Research Topics
Genomes and Genes
| Jun ZhangSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
Placental anti-oxidant gene polymorphisms, enzyme activity, and oxidative stress in preeclampsiaJ Zhang
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Building 6100 Room 7B03, Bethesda, MD 20892, USA
Placenta 29:439-43. 2008..8 vs. 27.9 pg/ml, p=0.03). In conclusion, our study showed that polymorphisms of CuZn-SOD, MnSOD, GSTM1 and GSTT1 in the placental tissue were not associated with preeclampsia...
Contemporary patterns of spontaneous labor with normal neonatal outcomesJun Zhang
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Obstet Gynecol 116:1281-7. 2010..To use contemporary labor data to examine the labor patterns in a large, modern obstetric population in the United States...- Prenatal application of the individualized fetal growth referenceJun Zhang
Epidemiology Branch, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Epidemiol 173:539-43. 2011..71). The authors conclude that neither the ultrasound-based nor the individualized reference does well in predicting adverse perinatal outcomes. The 5th percentile may be a better cutpoint than the 10th percentile in defining SGA... - Fetal growth and timing of parturition in humansJun Zhang
Epidemiology Branch, National Institute of Child Health and Human Development, NIH Building 6100, Room 7B03, Bethesda, MD 20892, USA
Am J Epidemiol 168:946-51. 2008..Thus, in low-risk pregnancies where fetal growth is normal in early gestation, fetal growth in the second half of pregnancy does not affect the timing of normal parturition... 
A comparison of medical management with misoprostol and surgical management for early pregnancy failureJun Zhang
Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
N Engl J Med 353:761-9. 2005..Misoprostol is increasingly used to treat women who have a failed pregnancy in the first trimester. We assessed the efficacy, safety, and acceptability of this treatment in a large, randomized trial...- Frequency of douching and risk of bacterial vaginosis in African-American womenJun Zhang
Departments of Community and Preventive Medicine, Pathology, and Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai School of Medicine, New York, NY, USA
Obstet Gynecol 104:756-60. 2004..Frequent vaginal douching has been associated with bacterial vaginosis. We investigated whether infrequent douching is also a risk factor for bacterial vaginosis... - Cesarean delivery on maternal request in southeast ChinaJun Zhang
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Obstet Gynecol 111:1077-82. 2008..To estimate the incidence of overall cesarean delivery and cesarean delivery on maternal request in southeast China in the past decade... - Partner change, birth interval and risk of pre-eclampsia: a paradoxical triangleJun Zhang
Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Paediatr Perinat Epidemiol 21:31-5. 2007..Controlling for or stratifying birth interval in the association between partner change and risk of pre-eclampsia could be inappropriate and may have produced a spurious association... - The natural history of the normal first stage of laborJun Zhang
Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Obstet Gynecol 115:705-10. 2010..To examine labor patterns in a large population and to explore an alternative approach for diagnosing abnormal labor progression... - Contemporary cesarean delivery practice in the United StatesJun Zhang
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
Am J Obstet Gynecol 203:326.e1-326.e10. 2010..To describe contemporary cesarean delivery practice in the United States... - Placental characteristics and birthweightCarolyn M Salafia
Department of Epidemiology, Mailman School of Public Health, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Paediatr Perinat Epidemiol 22:229-39. 2008..Analysis suggested that the impact of all maternal characteristics except smoking was consistent with mediation by placental characteristics... - Neonatal mortality by attempted route of delivery in early preterm birthUma M Reddy
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
Am J Obstet Gynecol 207:117.e1-8. 2012..We sought to study neonatal outcomes in early preterm births by delivery route... - Personal hygienic behaviors and bacterial vaginosisMark A Klebanoff
Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7510, USA
Sex Transm Dis 37:94-9. 2010..Lack of association between nondouching hygiene behavior and BV would argue against reverse causation... - Induction of labor in a contemporary obstetric cohortS Katherine Laughon
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
Am J Obstet Gynecol 206:486.e1-9. 2012..We sought to describe details of labor induction, including precursors and methods, and associated vaginal delivery rates... - Race of male sex partners and occurrence of bacterial vaginosisMark A Klebanoff
Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Sex Transm Dis 37:184-90. 2010..An association of BV with a characteristic of the male sex partner, such as race, might support sexual transmission as well as account for the observed ethnic disparity in BV... - Umbilical cord serum cytokine levels and risks of small-for-gestational-age and preterm birthGila I Neta
Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, Rockville, MD 20852, USA
Am J Epidemiol 171:859-67. 2010..31, 1.01). The observations regarding IFN-gamma, which is involved in the activation of adaptive immune responses and regulation of trophoblast function, suggest that IFN-gamma levels at birth may be related to fetal growth restriction... - Prepregnancy risk factors for antepartum stillbirth in the United StatesUma M Reddy
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
Obstet Gynecol 116:1119-26. 2010..To identify possible prepregnancy risk factors for antepartum stillbirth and to determine whether these factors identify women at higher risk for term stillbirth... - Mutation in Caenorhabditis elegans Krüppel-like factor, KLF-3 results in fat accumulation and alters fatty acid compositionJun Zhang
Laboratories of Developmental Biology, New York Blood Center, New York, NY 10065, USA
Exp Cell Res 315:2568-80. 2009..We present the first clear in vivo evidence supporting essential regulatory roles of KLF-3 in fat storage in C. elegans and shed light on the human equivalent in disease-gene association... - Delayed interval delivery and infant survival: a population-based studyJun Zhang
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health/DHHS, Bethesda, MD, USA
Am J Obstet Gynecol 191:470-6. 2004..CONCLUSION: Delayed delivery of the remaining fetus(es) before 30 weeks of gestation for 2 or more days was associated with improved infant survival... - Obstetric complications among US women with asthmaPauline Mendola
Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, USA
Am J Obstet Gynecol 208:127.e1-8. 2013..We sought to characterize complications of pregnancy, labor, and delivery associated with maternal asthma in a contemporary US cohort... - Long-term survival and integration of transplanted engineered nervous tissue constructs promotes peripheral nerve regenerationJason H Huang
Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York, USA
Tissue Eng Part A 15:1677-85. 2009..These findings demonstrate the promise of living tissue-engineered axonal constructs to bridge major nerve lesions and promote host regeneration, potentially by providing axon-mediated axonal outgrowth and guidance... - Misoprostol for treatment of early pregnancy failure in women with previous uterine surgeryBeatrice A Chen
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, and Magee Womens Research Institute, Pittsburgh, PA, USA
Am J Obstet Gynecol 198:626.e1-5. 2008..Misoprostol use in early pregnancy may incur a risk of uterine rupture in women with previous uterine surgery... - Oxytocin regimen for labor augmentation, labor progression, and perinatal outcomesJun Zhang
Division of Epidemiology, Statistics and Prevention Research, and the Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
Obstet Gynecol 118:249-56. 2011..To examine the effects and safety of high-dose (compared with low-dose) oxytocin regimen for labor augmentation on perinatal outcomes... - The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1R Arudchandran
Section on Chemical Immunology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 191:47-60. 2000..In addition, FcinRI-dependent activation of c-Jun NH(2)-terminal kinase 1 (JNK1) was also inhibited. Thus, Vav localization to the plasma membrane is mediated by its SH2 domain and may serve to regulate downstream effectors like JNK1... - Using a simplified Bishop score to predict vaginal deliveryS Katherine Laughon
Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
Obstet Gynecol 117:805-11. 2011..However, it was created without modern statistical methods. Our objective was to determine whether a simplified score can predict vaginal delivery equally well... - Long-term physical and neurologic development in newborn infants with isolated single umbilical arteryShilpa Chetty-John
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
Am J Obstet Gynecol 203:368.e1-7. 2010..This study compared birth parameters and the longitudinal course in physical and neurologic development between children with 2 and 3 vessel umbilical cords... - The p25 subunit of the dynactin complex is required for dynein-early endosome interactionJun Zhang
Department of Biochemistry and Molecular Biology, The Uniformed Services University, Bethesda, MD 20814, USA
J Cell Biol 193:1245-55. 2011..These results indicate that p25, in conjunction with the rest of the dynactin complex, is important for dynein-early endosome interaction... - Regulation of fat storage and reproduction by Krüppel-like transcription factor KLF3 and fat-associated genes in Caenorhabditis elegansJun Zhang
Laboratory of Developmental Biology, Lindsley F Kimball Research Institute, New York Blood Center, 310 East 67th Street, New York, NY 10065, USA
J Mol Biol 411:537-53. 2011..1, and F08A8.2, by promoting FA β-oxidation and, in parallel, may contribute to normal reproductive behavior and fecundity in C. elegans... - Risk of cesarean delivery when second-trimester ultrasound dating disagrees with definite last menstrual periodJagteshwar Grewal
Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20852, USA
Am J Perinatol 27:587-93. 2010..A negative discrepancy, by contrast, may reflect early intrauterine growth restriction and an increased risk of low birth weight... - The impact of parity on course of labor in a contemporary populationAnjel Vahratian
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Birth 33:12-7. 2006..The difference in duration of the active phase between nulliparas and multiparas is substantially smaller in a contemporary population... - Bleeding patterns after misoprostol vs surgical treatment of early pregnancy failure: results from a randomized trialAnne R Davis
Columbia University, Department of Obstetrics and Gynecology, 622 West 168th St, PH 16 Room 80, New York, NY 10032, USA
Am J Obstet Gynecol 196:31.e1-7. 2007..The purpose of this study was to describe bleeding patterns after misoprostol or curettage for early pregnancy failure (EPF)... - Changes in labor patterns over 50 yearsS Katherine Laughon
Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
Am J Obstet Gynecol 206:419.e1-9. 2012..The objective of the study was to examine differences in labor patterns in a modern cohort compared with the 1960s in the United States... - Effects of interpregnancy interval on blood pressure in consecutive pregnanciesRafael T Mikolajczyk
Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Am J Epidemiol 168:422-6. 2008..However, it does not rule out the possibility that other mechanisms of cardiovascular adaptation persist longer... - Dynein light intermediate chain in Aspergillus nidulans is essential for the interaction between heavy and intermediate chainsJun Zhang
From the Department of Biochemistry and Molecular Biology, The Uniformed Services University of the Health Sciences F Edward Hébert School of Medicine, Bethesda, Maryland 20814, USA
J Biol Chem 284:34760-8. 2009..Without a functional LIC, the HC-IC association is significantly weakened, and the HCs could no longer accumulate at the microtubule plus end. Thus, the LIC is essential for the assembly of the core complex of dynein in Aspergillus... - Identification of a novel site in the tail of dynein heavy chain important for dynein function in vivoRongde Qiu
Department of Biochemistry and Molecular Biology, The Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Biol Chem 288:2271-80. 2013.... - Early childhood development when second-trimester ultrasound dating disagrees with last menstrual period: a prospective cohort studyJagteshwar Grewal
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, 6100 Executive Boulevard, Room 7B03G, Rockville, MD 20852, USA
BMC Pregnancy Childbirth 12:32. 2012..While the association between these discrepancies in GA estimates and adverse perinatal outcomes has been examined extensively, there is scant evidence about long-term effects, such as child neurodevelopment... - In vivo roles of the basic domain of dynactin p150 in microtubule plus-end tracking and dynein functionXuanli Yao
Department of Biochemistry and Molecular Biology, The Uniformed Services University, Bethesda, MD, USA
Traffic 13:375-87. 2012..We suggest that the basic amino acids are required for the electrostatic interaction between p150 and MTs, which is important for kinesin-1-mediated plus-end targeting of dynactin and dynein in A. nidulans... - A pilot study of vaginal flora changes with randomization to cessation of douchingMark A Klebanoff
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Sex Transm Dis 33:610-3. 2006.... - Isolated oligohydramnios is not associated with adverse perinatal outcomesJun Zhang
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, NIH/DHHS, NIH Building 6100, Room 7B03, Bethesda, MD 20892, USA
BJOG 111:220-5. 2004..CONCLUSION: Isolated oligohydramnios is not associated with impaired fetal growth or an increased risk of adverse perinatal outcomes... - Defining normal and abnormal fetal growth: promises and challengesJun Zhang
Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
Am J Obstet Gynecol 202:522-8. 2010..Although the concept of an integrated definition appears promising, further development and testing are required. An improved definition of abnormal fetal growth should benefit both research and clinical practice... - Primary cesarean delivery among parous women in the United States, 1990-2003Jessie Ford
Epidemiology and Contraception and Reproductive Health Branches, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20852, USA
Obstet Gynecol 112:1235-41. 2008..To explore trends in primary cesarean delivery rates among parous women with singleton pregnancies in the United States between 1990 and 2003... - Quality of life in women undergoing medical treatment for early pregnancy failureTonja R Nansel
Investigator, Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Blvd, Rm 7B13, MSC 7510, Bethesda, MD 20892 7510, USA
J Obstet Gynecol Neonatal Nurs 34:473-81. 2005.... - Rapid evolution of the ribonuclease A superfamily: adaptive expansion of independent gene clusters in rats and miceN A Singhania
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Bethesda, MD 20892, USA
J Mol Evol 49:721-8. 1999.... - Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemiasS Mao
Laboratory of Molecular Aspects of Hematopoiesis, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Mol Cell Biol 19:3635-44. 1999..Interference with MEF function by AML1/ETO may lead to dysregulation of genes important for myeloid differentiation, thereby contributing to the pathogenesis of t(8;21) AML... - Predicting large fetuses at birth: do multiple ultrasound examinations and longitudinal statistical modelling improve prediction?Jun Zhang
MOE and Shanghai Key Laboratory of Children s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine and School of Public Health, Shanghai, China
Paediatr Perinat Epidemiol 26:199-207. 2012..Adjusting for maternal characteristics had limited impact on the accuracy of prediction. Thus, a single ultrasound examination at late gestation close to birth is the simplest method currently available to predict LGA and macrosomia... - Risk factors for birth canal lacerations in primiparous womenRafael T Mikolajczyk
Division of Epidemiology, Statistics and Prevention Research, The National Institute of Child Health and Human Development, Rockville, Maryland 20852, USA
Am J Perinatol 25:259-64. 2008..0 versus < 3 for outlet forceps, outlet vacuum, and low vacuum). We concluded that separating different birth canal lacerations is critical in identifying risk factors and potential preventive strategies... - Severe maternal morbidity associated with hypertensive disorders in pregnancy in the United StatesJun Zhang
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Hypertens Pregnancy 22:203-12. 2003..This study was to report the incidence of severe maternal morbidity associated with hypertensive disorders of pregnancy in the United States... - Cervical cerclage in delayed interval delivery in a multifetal pregnancy: a review of seven case seriesJun Zhang
Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, NIH Building 6100, Room 7B03, Bethesda, MD 20892, USA
Eur J Obstet Gynecol Reprod Biol 108:126-30. 2003..To examine whether cervical cerclage after the first delivery prolongs the inter-delivery interval in delayed interval deliveries... - Multifetal pregnancy in older women and perinatal outcomesJun Zhang
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
Fertil Steril 78:562-8. 2002..To examine multifetal pregnancy in older women and perinatal outcomes... - Methodological challenges in studying labour progression in contemporary practiceAnjel Vahratian
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Paediatr Perinat Epidemiol 20:72-8. 2006..Moreover, such detailed information could have important clinical implications towards reducing the rate of primary caesarean delivery in the United States... - Longitudinal association between hormonal contraceptives and bacterial vaginosis in women of reproductive ageMargaret Riggs
National Institutes of Health, Rockville, Maryland, USA
Sex Transm Dis 34:954-9. 2007..This study examined whether hormonal contraceptive use is associated with diagnosis of bacterial vaginosis (BV) over 1 year... - Labor progression and risk of cesarean delivery in electively induced nulliparasAnjel Vahratian
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Obstet Gynecol 105:698-704. 2005..Furthermore, elective induction in nulliparous women with an unfavorable cervix has a high rate of labor arrest and a substantially increased risk of cesarean delivery. LEVEL OF EVIDENCE: II-2... - Fetal trisomy 21 and maternal preeclampsiaJun Zhang
Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, NIH Building 6100, Room 7B03, Bethesda, MD 20892, USA
Epidemiology 15:195-201. 2004..Because pregnancies with a trisomy 21 fetus also have high levels of fetal cells and cell-free fetal DNA in maternal circulation, we examined whether trisomy 21 pregnancies have a higher risk of preeclampsia than euploid pregnancies... - Sequence variation at two eosinophil-associated ribonuclease loci in humansJ Zhang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Genetics 156:1949-58. 2000.... - Evaluation of logistic regression reporting in current obstetrics and gynecology literatureRafael T Mikolajczyk
Epidemiology Branch, The National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland 20892 7510, USA
Obstet Gynecol 111:413-9. 2008..To evaluate the quality of logistic regression reporting in the obstetrics and gynecology literature... - Small-for-gestational-age infants and risk of fetal death in subsequent pregnanciesJun Zhang
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
N Engl J Med 350:754-6. 2004 - The effect of early epidural versus early intravenous analgesia use on labor progression: a natural experimentAnjel Vahratian
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Am J Obstet Gynecol 191:259-65. 2004..CONCLUSION: Our data support recent American College of Obstetricians and Gynecologists guidelines that the restraining use of epidural analgesia at <4 cm of cervical dilation is unnecessary... - Vulvovaginal symptoms in women with bacterial vaginosisMark A Klebanoff
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Obstet Gynecol 104:267-72. 2004..The purpose of this study was to estimate the prevalence of symptoms among women with bacterial vaginosis compared with women without bacterial vaginosis by direct, explicit, and detailed questioning of these women... - Precursors for late preterm birth in singleton gestationsS Katherine Laughon
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland USA
Obstet Gynecol 116:1047-55. 2010..To characterize precursors for late preterm birth in singletons and incidences of neonatal morbidities and perinatal mortality by gestational age and precursor... - Placental growth patterns affect birth weight for given placental weightCarolyn M Salafia
Department of Epidemiology, Mailman School of Public Health, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Birth Defects Res A Clin Mol Teratol 79:281-8. 2007.... - The microtubule plus-end localization of Aspergillus dynein is important for dynein-early-endosome interaction but not for dynein ATPase activationJun Zhang
Department of Biochemistry and Molecular Biology, USUHS, Bethesda, MD 20814, USA
J Cell Sci 123:3596-604. 2010..We suggest that the normal ability of dyenin to interact with microtubules as an active minus-end-directed motor demands kinesin-1-mediated plus-end accumulation for effective interactions with early endosomes... - The research implications of the selection of a gestational age estimation methodCourtney D Lynch
Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Paediatr Perinat Epidemiol 21:86-96. 2007..Risk factors for post-term delivery are shown to vary according to the choice of a gestational dating method, suggesting that some findings are an artefact of the choice of a method rather than evidence of causality... - U.S. national trends in labor induction, 1989-1998Jun Zhang
Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, NIH Building 6100, Room 7B03, Bethesda, MD 20892, USA
J Reprod Med 47:120-4. 2002..To examine the epidemiology of labor induction in the United States... - Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell deathZ Li
Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cell Death Differ 14:318-26. 2007..These data indicate that different chemotherapeutic drugs induce distinct death pathways and growth factors utilize different signal transduction pathways to modulate the effects of chemotherapy on cells... - Differences in birth weight and blood pressure at age 7 years among twinsJ Zhang
Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
Am J Epidemiol 153:779-82. 2001..The authors' findings fail to support the hypothesis that an unfavorable intrauterine environment adversely affects blood pressure in children... - Relative validity of a food frequency questionnaire among tin miners in China: 1992/93 and 1995/96 diet validation studiesM R Forman
Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892 7326, USA
Public Health Nutr 2:301-15. 1999..Because the population received annual salary increments that could modify food intake, diet validation studies (DVSs) were conducted during two time intervals... - Mutations in the activation loop tyrosines of protein tyrosine kinase Syk abrogate intracellular signaling but not kinase activityJ Zhang
Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 161:4366-74. 1998..However, these tyrosines are necessary for Syk-mediated propagation of Fc epsilonRI signaling... - SH2 domain-mediated targeting, but not localization, of Syk in the plasma membrane is critical for FcepsilonRI signalingK Sada
Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Blood 97:1352-9. 2001..Furthermore, the localization of Syk in glycolipid-enriched microdomains by itself is not enough to generate or enhance signaling events... - Rapid diversification of RNase A superfamily ribonucleases from the bullfrog, Rana catesbeianaH F Rosenberg
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Mol Evol 53:31-8. 2001.... - Low blood pressure during pregnancy and poor perinatal outcomes: an obstetric paradoxJ Zhang
Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda 20892, MD, USA
Am J Epidemiol 153:642-6. 2001..However, this conclusion may not apply to individual patients who also have a compromised plasma volume expansion or pathologic homeostasis... - Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformationW Li
Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
Mol Cell Biol 18:5888-98. 1998..Competition with endogenous PKC-delta for NM1 and IGF-IR association by PKC-deltaK376R is probably an important mechanism underlying the PKC-deltaK376R-mediated inhibition of cell transformation by NM1 and IGF-IR... - PowerBLAST: a new network BLAST application for interactive or automated sequence analysis and annotationJ Zhang
National Center for Biotechnology Information NCBI, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 208944, USA
Genome Res 7:649-56. 1997..1 form may be "dragged and dropped" into NCBI's Sequin program for sequence annotation and submission. PowerBLAST is capable of analyzing and annotating a 100-kb query in 60 min on NCBI's BLAST server... - Gapped BLAST and PSI-BLAST: a new generation of protein database search programsS F Altschul
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Nucleic Acids Res 25:3389-402. 1997..PSI-BLAST is used to uncover several new and interesting members of the BRCT superfamily... - Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranesG Basanez
Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1855, USA
J Biol Chem 276:31083-91. 2001..Taken together, these data are consistent with the hypothesis that Bax-like proteins oligomerize to form lipid-containing pores in the outer mitochondrial membrane, thereby releasing intermembrane apoptogenic factors into the cytosol... - Identification of serine 643 of protein kinase C-delta as an important autophosphorylation site for its enzymatic activityW Li
Laboratory of Cellular and Molecular Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 272:24550-5. 1997..Taken together, our results demonstrate that serine 643 of PKC-delta is a major autophosphorylation site, and phosphorylation of this site plays an important role in controlling its enzymatic activity and biological function... - Activation of protein-tyrosine kinase Pyk2 is downstream of Syk in FcepsilonRI signalingH Okazaki
Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, NIDR, National Institutes of Health, Bethesda, Maryland 20892 1188, USA
J Biol Chem 272:32443-7. 1997..Therefore, the FcepsilonRI-induced tyrosine phosphorylation of Pyk2 is downstream of Syk and may play a role in cell secretion... - Prediction of adverse outcomes by common definitions of hypertension in pregnancyJ Zhang
Epidemiology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA
Obstet Gynecol 97:261-7. 2001..To examine the ability of five common definitions of hypertension in pregnancy to predict adverse maternal and perinatal outcomes... - What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomesJ Zhang
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
JAMA 280:1690-1. 1998..We propose a simple method to approximate a risk ratio from the adjusted odds ratio and derive an estimate of an association or treatment effect that better represents the true relative risk... - CD45 is essential for Fc epsilon RI signaling by ZAP70, but not Syk, in Syk-negative mast cellsJ Zhang
Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
J Immunol 163:2508-16. 1999..Furthermore, unlike Syk, ZAP70 required CD45 to display receptor-induced increase in kinase activity. Therefore, in mast cells, ZAP70, but not Syk, requires CD45 for Ag receptor-induced signaling... - Point mutation of a tyrosine in the linker region of Syk results in a gain of functionK Sada
Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, Bethesda, MD 20892, USA
J Immunol 164:338-44. 2000..These data indicate that Tyr317 in the linker region of Syk functions to negatively regulate the signals leading to degranulation... - Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cellsZ H Xie
Receptors and Signal Transduction Section, OIIB, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 164:1521-8. 2000..The substrate-trapping mutant SHP1/D419A identified pp25 and pp30 as two major potential substrates of SHP-1 in RBL-2H3 cells. Therefore, SHP-1 may play a role in allergy and inflammation by regulating mast cell cytokine production... - Performance of likelihood ratio tests of evolutionary hypotheses under inadequate substitution modelsJ Zhang
Institute of Molecular Evolutionary Genetics, Pennsylvania State University, USA
Mol Biol Evol 16:868-75. 1999..The dependence of LRTs on substitution models calls for caution in interpreting test results and highlights the importance of clarifying the substitution patterns of genes and proteins and building more realistic models... - Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequencesW Makałowski
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
Genome Res 6:846-57. 1996..Also, they should prove useful in estimating the additional sampling diversity provided by mouse EST sequencing projects designed to complement the existing human cDNA collection... - Rates of conservative and radical nonsynonymous nucleotide substitutions in mammalian nuclear genesJ Zhang
Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802, USA
J Mol Evol 50:56-68. 2000..5) Transversions induce more dramatic genetic alternations than transitions in that transversions produce more amino acid altering changes and among which, more radical changes... - Phosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibodyJ Zhang
Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 275:35442-7. 2000..These results demonstrate that phosphorylation of the activation loop tyrosines is important for mediating receptor signaling and is a better marker of Syk function than is total Syk tyrosine phosphorylation... - Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptorT Kimura
Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 159:4426-34. 1997..Thus, unlike other immune cells in which inhibitory molecules are recruited by accessory proteins, Fc epsilonRI bind molecules that both activate and inhibit signal transduction... - Birth weight for gestational age of Mexican American infants born in the United StatesM D Overpeck
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 7510, USA
Obstet Gynecol 93:943-7. 1999..To develop a reference for birth weight for gestational age to identify Mexican American infants born in the United States who are small or large for gestational age... - Childhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: identification of a BAC contig spanning the translocation breakpoint at 7q21W L Yan
Child Psychiatry, National Institute of Mental Health, Bethesda, Maryland 20892 4405, USA
Am J Med Genet 96:749-53. 2000..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:749-753, 2000. Published 2000 Wiley-Liss, Inc... - Risks of hypertensive disorders in the second pregnancyJ Zhang
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Paediatr Perinat Epidemiol 15:226-31. 2001..The earlier the onset of hypertension in the first pregnancy, the higher the overall recurrence rate. Intrauterine growth restriction of the first birth is an independent risk factor for hypertension in the second pregnancy... - Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesisRivka A Rachel
Neurobiology Neurodegeneration and Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 122:1233-45. 2012..Amelioration of the sensory phenotypes caused by specific mutations in one protein by removal of an interacting domain/protein suggests a possible novel approach for treating human ciliopathies... - A cost-effectiveness analysis of surgical versus medical management of early pregnancy lossMary Rausch
North Shore University Hospital, Manhasset, New York, USA
Fertil Steril 97:355-60. 2012..To determine the cost-effectiveness of medical and surgical management of early pregnancy loss... - Arp11 affects dynein-dynactin interaction and is essential for dynein function in Aspergillus nidulansJun Zhang
Department of Biochemistry and Molecular Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Traffic 9:1073-87. 2008..We suggest that loss of the pointed-end proteins alters the Arp1 filament in a way that affects the conformation of p150 required for its proper interaction with the dynein motor... - Maternal serum theobromine and the development of preeclampsiaMark A Klebanoff
Epidemiology Branch, Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Epidemiology 20:727-32. 2009.... - Functional analysis of the cathepsin-like cysteine protease genes in adult Brugia malayi using RNA interferenceLouise Ford
Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York, United States of America
PLoS Negl Trop Dis 3:e377. 2009..Ce-cpz-1 also has an important role during molting... - Blood pressure dynamics during pregnancy and spontaneous preterm birthJun Zhang
Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Am J Obstet Gynecol 197:162.e1-6. 2007..The objective of the study was to examine whether blood pressure in early pregnancy and its rise in the second half of gestation are associated with spontaneous preterm birth in healthy, normotensive, nulliparous women... - Reassessing the labor curve in nulliparous womenJun Zhang
Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development NIH, Building 6100, Room 7B03, Bethesda, MD 20892, USA
Am J Obstet Gynecol 187:824-8. 2002..Our purpose was to examine the pattern of labor progression in nulliparous parturients in contemporary obstetric practice... - Partner change and perinatal outcomes: a systematic reviewJun Zhang
Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Paediatr Perinat Epidemiol 21:46-57. 2007..Whether birth interval should be controlled for in the association between partner change and pre-eclampsia warrants caution... - Comparison of assisted reproductive technology utilization and outcomes between Caucasian and African American patients in an equal-access-to-care settingEve C Feinberg
Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA
Fertil Steril 85:888-94. 2006..The persistence of racial differences in an equal-access-to-care environment might be explained, in part, by the increased prevalence of leiomyomas in AA women... - BCL-6 protein is expressed in germinal-center B cellsG Cattoretti
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Blood 86:45-53. 1995..Because DLCL derive from germinal-center B cells, deregulated BCL-6 expression may contribute to lymphomagenesis by preventing postgerminal center differentiation... - MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating propertiesY Miyazaki
Laboratory of Molecular Aspects of Hematopoiesis, Sloan Kettering Institute for Cancer Research, New York, NY 10021, USA
Oncogene 13:1721-9. 1996..MEF is a new member of the elf-1/E74 family of ETS proteins, that has DNA binding properties similar to elf-1 but distinct transcriptional activating effects in several hematopoietic cell lineages... - The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammationB H Ye
Department of Pathology, Columbia University, New York, New York 10032, USA
Nat Genet 16:161-70. 1997..Altered expression of BCL-6 in lymphoma represents a deregulation of the pathway normally leading to B cell proliferation and germinal centre formation...