Research Topics
Species | Dan ZhangSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Astrogliosis in CNS pathologies: is there a role for microglia?Dan Zhang
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA
Mol Neurobiol 41:232-41. 2010..Development of targeted anti-microglial activation therapies might slow or halt the progression of astrogliosis and, therefore, help achieve a more beneficial environment in various CNS pathologies...
Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activityDan Zhang
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Neuroinflammation 5:21. 2008..Hence, prevention of microglial over-activation has been shown to be a prime target for the development of therapeutic agents for inflammation-mediated neurodegenerative diseases...- Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicityDan Zhang
Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Neuroinflammation 8:3. 2011..However, the upstream signaling pathway of superoxide production remains unclear... - Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's diseaseXiaoming Hu
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
J Immunol 181:7194-204. 2008.... - Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivationXiaoming Hu
Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
J Neuroimmune Pharmacol 7:187-201. 2012.... - Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration?Xi Gao
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Environ Health Perspect 116:593-8. 2008..Microglial activation is important in the pathogenesis of PD... - Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia cultureSufen Yang
Laboratory of Pharmacology and Chemistry, National Institute of Environmental, Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
Neurochem Res 33:2044-53. 2008..Taken together, our study implicated that curcumin might be a potential preventive and therapeutic strategy for inflammation-related neurodegenerative diseases... - Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitroDan Zhang
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 238:64-70. 2009..These findings are important in elucidating the role of activated microglia and PGE(2) in astrocyte proliferation and in suggesting a potential avenue in the use of anti-inflammatory agents for the therapy of astroglioma... - Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phoxHui Zhou
Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 52:303-13. 2012..In conclusion, rotenone directly interacted with gp91(phox); such an interaction triggered membrane translocation of p67(phox), leading to PHOX activation and superoxide production... 
Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synucleinWei Zhang
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
Glia 55:1178-88. 2007..These results have, for the first time, demonstrated that microglia are also critical in enhanced neurotoxicity induced by mutant alpha-synuclein...- Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microgliaLi Qian
Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7455, USA
J Immunol 181:660-8. 2008.... - The novel squamosamide derivative FLZ protects against 6-hydroxydopamine-induced apoptosis through inhibition of related signal transduction in SH-SY5Y cellsDan Zhang
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Eur J Pharmacol 561:1-6. 2007..The results suggested that FLZ has potential neuroprotective effect on 6-OHDA-induced apoptosis of SH-SY5Y cells through regulating related signal-transduction... - Disruption of imprinting and aberrant embryo development in completely inbred embryonic stem cell-derived miceTao Deng
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology and Model Organism Research Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Dev Growth Differ 49:603-10. 2007..These results indicate that the ES fetuses did retain the epigenetic alterations in imprinted genes from the donor ES cells... - The novel squamosamide derivative (compound FLZ) attenuated 1-methyl, 4-phenyl-pyridinium ion (MPP+)-induced apoptosis and alternations of related signal transduction in SH-SY5Y cellsDan Zhang
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
Neuropharmacology 52:423-9. 2007..The results suggest that cFLZ possesses potent neuroprotective activity and may be a potential anti-Parkinson's disease drug worthy for further study... - Dactylorhin B reduces toxic effects of beta-amyloid fragment (25-35) on neuron cells and isolated rat brain mitochondriaDan Zhang
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Naunyn Schmiedebergs Arch Pharmacol 374:117-25. 2006..Co-incubation of DHB attenuated Abeta(25-35)-induced pathological changes. The significance of DHB in the management of mitochondria-related disorders is discussed... - Effects of Coeloglossum. viride var. bracteatum extract on memory deficits and pathological changes in senescent miceDan Zhang
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Basic Clin Pharmacol Toxicol 98:55-60. 2006..Treatment of CE (2.5, 5 mg.kg(-1)) ameliorated the memory impairment; rectified the biochemistry and neural system changes in mice. These results suggest that CE offers promise as a tool for treatment of senescence-related diseases... - Correlation between inactive cathepsin D expression and retinal changes in mcd2/mcd2 transgenic miceDan Zhang
Department of Molecular Ophthalmology, Lions Eye Institute, Perth, Australia
Invest Ophthalmol Vis Sci 46:3031-8. 2005..To investigate the correlation between the presence of the inactive cathepsin D (CatD) and retinal changes in mcd2/mcd2 transgenic mice...