Lixin Zheng

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Quantitating lymphocyte programmed cell death in vitro using simple kill assays
    Lixin Zheng
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 979:1-14. 2013
  2. pmc Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib
    Lilia L Bi
    Center for Biologics Evaluation and Research, FDA, Rockville, Maryland, USA
    BMC Med Genet 8:41. 2007
  3. pmc Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1
    Lixin Zheng
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, 9000 Rockville Pike, 10 11D09, Bethesda, MD 20892, USA
    Mol Cell Biol 26:3505-13. 2006
  4. pmc Critical role for BIM in T cell receptor restimulation-induced death
    Andrew L Snow
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1508, USA
    Biol Direct 3:34. 2008
  5. ncbi request reprint Requirement for caspase-8 in NF-kappaB activation by antigen receptor
    Helen Su
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 307:1465-8. 2005
  6. pmc Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival
    Nicolas Bidere
    Molecular Development Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 458:92-6. 2009
  7. ncbi request reprint Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation
    Nicolas Bidere
    Molecular Development Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Biol 16:1666-71. 2006
  8. ncbi request reprint Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation
    Fengyi Wan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Cell 131:927-39. 2007
  9. pmc Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagy
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8003, USA
    Autophagy 5:232-4. 2009
  10. pmc The power and the promise of restimulation-induced cell death in human immune diseases
    Andrew L Snow
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 236:68-82. 2010

Collaborators

Detail Information

Publications31

  1. doi request reprint Quantitating lymphocyte programmed cell death in vitro using simple kill assays
    Lixin Zheng
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 979:1-14. 2013
    ..The detection methods discussed are generally applicable for assessing cell death in several contexts, expanded upon in further detail in subsequent chapters...
  2. pmc Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib
    Lilia L Bi
    Center for Biologics Evaluation and Research, FDA, Rockville, Maryland, USA
    BMC Med Genet 8:41. 2007
    ....
  3. pmc Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1
    Lixin Zheng
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, 9000 Rockville Pike, 10 11D09, Bethesda, MD 20892, USA
    Mol Cell Biol 26:3505-13. 2006
    ..These single transducers determine cell fate by triggering NF-kappaB activation, apoptosis, and nonapoptotic death signals through separate and competing signaling pathways...
  4. pmc Critical role for BIM in T cell receptor restimulation-induced death
    Andrew L Snow
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1508, USA
    Biol Direct 3:34. 2008
    ....
  5. ncbi request reprint Requirement for caspase-8 in NF-kappaB activation by antigen receptor
    Helen Su
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 307:1465-8. 2005
    ..These findings thus explain the paradoxical association of defective apoptosis and combined immunodeficiency in human CED...
  6. pmc Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival
    Nicolas Bidere
    Molecular Development Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 458:92-6. 2009
    ..ABC DLBCL cells required CK1alpha for constitutive NF-kappaB activity, indicating that CK1alpha functions as a conditionally essential malignancy gene-a member of a new class of potential cancer therapeutic targets...
  7. ncbi request reprint Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation
    Nicolas Bidere
    Molecular Development Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Biol 16:1666-71. 2006
    ..Our results suggest that PKCtheta independently controls CARMA1 phosphorylation and BCL10-dependent caspase-8 activation and unveil an essential role for TRAF6 as a critical adaptor linking these two convergent signaling events...
  8. ncbi request reprint Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation
    Fengyi Wan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Cell 131:927-39. 2007
    ..Our observations provide insight into how NF-kappaB selectively controls gene expression...
  9. pmc Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagy
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8003, USA
    Autophagy 5:232-4. 2009
    ..We propose that Irgm1 plays a major role in maintaining T lymphocyte homeostasis during host IFN gamma responses by protecting these cells from autophagy-dependent cell death...
  10. pmc The power and the promise of restimulation-induced cell death in human immune diseases
    Andrew L Snow
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 236:68-82. 2010
    ..Here, we review how these advances offer a refreshing new perspective on the phenomenon of T-cell apoptosis induced through antigen restimulation, including its relevance to immune homeostasis and potential for therapeutic interventions...
  11. pmc The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes
    Pushpa Pandiyan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 189:4237-46. 2012
    ..Taken together, these data indicate that IL-15 has a negative regulatory role in fine-tuning of IL-17A production and Th17-mediated inflammation...
  12. ncbi request reprint A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses
    Francis Ka Ming Chan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:51613-21. 2003
    ..Thus, TNF-induced programmed necrosis is facilitated by TNFR-2 signaling and caspase inhibition and may play a role in controlling viral infection...
  13. pmc Congenital B cell lymphocytosis explained by novel germline CARD11 mutations
    Andrew L Snow
    Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 209:2247-61. 2012
    ....
  14. ncbi request reprint Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors
    Guo Min Deng
    Laboratory of Immunology, Building 10, Room 11N311, 10 Center Drive, MSC 1892, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 11:1066-72. 2005
    ..Thus, targeting the PLAD may have clinical value in the treatment of human arthritis and other disorders involving receptors of the TNFR superfamily...
  15. ncbi request reprint Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome
    Shigui Zhu
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Hum Genet 119:284-94. 2006
    ..05). Thus, different genetic variations in caspase-10 can produce contrasting phenotypic effects...
  16. pmc NRAS mutation causes a human autoimmune lymphoproliferative syndrome
    Joao B Oliveira
    Department of Laboratory Medicine, Clinical Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:8953-8. 2007
    ..Our observations on the effects of NRAS activation indicate that RAS-inactivating drugs, such as farnesyltransferase inhibitors should be examined in human autoimmune and lymphocyte homeostasis disorders...
  17. pmc The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death
    Carl G Feng
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 9:1279-87. 2008
    ..Our studies identify a feedback mechanism in the T helper type 1 response that limits the detrimental effects of IFN-gamma on effector T lymphocyte survival while promoting the antimicrobial functions of IFN-gamma...
  18. pmc Termination of autophagy and reformation of lysosomes regulated by mTOR
    Li Yu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 465:942-6. 2010
    ..Thus, an evolutionarily conserved cycle in autophagy governs nutrient sensing and lysosome homeostasis during starvation...
  19. ncbi request reprint The death effector domain protein family: regulators of cellular homeostasis
    Michael D Tibbetts
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 4:404-9. 2003
    ..Thus, the DED defines a family of proteins that may be pivotal to cellular homeostasis by establishing a 'cell renewal set point' that coregulates proliferation and apoptosis in parallel...
  20. doi request reprint Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D
    Benjamin Chaigne-Delalande
    Molecular Development of the Immune System Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 341:186-91. 2013
    ..Moreover, these findings reveal a specific molecular function of free basal intracellular Mg(2+) in eukaryotic cells. ..
  21. pmc The molecular mechanisms of regulatory T cell immunosuppression
    Pushpa Pandiyan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, MD, USA
    Front Immunol 2:60. 2011
    ..2011; Pandiyan et al., 2011). Although these points are at variance to varying degrees with the standard model of T(reg) behavior, we will recount developing findings that support these new concepts...
  22. pmc ALPS-ten lessons from an international workshop on a genetic disease of apoptosis
    Michael J Lenardo
    Molecular Development Section, Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 32:291-5. 2010
    ..Their discussions yielded ten broad messages applicable to genetic and immunological investigations of human disease...
  23. pmc CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model
    Pushpa Pandiyan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 34:422-34. 2011
    ....
  24. ncbi request reprint Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
    Hyung J Chun
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 419:395-9. 2002
    ..Thus, caspase-8 deficiency in humans is compatible with normal development and shows that caspase-8 has a postnatal role in immune activation of naive lymphocytes...
  25. ncbi request reprint T helper 2 cells' preferred way to die
    Lixin Zheng
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 25:187-8. 2006
  26. ncbi request reprint CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
    Pushpa Pandiyan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 8:1353-62. 2007
    ..Thus, cytokine deprivation-induced apoptosis is a prominent mechanism by which T(reg) cells inhibit effector T cell responses...
  27. pmc Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition
    Jin Kuk Yang
    Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA
    Mol Cell 20:939-49. 2005
    ..This interaction apparently competes with FADD self-association and disrupts higher-order oligomerization required for caspase activation in the DISC...
  28. pmc Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds
    Patrick Legembre
    The Ben May Institute for Cancer Research, University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA
    EMBO Rep 5:1084-9. 2004
    ..Mutations in CD95 may eliminate the tumour-suppressive function of CD95, at the same time allowing induction of survival or proliferative pathways, which could contribute to the increased risk for lymphoma seen in ALPS type Ia patients...
  29. ncbi request reprint Loss of BCL-XL in rod photoreceptors: Increased susceptibility to bright light stress
    Lixin Zheng
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Invest Ophthalmol Vis Sci 47:5583-9. 2006
    ....
  30. doi request reprint Role of BCL-XL in photoreceptor survival
    Yun Zheng Le
    Department of Medicine, Dean A McGee Eye Institute, Oklahoma City, OK, USA
    Adv Exp Med Biol 613:69-74. 2008
  31. pmc Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
    Hyung J Chun
    Department of Medicine and Department of Anesthesiology, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 118:3343-54. 2008
    ..Taken together, these findings indicate that apelin signaling can block Ang II actions in vascular disease by increasing NO production and inhibiting Ang II cellular signaling...