Jinghui Zhang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The Celera Discovery System
    Anthony Kerlavage
    Celera Genomics, 45 W Gudd Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 30:129-36. 2002
  2. pmc Systematic analysis of genetic alterations in tumors using Cancer Genome WorkBench (CGWB)
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 17:1111-7. 2007
  3. pmc HapScope: a software system for automated and visual analysis of functionally annotated haplotypes
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute National Institutes of Health, 8424 Helgerman Court, Room 101, MSC 8302, Bethesda, MD 20892 8302, USA
    Nucleic Acids Res 30:5213-21. 2002
  4. pmc Genomewide distribution of high-frequency, completely mismatching SNP haplotype pairs observed to be common across human populations
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 8302, USA
    Am J Hum Genet 73:1073-81. 2003
  5. ncbi request reprint Detecting false expression signals in high-density oligonucleotide arrays by an in silico approach
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute National Institutes of Health, 8424 Helgerman Court, Room 101, MSC 8302, Bethesda, MD 20892 8302, USA
    Genomics 85:297-308. 2005
  6. pmc SNPdetector: a software tool for sensitive and accurate SNP detection
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Comput Biol 1:e53. 2005
  7. pmc Integrated cross-species transcriptional network analysis of metastatic susceptibility
    Ying Hu
    Laboratory of Population Genetics, and Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Insitute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:3184-9. 2012
  8. pmc Bambino: a variant detector and alignment viewer for next-generation sequencing data in the SAM/BAM format
    Michael N Edmonson
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Bioinformatics 27:865-6. 2011
  9. pmc A high-resolution multistrain haplotype analysis of laboratory mouse genome reveals three distinctive genetic variation patterns
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 8302, USA
    Genome Res 15:241-9. 2005
  10. pmc Needles in the haystack: identifying individuals present in pooled genomic data
    Rosemary Braun
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 5:e1000668. 2009

Detail Information

Publications19

  1. pmc The Celera Discovery System
    Anthony Kerlavage
    Celera Genomics, 45 W Gudd Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 30:129-36. 2002
    ..A user workspace keeps track of queries and analyses. CDS is widely used by the academic research community and requires a subscription for access. The system and academic pricing information are available at http://cds.celera.com...
  2. pmc Systematic analysis of genetic alterations in tumors using Cancer Genome WorkBench (CGWB)
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 17:1111-7. 2007
    ....
  3. pmc HapScope: a software system for automated and visual analysis of functionally annotated haplotypes
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute National Institutes of Health, 8424 Helgerman Court, Room 101, MSC 8302, Bethesda, MD 20892 8302, USA
    Nucleic Acids Res 30:5213-21. 2002
    ..We envision that the systematic approach of integrating functional genomic analysis with population haplotypes, supported by HapScope, will greatly facilitate current genetic disease research...
  4. pmc Genomewide distribution of high-frequency, completely mismatching SNP haplotype pairs observed to be common across human populations
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 8302, USA
    Am J Hum Genet 73:1073-81. 2003
    ....
  5. ncbi request reprint Detecting false expression signals in high-density oligonucleotide arrays by an in silico approach
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute National Institutes of Health, 8424 Helgerman Court, Room 101, MSC 8302, Bethesda, MD 20892 8302, USA
    Genomics 85:297-308. 2005
    ..A Web application was developed to apply our results for improving the accuracy of expression analysis...
  6. pmc SNPdetector: a software tool for sensitive and accurate SNP detection
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Comput Biol 1:e53. 2005
    ..SNPdetector runs on Unix/Linux platform and is available publicly (http://lpg.nci.nih.gov)...
  7. pmc Integrated cross-species transcriptional network analysis of metastatic susceptibility
    Ying Hu
    Laboratory of Population Genetics, and Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Insitute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:3184-9. 2012
    ..These results suggest that the application of network analysis across species may provide a robust method to identify key biological programs associated with human cancer progression...
  8. pmc Bambino: a variant detector and alignment viewer for next-generation sequencing data in the SAM/BAM format
    Michael N Edmonson
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Bioinformatics 27:865-6. 2011
    ....
  9. pmc A high-resolution multistrain haplotype analysis of laboratory mouse genome reveals three distinctive genetic variation patterns
    Jinghui Zhang
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 8302, USA
    Genome Res 15:241-9. 2005
    ..The results suggest that the controlled complexity of the laboratory inbred strains may provide a means for uncovering the biological factors that have shaped genetic variation patterns...
  10. pmc Needles in the haystack: identifying individuals present in pooled genomic data
    Rosemary Braun
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 5:e1000668. 2009
    ..We also discuss the implications of our findings in forensics applications and in the protection of GWAS participant privacy...
  11. pmc The BRCA1 Ashkenazi founder mutations occur on common haplotypes and are not highly correlated with anonymous single nucleotide polymorphisms likely to be used in genome-wide case-control association studies
    Lutecia H Mateus Pereira
    Laboratory of Population Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    BMC Genet 8:68. 2007
    ..We evaluated LD using pairwise and haplotype-based methods, and assessed correlation of SNPs with the founder mutations using Pearson's correlation coefficient...
  12. ncbi request reprint Methods for reverse genetic screening in zebrafish by resequencing and TILLING
    Raman Sood
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Methods 39:220-7. 2006
    ..Amplicons with fewer common SNPs are ideal for TILLING whereas amplicons with multiple SNPs and in/del polymorphisms are best suited for sequencing followed by analysis with SNPdetector...
  13. pmc Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis
    Nigel P S Crawford
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 3:e214. 2007
    ..These data suggest that RRP1B may be a novel susceptibility gene for breast cancer progression and metastasis...
  14. doi request reprint Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma
    Robert J Clifford
    Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 52:2034-43. 2010
    ..Conclusion: Combined analysis of CNV, individual SNPs, and pathways suggest that HCC susceptibility is mediated by germline factors affecting the immune response and differences in T-cell receptor processing...
  15. pmc Gene functional similarity search tool (GFSST)
    Peisen Zhang
    Laboratory of Population Genetics, National Cancer Institute, NIH, Bethesda, USA
    BMC Bioinformatics 7:135. 2006
    ..In recent years, the development of Gene Ontology (GO) has established structured, controlled vocabularies describing gene functions, which makes it possible to develop novel tools to search genes by functional similarity...
  16. pmc The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells
    Anne Gegonne
    Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cell Biol 32:1984-97. 2012
    ..However, T cells with TAF7 deleted are not able to undergo activation and expansion in response to antigenic stimuli. These findings suggest that TAF7 is essential for proliferation but not for proliferation-independent differentiation...
  17. ncbi request reprint Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals
    Joni L Rutter
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
    Hum Mutat 22:121-8. 2003
    ..Further analysis in unselected cases will be required to know whether the identified variants play a role in genetic predisposition to breast cancer in the general population. Hum Mutat 22:121-128, 2003. Published 2003 Wiley-Liss, Inc...
  18. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach...