Weihua Zeng

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Selective reduction of natural killer T cells in the bone marrow of aplastic anaemia
    Weihua Zeng
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Br J Haematol 119:803-9. 2002
  2. ncbi request reprint Gene expression profiling in CD34 cells to identify differences between aplastic anemia patients and healthy volunteers
    Weihua Zeng
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 103:325-32. 2004
  3. ncbi request reprint Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities
    Guibin Chen
    Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Blood 104:4210-8. 2004
  4. ncbi request reprint Transcript profile of CD4+ and CD8+ T cells from the bone marrow of acquired aplastic anemia patients
    Weihua Zeng
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Exp Hematol 32:806-14. 2004
  5. ncbi request reprint In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing
    Antonio M Risitano
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Lancet 364:355-64. 2004
  6. pmc Interferon-gamma-induced gene expression in CD34 cells: identification of pathologic cytokine-specific signature profiles
    Weihua Zeng
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 107:167-75. 2006
  7. ncbi request reprint Is there a direct effect of antithymocyte globulin on hematopoiesis?
    Guibin Chen
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hematol J 5:255-61. 2004
  8. ncbi request reprint Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V beta CDR3 spectratyping and flow cytometry
    Antonio M Risitano
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 100:178-83. 2002
  9. ncbi request reprint The relationship of aplastic anemia and PNH
    Neal S Young
    Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Int J Hematol 76:168-72. 2002
  10. ncbi request reprint Superior growth of glycophosphatidy linositol-anchored protein-deficient progenitor cells in vitro is due to the higher apoptotic rate of progenitors with normal phenotype in vivo
    Guibin Chen
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Exp Hematol 30:774-82. 2002

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Selective reduction of natural killer T cells in the bone marrow of aplastic anaemia
    Weihua Zeng
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Br J Haematol 119:803-9. 2002
    ..These results show that NKT cells are profoundly decreased in AA and MDS, and their deficiency may, as in other human autoimmune diseases, play a role in the local immune dysregulation in AA and MDS...
  2. ncbi request reprint Gene expression profiling in CD34 cells to identify differences between aplastic anemia patients and healthy volunteers
    Weihua Zeng
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 103:325-32. 2004
    ..Many of the genes showing differential expression in AA deserve further detailed analysis, including comparison with other marrow failure states and autoimmune disease...
  3. ncbi request reprint Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities
    Guibin Chen
    Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Blood 104:4210-8. 2004
    ..These results imply distinct molecular mechanisms for monosomy 7 and trisomy 8 MDS and implicate specific pathogenic pathways...
  4. ncbi request reprint Transcript profile of CD4+ and CD8+ T cells from the bone marrow of acquired aplastic anemia patients
    Weihua Zeng
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Exp Hematol 32:806-14. 2004
    ..T cells producing IFN-gamma and TNF-alpha have been implicated in hematopoietic destruction in AA. We sought to characterize T cells as immune mediators using the microarray approach...
  5. ncbi request reprint In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing
    Antonio M Risitano
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Lancet 364:355-64. 2004
    ..In most cases, no obvious aetiological factor can be identified. However, clinical responses to immunosuppression strongly suggest an immune pathophysiology...
  6. pmc Interferon-gamma-induced gene expression in CD34 cells: identification of pathologic cytokine-specific signature profiles
    Weihua Zeng
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 107:167-75. 2006
    ....
  7. ncbi request reprint Is there a direct effect of antithymocyte globulin on hematopoiesis?
    Guibin Chen
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hematol J 5:255-61. 2004
    ..In summary, the spectrum of effects of ATG on hematopoietic progenitors is dependent upon the concentrations of ATG and may not be related to its antigenic specificity...
  8. ncbi request reprint Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V beta CDR3 spectratyping and flow cytometry
    Antonio M Risitano
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 100:178-83. 2002
    ..As V beta skewing may correlate with relative V beta size, oligoclonality in combination with numerical V beta expansion can be applied to recognition of disease-specific T-cell receptors...
  9. ncbi request reprint The relationship of aplastic anemia and PNH
    Neal S Young
    Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Int J Hematol 76:168-72. 2002
    ....
  10. ncbi request reprint Superior growth of glycophosphatidy linositol-anchored protein-deficient progenitor cells in vitro is due to the higher apoptotic rate of progenitors with normal phenotype in vivo
    Guibin Chen
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Exp Hematol 30:774-82. 2002
    ..These results are consistent with the theory that PNH cells have an intrinsic growth advantage, but their superior expansion in vitro could also be the outcome of selective extrinsic pressure in vivo...
  11. ncbi request reprint Frequent HPRT mutations in paroxysmal nocturnal haemoglobinuria reflect T cell clonal expansion, not genomic instability
    Guibin Chen
    Haematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1652, USA
    Br J Haematol 125:383-91. 2004
    ..HPRT mutant analysis does not support underlying genomic instability in PNH...
  12. ncbi request reprint Changes in T-cell receptor VB repertoire in aplastic anemia: effects of different immunosuppressive regimens
    Hoon Kook
    Hematology Branch of the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 99:3668-75. 2002
    ..Our data indicate that multiple specific clones mediate the immune process in AA...
  13. ncbi request reprint Genetic and transcriptional analysis of spindle checkpoint genes in bone marrow failure patients
    Hiroki Yamaguchi
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood Cells Mol Dis 30:307-11. 2003
    ..We conclude that mutations in mitotic spindle checkpoint genes do not account for aneuploidy in marrow failure states. However, we cannot exclude epigenetic inactivation of hBUB1 as a potential mechanism in some patients...
  14. ncbi request reprint Label-free protein quantification using LC-coupled ion trap or FT mass spectrometry: Reproducibility, linearity, and application with complex proteomes
    Guanghui Wang
    Proteomics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Proteome Res 5:1214-23. 2006
    ..The utility of this method to biomarker discovery is likely to synergize with future improvements in the detecting sensitivity of mass spectrometers...
  15. ncbi request reprint Immune pathophysiology of aplastic anemia
    Jaroslaw P Maciejewski
    Experimental Hematology and Hematopoiesis Section, Taussig Cancer Center, Cleveland Clinic Foundation, OH, USA
    Int J Hematol 76:207-14. 2002
    ..Persistence and patterns of clonotypes may be helpful in the classification of immune-mediated marrow failure based on the immune characteristics and will allow inferences into the inciting pathways...
  16. ncbi request reprint In situ analysis of DNA damage response and repair using laser microirradiation
    Jong Soo Kim
    Department of Biological Chemistry, School of Medicine, University of California, Irvine, California 92697, USA
    Methods Cell Biol 82:377-407. 2007
    ..In this chapter, the strategy developed to study the DNA damage response using the 532-nm Nd:YAG laser will be summarized...