Baozhong Zhao

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Studies on the photosensitized reduction of resorufin and implications for the detection of oxidative stress with Amplex Red
    Baozhong Zhao
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 51:153-9. 2011
  2. doi request reprint Photo-induced reactive oxygen species generation by different water-soluble fullerenes (C) and their cytotoxicity in human keratinocytes
    Baozhong Zhao
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC, USA
    Photochem Photobiol 84:1215-23. 2008
  3. pmc Pristine (C60) and hydroxylated [C60(OH)24] fullerene phototoxicity towards HaCaT keratinocytes: type I vs type II mechanisms
    Baozhong Zhao
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 21:1056-63. 2008
  4. pmc Detection and prevention of ocular phototoxicity of ciprofloxacin and other fluoroquinolone antibiotics
    Baozhong Zhao
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    Photochem Photobiol 86:798-805. 2010
  5. doi request reprint In vitro phototoxicity and hazard identification of nano-scale titanium dioxide
    Kristen Sanders
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Appl Pharmacol 258:226-36. 2012
  6. pmc Real-time visualization of photochemically induced fluorescence of 8-halogenated quinolones: lomefloxacin, clinafloxacin and Bay3118 in live human HaCaT keratinocytes
    Edmond B Koker
    Department of Chemistry and Physics, Elizabeth City State University, Elizabeth City, NC, USA
    Photochem Photobiol 86:792-7. 2010
  7. pmc Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles
    Baozhong Zhao
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Toxicol Appl Pharmacol 241:163-72. 2009
  8. doi request reprint Phototoxicity and cytotoxicity of fullerol in human retinal pigment epithelial cells
    Albert R Wielgus
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 242:79-90. 2010
  9. doi request reprint Photooxidation of Amplex Red to resorufin: implications of exposing the Amplex Red assay to light
    Fiona A Summers
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA
    Methods Enzymol 526:1-17. 2013
  10. pmc Photooxidation of Amplex Red to resorufin: implications of exposing the Amplex Red assay to light
    Baozhong Zhao
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 53:1080-7. 2012

Collaborators

Detail Information

Publications16

  1. pmc Studies on the photosensitized reduction of resorufin and implications for the detection of oxidative stress with Amplex Red
    Baozhong Zhao
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 51:153-9. 2011
    ..The suppression of oxygen consumption by addition of SOD or catalase further confirmed the production of superoxide and hydrogen peroxide...
  2. doi request reprint Photo-induced reactive oxygen species generation by different water-soluble fullerenes (C) and their cytotoxicity in human keratinocytes
    Baozhong Zhao
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC, USA
    Photochem Photobiol 84:1215-23. 2008
    ..In vitro tests with HaCaT keratinocytes provided evidence that (gamma-CyD)(2)/C(60) phototoxicity is mainly mediated by (1)O(2) (Type II mechanism) with only a minor contribution from free radicals (Type I mechanism)...
  3. pmc Pristine (C60) and hydroxylated [C60(OH)24] fullerene phototoxicity towards HaCaT keratinocytes: type I vs type II mechanisms
    Baozhong Zhao
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 21:1056-63. 2008
    ..Our results clearly show that the phototoxicity induced by (gamma-CyD) 2/C 60 is mainly mediated by singlet oxygen with a minor contribution from superoxide, while C 60(OH) 24 phototoxicity is mainly due to superoxide...
  4. pmc Detection and prevention of ocular phototoxicity of ciprofloxacin and other fluoroquinolone antibiotics
    Baozhong Zhao
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    Photochem Photobiol 86:798-805. 2010
    ..However, if precautions are taken to filter all UV radiation from the eye while taking these antibiotics, eye damage may be prevented...
  5. doi request reprint In vitro phototoxicity and hazard identification of nano-scale titanium dioxide
    Kristen Sanders
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Appl Pharmacol 258:226-36. 2012
    ..LC(50) values under UVA were correlated with TBARS reactivity, particle size, and surface area...
  6. pmc Real-time visualization of photochemically induced fluorescence of 8-halogenated quinolones: lomefloxacin, clinafloxacin and Bay3118 in live human HaCaT keratinocytes
    Edmond B Koker
    Department of Chemistry and Physics, Elizabeth City State University, Elizabeth City, NC, USA
    Photochem Photobiol 86:792-7. 2010
    ..Our images not only help to localize these phototoxic agents in the cell, but also provide means for dynamic monitoring of their phototransformations in the cellular environment...
  7. pmc Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles
    Baozhong Zhao
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Toxicol Appl Pharmacol 241:163-72. 2009
    ..We expect that modifying the surface of silicon nanoparticles encapsulating the photosensitizers with antibodies specific to melanoma cells will lead to even better early diagnosis and targeted treatment of melanoma in the future...
  8. doi request reprint Phototoxicity and cytotoxicity of fullerol in human retinal pigment epithelial cells
    Albert R Wielgus
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 242:79-90. 2010
    ..In conclusion, ocular exposure to fullerol, particularly in the presence of sunlight, may lead to retinal damage...
  9. doi request reprint Photooxidation of Amplex Red to resorufin: implications of exposing the Amplex Red assay to light
    Fiona A Summers
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA
    Methods Enzymol 526:1-17. 2013
    ..In general, precautions should be taken to minimize exposure to light, including that from instrumental light, during measurement of oxidative stress with Amplex Red. ..
  10. pmc Photooxidation of Amplex Red to resorufin: implications of exposing the Amplex Red assay to light
    Baozhong Zhao
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 53:1080-7. 2012
    ..In general, precautions should be taken to minimize exposure to light during measurement of oxidative stress with Amplex Red...
  11. pmc Immunological detection of N-formylkynurenine in porphyrin-mediated photooxided lens α-crystallin
    Marilyn Ehrenshaft
    Laboratory of Pharmacology and Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Photochem Photobiol 87:1321-9. 2011
    ..Confocal microscopy of cultured human lens epithelial cells indicates that while all four porphyrins photosensitize cellular proteins, not all oxidize the tryptophans of cellular α-crystallin to NFK...
  12. pmc Difference in phototoxicity of cyclodextrin complexed fullerene [(gamma-CyD)2/C60] and its aggregated derivatives toward human lens epithelial cells
    Baozhong Zhao
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 22:660-7. 2009
    ..Our results also demonstrate that UVA-blocking sunglasses can limit the ocular phototoxicity of this nanomaterial, while nontoxic endogenous antioxidants like lutein or Trolox cannot provide adequate protection...
  13. pmc Recent advances in the prevention and treatment of skin cancer using photodynamic therapy
    Baozhong Zhao
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Expert Rev Anticancer Ther 10:1797-809. 2010
    ..This article summarizes the main principles of PDT and its current clinical use in the management of non-melanoma skin cancers, as well as recent developments and possible future research directions...
  14. ncbi request reprint Spectroscopic studies of the interaction between hypocrellin B and human serum albumin
    Baozhong Zhao
    Key Laboratory of Photochemistry, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    Bioorg Med Chem 14:2428-32. 2006
    ....
  15. ncbi request reprint Binding of hypocrellin B to human serum albumin and photo-induced interactions
    Baozhong Zhao
    Key Laboratory of Photochemistry, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, People s Republic of China
    Biochim Biophys Acta 1722:124-30. 2005
    ....
  16. ncbi request reprint A novel water-soluble nanoparticles of hypocrellin B and their interaction with a model protein: C-phycocyanin
    Baozhong Zhao
    Key Laboratory of Photochemistry, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, PR China
    Biochim Biophys Acta 1670:113-20. 2004
    ..Considering the short free diffusion path length of the reactive oxygen species, it can be deduced that smaller or ring-like particles should be more effective for photo-damage of biomolecules or target tissues...