Research Topics
Genomes and Genes | Keji ZhaoSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Dynamic regulation of epigenomic landscapes during hematopoiesisBrian J Abraham
Systems Biology Center, NHLBI, NIH, Rockville Pike, Bethesda, MD, USA
BMC Genomics 14:193. 2013..Transcriptional regulation has been mostly studied using in vitro systems while epigenetic changes occurring during in vivo development remain poorly understood...- An anti-cancer SmurfKeji Zhao
Systems Biology Center, National Heart, Lung, and Blood Institute NHLBI, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
Cell Biosci 2:10. 2012..ABSTRACT: A novel, cancer-fighting function was recently discovered for Smad ubiquitination regulatory factor 2 (Smurf2)... - SWI/SNF-mediated chromatin remodeling induces Z-DNA formation on a nucleosomeNiveen Mulholland
Systems Biology Center, Division of Intramural Research, National Heart, Lung and Blood Institute, NIH, Maryland, USA
Cell Biosci 2:3. 2012..abstract:.. - Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testisQiang Gan
Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
Genome Biol 11:R42. 2010..Previous studies have been performed using cultured mammalian embryonic stem cells. To a lesser extent, chromatin structure has been delineated in other model organisms, such as Drosophila, to open new avenues for genetic analyses... - Profiling RE1/REST-mediated histone modifications in the human genomeDeyou Zheng
Institute for Brain Disorders and Neural Regeneration, Department of Neurology, Rose F Kennedy Center for the Study of Intellectual and Developmental Disabilities, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Genome Biol 10:R9. 2009.... 
Genome-wide mapping of nucleosome occupancy, histone modifications, and gene expression using next-generation sequencing technologyGang Wei
Systems Biology Center, NHLBI, NIH, Bethesda, Maryland, USA
Methods Enzymol 513:297-313. 2012..We also describe RNA-Seq protocols used to map global gene expression profiles...- T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosisHeather Rogers
Molecular Medicine Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1822, USA
J Biol Chem 287:36720-31. 2012..These data suggest that TAL1 binds to the EPO-R promoter to activate EPO-R expression and provides a potential link to elevated EPO-R expression leading to hypersensitivity to erythropoietin and the resultant excessive erythrocytosis... - Marek's disease virus infection induces widespread differential chromatin marks in inbred chicken linesApratim Mitra
Department of Animal and Avian Sciences, University of Maryland, College Park, MD, USA
BMC Genomics 13:557. 2012..Also, epigenetic factors are believed to be one of the major determinants of disease response... - The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responsesJinfang Zhu
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 37:660-73. 2012..Our study revealed redundancy and synergy among several Th1 cell-inducing pathways in regulating the expression of T-bet and IFN-γ, and a critical role of T-bet in suppressing an endogenous Th2 cell-associated program... - H2A.Z Facilitates Access of Active and Repressive Complexes to Chromatin in Embryonic Stem Cell Self-Renewal and DifferentiationGangqing Hu
Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cell Stem Cell 12:180-92. 2013..We propose that H2A.Z mediates such contrasting activities by acting as a general facilitator that generates access for a variety of complexes, both activating and repressive... - Genome-wide approaches to determining nucleosome occupancy in metazoans using MNase-SeqKairong Cui
Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Methods Mol Biol 833:413-9. 2012..This chapter outlines the reagents and experimental procedures of MNase-Seq for mapping nucleosome positions in the human genome... - c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cellsZuqin Nie
Laboratory of Pathology, NCI, Bethesda, MD 20892, USA
Cell 151:68-79. 2012..This rule of Myc action explains the vast majority of Myc biology observed in literature... - Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organizationIouri Chepelev
Systems Biology Center, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA
Cell Res 22:490-503. 2012..The Gene Expression Omnibus accession number for the raw and analyzed chromatin interaction data is GSE32677... - Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1Gangqing Hu
Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Genome Res 21:1650-8. 2011..Intriguingly, we find that the nucleosome shifting specifically facilitates binding of TAL1 but not GATA1 and is linked to subsequent transcriptional regulation of target genes... - Transcriptional regulation of rod photoreceptor homeostasis revealed by in vivo NRL targetome analysisHong Hao
Neurobiology Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Genet 8:e1002649. 2012..Our studies identify candidate genes for retinal dystrophies, define cis-regulatory module(s) for photoreceptor-expressed genes and provide a framework for decoding transcriptional regulatory networks that dictate rod homeostasis... - Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell typesGang Wei
Laboratory of Molecular Immunology, NHLBI, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Immunity 35:299-311. 2011.... - GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in miceElizabeth A Wohlfert
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
J Clin Invest 121:4503-15. 2011..Overall, our work reveals what we believe to be a new facet in the complex role of GATA3 in T cells and highlights what may be a fundamental role in controlling Treg physiology during inflammation... - DNA double-strand breaks induced by high NaCl occur predominantly in gene desertsNatalia I Dmitrieva
Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 108:20796-801. 2011..We propose that the universal presence of NaCl around animal cells has directly influenced the evolution of the structure of their genomes... - Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparumMaría J López-Barragán
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
BMC Genomics 12:587. 2011..Antisense transcripts have widely been reported in P. falciparum; however, the extent and pattern of antisense transcripts in different developmental stages remain largely unknown...