Dan Zhang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Astrogliosis in CNS pathologies: is there a role for microglia?
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA
    Mol Neurobiol 41:232-41. 2010
  2. pmc Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 5:21. 2008
  3. pmc Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
    Dan Zhang
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 8:3. 2011
  4. pmc Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Immunol 181:7194-204. 2008
  5. pmc Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    J Neuroimmune Pharmacol 7:187-201. 2012
  6. doi Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture
    Sufen Yang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental, Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neurochem Res 33:2044-53. 2008
  7. pmc Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration?
    Xi Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 116:593-8. 2008
  8. pmc Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:64-70. 2009
  9. pmc Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox
    Hui Zhou
    Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:303-13. 2012
  10. ncbi Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    Glia 55:1178-88. 2007

Collaborators

Detail Information

Publications17

  1. pmc Astrogliosis in CNS pathologies: is there a role for microglia?
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA
    Mol Neurobiol 41:232-41. 2010
    ..Development of targeted anti-microglial activation therapies might slow or halt the progression of astrogliosis and, therefore, help achieve a more beneficial environment in various CNS pathologies...
  2. pmc Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 5:21. 2008
    ..Hence, prevention of microglial over-activation has been shown to be a prime target for the development of therapeutic agents for inflammation-mediated neurodegenerative diseases...
  3. pmc Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
    Dan Zhang
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroinflammation 8:3. 2011
    ..However, the upstream signaling pathway of superoxide production remains unclear...
  4. pmc Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Immunol 181:7194-204. 2008
    ....
  5. pmc Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    J Neuroimmune Pharmacol 7:187-201. 2012
    ....
  6. doi Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture
    Sufen Yang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental, Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Neurochem Res 33:2044-53. 2008
    ..Taken together, our study implicated that curcumin might be a potential preventive and therapeutic strategy for inflammation-related neurodegenerative diseases...
  7. pmc Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration?
    Xi Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 116:593-8. 2008
    ..Microglial activation is important in the pathogenesis of PD...
  8. pmc Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro
    Dan Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:64-70. 2009
    ..These findings are important in elucidating the role of activated microglia and PGE(2) in astrocyte proliferation and in suggesting a potential avenue in the use of anti-inflammatory agents for the therapy of astroglioma...
  9. pmc Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox
    Hui Zhou
    Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:303-13. 2012
    ..In conclusion, rotenone directly interacted with gp91(phox); such an interaction triggered membrane translocation of p67(phox), leading to PHOX activation and superoxide production...
  10. ncbi Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    Glia 55:1178-88. 2007
    ..These results have, for the first time, demonstrated that microglia are also critical in enhanced neurotoxicity induced by mutant alpha-synuclein...
  11. pmc Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Immunol 181:660-8. 2008
    ....
  12. ncbi The novel squamosamide derivative FLZ protects against 6-hydroxydopamine-induced apoptosis through inhibition of related signal transduction in SH-SY5Y cells
    Dan Zhang
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Eur J Pharmacol 561:1-6. 2007
    ..The results suggested that FLZ has potential neuroprotective effect on 6-OHDA-induced apoptosis of SH-SY5Y cells through regulating related signal-transduction...
  13. ncbi Disruption of imprinting and aberrant embryo development in completely inbred embryonic stem cell-derived mice
    Tao Deng
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology and Model Organism Research Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Dev Growth Differ 49:603-10. 2007
    ..These results indicate that the ES fetuses did retain the epigenetic alterations in imprinted genes from the donor ES cells...
  14. ncbi The novel squamosamide derivative (compound FLZ) attenuated 1-methyl, 4-phenyl-pyridinium ion (MPP+)-induced apoptosis and alternations of related signal transduction in SH-SY5Y cells
    Dan Zhang
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
    Neuropharmacology 52:423-9. 2007
    ..The results suggest that cFLZ possesses potent neuroprotective activity and may be a potential anti-Parkinson's disease drug worthy for further study...
  15. ncbi Dactylorhin B reduces toxic effects of beta-amyloid fragment (25-35) on neuron cells and isolated rat brain mitochondria
    Dan Zhang
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Naunyn Schmiedebergs Arch Pharmacol 374:117-25. 2006
    ..Co-incubation of DHB attenuated Abeta(25-35)-induced pathological changes. The significance of DHB in the management of mitochondria-related disorders is discussed...
  16. ncbi Effects of Coeloglossum. viride var. bracteatum extract on memory deficits and pathological changes in senescent mice
    Dan Zhang
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Basic Clin Pharmacol Toxicol 98:55-60. 2006
    ..Treatment of CE (2.5, 5 mg.kg(-1)) ameliorated the memory impairment; rectified the biochemistry and neural system changes in mice. These results suggest that CE offers promise as a tool for treatment of senescence-related diseases...
  17. ncbi Correlation between inactive cathepsin D expression and retinal changes in mcd2/mcd2 transgenic mice
    Dan Zhang
    Department of Molecular Ophthalmology, Lions Eye Institute, Perth, Australia
    Invest Ophthalmol Vis Sci 46:3031-8. 2005
    ..To investigate the correlation between the presence of the inactive cathepsin D (CatD) and retinal changes in mcd2/mcd2 transgenic mice...