, NTP, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
    Toxicol Lett 196:133-41. 2010
    ..Our results indicate that Fen exposure could be considered a novel risk factor for uterine fibroids through molecular mechanisms that do not directly involve the ERs...
  29. pmc Receptor tyrosine kinases and their hormonal regulation in uterine leiomyoma
    Linda Yu
    Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Semin Reprod Med 28:250-9. 2010
    ..It also presents data on specific signaling pathways activated in uterine leiomyomas and the "cross talk" between the estrogen receptor alpha and RTK signaling pathways...
  30. pmc Etiology and pathogenesis of uterine leiomyomas: a review
    Gordon P Flake
    Comparative Pathobiology Group, Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:1037-54. 2003
    ..These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review...
  31. ncbi request reprint Enhanced susceptibility of staggerer (RORalphasg/sg) mice to lipopolysaccharide-induced lung inflammation
    Cliona M Stapleton
    Division of Intramural Research, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Physiol Lung Cell Mol Physiol 289:L144-52. 2005
    ..Our observations indicate that RORalpha(sg/sg) mice are more susceptible to LPS-induced airway inflammation and are in agreement with the hypothesis that RORalpha functions as a negative regulator of LPS-induced inflammatory responses...
  32. ncbi request reprint Uterine smooth muscle tumors in potbellied pigs (Sus scrofa) resemble human fibroids: a potential animal model
    Kristie Mozzachio
    Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Pathol 32:402-7. 2004
    ..These results support further investigation of uterine leiomyomas in potbellied pigs as a potentially valuable animal model for studying human fibroids...
  33. ncbi request reprint Bromoethane, chloroethane and ethylene oxide induced uterine neoplasms in B6C3F1 mice from 2-year NTP inhalation bioassays: pathology and incidence data revisited
    Catherine A Picut
    Biotechnics, Inc, Hillsborough, North Carolina, USA
    Exp Toxicol Pathol 55:1-9. 2003
    ..The earlier results were confirmed. The mechanism of uterine carcinogenesis by chloroethane, bromoethane and ethylene oxide is unclear...
  34. ncbi request reprint Assessment of hyperplastic lesions in rodent carcinogenicity studies
    Gary Boorman
    Toxicol Pathol 31:709-10. 2003
  35. ncbi request reprint Society of toxicologic pathology position on assessment of hyperplastic lesions in rodent carcinogenicity studies
    Gary Boorman
    Toxicol Pathol 32:124-5. 2004
  36. ncbi request reprint Karyotypic characteristics of human uterine leiomyoma and myometrial cell lines following telomerase induction
    Marileila Varella-Garcia
    Department of Medicine, Division of Medical Oncology, University of Colorado Health Sciences Center, Aurora, 80045, USA
    Cancer Genet Cytogenet 170:71-5. 2006
    ..This phenomenon was not observed in the UtSMC cells...
  37. ncbi request reprint Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathway
    Vishal S Vaidya
    Department of Toxicology, School of Pharmacy, The University of Louisiana at Monroe, Louisiana 71209 0470, USA
    Toxicol Pathol 31:604-18. 2003
    ....
  38. ncbi request reprint Inhibition of urethane-induced genotoxicity and cell proliferation in CYP2E1-null mice
    Undi Hoffler
    Department of Pharmacology, Meharry Medical College, Nashville, TN, USA
    Mutat Res 572:58-72. 2005
    ..In conclusion, these data demonstrated that CYP2E1-mediated metabolism of urethane, presumably via epoxide formation, is necessary for the induction of genotoxicity, and cell proliferation in the liver and lung of wild-type mice...
  39. ncbi request reprint Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium
    Alexander Yu Nikitin
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
    Cancer Res 64:2307-16. 2004
    ....