J Zhang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi CD45 is essential for Fc epsilon RI signaling by ZAP70, but not Syk, in Syk-negative mast cells
    J Zhang
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Immunol 163:2508-16. 1999
  2. ncbi Phosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibody
    J Zhang
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:35442-7. 2000
  3. ncbi Mutations in the activation loop tyrosines of protein tyrosine kinase Syk abrogate intracellular signaling but not kinase activity
    J Zhang
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 161:4366-74. 1998
  4. ncbi Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells
    Z H Xie
    Receptors and Signal Transduction Section, OIIB, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:1521-8. 2000
  5. ncbi SH2 domain-mediated targeting, but not localization, of Syk in the plasma membrane is critical for FcepsilonRI signaling
    K Sada
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 97:1352-9. 2001
  6. ncbi Point mutation of a tyrosine in the linker region of Syk results in a gain of function
    K Sada
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Immunol 164:338-44. 2000
  7. ncbi Activation of protein-tyrosine kinase Pyk2 is downstream of Syk in FcepsilonRI signaling
    H Okazaki
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, NIDR, National Institutes of Health, Bethesda, Maryland 20892 1188, USA
    J Biol Chem 272:32443-7. 1997
  8. ncbi Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor
    T Kimura
    Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 159:4426-34. 1997
  9. ncbi Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death
    Z Li
    Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Death Differ 14:318-26. 2007
  10. ncbi Rapid evolution of the ribonuclease A superfamily: adaptive expansion of independent gene clusters in rats and mice
    N A Singhania
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Bethesda, MD 20892, USA
    J Mol Evol 49:721-8. 1999

Collaborators

Detail Information

Publications93

  1. ncbi CD45 is essential for Fc epsilon RI signaling by ZAP70, but not Syk, in Syk-negative mast cells
    J Zhang
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Immunol 163:2508-16. 1999
    ..Furthermore, unlike Syk, ZAP70 required CD45 to display receptor-induced increase in kinase activity. Therefore, in mast cells, ZAP70, but not Syk, requires CD45 for Ag receptor-induced signaling...
  2. ncbi Phosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibody
    J Zhang
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:35442-7. 2000
    ..These results demonstrate that phosphorylation of the activation loop tyrosines is important for mediating receptor signaling and is a better marker of Syk function than is total Syk tyrosine phosphorylation...
  3. ncbi Mutations in the activation loop tyrosines of protein tyrosine kinase Syk abrogate intracellular signaling but not kinase activity
    J Zhang
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 161:4366-74. 1998
    ..However, these tyrosines are necessary for Syk-mediated propagation of Fc epsilonRI signaling...
  4. ncbi Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells
    Z H Xie
    Receptors and Signal Transduction Section, OIIB, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:1521-8. 2000
    ..The substrate-trapping mutant SHP1/D419A identified pp25 and pp30 as two major potential substrates of SHP-1 in RBL-2H3 cells. Therefore, SHP-1 may play a role in allergy and inflammation by regulating mast cell cytokine production...
  5. ncbi SH2 domain-mediated targeting, but not localization, of Syk in the plasma membrane is critical for FcepsilonRI signaling
    K Sada
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 97:1352-9. 2001
    ..Furthermore, the localization of Syk in glycolipid-enriched microdomains by itself is not enough to generate or enhance signaling events...
  6. ncbi Point mutation of a tyrosine in the linker region of Syk results in a gain of function
    K Sada
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, Bethesda, MD 20892, USA
    J Immunol 164:338-44. 2000
    ..These data indicate that Tyr317 in the linker region of Syk functions to negatively regulate the signals leading to degranulation...
  7. ncbi Activation of protein-tyrosine kinase Pyk2 is downstream of Syk in FcepsilonRI signaling
    H Okazaki
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, NIDR, National Institutes of Health, Bethesda, Maryland 20892 1188, USA
    J Biol Chem 272:32443-7. 1997
    ..Therefore, the FcepsilonRI-induced tyrosine phosphorylation of Pyk2 is downstream of Syk and may play a role in cell secretion...
  8. ncbi Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor
    T Kimura
    Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 159:4426-34. 1997
    ..Thus, unlike other immune cells in which inhibitory molecules are recruited by accessory proteins, Fc epsilonRI bind molecules that both activate and inhibit signal transduction...
  9. ncbi Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death
    Z Li
    Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Death Differ 14:318-26. 2007
    ..These data indicate that different chemotherapeutic drugs induce distinct death pathways and growth factors utilize different signal transduction pathways to modulate the effects of chemotherapy on cells...
  10. ncbi Rapid evolution of the ribonuclease A superfamily: adaptive expansion of independent gene clusters in rats and mice
    N A Singhania
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Bethesda, MD 20892, USA
    J Mol Evol 49:721-8. 1999
    ....
  11. ncbi The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1
    R Arudchandran
    Section on Chemical Immunology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 191:47-60. 2000
    ..In addition, FcinRI-dependent activation of c-Jun NH(2)-terminal kinase 1 (JNK1) was also inhibited. Thus, Vav localization to the plasma membrane is mediated by its SH2 domain and may serve to regulate downstream effectors like JNK1...
  12. ncbi Sequence variation at two eosinophil-associated ribonuclease loci in humans
    J Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genetics 156:1949-58. 2000
    ....
  13. ncbi Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation
    W Li
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Mol Cell Biol 18:5888-98. 1998
    ..Competition with endogenous PKC-delta for NM1 and IGF-IR association by PKC-deltaK376R is probably an important mechanism underlying the PKC-deltaK376R-mediated inhibition of cell transformation by NM1 and IGF-IR...
  14. ncbi What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes
    J Zhang
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    JAMA 280:1690-1. 1998
    ..We propose a simple method to approximate a risk ratio from the adjusted odds ratio and derive an estimate of an association or treatment effect that better represents the true relative risk...
  15. ncbi Relative validity of a food frequency questionnaire among tin miners in China: 1992/93 and 1995/96 diet validation studies
    M R Forman
    Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892 7326, USA
    Public Health Nutr 2:301-15. 1999
    ..Because the population received annual salary increments that could modify food intake, diet validation studies (DVSs) were conducted during two time intervals...
  16. ncbi Performance of likelihood ratio tests of evolutionary hypotheses under inadequate substitution models
    J Zhang
    Institute of Molecular Evolutionary Genetics, Pennsylvania State University, USA
    Mol Biol Evol 16:868-75. 1999
    ..The dependence of LRTs on substitution models calls for caution in interpreting test results and highlights the importance of clarifying the substitution patterns of genes and proteins and building more realistic models...
  17. ncbi Placental anti-oxidant gene polymorphisms, enzyme activity, and oxidative stress in preeclampsia
    J Zhang
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Building 6100 Room 7B03, Bethesda, MD 20892, USA
    Placenta 29:439-43. 2008
    ..8 vs. 27.9 pg/ml, p=0.03). In conclusion, our study showed that polymorphisms of CuZn-SOD, MnSOD, GSTM1 and GSTT1 in the placental tissue were not associated with preeclampsia...
  18. ncbi Identification of serine 643 of protein kinase C-delta as an important autophosphorylation site for its enzymatic activity
    W Li
    Laboratory of Cellular and Molecular Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:24550-5. 1997
    ..Taken together, our results demonstrate that serine 643 of PKC-delta is a major autophosphorylation site, and phosphorylation of this site plays an important role in controlling its enzymatic activity and biological function...
  19. ncbi Rates of conservative and radical nonsynonymous nucleotide substitutions in mammalian nuclear genes
    J Zhang
    Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802, USA
    J Mol Evol 50:56-68. 2000
    ..5) Transversions induce more dramatic genetic alternations than transitions in that transversions produce more amino acid altering changes and among which, more radical changes...
  20. ncbi Rapid diversification of RNase A superfamily ribonucleases from the bullfrog, Rana catesbeiana
    H F Rosenberg
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Mol Evol 53:31-8. 2001
    ....
  21. ncbi Risks of hypertensive disorders in the second pregnancy
    J Zhang
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Paediatr Perinat Epidemiol 15:226-31. 2001
    ..The earlier the onset of hypertension in the first pregnancy, the higher the overall recurrence rate. Intrauterine growth restriction of the first birth is an independent risk factor for hypertension in the second pregnancy...
  22. ncbi Does the individualized reference outperform a simple ultrasound-based reference applied to birth weight in predicting child neurodevelopment?
    G Neta
    Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Ultrasound Obstet Gynecol 38:62-6. 2011
    ..The authors sought to compare an individualized reference for defining SGA with simple birth weight-based and ultrasound-based references applied to birth weight in predicting poor cognitive development at age five...
  23. ncbi Differences in birth weight and blood pressure at age 7 years among twins
    J Zhang
    Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Am J Epidemiol 153:779-82. 2001
    ..The authors' findings fail to support the hypothesis that an unfavorable intrauterine environment adversely affects blood pressure in children...
  24. ncbi Low blood pressure during pregnancy and poor perinatal outcomes: an obstetric paradox
    J Zhang
    Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda 20892, MD, USA
    Am J Epidemiol 153:642-6. 2001
    ..However, this conclusion may not apply to individual patients who also have a compromised plasma volume expansion or pathologic homeostasis...
  25. ncbi Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences
    W Makałowski
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Genome Res 6:846-57. 1996
    ..Also, they should prove useful in estimating the additional sampling diversity provided by mouse EST sequencing projects designed to complement the existing human cDNA collection...
  26. ncbi Prediction of adverse outcomes by common definitions of hypertension in pregnancy
    J Zhang
    Epidemiology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA
    Obstet Gynecol 97:261-7. 2001
    ..To examine the ability of five common definitions of hypertension in pregnancy to predict adverse maternal and perinatal outcomes...
  27. ncbi Childhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: identification of a BAC contig spanning the translocation breakpoint at 7q21
    W L Yan
    Child Psychiatry, National Institute of Mental Health, Bethesda, Maryland 20892 4405, USA
    Am J Med Genet 96:749-53. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:749-753, 2000. Published 2000 Wiley-Liss, Inc...
  28. ncbi PowerBLAST: a new network BLAST application for interactive or automated sequence analysis and annotation
    J Zhang
    National Center for Biotechnology Information NCBI, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 208944, USA
    Genome Res 7:649-56. 1997
    ..1 form may be "dragged and dropped" into NCBI's Sequin program for sequence annotation and submission. PowerBLAST is capable of analyzing and annotating a 100-kb query in 60 min on NCBI's BLAST server...
  29. ncbi Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
    S F Altschul
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 25:3389-402. 1997
    ..PSI-BLAST is used to uncover several new and interesting members of the BRCT superfamily...
  30. ncbi Birth weight for gestational age of Mexican American infants born in the United States
    M D Overpeck
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 7510, USA
    Obstet Gynecol 93:943-7. 1999
    ..To develop a reference for birth weight for gestational age to identify Mexican American infants born in the United States who are small or large for gestational age...
  31. ncbi Linkage analysis of schizophrenia to chromosome 15
    P V Gejman
    Unit on Molecular Clinical Investigation, Clinical Neurogenetics Branch, National Institute of Mental Health, Natinaol Institutes of Health, Bethesda, Maryland, USA
    Am J Med Genet 105:789-93. 2001
    ..6%). The multipoint MLS scores were greater than 1.0 in the 30-52 cM interval delimited by ACTC and D15S150, with a maximum value of 2.0 with GENEHUNTER PLUS near D15S1039...
  32. ncbi Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranes
    G Basanez
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1855, USA
    J Biol Chem 276:31083-91. 2001
    ..Taken together, these data are consistent with the hypothesis that Bax-like proteins oligomerize to form lipid-containing pores in the outer mitochondrial membrane, thereby releasing intermembrane apoptogenic factors into the cytosol...
  33. ncbi Does epidural analgesia prolong labor and increase risk of cesarean delivery? A natural experiment
    J Zhang
    Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building6100, Bethesda, MD 20892, USA
    Am J Obstet Gynecol 185:128-34. 2001
    ..More than 50% of pregnant women in the United States are using epidural analgesia for labor pain. However, whether epidural analgesia prolongs labor and increases the risk of cesarean delivery remains controversial...
  34. ncbi Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees
    Q Cao
    Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Genomics 43:1-8. 1997
    ..35). Our results provide very suggestive evidence for a susceptibility locus for schizophrenia in chromosome 6q from two independent data sets...
  35. ncbi Clinical indicators for success of misoprostol treatment after early pregnancy failure
    C Robledo
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Gynaecol Obstet 99:46-51. 2007
    ..To identify clinical indicators for success of misoprostol treatment after early pregnancy failure...
  36. ncbi The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants
    J Zhang
    National Center for Biotechnology Information, National Institute of Health, Bethesda, MD, USA
    Pharmacogenetics 11:555-72. 2001
    ....
  37. ncbi Control of the proinflammatory state in cystic fibrosis lung epithelial cells by genes from the TNF-alphaR/NFkappaB pathway
    O Eidelman
    Department of Anatomy, Institute of Molecular Medicine F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Mol Med 7:523-34. 2001
    ....
  38. ncbi The Aspergillus cytoplasmic dynein heavy chain and NUDF localize to microtubule ends and affect microtubule dynamics
    G Han
    Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Curr Biol 11:719-24. 2001
    ..The microtubules in the mutant cells also paused longer at the hyphal tip than wild-type microtubules. These results indicate that cytoplasmic dynein and the LIS1 homolog NUDF affect microtubule dynamics in vivo...
  39. ncbi D(4) dopamine receptor differentially regulates Akt/nuclear factor-kappa b and extracellular signal-regulated kinase pathways in D(4)MN9D cells
    X Zhen
    Laboratory of Molecular Pharmacology, Department of Pharmacology and Physiology, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania, USA
    Mol Pharmacol 60:857-64. 2001
    ..We also demonstrated that D(4) receptor-stimulated cell proliferation is mediated by the Src/SHC/Ras/ERK pathway...
  40. ncbi Molecular characterization and expression of the M6 gene of grass carp hemorrhage virus (GCHV), an aquareovirus
    T Qiu
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan
    Arch Virol 146:1391-7. 2001
    ..The result indicates that the protein encoded by M6 may share a putative Asn-42-Pro-43 proteolytic cleavage site with mu1...
  41. ncbi Cyclin A-dependent phosphorylation of the ETS-related protein, MEF, restricts its activity to the G1 phase of the cell cycle
    Y Miyazaki
    Laboratory of Molecular Aspects of Hematopoiesis, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 276:40528-36. 2001
    ..Phosphorylation of MEF by the cyclin A-CDK2 complex controls its transcriptional activity during the cell cycle, establishing a novel link between the ETS family of proteins and the cell cycle machinery...
  42. ncbi Hydrogen peroxide activates NFkappaB and the interleukin-6 promoter through NFkappaB-inducing kinase
    J Zhang
    Department of Pathology, University of Michigan, Ann Arbor 48109, USA
    Antioxid Redox Signal 3:493-504. 2001
    ..Taken together, these results demonstrate that H2O2 induces the IL-6 promoter by activating NFkappaB through NIK. These data provide a candidate mechanism through which oxidant challenge induces IL-6 gene expression with age...
  43. ncbi Phosphorylation of Thr642 is an early event in the processing of newly synthesized protein kinase C beta 1 and is essential for its activation
    J Zhang
    Molecular Pharmacology Section, Schering Plough Research Institute, Kenilworth, New Jersey 07003
    J Biol Chem 269:19578-84. 1994
    ..These results support a role for a PKC kinase in PKC processing and activation...
  44. ncbi Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites
    J Zhang
    Molecular Pharmacology Section, Schering Plough Research Institute, Kenilworth, NJ 07033 0539
    Proc Natl Acad Sci U S A 90:6130-4. 1993
    ....
  45. ncbi Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival
    J Kalesnikoff
    The Terry Fox Laboratory, British Columbia Cancer Agency, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    Immunity 14:801-11. 2001
    ..Since IgE concentrations as low as 0.1 microg/ml enhance BMMC survival, elevated plasma IgE levels in humans with atopic disorders may contribute to the elevated mast cell numbers seen in these individuals...
  46. ncbi Altered antioxidant defence in a mouse adriamycin model of glomerulosclerosis
    A Deman
    Department of Human Anatomy, Vrije Universiteit Brussel and Academic Hospital of the Vrije Universiteit Brussel, Brussels, Belgium
    Nephrol Dial Transplant 16:147-50. 2001
    ..CONCLUSION: The fast development of glomerulosclerosis combined with an altered antioxidant status makes this mouse adriamycin model a suitable alternative for the slower rat models...
  47. ncbi Molecular cloning and characterization of a novel calcium/calmodulin-dependent protein kinase II inhibitor from human dendritic cells
    J Zhang
    Department of Clinical Laboratory, Changzheng Hospital, Shanghai 200003, People s Republic of China
    Biochem Biophys Res Commun 285:229-34. 2001
    ..These results characterize a potential cellular inhibitor protein of CaMKII that plays an important role in the regulation of cell growth...
  48. ncbi Protein kinase C epsilon-Src modules direct signal transduction in nitric oxide-induced cardioprotection: complex formation as a means for cardioprotective signaling
    T M Vondriska
    Department of Physiology, Division of Cardiology, University of Louisville, Louisville, KY, USA
    Circ Res 88:1306-13. 2001
    ....
  49. ncbi Anorectal malformations caused by defects in sonic hedgehog signaling
    R Mo
    Program in Developmental Biology, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 159:765-74. 2001
    ....
  50. ncbi Induction of heparin-binding EGF-like growth factor expression during myogenesis. Activation of the gene by MyoD and localization of the transmembrane form of the protein on the myotube surface
    X Chen
    Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 270:18285-94. 1995
    ....
  51. ncbi Impairment of Na(+),K(+)-ATPase in CD95(APO-1)-induced human T-cell leukemia cell apoptosis mediated by glutathione depletion and generation of hydrogen peroxide
    W Yin
    The State Key Lab of Pharmaceutical Biotechnology, College of Life Science, Nanjing University, Nanjing, People s Republic of China
    Leukemia 21:1669-78. 2007
    ..Taken together, this study presents a novel regulatory mechanism of Na(+),K(+)-ATPase in CD95(APO-1)-mediated human T-leukemia cell apoptosis...
  52. ncbi Vitamin D receptor signaling of monocytic differentiation in human leukemia cells: role of MAPK pathways in transcription factor activation
    G P Studzinski
    Department of Pathology and Laboratory Medicine, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Curr Top Med Chem 6:1267-71. 2006
    ..The details of the scheme will be discussed in the sections below...
  53. ncbi Human DNA helicase IV is nucleolin, an RNA helicase modulated by phosphorylation
    N Tuteja
    International Centre for Genetic Engineering and Biotechnology, Area Science Park, Trieste, Italy
    Gene 160:143-8. 1995
    ..The Gly-rich C-terminal domain possesses a limited ATP-dependent duplex-unwinding activity which contributes to the helicase activity of HDH IV/nucleolin...
  54. ncbi Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery
    J Ratajczak
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 20:847-56. 2006
    ..We postulate that ES-MV may efficiently expand HPC by stimulating them with ES-MV expressed ligands (e.g., Wnt-3) as well as increase their pluripotency after horizontal transfer of ES-derived mRNA...
  55. ncbi Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPARgamma-independent pathway in human aortic smooth muscle cells
    X Zhu
    Cardiovascular Research Institute, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    Cell Mol Life Sci 60:212-8. 2003
    ..In addition, PPARgamma antagonist GW9662 did not rescue TZD-induced Id2 repression. Taken together, our data suggest that TZDs repress Id2 expression through a PPARgamma-independent pathway...
  56. ncbi Characterization of three Toll-like genes from mosquito Aedes aegypti
    C Luna
    Yale University School of Medicine, Epidemiology and Public Health, New Haven, CT 06520, USA
    Insect Mol Biol 12:67-74. 2003
    ..2) Only one of three amino acid residues essential for DmToll function is required for AeToll1A function...
  57. ncbi Changes in cortical and cerebellar bcl-2 mRNA levels in the developing hydrocephalic rat (LEW-HYR) as measured by a real time quantified RT-PCR
    Y Yamada
    Department of Neurosurgery, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
    Neuroscience 114:165-71. 2002
    ....
  58. ncbi A locust DNA-binding protein involved in gene regulation by juvenile hormone
    S Zhou
    Department of Biology, Queen's University, Kingston, Ont, Canada K7L 3N6
    Mol Cell Endocrinol 190:177-85. 2002
    ..The DNA-binding protein is thus believed to be a transcription factor, which is brought to an active state through the action of JH and then participates in the regulation of certain JH-dependent genes...
  59. ncbi Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin
    E V Pindel
    Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana 46202 5122, USA
    J Biol Chem 272:14769-75. 1997
    ..hCE-2 may play an important role in the degradation of cocaine and heroin in human tissues...
  60. ncbi Activation of the NPTA element of the CYP2A3 gene by NFI-A2, a nasal mucosa-selective nuclear factor 1 isoform
    Y Xie
    Wadsworth Center, State University of New York, Albany, New York 12201, USA
    Biochem Biophys Res Commun 289:1225-8. 2001
    ..These findings suggest that NFI-A2 may be involved in the tissue-selective transcriptional activation of the CYP2A3 gene in the olfactory mucosa...
  61. ncbi Effect of abscisic acid on active oxygen species, antioxidative defence system and oxidative damage in leaves of maize seedlings
    M Jiang
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong
    Plant Cell Physiol 42:1265-73. 2001
    ....
  62. ncbi BCL-6 protein is expressed in germinal-center B cells
    G Cattoretti
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Blood 86:45-53. 1995
    ..Because DLCL derive from germinal-center B cells, deregulated BCL-6 expression may contribute to lymphomagenesis by preventing postgerminal center differentiation...
  63. ncbi Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells
    N Li
    Institute of Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    J Biol Chem 276:28106-12. 2001
    ....
  64. ncbi Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6
    W Zhang
    Institute of Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People s Republic of China
    Biochem Biophys Res Commun 282:1067-73. 2001
    ..These indicate that DPZF may be a transcription factor closely related to BCL-6, and may be involved in hematopoiesis, oncogenesis, and immune responses...
  65. ncbi Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice
    K Salojin
    Autoimmunity Diabetes Group, The John P Robarts Research Institute, London, Ontario, Canada N6G 2V4
    J Exp Med 186:887-97. 1997
    ..These findings implicate mSOS as an important mediator of downregulation of Ras signaling in hyporesponsive NOD T cells...
  66. ncbi The promoter of the HaCaT keratinocyte differentiation-related gene keratin 4 contains a functional AP-2 binding site
    R Wanner
    Institute of Molecular Biology and Biochemistry, UKBF, FU Berlin, Berlin, Germany
    Arch Dermatol Res 289:705-8. 1997
    ..Thus, the role of AP-2 in the process of keratinocyte differentiation appears to be considerable. In addition, further regulatory elements were found to be necessary for full transcription of K4...
  67. ncbi A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling
    S Latour
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
    EMBO J 17:2584-95. 1998
    ..Furthermore, they provided evidence that the linker region can regulate the ability of Syk to bind ITAMs, thus identifying a novel function for this domain...
  68. ncbi Sry interactive proteins: implication for the mechanisms of sex determination
    Y F Lau
    Department of Medicine, VA Medical Center, University of California at San Francisco, 94121, USA
    Cytogenet Cell Genet 80:128-32. 1998
  69. ncbi AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle
    J A West-Mays
    Department of Ophthalmology, New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, 02111, USA
    Dev Biol 206:46-62. 1999
    ..Together these findings demonstrate a requirement for AP-2alpha in early morphogenesis of the eye...
  70. ncbi Site-directed mutagenesis of charged and potentially proton-carrying residues in the beta subunit of the proton-translocating nicotinamide nucleotide transhydrogenase from Escherichia coli. Characterization of the beta H91, beta D392, and beta K424 mutant
    X Hu
    Department of Biochemistry and Biophysics, Goteborg University, Chalmers University of Technology, Sweden
    Biochemistry 38:1652-8. 1999
    ..The pH dependences of the forward and reverse reactions, as well as the cyclic reaction, were shifted to a lower pH as compared to the wild-type enzyme, and the salt dependence was also altered...
  71. ncbi SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity
    B Cuevas
    Division of Medicine, and the Cell Growth Regulation Laboratory, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 274:27583-9. 1999
    ....
  72. ncbi Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection
    J Zhang
    Department of Immunology, University of Toronto, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Immunol 163:3012-21. 1999
    ....
  73. ncbi Identification of (CAG)(n) and (CGG)(n) repeat-binding proteins, CAGERs expressed in mature neurons of the mouse brain
    H Yano
    Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Exp Cell Res 251:388-400. 1999
    ..We conclude that CAGERs and Puralpha/beta are unrelated proteins, and CAGERs are neuronal single-stranded sequence-binding proteins in the mouse brain. Misassignment of cDNAs is described...
  74. ncbi Translocation of ornithine decarboxylase to the surface membrane during cell activation and transformation
    M Heiskala
    Department of Pathology, Haartman Institute, and Helsinki University Hospital, University of Helsinki, Haartmaninkatu 3, FIN 00014 Helsinki, Finland
    EMBO J 18:1214-22. 1999
    ..Impaired cytokinesis confirms that ODC is involved in mitotic cytoskeletal rearrangement events and pinpoints the importance of relevant membrane targeting to its physiological function...
  75. ncbi In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination
    J Zhang
    Department of Medicine, University of California, San Francisco 94121, USA
    Int J Dev Biol 43:219-27. 1999
    ..These observations support the hypothesis that the Q-rich domain may contribute to the biological function(s) of mouse Sry through a protein-protein interactive role(s)...
  76. ncbi Pro-B-cell-specific transcription and proapoptotic function of protein kinase Ceta
    T A Morrow
    Graduate Program in Immunology, The Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    Mol Cell Biol 19:5608-18. 1999
    ..These results suggest that the expression and proteolytic activation of PKCeta play an important role in the regulation of cell division and cell death during early B-cell development...
  77. ncbi Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias
    S Mao
    Laboratory of Molecular Aspects of Hematopoiesis, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 19:3635-44. 1999
    ..Interference with MEF function by AML1/ETO may lead to dysregulation of genes important for myeloid differentiation, thereby contributing to the pathogenesis of t(8;21) AML...
  78. ncbi Molecular characterization of the mouse Fas ligand promoter in airway epithelial cells
    J Zhang
    The Pulmonary Center and the Department of Biochemistry, Boston University School of Medicine, 80 E Concord Street, Boston, MA 02118, USA
    Biochim Biophys Acta 1490:291-301. 2000
    ....
  79. ncbi Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta
    K Slentz-Kesler
    Department of Genomic Sciences, Glaxo Wellcome, Inc, 5 Moore Drive, Research Triangle Park, North Carolina, 27709, USA
    Genomics 69:63-71. 2000
    ....
  80. ncbi Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase
    B D Cuevas
    Division of Medicine, Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 276:27455-61. 2001
    ..Taken together, the data indicate that phosphorylation of Tyr(688) in p85 leads to a novel mechanism of PI3K regulation...
  81. ncbi Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse
    J E Hunt
    Department of Medicine, Harvard Medical School, Boston, Masschusetts 02115
    J Biol Chem 271:2851-5. 1996
    ..Moreover, the mMCP-7 gene is the first found in any species that sequentially has undergone a splice site mutation to cause retention of an intron and then a second splice site mutation to cause activation of a cryptic splice site...
  82. ncbi Ras1 signaling and transcriptional competence in the R7 cell of Drosophila
    R C Kauffmann
    Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
    Genes Dev 10:2167-78. 1996
    ..Our results suggest that specific transcriptional responses are linked to the mode of activation of the Ras1/MAP kinase signal transduction pathway...
  83. ncbi Mouse phosphoglycerate mutase M and B isozymes: cDNA cloning, enzyme activity assay and mapping
    J Zhang
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, No 220 Handan Road, Shanghai 200433, P R China
    Gene 264:273-9. 2001
    ..The partial genomic sequence of Pgam2 was determined, which showed that mouse Pgam2 consisted at least three exons and two introns. In addition, a pseudogene of Pgam1, Pgam1-ps1, was identified from mouse genomic sequence...
  84. ncbi Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes
    W Zhang
    Institute of Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People s Republic of China
    Biochem Biophys Res Commun 281:878-83. 2001
    ..We also prepared a CRL2Ig fusion protein. The identification of its ligand and involvement of signal transduction will help to elucidate its potential function...
  85. ncbi Casein kinase I alpha and alpha L: alternative splicing-generated kinases exhibit different catalytic properties
    J Zhang
    Department of Pharmacology, University of Wisconsin Medical School, Madison 53706, USA
    Biochemistry 35:16319-27. 1996
    ..These observations demonstrate that the alpha L insert within the kinase domain modulates substrate kinetics. These kinetic differences suggest that CKI alpha and CKI alpha L may perform different biological roles...
  86. ncbi SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells
    L R Hendricks-Taylor
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52246, USA
    J Biol Chem 272:1363-7. 1997
    ....
  87. ncbi Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning
    J Zhang
    Department of Cell Biology and Anatomy R 124, University of Miami School of Medicine, Florida 33101, USA
    Development 122:4119-29. 1996
    ..Our results suggest that VegT is a localized transcription factor, which operates sequentially in several developmental pathways during embryogenesis, including dorsoventral and posterior patterning of mesoderm...
  88. ncbi Oligomerization of ETO is obligatory for corepressor interaction
    J Zhang
    Division of Endocrinology, Diabetes, and Metabolism, Departments of Medicine and Genetics, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 21:156-63. 2001
    ..As nuclear receptors also interact with corepressors as dimers, oligomerization may be a common mechanism regulating corepressor interactions...
  89. ncbi The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
    B H Ye
    Department of Pathology, Columbia University, New York, New York 10032, USA
    Nat Genet 16:161-70. 1997
    ..Altered expression of BCL-6 in lymphoma represents a deregulation of the pathway normally leading to B cell proliferation and germinal centre formation...
  90. ncbi Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye
    C Xu
    Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
    Cell 103:87-97. 2000
    ..We show that Sevenless activates prospero independent of the enhancer and involves targeted degradation of Tramtrack, a transcription repressor...
  91. ncbi The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells
    A K Somani
    Department of Medicine, University of Toronto, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital and the University Health Network Research Institute, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 276:1938-44. 2001
    ....
  92. ncbi A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency
    C M Roifman
    Division of Immunology Allergy, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada
    Blood 96:2803-7. 2000
    ..This underscores the critical role of IL-7R alpha chain in the differentiation of T cells. (Blood. 2000;96:2803-2807)..
  93. ncbi HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma
    S Bao
    Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 59:2023-8. 1999
    ....