Xianmin Zeng

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint BG01V: a variant human embryonic stem cell line which exhibits rapid growth after passaging and reliable dopaminergic differentiation
    Xianmin Zeng
    Cellular Neurobiology Branch, National Institute on Drug Abuse and NIH, DHHS, Baltimore, MD 21224, USA
    Restor Neurol Neurosci 22:421-8. 2004
  2. pmc Assessing self-renewal and differentiation in human embryonic stem cell lines
    Jingli Cai
    Laboratory of Neurosciences, National Institute on Aging, Department of Health and Human Services, Baltimore, Maryland, USA
    Stem Cells 24:516-30. 2006
  3. ncbi request reprint Dopaminergic differentiation of human embryonic stem cells
    Xianmin Zeng
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    Stem Cells 22:925-40. 2004
  4. pmc Gene expression profile of neuronal progenitor cells derived from hESCs: activation of chromosome 11p15.5 and comparison to human dopaminergic neurons
    William J Freed
    Cellular Neurobiology Research Branch, Intramural Research Program IRP, National Institute on Drug Abuse, National Institutes of Health NIH, Baltimore, Maryland, USA
    PLoS ONE 3:e1422. 2008
  5. pmc Genome wide profiling of human embryonic stem cells (hESCs), their derivatives and embryonal carcinoma cells to develop base profiles of U.S. Federal government approved hESC lines
    Ying Liu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    BMC Dev Biol 6:20. 2006
  6. ncbi request reprint NTera2: a model system to study dopaminergic differentiation of human embryonic stem cells
    Catherine M Schwartz
    Gerontology Research Center, Stem Cell Biology Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Stem Cells Dev 14:517-34. 2005
  7. ncbi request reprint A focused microarray to assess dopaminergic and glial cell differentiation from fetal tissue or embryonic stem cells
    Yongquan Luo
    Gerontology Research Center, Stem Cell Biology Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Stem Cells 24:865-75. 2006
  8. pmc An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP+ toxicity and GDNF neuroprotection
    Xianmin Zeng
    Intramural Research Program IRP, Cellular Neurobiology Research Branch, Department of Health and Human Services DHHS, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, MD, USA
    Neuropsychopharmacology 31:2708-15. 2006
  9. ncbi request reprint Properties of pluripotent human embryonic stem cells BG01 and BG02
    Xianmin Zeng
    Development and Plasticity Section, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Stem Cells 22:292-312. 2004
  10. ncbi request reprint Stable expression of hrGFP by mouse embryonic stem cells: promoter activity in the undifferentiated state and during dopaminergic neural differentiation
    Xianmin Zeng
    Section on Development and Plasticity, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Stem Cells 21:647-53. 2003

Collaborators

Detail Information

Publications25

  1. ncbi request reprint BG01V: a variant human embryonic stem cell line which exhibits rapid growth after passaging and reliable dopaminergic differentiation
    Xianmin Zeng
    Cellular Neurobiology Branch, National Institute on Drug Abuse and NIH, DHHS, Baltimore, MD 21224, USA
    Restor Neurol Neurosci 22:421-8. 2004
    ..To explore a karyotypically abnormal variant human embryonic stem cell (hESC) line, BG01V, as a potential model for studies of dopaminergic neuronal differentiation...
  2. pmc Assessing self-renewal and differentiation in human embryonic stem cell lines
    Jingli Cai
    Laboratory of Neurosciences, National Institute on Aging, Department of Health and Human Services, Baltimore, Maryland, USA
    Stem Cells 24:516-30. 2006
    ..We show that qPCR, with as few as 12 selected genes, can reliably distinguish differentiated cells from undifferentiated hESC populations...
  3. ncbi request reprint Dopaminergic differentiation of human embryonic stem cells
    Xianmin Zeng
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    Stem Cells 22:925-40. 2004
    ..Therefore, hESCs can be used to generate human dopaminergic cells that exhibit biochemical and functional properties consistent with the expected properties of mature dopaminergic neurons...
  4. pmc Gene expression profile of neuronal progenitor cells derived from hESCs: activation of chromosome 11p15.5 and comparison to human dopaminergic neurons
    William J Freed
    Cellular Neurobiology Research Branch, Intramural Research Program IRP, National Institute on Drug Abuse, National Institutes of Health NIH, Baltimore, Maryland, USA
    PLoS ONE 3:e1422. 2008
    ..We initiated differentiation of human embryonic stem cells (hESCs) into dopamine neurons, obtained a purified population of neuronal precursor cells by cell sorting, and determined patterns of gene transcription...
  5. pmc Genome wide profiling of human embryonic stem cells (hESCs), their derivatives and embryonal carcinoma cells to develop base profiles of U.S. Federal government approved hESC lines
    Ying Liu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    BMC Dev Biol 6:20. 2006
    ....
  6. ncbi request reprint NTera2: a model system to study dopaminergic differentiation of human embryonic stem cells
    Catherine M Schwartz
    Gerontology Research Center, Stem Cell Biology Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Stem Cells Dev 14:517-34. 2005
    ..Therefore, NTera2 cell dopaminergic neuronal differentiation and PSA-NCAM enrichment provides a useful system for the future study of hESCs...
  7. ncbi request reprint A focused microarray to assess dopaminergic and glial cell differentiation from fetal tissue or embryonic stem cells
    Yongquan Luo
    Gerontology Research Center, Stem Cell Biology Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Stem Cells 24:865-75. 2006
    ..We suggest that this focused array will serve as a useful complement to other large-scale arrays in routine assessment of cell properties prior to their therapeutic use...
  8. pmc An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP+ toxicity and GDNF neuroprotection
    Xianmin Zeng
    Intramural Research Program IRP, Cellular Neurobiology Research Branch, Department of Health and Human Services DHHS, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, MD, USA
    Neuropsychopharmacology 31:2708-15. 2006
    ....
  9. ncbi request reprint Properties of pluripotent human embryonic stem cells BG01 and BG02
    Xianmin Zeng
    Development and Plasticity Section, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Stem Cells 22:292-312. 2004
    ..These data provide a detailed characterization and an initial gene expression profile for the BG01 and BG02 human ES cell lines...
  10. ncbi request reprint Stable expression of hrGFP by mouse embryonic stem cells: promoter activity in the undifferentiated state and during dopaminergic neural differentiation
    Xianmin Zeng
    Section on Development and Plasticity, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
    Stem Cells 21:647-53. 2003
    ..The RSV promoter was inactive in undifferentiated, nestin-positive, and TH-positive cells. Thus, EF1 and CMV are effective promoters for transgene expression in undifferentiated ES cells and nestin-positive neural precursors...
  11. pmc GABAergic lineage differentiation of AF5 neural progenitor cells in vitro
    Joseph F Sanchez
    Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Cell Tissue Res 324:1-8. 2006
    ..Therefore, AF5 cells can be induced to differentiate to a neuronal phenotype with a GABAergic lineage...
  12. pmc Human embryonic stem cells have enhanced repair of multiple forms of DNA damage
    Scott Maynard
    Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Box 1, 5600 Nathan Shock Drive, Baltimore, Maryland 21224 6825, USA
    Stem Cells 26:2266-74. 2008
    ..These data suggest that genomic maintenance pathways are enhanced in human embryonic stem cells, relative to differentiated human cells...
  13. ncbi request reprint Genomic alterations in cultured human embryonic stem cells
    Anirban Maitra
    McKusick Nathans Institute of Genetic Medicine, Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 37:1099-103. 2005
    ....
  14. doi request reprint Enhanced differentiation of human neural crest stem cells towards the Schwann cell lineage by aligned electrospun fiber matrix
    Yong Juan Ren
    Department of Materials Science and Engineering, Johns Hopkins University, 205 Maryland Hall, Baltimore, MD 21218, USA
    Acta Biomater 9:7727-36. 2013
    ....
  15. ncbi request reprint Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein
    Jingsheng Tuo
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    DNA Repair (Amst) 1:913-27. 2002
    ..We conclude that CSB functions in the catalysis of 8-OH-Gua BER and in the maintenance of efficient hOgg1 expression, and that motif VI of the putative helicase domain of CSB is crucial in these functions...
  16. pmc Comparison of the gene expression profile of undifferentiated human embryonic stem cell lines and differentiating embryoid bodies
    Bhaskar Bhattacharya
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    BMC Dev Biol 5:22. 2005
    ....
  17. ncbi request reprint Karyotypic stability, genotyping, differentiation, feeder-free maintenance, and gene expression sampling in three human embryonic stem cell lines derived prior to August 9, 2001
    Sandii N Brimble
    BresaGen, Inc, Athens, GA 30605, USA
    Stem Cells Dev 13:585-97. 2004
    ..BG01, BG02, and BG03 hESCs are therefore independent, undifferentiated, and pluripotent lines that can be maintained without accumulation of karyotypic abnormalities...
  18. ncbi request reprint Generation and transplantation of dopaminergic neurons derived from embryonic stem cells
    Aparna Khanna
    Embryonic Stem Cell Group, Reliance Life Sciences Pvt Ltd, Dhirubhai Ambani Life Sciences Centre, R 282, TTC Industrial Area of MIDC, Thane Belapur Road, Rabale, Navi Mumbai 400 701, India
    Curr Stem Cell Res Ther 2:139-47. 2007
    ..In this manuscript we discuss recent results, review the remarkable progress that has been made in the field, and compare these results with those obtained from mouse ESCs (mESCs)...
  19. ncbi request reprint Development of a focused microarray to assess human embryonic stem cell differentiation
    Amy X Yang
    Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Stem Cells Dev 14:270-84. 2005
    ..We expect that the described array will be extremely useful in evaluating the extent of differentiation and the state of the hESC-derived population utilized for therapeutic purposes...
  20. ncbi request reprint Human embryonic stem cells: mechanisms to escape replicative senescence?
    Xianmin Zeng
    Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA, 94945, USA
    Stem Cell Rev 3:270-9. 2007
    ..We will also discuss the genomic and epigenetic changes in long-term hESC culture and their potential roles in bypassing senescence, as well as alternative sources of pluripotent stem cells...
  21. ncbi request reprint Characterization of a new NIH-registered variant human embryonic stem cell line, BG01V: a tool for human embryonic stem cell research
    Todd W Plaia
    Stem Cell Center, American Type Culture Collection, 10801 University Boulevard, Manassas, Virginia 20110, USA
    Stem Cells 24:531-46. 2006
    ....
  22. ncbi request reprint The therapeutic potential of embryonic stem cells: A focus on stem cell stability
    Xianmin Zeng
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Curr Opin Mol Ther 8:338-44. 2006
    ..Recent findings suggesting that the level of cell stability is not homogeneous throughout all stem cells are also discussed...
  23. pmc A molecular scheme for improved characterization of human embryonic stem cell lines
    Richard Josephson
    Stem Cell Center, American Type Culture Collection ATCC, Manassas, VA, USA
    BMC Biol 4:28. 2006
    ..However, hESC must be routinely analyzed at the genomic level to guard against deleterious changes during extensive propagation, expansion, and manipulation in vitro...
  24. ncbi request reprint Derivation and characterization of neuronal precursors and dopaminergic neurons from human embryonic stem cells in vitro
    Melissa Carpenter
    The John P Robarts Research Institute, Stem Cell Biology and Regenerative Medicine, London, Ontario, Canada
    Methods Mol Biol 331:153-67. 2006
    ....
  25. ncbi request reprint Monitoring differentiation of human embryonic stem cells using real-time PCR
    Karin Noaksson
    Cellartis AB, Arvid Wallgrens Backe 20, 413 46 Goteborg, Sweden
    Stem Cells 23:1460-7. 2005
    ..The combination of QPCR with hESC-based technologies opens novel avenues for high-throughput analysis of hESCs in, for example, pharmacological and cytotoxicity screening...