D C Zeldin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Exposure to mouse allergen in U.S. homes associated with asthma symptoms
    Päivi M Salo
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:387-91. 2009
  2. pmc Dust weight and asthma prevalence in the National Survey of Lead and Allergens in Housing (NSLAH)
    Leslie Elliott
    Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:215-20. 2007
  3. pmc Pharmacologic inhibition of COX-1 and COX-2 in influenza A viral infection in mice
    Michelle A Carey
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 5:e11610. 2010
  4. pmc Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily
    Joan P Graves
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Drug Metab Dispos 41:763-73. 2013
  5. pmc Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic mice
    Qingen Ke
    National Institutes of Health NIEHS, 111 T W Alexander Drive, Building 101, Room D236, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 72:1063-73. 2007
  6. ncbi request reprint Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide
    D C Zeldin
    National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Bldg 101, Rm D 236, Research Triangle Park, NC 27709, USA
    Am J Respir Cell Mol Biol 25:457-65. 2001
  7. pmc How exposures to biologics influence the induction and incidence of asthma
    Darryl C Zeldin
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health DHHS, 111 T W Alexander Drive, Bldg 101, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 114:620-6. 2006
  8. ncbi request reprint CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance
    D C Zeldin
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 50:1111-7. 1996
  9. ncbi request reprint Predominant expression of an arachidonate epoxygenase in islets of Langerhans cells in human and rat pancreas
    D C Zeldin
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 138:1338-46. 1997
  10. ncbi request reprint CYP2J subfamily cytochrome P450s in the gastrointestinal tract: expression, localization, and potential functional significance
    D C Zeldin
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 51:931-43. 1997

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. pmc Exposure to mouse allergen in U.S. homes associated with asthma symptoms
    Päivi M Salo
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:387-91. 2009
    ..Most studies investigating the role of residential mouse allergen exposures in asthma have focused on inner-city populations...
  2. pmc Dust weight and asthma prevalence in the National Survey of Lead and Allergens in Housing (NSLAH)
    Leslie Elliott
    Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:215-20. 2007
    ..Settled dust has been used in studies to assess exposures to allergens and other biologically active components, but it has not been considered in the aggregate in relation to respiratory health outcomes in the general population...
  3. pmc Pharmacologic inhibition of COX-1 and COX-2 in influenza A viral infection in mice
    Michelle A Carey
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 5:e11610. 2010
    ..We previously demonstrated that cyclooxygenase (COX)-1 deficiency results in greater morbidity and inflammation, whereas COX-2 deficiency leads to reduced morbidity, inflammation and mortality in influenza infected mice...
  4. pmc Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily
    Joan P Graves
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Drug Metab Dispos 41:763-73. 2013
    ..We conclude that the four new CYP2J isoforms might be involved in the metabolism of AA and LA to bioactive lipids in mouse hepatic and extrahepatic tissues...
  5. pmc Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic mice
    Qingen Ke
    National Institutes of Health NIEHS, 111 T W Alexander Drive, Building 101, Room D236, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 72:1063-73. 2007
    ..Together, our data demonstrate that shortening of the action potential in CYP2J2 Tr cardiomyocytes is associated with enhanced I(to,peak) via an EET-dependent, cAMP-mediated mechanism...
  6. ncbi request reprint Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide
    D C Zeldin
    National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Bldg 101, Rm D 236, Research Triangle Park, NC 27709, USA
    Am J Respir Cell Mol Biol 25:457-65. 2001
    ....
  7. pmc How exposures to biologics influence the induction and incidence of asthma
    Darryl C Zeldin
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health DHHS, 111 T W Alexander Drive, Bldg 101, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 114:620-6. 2006
    ..In this review we examine the biology of the response to allergens, viruses, and bacterial products in the context of the development of allergy and asthma...
  8. ncbi request reprint CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance
    D C Zeldin
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 50:1111-7. 1996
    ....
  9. ncbi request reprint Predominant expression of an arachidonate epoxygenase in islets of Langerhans cells in human and rat pancreas
    D C Zeldin
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 138:1338-46. 1997
    ....
  10. ncbi request reprint CYP2J subfamily cytochrome P450s in the gastrointestinal tract: expression, localization, and potential functional significance
    D C Zeldin
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 51:931-43. 1997
    ....
  11. ncbi request reprint Identification and localization of five CYP2Cs in murine extrahepatic tissues and their metabolism of arachidonic acid to regio- and stereoselective products
    C C Tsao
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 299:39-47. 2001
    ..Our results suggest that the presence of CYP2C enzymes in heart muscle, aorta, kidney, lung, adrenals, eyes, and reproductive organs could regulate important physiological and/or pathological processes in these tissues...
  12. ncbi request reprint Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes
    S Wu
    From, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 272:12551-9. 1997
    ....
  13. ncbi request reprint Molecular cloning, enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome P450 highly expressed in kidney
    J Ma
    Laboratories of Pulmonary Pathobiology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 274:17777-88. 1999
    ..In light of the well documented effects of epoxyeicosatrienoic acids in modulating renal tubular transport processes, we postulate that CYP2J5 products play important functional roles in the kidney...
  14. pmc Allergic lung responses are increased in prostaglandin H synthase-deficient mice
    S H Gavett
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Clin Invest 104:721-32. 1999
    ....
  15. ncbi request reprint Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning
    M G Camitta
    NIEHS, NIH, Research Triangle Park, Division of Pediatric Cardiology, Duke University Medical Center, Durham, NC, USA
    Circulation 104:2453-8. 2001
    ....
  16. ncbi request reprint Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain
    W Qu
    Division of Intramural Research, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 276:25467-79. 2001
    ..We postulate that CYP2J9 arachidonic acid products play important functional roles in the brain...
  17. ncbi request reprint Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid
    D Dai
    Laboratories of Pharmacology and Chemistry and Pulmonary and Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Pharmacogenetics 11:597-607. 2001
    ..This polymorphism has important clinical and physiological implications in individuals homozygous for this allele...
  18. ncbi request reprint Functional characterization of cyclooxygenase-2 polymorphisms
    E Fritsche
    Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 299:468-76. 2001
    ....
  19. ncbi request reprint P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues
    P E Scarborough
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Drug Metab Rev 31:205-34. 1999
    ..This review details the emerging CYP2J subfamily of P450s and their role as catalysts of arachidonic acid metabolism...
  20. ncbi request reprint Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart
    S Wu
    Laboratory of Pulmonary Pathobiology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 271:3460-8. 1996
    ..We propose that CYP2J2 is one of the enzymes responsible for epoxidation of endogenous arachidonic acid pools in human heart and that epoxyeicosatrienoic acids may, therefore, play important functional roles in cardiac physiology...
  21. ncbi request reprint Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid
    G Luo
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, North Carolina 27709, USA
    Arch Biochem Biophys 357:45-57. 1998
    ..CYP2C38 and CYP2C40 were found in liver, brain, kidney, and intestine, with trace amounts in lung and heart, while CYP2C37 and CYP2C39 appeared to be liver specific...
  22. ncbi request reprint Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells
    B Yang
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina
    Mol Pharmacol 60:310-20. 2001
    ....
  23. pmc Effects of physical interventions on house dust mite allergen levels in carpet, bed, and upholstery dust in low-income, urban homes
    P J Vojta
    Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 109:815-9. 2001
    ..005). Based on these data, we conclude that physical interventions offer practical, effective means of reducing house dust mite allergen levels in low-income, urban home environments...
  24. pmc NAG-1/GDF15 transgenic mouse has less white adipose tissue and a reduced inflammatory response
    J M Kim
    Laboratory of Molecular Carcinogenesis, National Institutes of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Mediators Inflamm 2013:641851. 2013
    ..We propose that the reduced white adipose tissue and reduced leptin expression may be responsible, in part, for the reduced inflammatory response to LPS and the decrease in intestinal tumors observed in NAG-1 (Tg/Lox) mice...
  25. ncbi request reprint Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4
    J Ma
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Genomics 49:152-5. 1998
    ..3-p31.2 by fluorescence in situ hybridization analysis. The proximity of the Cyp2j cluster to the Cyp4a cluster suggests that these genes may be part of a cassette of P450 genes involved in the oxidation of fatty acids...
  26. pmc Research on environmental health interventions: ethical problems and solutions
    David B Resnik
    National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, Mail Drop NH 06, Research Triangle Park, NC 27709, USA
    Account Res 12:69-101. 2005
    ....
  27. pmc Total IgE levels and asthma prevalence in the US population: results from the National Health and Nutrition Examination Survey 2005-2006
    Peter J Gergen
    Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md 20892 6601, USA
    J Allergy Clin Immunol 124:447-53. 2009
    ..The inability to measure IgE-based sensitivity to all allergens has limited our understanding of what portion of asthma is related to IgE. Total IgE measurement can potentially overcome this limitation...
  28. ncbi request reprint Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection
    Michelle A Carey
    Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Research Triangle Park, NC 27709, USA
    J Immunol 175:6878-84. 2005
    ..COX-1 deficiency is detrimental whereas COX-2 deficiency is beneficial to the host during influenza viral infection...
  29. pmc Questionnaire predictors of atopy in a US population sample: findings from the National Health and Nutrition Examination Survey, 2005-2006
    Jane A Hoppin
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709 2233, USA
    Am J Epidemiol 173:544-52. 2011
    ....
  30. pmc Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA
    Am J Respir Cell Mol Biol 37:300-8. 2007
    ..Collectively, these data suggest an important regulatory role for COX-2 in the maintenance of lung function in the setting of lung fibrosis, but not in the progression of the fibrotic process per se...
  31. pmc Environmental health research on hazards in the home and the duty to warn
    David B Resnik
    National Instituteof Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27516, USA
    Bioethics 22:209-17. 2008
    ..Investigators should discuss these issues with research subjects during the informed consent process...
  32. pmc Novel relationship of serum cholesterol with asthma and wheeze in the United States
    Michael B Fessler
    Department of Health and Human Services, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 124:967-74.e1-15. 2009
    ..Cholesterol exerts complex effects on inflammation. There has been little investigation of whether serum cholesterol is associated with asthma, an inflammatory airways disease with great public health impact...
  33. ncbi request reprint Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway
    John Seubert
    Division of Intramural Research, NIEHS NIH, Research Triangle Park, NC 27709, USA
    Circ Res 95:506-14. 2004
    ..Together, these data suggest that CYP2J2-derived metabolites are cardioprotective after ischemia, and the mechanism for this cardioprotection involves activation of mitoK(ATP) and p42/p44 MAPK...
  34. pmc Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis
    James C Bonner
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 161:459-70. 2002
    ..These findings indicate that the COX-2 enzyme is protective against pulmonary fibrogenesis, and we suggest that COX-2 generation of PGE(2) is an important factor in resolving inflammation...
  35. pmc First National Survey of Lead and Allergens in Housing: survey design and methods for the allergen and endotoxin components
    Patrick J Vojta
    Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 110:527-32. 2002
    ..S. households, their distribution by various housing characteristics, and their associations with allergic diseases such as asthma and rhinitis...
  36. pmc Relationship of serum cholesterol levels to atopy in the US population
    M B Fessler
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Allergy 65:859-64. 2010
    ....
  37. pmc Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study
    C R Lee
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Clin Pharmacol Ther 83:52-60. 2008
    ..072). These findings suggest that genetic variation in PTGS1 and PTGS2 may be important risk factors for the development of cardiovascular disease events. Confirmation in independent populations is necessary...
  38. pmc Exposure to Alternaria alternata in US homes is associated with asthma symptoms
    Päivi M Salo
    National Institute of Environmental Health Sciences, National Institutes of Health NIH, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 118:892-8. 2006
    ..Exposure to the fungus Alternaria alternata is a risk factor for asthma. Few studies have examined Alternaria exposures in indoor environments...
  39. ncbi request reprint Breast-feeding and the prevalence of asthma and wheeze in children: analyses from the Third National Health and Nutrition Examination Survey, 1988-1994
    Patricia C Chulada
    Office of Clinical Research, National Institute of Environmental Health Sciences NIH, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 111:328-36. 2003
    ..Breast-feeding might protect children against asthma and related conditions (recurrent wheeze), and this protective effect might depend on the duration and exclusivity of the breast-feeding regimen...
  40. ncbi request reprint House dust mite allergen in US beds: results from the First National Survey of Lead and Allergens in Housing
    Samuel J Arbes
    Division of Intramural Research, National Institute of Environmental Health Sciences NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 111:408-14. 2003
    ..Although exposure to house dust mite allergen is a major risk factor for allergic sensitization and asthma, nationwide estimates of dust mite allergen levels in US homes have not been reported...
  41. ncbi request reprint Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats
    J M Seubert
    Division of Intramural Research, National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Physiol Renal Physiol 289:F552-61. 2005
    ..Together, our data highlight the complexity of hypertension and the numerous genes involved in and affected by this condition...
  42. pmc CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study
    Craig R Lee
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Pharmacogenet Genomics 17:349-58. 2007
    ..The cytochromes P450 epoxygenases CYP2J2 and CYP2C8 synthesize epoxyeicosatrienoic acids, which regulate endothelial function. We sought to determine if genetic variation in CYP2J2 and CYP2C8 was associated with coronary heart disease risk...
  43. pmc Cyclooxygenase-1 overexpression decreases Basal airway responsiveness but not allergic inflammation
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709
    J Immunol 177:4785-93. 2006
    ..Collectively, these data indicate that COX-1 overexpression attenuates airway responsiveness under basal conditions but does not influence allergic airway inflammation...
  44. ncbi request reprint Molecular cloning and characterization of mouse CYP2J6, an unstable cytochrome P450 isoform
    Jixiang Ma
    Division of Intramural Research, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Building 101, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 64:1447-60. 2002
    ..We conclude that CYP2J6 is an unstable P450 that is active in the metabolism of benzphetamine, but not arachidonic acid...
  45. pmc Asthma cases attributable to atopy: results from the Third National Health and Nutrition Examination Survey
    Samuel J Arbes
    Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 120:1139-45. 2007
    ..The percentage of asthma cases attributable to atopy is the subject of debate...
  46. pmc Exposure to multiple indoor allergens in US homes and its relationship to asthma
    Päivi M Salo
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 121:678-684.e2. 2008
    ..The National Survey of Lead and Allergens in Housing was the first population-based study to measure indoor allergen levels in US homes...
  47. pmc Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis
    James W Voltz
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Respir Cell Mol Biol 39:45-52. 2008
    ..Sex differences should be carefully considered when designing and interpreting experimental models of pulmonary fibrosis in mice...
  48. pmc Dustborne Alternaria alternata antigens in US homes: results from the National Survey of Lead and Allergens in Housing
    Päivi M Salo
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 116:623-9. 2005
    ..Alternaria alternata is one of the most common fungi associated with allergic disease. However, Alternaria exposure in indoor environments is not well characterized...
  49. pmc Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice
    Craig R Lee
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 24:3770-81. 2010
    ..We conclude that endothelial CYP epoxygenase function contributes to the regulation of blood pressure...
  50. pmc Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissues
    Tracy C DeLozier
    National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Drug Metab Dispos 35:682-8. 2007
    ..The expression of CYP2J2 and CYP2C8 in human heart, and CYPC9 and CYP2J2 in aorta and coronary artery is consistent with a physiological role for these enzymes in these tissues...
  51. pmc Modulation of allergic airway inflammation by the oral pathogen Porphyromonas gingivalis
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Infect Immun 78:2488-96. 2010
    ..Furthermore, a temporal importance of the establishment of infection relative to allergen sensitization is demonstrated for allergic outcomes...
  52. ncbi request reprint Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development
    Donghui Zhang
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park, North Carolina 27709, USA
    J Neurochem 98:860-75. 2006
    ..These data suggest that RFX4_v3 may act upstream of critical signaling pathways in the process of brain development...
  53. ncbi request reprint Cloning of CYP2J2 gene and identification of functional polymorphisms
    Lorraine M King
    Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 61:840-52. 2002
    ..Insofar as CYP2J2 products have effects in the cardiovascular system, we speculate that these variants may be functionally relevant...
  54. pmc Oral pathogens and allergic disease: results from the Third National Health and Nutrition Examination Survey
    Samuel J Arbes
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 118:1169-75. 2006
    ..The hygiene hypothesis contends that fewer opportunities for infection have led to increases in the prevalences of asthma and other allergic diseases...
  55. pmc Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice
    Michelle A Carey
    Division of Intramural Research, NIH NIEHS, Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 175:126-35. 2007
    ..Airway hyperresponsiveness is a critical feature of asthma. Substantial epidemiologic evidence supports a role for female sex hormones in modulating lung function and airway hyperresponsiveness in humans...
  56. ncbi request reprint Abatement of cockroach allergens (Bla g 1 and Bla g 2) in low-income, urban housing: month 12 continuation results
    Samuel J Arbes
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle, NC 27709, USA
    J Allergy Clin Immunol 113:109-14. 2004
    ....
  57. pmc It's all about sex: gender, lung development and lung disease
    Michelle A Carey
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Trends Endocrinol Metab 18:308-13. 2007
    ..In this review, the influence of gender and sex hormones on lung development and pathology will be discussed, with specific emphasis on pulmonary fibrosis, asthma and cancer...
  58. pmc The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver
    Yoshihiro Konno
    Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Drug Metab Dispos 38:1177-82. 2010
    ..Chronic PB treatment increased hepatic microsomal CYP2C55 protein and serum 19-HETE levels. These findings indicate that CAR and PXR may play a role in regulation of drug-induced synthesis of 19-HETE in the mouse...
  59. ncbi request reprint Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1-/- but not cyclooxygenase-2-/- mice
    Michelle A Carey
    National Institute of Environmental Health Sciences NIH, 111 TW Alexander Drive, Building 101, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 167:1509-15. 2003
    ..These data suggest that genetic deficiency of COX-1 but not COX-2 modulates T cell recruitment, Th2 cytokine secretion, and lung function in the allergic airway...
  60. ncbi request reprint Abatement of cockroach allergen (Bla g 1) in low-income, urban housing: A randomized controlled trial
    Samuel J Arbes
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Allergy Clin Immunol 112:339-45. 2003
    ..Clinically relevant reductions in exposure to cockroach allergen, an important risk factor for asthma in inner-city households, have proven difficult to achieve in intervention trials...
  61. ncbi request reprint CYP2C44, a new murine CYP2C that metabolizes arachidonic acid to unique stereospecific products
    Tracy C DeLozier
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, P O Box 12233, 111 T W Alexander Drive, Building 101, Research Triangle Park, NC 27709
    J Pharmacol Exp Ther 310:845-54. 2004
    ....
  62. ncbi request reprint Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension
    Lorraine M King
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Pharmacogenet Genomics 15:7-13. 2005
    ..Confirmation of these findings in additional populations is warranted...
  63. ncbi request reprint Cyclooxygenase enzymes in allergic inflammation and asthma
    Michelle A Carey
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive Mail Drop D2 02, Research Triangle Park, NC 27709, USA
    Prostaglandins Leukot Essent Fatty Acids 69:157-62. 2003
    ....
  64. ncbi request reprint Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities
    Hong Wang
    Laboratories of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 65:1148-58. 2004
    ..We conclude that these new CYP2C enzymes are probably involved in AA and linoleic acid metabolism in mouse hepatic and extrahepatic tissues...
  65. ncbi request reprint Dog allergen (Can f 1) and cat allergen (Fel d 1) in US homes: results from the National Survey of Lead and Allergens in Housing
    Samuel J Arbes
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 114:111-7. 2004
    ..Exposures to dog and cat allergens are believed to play important roles in the etiology of asthma; however, the levels of these allergens have never been assessed in a representative sample of US homes...
  66. ncbi request reprint Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey
    Samuel J Arbes
    Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, USA
    J Allergy Clin Immunol 116:377-83. 2005
    ..Allergy skin tests were administered in the second and third National Health and Nutrition Examination Surveys (NHANES II and III) conducted in the United States from 1976 through 1980 and 1988 through 1994, respectively...
  67. pmc Prostaglandin E₂ protects murine lungs from bleomycin-induced pulmonary fibrosis and lung dysfunction
    Ryan T Dackor
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Lung Cell Mol Physiol 301:L645-55. 2011
    ..In summary, PGE(2) prevented the decline in lung static compliance and protected against lung fibrosis when it was administered before bleomycin challenge but had no therapeutic effect when administered after bleomycin challenge...
  68. pmc Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart
    Matthew L Edin
    Division of Intramural Research, National Institute for Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 25:3436-47. 2011
    ..These data demonstrate that increased ROS generation and enhanced DiHOME synthesis by endothelial CYP2C8 impair functional recovery and mask the beneficial effects of increased EET production following I/R...
  69. pmc Cyclooxygenase-2 regulates Th17 cell differentiation during allergic lung inflammation
    Hong Li
    Laboratories of Respiratory Biology National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Respir Crit Care Med 184:37-49. 2011
    ..It is unknown whether cyclooxygenase (COX)-derived eicosanoids regulate Th17 cells during allergic lung inflammation...
  70. pmc Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury
    Abe C Thomas
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Respir Cell Mol Biol 44:648-54. 2011
    ..Thus, this study defines the anatomic, functional, and biochemical characteristics of ventilation defects associated with the administration of LPS in a murine model of acute lung injury...
  71. pmc Male sex hormones promote vagally mediated reflex airway responsiveness to cholinergic stimulation
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, 111 T W Alexander Dr, Bldg 101, Rm D236, Research Triangle Park, NC 27709, USA
    Am J Physiol Lung Cell Mol Physiol 292:L908-14. 2007
    ..Together, these data indicate that male sex hormones promote cholinergic airway responsiveness via a vagally mediated reflex mechanism that may be important in the regulation of airway tone in the normal and diseased lung...
  72. ncbi request reprint Exposure to indoor allergens in day-care facilities: results from 2 North Carolina counties
    Samuel J Arbes
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, MD, USA
    J Allergy Clin Immunol 116:133-9. 2005
    ..With 63% of US children under 5 years of age in regular child care, day-care facilities could be an important source of exposure to indoor allergens...
  73. pmc Cockroach allergen reduction by cockroach control alone in low-income urban homes: a randomized control trial
    Michelle L Sever
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 120:849-55. 2007
    ..We previously reported significant reductions in cockroach allergen concentrations in urban homes by reducing cockroach infestations...
  74. pmc Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study
    Craig R Lee
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health Research, Triangle Park, NC 27709, USA
    Hum Mol Genet 15:1640-9. 2006
    ..315). Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene...
  75. pmc Indoor allergens in school and day care environments
    Päivi M Salo
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 124:185-92, 192.e1-9; quiz 193-4. 2009
    ....
  76. ncbi request reprint Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4
    Perry J Blackshear
    Office of Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Development 130:4539-52. 2003
    ..These findings may be relevant to human congenital hydrocephalus, a birth defect that affects approximately 0.6 per 1000 newborns...
  77. ncbi request reprint Regulation of mouse renal CYP2J5 expression by sex hormones
    Jixiang Ma
    Division of Intramural Research, National Institutes of Health NIEHS, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 65:730-43. 2004
    ..Based on these data, we conclude that the renal expression of CYP2J5 is up-regulated by androgen and down-regulated by estrogen...
  78. pmc Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    J Immunol 177:621-30. 2006
    ..These gender differences are mediated, at least in part, by effects of androgens...
  79. pmc Feasibility of using subject-collected dust samples in epidemiologic and clinical studies of indoor allergens
    Samuel J Arbes
    Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 113:665-9. 2005
    ..With some limitations, subject-collected dust sampling appears to be a valid and practical option for epidemiologic and clinical studies that report allergen concentration as a measure of exposure...
  80. ncbi request reprint Induction of cardiac cytochrome p450 in cocaine-treated mice
    Ju Feng Wang
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Exp Biol Med (Maywood) 227:182-8. 2002
    ..We speculate that induction of P450 isoforms may cause cardiac injury due to cocaine metabolites locally catalyzed by P450 or the increase in P450 expression itself...
  81. pmc The prevalence of lead-based paint hazards in U.S. housing
    David E Jacobs
    U S Department of Housing and Urban Development, Office of Healthy Homes and Lead Hazard Control, Washington, DC 20410, USA
    Environ Health Perspect 110:A599-606. 2002
    ..Public- and private-sector resources should be directed to units posing the greatest risk if future lead poisoning is to be prevented...
  82. ncbi request reprint Excess nitric oxide decreases cytochrome P-450 2J4 content and P-450-dependent arachidonic acid metabolism in lungs of rats with acute pneumonia
    Asma Yaghi
    London Health Sciences Research Institute, AC Burton Vascular Biology Laboratory, London Health Sciences Centre, Victoria Campus, 375 South St, London, Ontario, Canada N6A 4G5
    Am J Physiol Lung Cell Mol Physiol 286:L1260-7. 2004
    ..We speculate CYP2J4 and its AA metabolites are involved in the modulation of pulmonary function in health and disease...
  83. pmc Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes
    Robert A B van Waterschoot
    Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Pharmacol 73:1029-36. 2008
    ..Such flexible compensatory interplay between functionally related detoxifying systems is probably essential to their biological role in xenobiotic protection...
  84. pmc Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine
    Michael Zhuo Wang
    School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Drug Metab Dispos 35:2067-75. 2007
    ..We conclude that enteric CYP4F enzymes could play a role in the first-pass biotransformation of DB289 and other xenobiotics...
  85. pmc The human intestinal cytochrome P450 "pie"
    Mary F Paine
    General Clinical Research Center, Room 3005 Bldg APCF, CB 7600, UNC Hospitals, Chapel Hill, NC 27599 7600, USA
    Drug Metab Dispos 34:880-6. 2006
    ..On average, CYP3A and CYP2C9 represents the major pieces of the intestinal P450 pie, accounting for 80 and 15%, respectively, of total immunoquantified P450s...
  86. pmc Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2
    Martin Spiecker
    Department of Medicine II Cardiology, St Josef Hospital, University of Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Circulation 110:2132-6. 2004
    ..The EETs are potent endogenous vasodilators and inhibitors of vascular inflammation. However, it is not known whether genetic polymorphisms of CYP2J2 are associated with increased cardiovascular risks...
  87. ncbi request reprint Pulmonary cytochrome P-450 2J4 is reduced in a rat model of acute Pseudomonas pneumonia
    Asma Yaghi
    AC Burton Vascular Biology Laboratory, Lawson Health Research Institute, Respirology, London Health Sciences Centre, Victoria Campus, London, Ontario N6A 4G5, Canada
    Am J Physiol Lung Cell Mol Physiol 285:L1099-105. 2003
    ..We speculate that CYP2J (but not CYP2B) enzymes and their AA metabolic products (EETs) are involved in the modulation of pulmonary vascular tone in pneumonia in rats...
  88. pmc Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2
    Pierre Lafite
    Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 Université Paris Descartes, CNRS, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    Arch Biochem Biophys 464:155-68. 2007
    ..These new selective inhibitors should be interesting tools to study the biological roles of CYP2J2...
  89. ncbi request reprint Inhaled nitric oxide attenuates hyperoxic lung injury in lambs
    Robert B Cotton
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Pediatr Res 59:142-6. 2006
    ..However, this study provides no direct evidence that NO is inhibiting CYP-mediated oxidant lung injury...
  90. pmc Endotoxin exposure is a risk factor for asthma: the national survey of endotoxin in United States housing
    Peter S Thorne
    Department of Occupational and Environmental Health, College of Public Health, University of Iowa, 100 Oakdale Campus, 176 IREH, Iowa City, IA 52242 5000, USA
    Am J Respir Crit Care Med 172:1371-7. 2005
    ..We assayed 2,552 house dust samples in a representative nationwide sam- ple to explore relationships between endotoxin exposures and risk factors for asthma, asthma symptoms, and medication use...
  91. ncbi request reprint Enhancement of cardiac L-type Ca2+ currents in transgenic mice with cardiac-specific overexpression of CYP2J2
    Yong Fu Xiao
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Mol Pharmacol 66:1607-16. 2004
    ..In conclusion, overexpression of CYP2J2 increases ICa in CYP2J2 transgenic cardiomyocytes via a mechanism that involves cAMP-protein kinase A-dependent phosphorylation of the L-type Ca2+ channel...
  92. ncbi request reprint Cytochrome p450 epoxygenase promotes human cancer metastasis
    Jian Gang Jiang
    The Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, People s Republic of China
    Cancer Res 67:6665-74. 2007
    ..Together, these data suggest that CYP epoxygenase inhibition may represent a novel approach to prevent metastasis of human cancers...
  93. ncbi request reprint Alternaria alternata antigens in US homes
    Päivi M Salo
    J Allergy Clin Immunol 117:473; author reply 474. 2006
  94. pmc Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms
    Tong Lu
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 575:627-44. 2006
    ....
  95. pmc Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function
    John M Seubert
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada
    Circ Res 99:442-50. 2006
    ..Together, these data suggest that targeted disruption of sEH increases the availability of cardioprotective EETs that work by activating PI3K signaling pathways and K+ channels...
  96. pmc Unusual regioselectivity and active site topology of human cytochrome P450 2J2
    Pierre Lafite
    Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS UMR 8601, Universite Paris Descartes, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    Biochemistry 46:10237-47. 2007
    ..The structural features that have been found to be important for recognition of substrates or inhibitors by CYP2J2 were also interpreted on the basis of CYP2J2-substrate interactions in this model...
  97. pmc Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1)
    Craig R Lee
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Chapel Hill, North Carolina, USA
    Pharmacogenet Genomics 17:145-60. 2007
    ..We sought to identify and characterize the functional relevance of genetic polymorphisms in PTGS1...
  98. pmc Variability of CYP2J2 expression in human fetal tissues
    Andrea Gaedigk
    Children s Mercy Hospital, Division of Clinical Pharmacology, 2401 Gillham Rd, Kansas City, MO 64108, USA
    J Pharmacol Exp Ther 319:523-32. 2006
    ..Due to premature termination codons, none encodes functional protein. The mechanisms leading to variable amounts of immunoreactive protein and distinct pre- and postnatal CYP2J2 protein patterns warrant further investigation...
  99. pmc Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2
    Pierre Lafite
    Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Universite Paris 5 Rene Descartes, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    Bioorg Med Chem Lett 16:2777-80. 2006
    ..This paper reports a first series of high-affinity, selective CYP2J2 inhibitors that are related to terfenadine, with K(i) values as low as 160nM, that should be useful tools to determine the biological roles of CYP2J2...
  100. ncbi request reprint Proficiency testing of allergen measurements in residential dust
    Alan D Pate
    Battelle Memorial Institute, Columbus, OH, USA
    J Allergy Clin Immunol 116:844-50. 2005
    ..Moreover, there is an absence of peer-reviewed data on within-laboratory and between-laboratory variability that is achievable for these analyses...
  101. ncbi request reprint National prevalence and exposure risk for mouse allergen in US households
    Richard D Cohn
    Constella Group Inc, Durham, North Carolina, USA
    J Allergy Clin Immunol 113:1167-71. 2004
    ..It has never been characterized on a nationally representative scale...